Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain

Journal of Medicinal Chemistry

Volumn 43, Issue 26, 2000, Pages 4993-4997

  McGuigan, C ^a   Barucki, H ^a   Blewett, S ^a   Carangio, A ^a   Erichsen, J T ^b   Andrei, G ^a   Snoeck, R ^a   De Clercq, E ^a   Balzarini, J ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; ACICLOVIR; COPPER; FUROPYRIMIDINE NUCLEOSIDE DERIVATIVE; IDOXURIDINE; NUCLEOSIDE; PALLADIUM; PHENYL GROUP; PYRIMIDINE NUCLEOSIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYCLIZATION; CYTOTOXICITY; DNA VIRUS; DRUG INHIBITION; DRUG SYNTHESIS; HERPES ZOSTER; PHYSICAL CHEMISTRY; RNA VIRUS; VARICELLA ZOSTER VIRUS;

ANTIVIRAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; HERPESVIRUS 3, HUMAN; HUMANS; PYRIMIDINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034727849     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000210m     Document Type: Article

References (9)

1. Potent and selective inhibition of Varicella-Zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
2. Bicyclic nucleoside inhibitors of Varicella-Zoster virus (VZV): The effect of a terminal halogen substitution in the side chain
3. Novel bicyclic fluorescent nucleosides as potent and selective inhibitors of VZV
4. Design, synthesis and evaluation of new antiviral nucleosides
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6. Nucleic-acid related-compounds 0.31. Smooth and efficient palladium copper catalyzed coupling of terminal alkynes with 5-iodouracil nucleosides
7. Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy)-pyrimidine nucleosides
8. A novel selective broad-spectrum anti-DNA virus agent