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Volumn 23, Issue 7, 2012, Pages 768-776

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice

Author keywords

Adiponectin; AMPK; Fatty acid oxidation; Insulin resistance; PPAR ; Tiliroside

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; ANTIOBESITY AGENT; FATTY ACID; FLAVONOID GLYCOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MESSENGER RNA; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TILIROSIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84859208777     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.04.001     Document Type: Article
Times cited : (99)

References (64)
  • 2
    • 30044439080 scopus 로고    scopus 로고
    • Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
    • Yach D., Stuckler D., Brownell K.D. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 2006, 12:62-66.
    • (2006) Nat Med , vol.12 , pp. 62-66
    • Yach, D.1    Stuckler, D.2    Brownell, K.D.3
  • 3
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: new perspective on obesity and related disorders
    • Unger R.H., Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 2001, 15:312-321.
    • (2001) FASEB J , vol.15 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 4
    • 42949116365 scopus 로고    scopus 로고
    • Lipid accumulation in non-adipose tissue and lipotoxicity
    • van Herpen N.A., Schrauwen-Hinderling V.B. Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav 2008, 94:231-241.
    • (2008) Physiol Behav , vol.94 , pp. 231-241
    • van Herpen, N.A.1    Schrauwen-Hinderling, V.B.2
  • 5
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • Harborne J.B., Williams C.A. Advances in flavonoid research since 1992. Phytochemistry 2000, 55:481-504.
    • (2000) Phytochemistry , vol.55 , pp. 481-504
    • Harborne, J.B.1    Williams, C.A.2
  • 6
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: nomenclature, occurrence and intake
    • Beecher G.R. Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 2003, 133:3248S-3254S.
    • (2003) J Nutr , vol.133
    • Beecher, G.R.1
  • 7
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: bioavailability, metabolic effects, and safety
    • Ross J.A., Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002, 22:19-34.
    • (2002) Annu Rev Nutr , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 8
    • 0022568216 scopus 로고
    • Plant pigments as natural food colours
    • Timberlake C.F., Henry B.S. Plant pigments as natural food colours. Endeavour 1986, 10:31-36.
    • (1986) Endeavour , vol.10 , pp. 31-36
    • Timberlake, C.F.1    Henry, B.S.2
  • 9
    • 12844272321 scopus 로고    scopus 로고
    • Polyphenols and disease risk in epidemiologic studies
    • Arts I.C., Hollman P.C. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005, 81:317S-325S.
    • (2005) Am J Clin Nutr , vol.81
    • Arts, I.C.1    Hollman, P.C.2
  • 11
    • 33748324543 scopus 로고    scopus 로고
    • Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver
    • Peluso M.R. Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Exp Biol Med (Maywood) 2006, 231:1287-1299.
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 1287-1299
    • Peluso, M.R.1
  • 12
    • 33846803914 scopus 로고    scopus 로고
    • Inhibition of the intestinal glucose transporter GLUT2 by flavonoids
    • Kwon O., Eck P., Chen S., Corpe C.P., Lee J.H., Kruhlak M., et al. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J 2007, 21:366-377.
    • (2007) FASEB J , vol.21 , pp. 366-377
    • Kwon, O.1    Eck, P.2    Chen, S.3    Corpe, C.P.4    Lee, J.H.5    Kruhlak, M.6
  • 13
    • 0036866660 scopus 로고    scopus 로고
    • Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver
    • Murase T., Nagasawa A., Suzuki J., Hase T., Tokimitsu I. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord 2002, 26:1459-1464.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 1459-1464
    • Murase, T.1    Nagasawa, A.2    Suzuki, J.3    Hase, T.4    Tokimitsu, I.5
  • 14
    • 80051853563 scopus 로고    scopus 로고
    • Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome
    • Tsuda T. Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome. J Agric Food Chem 2008, 56:642-646.
    • (2008) J Agric Food Chem , vol.56 , pp. 642-646
    • Tsuda, T.1
  • 15
    • 0036152763 scopus 로고    scopus 로고
    • Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action
    • Matsuda H., Ninomiya K., Shimoda H., Yoshikawa M. Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action. Bioorg Med Chem 2002, 10:707-712.
    • (2002) Bioorg Med Chem , vol.10 , pp. 707-712
    • Matsuda, H.1    Ninomiya, K.2    Shimoda, H.3    Yoshikawa, M.4
  • 16
    • 34247895642 scopus 로고    scopus 로고
    • Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside
    • Ninomiya K., Matsuda H., Kubo M., Morikawa T., Nishida N., Yoshikawa M. Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside. Bioorg Med Chem Lett 2007, 17:3059-3064.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 3059-3064
    • Ninomiya, K.1    Matsuda, H.2    Kubo, M.3    Morikawa, T.4    Nishida, N.5    Yoshikawa, M.6
  • 17
    • 10044247087 scopus 로고    scopus 로고
    • Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa
    • Tsukamoto S., Tomise K., Aburatani M., Onuki H., Hirorta H., Ishiharajima E., et al. Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa. J Nat Prod 2004, 67:1839-1841.
    • (2004) J Nat Prod , vol.67 , pp. 1839-1841
    • Tsukamoto, S.1    Tomise, K.2    Aburatani, M.3    Onuki, H.4    Hirorta, H.5    Ishiharajima, E.6
  • 18
  • 19
    • 44349158865 scopus 로고    scopus 로고
    • Human DNA topoisomerase inhibitors from Potentilla argentea and their cytotoxic effect against MCF-7
    • Tomczyk M., Drozdowska D., Bielawska A., Bielawski K., Gudej J. Human DNA topoisomerase inhibitors from Potentilla argentea and their cytotoxic effect against MCF-7. Pharmazie 2008, 63:389-393.
    • (2008) Pharmazie , vol.63 , pp. 389-393
    • Tomczyk, M.1    Drozdowska, D.2    Bielawska, A.3    Bielawski, K.4    Gudej, J.5
  • 20
    • 34547117120 scopus 로고    scopus 로고
    • Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study
    • Rao Y.K., Geethangili M., Fang S.H., Tzeng Y.M. Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol 2007, 45:1770-1776.
    • (2007) Food Chem Toxicol , vol.45 , pp. 1770-1776
    • Rao, Y.K.1    Geethangili, M.2    Fang, S.H.3    Tzeng, Y.M.4
  • 21
    • 0015450524 scopus 로고
    • Induction of diabetic alterations by goldthioglucose-obesity in KK,ICR and C57BL mice
    • Matsuo T., Shino A. Induction of diabetic alterations by goldthioglucose-obesity in KK,ICR and C57BL mice. Diabetologia 1972, 8:391-397.
    • (1972) Diabetologia , vol.8 , pp. 391-397
    • Matsuo, T.1    Shino, A.2
  • 23
    • 38349006256 scopus 로고    scopus 로고
    • Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
    • Muniyappa R., Lee S., Chen H., Quon M.J. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 2009, 294:E15-E26.
    • (2009) Am J Physiol Endocrinol Metab , vol.294
    • Muniyappa, R.1    Lee, S.2    Chen, H.3    Quon, M.J.4
  • 24
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 25
    • 0141924849 scopus 로고    scopus 로고
    • Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin
    • Waki H., Yamauchi T., Kamon J., Ito Y., Uchida S., Kita S., et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003, 278:40352-40363.
    • (2003) J Biol Chem , vol.278 , pp. 40352-40363
    • Waki, H.1    Yamauchi, T.2    Kamon, J.3    Ito, Y.4    Uchida, S.5    Kita, S.6
  • 26
    • 37549021158 scopus 로고    scopus 로고
    • Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
    • Kuroyanagi K., Kang M.S., Goto T., Hirai S., Ohyama K., Kusudo T., et al. Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2008, 366:219-225.
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 219-225
    • Kuroyanagi, K.1    Kang, M.S.2    Goto, T.3    Hirai, S.4    Ohyama, K.5    Kusudo, T.6
  • 27
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002, 8:1288-1295.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3    Ito, Y.4    Waki, H.5    Uchida, S.6
  • 28
    • 0037053361 scopus 로고    scopus 로고
    • Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma
    • Takahashi N., Kawada T., Yamamoto T., Goto T., Taimatsu A., Aoki N., et al. Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. J Biol Chem 2002, 277:16906-16912.
    • (2002) J Biol Chem , vol.277 , pp. 16906-16912
    • Takahashi, N.1    Kawada, T.2    Yamamoto, T.3    Goto, T.4    Taimatsu, A.5    Aoki, N.6
  • 29
    • 18344374193 scopus 로고    scopus 로고
    • Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes
    • Takahashi N., Kawada T., Goto T., Yamamoto T., Taimatsu A., Matsui N., et al. Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett 2002, 514:315-322.
    • (2002) FEBS Lett , vol.514 , pp. 315-322
    • Takahashi, N.1    Kawada, T.2    Goto, T.3    Yamamoto, T.4    Taimatsu, A.5    Matsui, N.6
  • 30
    • 26444457309 scopus 로고    scopus 로고
    • Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes
    • Goto T., Takahashi N., Kato S., Egawa K., Ebisu S., Moriyama T., et al. Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes. Biochem Biophys Res Commun 2005, 337:440-445.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 440-445
    • Goto, T.1    Takahashi, N.2    Kato, S.3    Egawa, K.4    Ebisu, S.5    Moriyama, T.6
  • 31
    • 33646572904 scopus 로고    scopus 로고
    • The metabolic syndrome and adipocytokines
    • Matsuzawa Y. The metabolic syndrome and adipocytokines. FEBS Lett 2006, 580:2917-2921.
    • (2006) FEBS Lett , vol.580 , pp. 2917-2921
    • Matsuzawa, Y.1
  • 32
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T., Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005, 26:439-451.
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 33
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Müller C., Carling D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002, 415:339-343.
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3    Fryer, L.G.4    Müller, C.5    Carling, D.6
  • 34
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001, 7:941-946.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Terauchi, Y.4    Kubota, N.5    Hara, K.6
  • 36
    • 1542319262 scopus 로고    scopus 로고
    • Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
    • Tsuda T., Ueno Y., Aoki H., Koda T., Horio F., Takahashi N., et al. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun 2004, 316:149-157.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 149-157
    • Tsuda, T.1    Ueno, Y.2    Aoki, H.3    Koda, T.4    Horio, F.5    Takahashi, N.6
  • 37
    • 56649109706 scopus 로고    scopus 로고
    • (-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation
    • Shin D.W., Kim S.N., Lee S.M., Lee W., Song M.J., Park S.M., et al. (-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation. Biochem Pharmacol 2009, 77:125-133.
    • (2009) Biochem Pharmacol , vol.77 , pp. 125-133
    • Shin, D.W.1    Kim, S.N.2    Lee, S.M.3    Lee, W.4    Song, M.J.5    Park, S.M.6
  • 38
    • 18644369745 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians
    • Vasseur F., Helbecque N., Dina C., Lobbens S., Delannoy V., Gaget S., et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002, 11:2607-2614.
    • (2002) Hum Mol Genet , vol.11 , pp. 2607-2614
    • Vasseur, F.1    Helbecque, N.2    Dina, C.3    Lobbens, S.4    Delannoy, V.5    Gaget, S.6
  • 39
    • 11144355637 scopus 로고    scopus 로고
    • Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    • Pajvani U.B., Hawkins M., Combs T.P., Rajala M.W., Doebber T., Berger J.P., et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004, 279:12152-12162.
    • (2004) J Biol Chem , vol.279 , pp. 12152-12162
    • Pajvani, U.B.1    Hawkins, M.2    Combs, T.P.3    Rajala, M.W.4    Doebber, T.5    Berger, J.P.6
  • 40
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1    Kamon, J.2    Ito, Y.3    Tsuchida, A.4    Yokomizo, T.5    Kita, S.6
  • 41
    • 33847733103 scopus 로고    scopus 로고
    • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
    • Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007, 13:332-339.
    • (2007) Nat Med , vol.13 , pp. 332-339
    • Yamauchi, T.1    Nio, Y.2    Maki, T.3    Kobayashi, M.4    Takazawa, T.5    Iwabu, M.6
  • 42
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant O., Foufelle F., Scotto C., Dauça M., Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 1996, 137:354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauça, M.4    Wahli, W.5
  • 43
    • 0037135623 scopus 로고    scopus 로고
    • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    • Muoio D.M., MacLean P.S., Lang D.B., Li S., Houmard J.A., Way J.M., et al. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. J Biol Chem 2002, 277:26089-26097.
    • (2002) J Biol Chem , vol.277 , pp. 26089-26097
    • Muoio, D.M.1    MacLean, P.S.2    Lang, D.B.3    Li, S.4    Houmard, J.A.5    Way, J.M.6
  • 44
    • 2942622680 scopus 로고    scopus 로고
    • Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of type 2 diabetic patients
    • Debard C., Laville M., Berbe V., Loizon E., Guillet C., Morio-Liondore B., et al. Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of type 2 diabetic patients. Diabetologia 2004, 47:917-925.
    • (2004) Diabetologia , vol.47 , pp. 917-925
    • Debard, C.1    Laville, M.2    Berbe, V.3    Loizon, E.4    Guillet, C.5    Morio-Liondore, B.6
  • 45
    • 4344713648 scopus 로고    scopus 로고
    • Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism
    • Staiger H., Kaltenbach S., Staiger K., Stefan N., Fritsche A., Guirguis A., et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes 2004, 53:2195-2201.
    • (2004) Diabetes , vol.53 , pp. 2195-2201
    • Staiger, H.1    Kaltenbach, S.2    Staiger, K.3    Stefan, N.4    Fritsche, A.5    Guirguis, A.6
  • 46
    • 33745279065 scopus 로고    scopus 로고
    • The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice
    • Huang H., Iida K.T., Sone H., Yokoo T., Yamada N., Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. J Endocrinol 2006, 189:643-653.
    • (2006) J Endocrinol , vol.189 , pp. 643-653
    • Huang, H.1    Iida, K.T.2    Sone, H.3    Yokoo, T.4    Yamada, N.5    Ajisaka, R.6
  • 47
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley D.E., Goodpaster B., Wing R.R., Simoneau J.A. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 1999, 277:E1130-E1141.
    • (1999) Am J Physiol , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 50
    • 3042569137 scopus 로고    scopus 로고
    • Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis
    • Lindén D., William-Olsson L., Rhedin M., Asztély A.K., Clapham J.C., Schreyer S. Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis. J Lipid Res 2004, 45:1279-1288.
    • (2004) J Lipid Res , vol.45 , pp. 1279-1288
    • Lindén, D.1    William-Olsson, L.2    Rhedin, M.3    Asztély, A.K.4    Clapham, J.C.5    Schreyer, S.6
  • 51
    • 33645820583 scopus 로고    scopus 로고
    • Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
    • Lindén D., William-Olsson L., Ahnmark A., Ekroos K., Hallberg C., Sjögren H.P., et al. Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation. FASEB J 2006, 20:434-443.
    • (2006) FASEB J , vol.20 , pp. 434-443
    • Lindén, D.1    William-Olsson, L.2    Ahnmark, A.3    Ekroos, K.4    Hallberg, C.5    Sjögren, H.P.6
  • 53
    • 66949149506 scopus 로고    scopus 로고
    • Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids
    • Akkaoui M., Cohen I., Esnous C., Lenoir V., Sournac M., Girard J., et al. Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids. Biochem J 2009, 420:429-438.
    • (2009) Biochem J , vol.420 , pp. 429-438
    • Akkaoui, M.1    Cohen, I.2    Esnous, C.3    Lenoir, V.4    Sournac, M.5    Girard, J.6
  • 54
    • 62749140758 scopus 로고    scopus 로고
    • Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance
    • Bruce C.R., Hoy A.J., Turner N., Watt M.J., Allen T.L., Carpenter K., et al. Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes 2009, 58:550-558.
    • (2009) Diabetes , vol.58 , pp. 550-558
    • Bruce, C.R.1    Hoy, A.J.2    Turner, N.3    Watt, M.J.4    Allen, T.L.5    Carpenter, K.6
  • 55
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N., Rosen E.D., Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440:944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 57
    • 0033735623 scopus 로고    scopus 로고
    • Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption
    • Walle T., Otake Y., Walle U.K., Wilson F.A. Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. J Nutr 2000, 130:2658-2661.
    • (2000) J Nutr , vol.130 , pp. 2658-2661
    • Walle, T.1    Otake, Y.2    Walle, U.K.3    Wilson, F.A.4
  • 58
    • 0031029038 scopus 로고    scopus 로고
    • The identification of flavonoids as glycosides in human plasma
    • Paganga G., Rice-Evans C.A. The identification of flavonoids as glycosides in human plasma. FEBS Lett 1997, 401:78-82.
    • (1997) FEBS Lett , vol.401 , pp. 78-82
    • Paganga, G.1    Rice-Evans, C.A.2
  • 59
    • 0031771058 scopus 로고    scopus 로고
    • Absorption and excretion of conjugated flavonols, including quercetin-4'-O-beta-glucoside and isorhamnetin-4'-O-beta-glucoside by human volunteers after the consumption of onions
    • Aziz A.A., Edwards C.A., Lean M.E., Crozier A. Absorption and excretion of conjugated flavonols, including quercetin-4'-O-beta-glucoside and isorhamnetin-4'-O-beta-glucoside by human volunteers after the consumption of onions. Free Radic Res 1998, 29:257-269.
    • (1998) Free Radic Res , vol.29 , pp. 257-269
    • Aziz, A.A.1    Edwards, C.A.2    Lean, M.E.3    Crozier, A.4
  • 60
    • 0032930287 scopus 로고    scopus 로고
    • Absorption and metabolism of cyanidin 3-O-beta-d-glucoside in rats
    • Tsuda T., Horio F., Osawa T. Absorption and metabolism of cyanidin 3-O-beta-d-glucoside in rats. FEBS Lett 1999, 449:179-182.
    • (1999) FEBS Lett , vol.449 , pp. 179-182
    • Tsuda, T.1    Horio, F.2    Osawa, T.3
  • 61
    • 0037462073 scopus 로고    scopus 로고
    • Absorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats
    • Shimoi K., Yoshizumi K., Kido T., Usui Y., Yumoto T. Absorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats. J Agric Food Chem 2003, 51:2785-2789.
    • (2003) J Agric Food Chem , vol.51 , pp. 2785-2789
    • Shimoi, K.1    Yoshizumi, K.2    Kido, T.3    Usui, Y.4    Yumoto, T.5
  • 62
    • 73449106123 scopus 로고    scopus 로고
    • Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats
    • Makino T., Shimizu R., Kanemaru M., Suzuki Y., Moriwaki M., Mizukami H. Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats. Biol Pharm Bull 2009, 32:2034-2040.
    • (2009) Biol Pharm Bull , vol.32 , pp. 2034-2040
    • Makino, T.1    Shimizu, R.2    Kanemaru, M.3    Suzuki, Y.4    Moriwaki, M.5    Mizukami, H.6
  • 63
    • 33847388961 scopus 로고    scopus 로고
    • The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation
    • da Silva W.S., Harney J.W., Kim B.W., Li J., Bianco S.D., Crescenzi A., et al. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes 2007, 56:767-776.
    • (2007) Diabetes , vol.56 , pp. 767-776
    • da Silva, W.S.1    Harney, J.W.2    Kim, B.W.3    Li, J.4    Bianco, S.D.5    Crescenzi, A.6
  • 64
    • 33644664433 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination
    • Tsuchida A., Yamauchi T., Takekawa S., Hada Y., Ito Y., Maki T., et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 2005, 54:3358-3370.
    • (2005) Diabetes , vol.54 , pp. 3358-3370
    • Tsuchida, A.1    Yamauchi, T.2    Takekawa, S.3    Hada, Y.4    Ito, Y.5    Maki, T.6


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