Mechanism of the antihypertensive and vasorelaxant effects of the flavonoid tiliroside in resistance arteries

Planta Medica

Volumn 79, Issue 12, 2013, Pages 1003-1008

  Silva, Grazielle C ^a   Pereira, Aline C ^a   Rezende, Bruno A ^a   Da Silva, José P Felippe ^a   Cruz, Jader S ^a   De Souza, Maria De Fátima V ^b   Gomes, Roosevelt A ^b   Teles, Yanna C F ^b   Cortes, Steyner F ^a   Lemos, Virginia S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

antihypertensive effect; CaV 1.2; flavonoids; mesenteric artery; tiliroside; vasodilation

Indexed keywords

ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL L TYPE; FLAVONOID; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; PHENYLEPHRINE; TILIROSIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HEART RATE; HYPERTENSION; MALE; NONHUMAN; PATCH CLAMP; RAT; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

RATTUS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; FLAVONOIDS; HYPERTENSION; MESENTERIC ARTERIES; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; RATS; VASODILATION; VASODILATOR AGENTS;

EID: 84882860495     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328765     Document Type: Article

References (29)

1. Palatini P., Casiglia E., Gasowski J., Głuszek J., Jankowski P., Narkiewicz K., Saladini F., Stolarz-Skrzypek K., Tikhonoff V., Van Bortel L., Wojciechowska W., Kawecka-Jaszcz K. Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension. Vasc Health Risk Manag: 2011; 7 725 739
2. White R. M., Rivera C. O., Davison C. B. Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone-salt hypertensive rats. Hypertension: 1996; 27 1245 1253 (Pubitemid 26165626)
3. 2+ channels in vascular smooth muscle: multiple functions. Cell Calcium: 2006; 40 221 230 (Pubitemid 43942303)
4. Richard S. Vascular effects of calcium channel antagonists: new evidence. Drugs: 2005; 65 1 10 (Pubitemid 41480575)
5. Wei D., He W. Y., Lv Q. Z. Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients. CNS Neurosci Ther: 2012; 18 400 405
6. Yao L. H., Jiang Y. M., Tomás-Barberán F. A., Datta N., Singanusong R., Chen S. S. Flavonoids in food and their health benefits. Plant Food Hum Nutr: 2004; 59 113 122 (Pubitemid 40172010)
7. Riemersma R. A., Rice-Evans C. A., Tyrrel R. M., Clifford M. N. Tea flavonoids and cardiovascular health. QJM: 2001; 94 277 282 (Pubitemid 32492751)
8. Kay C. D., Hooper L., Kroon P. A., Rimm E. B., Cassidy A. Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products. Mol Nutr Food Res: 2012; 56 605 616
9. Godse S., Mohan M., Kasture V., Kasture S. Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats. Pharm Biol: 2010; 48 494 498
10. Schinella G. R., Tournier H. A., Máñez S., de Buschiazzo P. M., Del Carmen Recio M., Ríos J. L. Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation. Fitoterapia: 2007; 78 1 6 (Pubitemid 44909361)
11. Sala A., Recio M. C., Schinella G. R., Máñez S., Giner R. M., Cerdá-Nicolás M., Ríos J. L. Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. Eur J Pharmacol: 2003; 461 53 61 (Pubitemid 36144265)
12. Qiao W., Zhao C., Qin N., Zhai H. Y., Duan H. Q. Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis. J Ethnopharmacol: 2011; 135 515 521
13. Goto T., Teraminamia A., Lee J. Y., Ohyamaa K., Funakoshia K., Kim Y. I., Hirai S., Uemura T., Yu R., Takahashi N., Kawada T. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J Nutr Biochem: 2012; 23 768 776
14. Rezende B. A., Cortes S. F., De Sousa F. B., Lula I. S., Schmitt M., Sinisterra R. D., Lemos V. S. Complexation with beta-cyclodextrin confers oral activity on the flavonoid dioclein. Int J Pharm: 2009; 367 133 139
15. Gross V., Luft F. C. Exercising restraint in measuring blood pressure in conscious mice. Hypertension: 2003; 41 879 881 (Pubitemid 36418460)
16. Rezende B. A., Lemos V. S., Cortes S. F. Activation of nitric oxide modulator effect by isometric contraction in rat resistance arteries. J Cardiovasc Pharmacol: 2006; 47 51 54 (Pubitemid 44378224)
17. 2+ currents and increases vascular contractility in a mouse model of type 1 diabetes. Br J Pharmacol: 2010; 161 1458 1471
18. Silva D. A., Costa D. A., Silva D., Souza M. FV, Agra M. F., Medeiros I. A., Barbosa-Filho J. M., Braz-Filho R. Glycosyl flavonoids from Herissantia tiubae (K. Schum) Brizicky (Malvaceae) and preliminary tests of kaempferol 3, 7-di-O-a-L-rhamnopyranoside. Rev Bras Farmacogn: 2005; 15 23 25
19. Chobanian A. V., Bakris G. L., Black H. R., Cushman W. C., Green L. A., Izzo J. L. Jr., Jones D. W., Materson B. J., Oparil S., Wright J. T. Jr., Roccella E. J. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute National High Blood Pressure Education Program Coordinating Committee Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension: 2003; 42 1206 1252 (Pubitemid 37553153)
20. Cortes S. F., Rezende B. A., Corriu C., Medeiros I. A., Teixeira M. M., Lopes M. J., Lemos V. S. Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries. Br J Pharmacol: 2001; 133 849 858 (Pubitemid 32751794)
21. Rezende B. A., Cortes S. F., Lemos V. S. Mechanisms involved in the vasodilator effect of the flavanol floranol in rat small mesenteric arteries. Planta Med: 2004; 70 465 467 (Pubitemid 38716482)
22. v 1.2 channels. Br J Pharmacol: 2011; 164 1684 1697
23. Nelson M. T., Quayle J. M. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol: 1995; 268 C799 C822
24. + channel openers, nitrate derivatives, salbutamol and papaverine in rat aortic rings. Naunyn Schmiedebergs Arch Pharmacol: 1998; 358 452 463 (Pubitemid 28470843)
25. Bolton T. B. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev: 1979; 59 606 718 (Pubitemid 9236600)
26. Nelson M. T., Standen N. B., Brayden J. E., Worley J. F. Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature: 1988; 336 382 385
27. Jim K., Harris A., Rosenberger L. B., Triggle D. J. Stereoselective and non-stereoselective effects of D 600 (methoxyverapamil) in smooth muscle preparations. Eur J Pharmacol: 1988; 76 67 72
28. Kochegarov A. A. Pharmacological modulators of voltage-gated calcium channels and their therapeutical application. Cell Calcium: 2003; 33 145 162 (Pubitemid 36336303)
29. 2+ channels. Naunyn Schmiedebergs Arch Pharmacol: 2009; 379 115 125