Complexation with β-cyclodextrin confers oral activity on the flavonoid dioclein

International Journal of Pharmaceutics

Volumn 367, Issue 1-2, 2009, Pages 133-139

  Rezende, Bruno A ^a   Cortes, Steyner F ^a   De Sousa, Frederico B ^a   Lula, Ivana S ^a   Schmitt, Martine ^b   Sinisterra, Rubén D ^a   Lemos, Virginia S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b CNRS   (France)

Author keywords

Cyclodextrins; Dioclein; Dioclein cyclodextrin complexation; Drug effects; Flavonoids; Inclusion complex; Oral therapeutic efficacy

Indexed keywords

BETA CYCLODEXTRIN; DIOCLEIN; ENZYME; FLAVONOID; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BIODEGRADATION; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFECT; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, ORAL; ANIMALS; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; FLAVANONES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MESENTERIC ARTERIES; MICE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS;

EID: 58349119768     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.09.046     Document Type: Article

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