Phosphatidylinositol 3-kinase-δ up-regulates L-type Ca 2+ currents and increases vascular contractility in a mouse model of type 1 diabetes

British Journal of Pharmacology

Volumn 161, Issue 7, 2010, Pages 1458-1471

  Pinho, J F ^a   Medeiros, M A A ^a   Capettini, L S A ^a   Rezende, B A ^a   Campos, P P ^a   Andrade, S P ^a   Cortes, S F ^a   Cruz, J S ^a   Lemos, Virginia S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Ca 2+ currents; Diabetes; L type Ca 2+ channels; PI3K ; Vascular dysfunction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BOSENTAN; CALCIUM CHANNEL L TYPE; IBUPROFEN; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; EX VIVO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; UPREGULATION;

ANIMALS; AORTA; CALCIUM; CALCIUM CHANNELS, L-TYPE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; MALE; MICE; MICE, INBRED C57BL; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION; UP-REGULATION; VASOCONSTRICTION; VASODILATION;

EID: 78149393247     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00955.x     Document Type: Article

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