Synthesis and biological evaluation of furopyrimidine N,O-nucleosides

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 18, 2013, Pages 5688-5693

  Romeo, Roberto ^a   Giofrè, Salvatore V ^a   Garozzo, Adriana ^b   Bisignano, Benedetta ^b   Corsaro, Antonino ^b   Chiacchio, Maria A ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Antiviral activity; Cytotoxicity; Furopyrimidines; N,O nucleosides; Sonogashira reaction

Indexed keywords

3 [3 (HYDROXYMETHYL) 2 (METHYLISOXAZOLIDIN 5 YL)]6 (4 METHOXYPHENYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 [3 (HYDROXYMETHYL) 2 (METHYLISOXAZOLIDIN 5 YL)]6 (4 PENTYLPHENYL)FURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 [3 (HYDROXYMETHYL) 2 (METHYLISOXAZOLIDIN 5 YL)]6 PHENYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 [3 (HYDROXYMETHYL) 2 (METHYLISOXAZOLIDIN 5 YL)]6 PROPYLFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 [3 (HYDROXYMETHYL) 2 (METHYLISOXAZOLIDIN 5 YL)]FURO[2,3 D]PYRIMIDIN 2(3H) ONE; ACICLOVIR; ANTIVIRUS AGENT; CYTOTOXIC AGENT; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; MITOSIS INHIBITION; NONHUMAN; SONOGASHIRA REACTION; VERO CELL; VIRUS INHIBITION;

DNA VIRUSES;

ANTIVIRAL ACTIVITY; CYTOTOXICITY; FUROPYRIMIDINES; N,O-NUCLEOSIDES; SONOGASHIRA REACTION;

ALKYNES; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; NUCLEOSIDES; PYRIMIDINES; URACIL; VERO CELLS; VIRUSES;

EID: 84882856230     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.07.031     Document Type: Article

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