Influence of depolarization on vasorelaxant potency and efficacy of CA2+ entry blockers, K+ channel openers, nitrate derivatives, salbutamol and papaverine in rat aortic rings

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 358, Issue 4, 1998, Pages 452-463

  Magnon, Martine ^a   Calderone, Vincenzo ^b   Floch, Anne ^a   Cavero, Icilio ^a  

^a SANOFI   (France)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Calcium antagonists; Efficacy; K+ channel openers; KCl and noradrenaline precontracted rat aorta; Nitrates; Papaverine; Potency; Vasorelaxation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; APRIKALIM; CALCIUM CHANNEL BLOCKING AGENT; LEMAKALIM; LINSIDOMINE; NITRENDIPINE; NITRIC ACID DERIVATIVE; NORADRENALIN; PAPAVERINE; PINACIDIL; POTASSIUM CHANNEL AFFECTING AGENT; SALBUTAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; MALE; NONHUMAN; OSMOLARITY; RAT; VASCULAR RING; VASODILATATION;

ALBUTEROL; ANIMALS; AORTA, THORACIC; CALCIUM; CALCIUM CHANNEL BLOCKERS; MALE; NITROGLYCERIN; OSMOLAR CONCENTRATION; PAPAVERINE; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA; VASODILATOR AGENTS;

EID: 0031689602     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005278     Document Type: Article

References (47)

1. Ahlner J, Andersson RGG, Torfgärd K, Axelsson KL (1991) Organic nitrate esters: clinical use and mechanisms of action. Pharmacol Rev 43:353-423
2. Anabuki J, Masatoshi H, Ozaki H, Kato I, Karaki H (1990) Mechanisms of pinacidil-induced vasodilatation. Eur J Pharmacol 190:373-379
3. Bolton TB (1979) Mechanism of action of transmitters and other substances on smooth muscle. Physiol Rev 59:606-718
4. Bolton TB, MacKenzie I, Aaronson PI (1988) Voltage-dependent calcium channels in smooth muscle cells. J Cardiovasc Pharmacol 12 [Suppl 6]:S3-S7
5. + channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin. J Pharmacol Exp Ther 259:526-534
6. Bray KM, Quast U (1992) Differential inhibition by tedisamil (KC 8857) and glibenclamide of the response to cromakalim and minoxidil sulphate in rat isolated aorta. Naunyn-Schmiedebergís Arch Pharmacol 345:244-250
7. Cavero I, Mondot S, Mestre M (1989) Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels. J Pharmacol Exp Ther 248:1261-1268
8. 2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase. J Biol Chem 264:1146-1155
9. Cornwell TL, Lincoln TM (1993) Intracellular cyclic GMP receptor proteins. FASEB J 7:328-338
10. Edwards G, Weston AH (1993) The pharmacology of ATP-sensitive potassium channels. Annu Rev Pharmacol Toxicol 33:597-637
11. Gaul G, Gierschik P, Marme D (1988) Pertussis toxin inhibits angiotensin II-mediated phosphatidylinositol breakdown and ADP-ribosylates a 40-kD protein in cultured smooth muscle cells. Biochem. Biophys Res Commun 150:841-847
12. Gomeni R, Gomeni C (1980) A conversational graphic program for the analysis of the sigmoid curve. Comput Biomed Res 13:489-499
13. Gray DW, Marshall I (1992) Novel signal transduction pathway mediating endothelium dependent β-adrenoceptor vasorelaxation in rat thoracic aorta. Br J Pharmacol 107:684-690
14. Greenwood IA, Weston AH (1993) Effects of rubidium on responses to potassium channel openers in rat isolated aorta. Br J Pharmacol 109:925-932
15. Gurney AM (1994) Mechanisms of drug-induced vasodilatation. J Pharm Pharmacol 46:242-251
16. 2+, crossbridge phosphorylation, and contraction. Annu Rev Physiol 51:285-298
17. Ignarro IJ, Harbison RG, Wood KS, Kadowitz PJ (1986) Activation of a purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther 237:893-900
18. Ikebe M, Koretz J. Hartshorne DJ (1988) Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin. J Biol Chem 263:6432-6437
19. + channels to glyceryl trinitrate-induced relaxation of rabbit aorta. Gen Pharmacol 26:543-552
20. Kai H, Kanaide H, Matsumoto T, Nakamura M (1987) 8-Bromoguanosine 3′:5′-cyclic monophosphate decreases intracellular free calcium concentrations in cultured vascular smooth muscle cells from rat aorta. FEBS Lett 221:284-288
21. Karaki H, Sato K, Ozaki H, Murakami K (1988) Effects of sodium nitroprusside on cytosolic calcium level in vascular smooth muscle. Eur J Pharmacol 156:259-266
22. Katsuki S, Arnold WP, Murad F (1977) Effects of sodium nitroprusside, nitroglycerin and sodium azide on levels of cyclic nucleotides and mechanical activity of varions tissues. J Cyclic Nucleotide Res 3:239-247
23. Kauffman RF, Schenck KW, Conery BG, Cohen ML (1986) Effects of pinacidil on serotonin-induced contractions and cyclic nucleotide levels in isolated rat aortae: comparison with nitroglycerin, minoxidil, and hydralazine. J Cardiovasc Pharmacol 8: 1195-1200
24. + channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide. J Pharmacol Exp Ther 267:1327-1335
25. Longman SD, Hamilton TC (1992) Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential. Med Res Rev 12:73-148
26. + and C1 in rat aorta. J Physiol (Lond) 421:411-424
27. + channel opening to nicorandil-induced vasorelaxation depends on the conduit vessel and on the nature of the spasmogen. J Pharmacol Exp Ther 268:1411-1418
28. Magnon M, Gullix P, Cavero I (1995) Intervessel (arteries and veins) and heart/vessel selectivities of therapeutically used calcium entry blockers: variable, vessel-dependent indexes. J Pharmacol Exp Ther 275:1157-1166
29. McHenry LC Jr, Jaffe ME, Kawamura J, Goldberg HI (1970) Effect of papaverine on regional blood flow in focal vascular disease of the brain. New Engl J Med 282:1167-1170
30. Means AR, VanBerkum MFA, Bagchi I, Lu KP, Rasmussen CD (1991) Regulatory functions of calmodulin. Pharmacol Ther 50:255-270
31. Miller-Hance MC, Miller JR, Wells JN, Stull JT, Kamm KE (1988) Biochemical events associated with activation of smooth muscle contraction. J Biol Chem 263:13979-13982
32. Morel N, Godfraind T (1991) Characterization in rat aorta of the binding sites responsible for blockade of noradrenaline-evoked calcium entry by nisoldipine. Br J Pharmacol 102:467-477
33. Morgan JP, Morgan KG (1984) Alteration of cytoplasmic ionized calcium levels in smooth muscle by vasodilators in the ferret. J Physiol (Lond) 357:539-551
34. 2+ levels. Jpn J Pharmacol 49:205-213
35. Nelson MT, Patlak JB, Worley JF, Standen NB (1990) Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. Am J Physiol 259:C3-C18
36. Pataricza J, Toth GK, Penke B, Hohn J, Papp JG (1995) Effect of selective inhibition of potassium channels on vasorelaxing response to cromakalim, nitroglycerin and nitric oxide of canine coronary arteries. J Pharm Pharmacol 47:921-925
37. + channels in cerebral vasodilatation induced by increases in cyclic GMP and cyclic AMP in the rat. Stroke 27:1603-1607
38. Quast U (1996) Effects of potassium channel activators in isolated blood vessels. In: Evans J, Hamilton TC, Longman SD, Stemp G (eds) Potassium channels and their modulators: from synthesis to clinical experience. Taylor and Francis, London, pp 173-195
39. Quast U, Guillon JM, Cavero I (1994) Cellular pharmacology of potassium channel openers in vascular smooth muscle. Cardiovasc Res 28:805-810
40. Rapoport RM, Waldman SA, Schwartz K, Winquist RJ, Murad F (1985) Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. Eur J Pharmacol 115:219-229
41. Rembold CM (1992) Regulation of contraction and relaxation in arterial smooth muscle. Hypertension 20:129-137
42. +. Acta Physiol Scand 136:152-159
43. Ryman T, Petersson J, Andersson K-E, Brandt L, Högestätt D (1993) Effects of pinacidil on cerebral and mesenteric arteries-influence of endothelium. Naunyn-Schiedeberg's Arch Pharmacol 348:298-304
44. Schmidt HMMW, Lohmann SM, Waller U (1993) The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim Biophys Acta 1178: 153-175
45. Somlyo AV, Somlyo AP (1968) Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther 159:129-145
46. Southerton JS, Weston AH, Bray KM, Newgreen DT, Taylor SG (1988) The potassium channel opening action of pinacidil; studies using biochemical, ion flux and micro-electrode techniques. Naunyn-Schmiedebergís Arch Pharmacol 338:310-318
47. + channels in arterial smooth muscle. Science 245:177-180