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Volumn 2, Issue 1, 2013, Pages 47-57

The role of the bone microenvironment in skeletal metastasis

Author keywords

Bone metastasis; Bone microenvironment; Bone remodelling; Cancer

Indexed keywords

ALENDRONIC ACID; CALCIUM; CLODRONIC ACID; DENOSUMAB; IBANDRONIC ACID; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; VITAMIN D; VITRONECTIN; ZOLEDRONIC ACID;

EID: 84882426625     PISSN: 22121374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbo.2012.11.002     Document Type: Review
Times cited : (66)

References (174)
  • 2
    • 0035010803 scopus 로고    scopus 로고
    • Metastatic bone disease: Clinical features, pathophysiology and treatment strategies
    • DOI 10.1053/ctrv.2000.0210
    • Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treatment Reviews 2001;27: 165-76. (Pubitemid 32452017)
    • (2001) Cancer Treatment Reviews , vol.27 , Issue.3 , pp. 165-176
    • Coleman, R.E.1
  • 7
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • DOI 10.1038/nrc867
    • Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Natural Review of Cancer 2002;2: 584-93. (Pubitemid 37328925)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 584-593
    • Mundy, G.R.1
  • 8
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • DOI 10.1038/nrc1098
    • Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Natural Review of Cancer 2003;3: 453-8. (Pubitemid 37328849)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 453-458
    • Fidler, I.J.1
  • 10
    • 13444306377 scopus 로고    scopus 로고
    • Crosstalk between cancer cells and bone microenvironment in bone metastasis
    • DOI 10.1016/j.bbrc.2004.11.070, Vertebrate Skeletal Biology
    • Yoneda T, Hiraga T. Crosstalk between cancer cells and bone microenviron-ment in bone metastasis. Biochemical and Biophysical Research Communications 2005;328: 679-87. (Pubitemid 40208305)
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , Issue.3 , pp. 679-687
    • Yoneda, T.1    Hiraga, T.2
  • 11
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy GR. Mechanisms of bone metastasis. Cancer 1997;80: 1546-56. (Pubitemid 27444026)
    • (1997) Cancer , vol.80 , Issue.8 SUPPL. , pp. 1546-1556
    • Mundy, G.R.1
  • 13
    • 0035360265 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis
    • Morony S, Capparelli C, Sarosi I, Lacey DL, Dunstan CR, Kostenuik PJ. Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Research 2001;61: 4432-6. (Pubitemid 32685771)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4432-4436
    • Morony, S.1    Capparelli, C.2    Sarosi, I.3    Lacey, D.L.4    Dunstan, C.R.5    Kostenuik, P.J.6
  • 14
    • 0142059049 scopus 로고    scopus 로고
    • Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: Model characterisation and in vivo effects of ibandronate on tumour growth
    • DOI 10.1002/ijc.11397
    • Neudert M, Fischer C, Krempien B, Bauss F, Seibel MJ. Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: model characterisation and in vivo effects of ibandronate on tumour growth. International Journal of Cancer 2003;107: 468-77. (Pubitemid 37266469)
    • (2003) International Journal of Cancer , vol.107 , Issue.3 , pp. 468-477
    • Neudert, M.1    Fischer, C.2    Krempien, B.3    Bauss, F.4    Seibel, M.J.5
  • 15
    • 33846085533 scopus 로고    scopus 로고
    • Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis
    • DOI 10.1016/j.bone.2006.09.016, PII S8756328206007095
    • Zheng Y, Zhou H, Brennan K, Blair JM, Modzelewski JR, Seibel MJ, et al. Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis. Bone 2007;40: 471-8. (Pubitemid 46070226)
    • (2007) Bone , vol.40 , Issue.2 , pp. 471-478
    • Zheng, Y.1    Zhou, H.2    Brennan, K.3    Blair, J.M.4    Modzelewski, J.R.K.5    Seibel, M.J.6    Dunstan, C.R.7
  • 16
    • 0142030701 scopus 로고    scopus 로고
    • Role of bisphosphonates in prostate cancer bone metastases
    • DOI 10.1016/S0093-7754(03)00347-6
    • Guise TA, Chirgwin JM. Role of bisphosphonates in prostate cancer bone metastases. Seminars in Oncology 2003;30: 717-23. (Pubitemid 37296796)
    • (2003) Seminars in Oncology , vol.30 , Issue.5 , pp. 717-723
    • Guise, T.A.1    Chirgwin, J.M.2
  • 17
    • 0035360867 scopus 로고    scopus 로고
    • The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases
    • Hiraga T, Williams PJ, Mundy GR, Yoneda T. The bisphosphonate ibandro-nate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases. Cancer Research 2001;61: 4418-24. (Pubitemid 32685769)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4418-4424
    • Hiraga, T.1    Williams, P.J.2    Mundy, G.R.3    Yoneda, T.4
  • 18
    • 0034980406 scopus 로고    scopus 로고
    • Preclinical studies with zoledronic acid and other bisphosphonates: Impact on the bone microenvironment
    • Mundy GR, Yoneda T, Hiraga T. Preclinical studies with zoledronic acid and other bisphosphonates: impact on the bone microenvironment. Seminars in Oncology 2001;28: 35-44. (Pubitemid 32494623)
    • (2001) Seminars in Oncology , vol.28 , Issue.2 SUPPL. 6 , pp. 35-44
    • Mundy, G.R.1    Yoneda, T.2    Hiraga, T.3
  • 19
    • 0030927205 scopus 로고    scopus 로고
    • Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2
    • Yoneda T, Sasaki A, Dunstan C, Williams PJ, Bauss F, De Clerck YA, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. Journal of Clinical Investigation 1997;99: 2509-17. (Pubitemid 27227730)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.10 , pp. 2509-2517
    • Yoneda, T.1    Sasaki, A.2    Dunstan, C.3    Williams, P.J.4    Bauss, F.5    De Clerck, Y.A.6    Mundy, G.R.7
  • 21
    • 77953438942 scopus 로고    scopus 로고
    • Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure
    • Body JJ, Lipton A, Gralow J, Steger GG, Gao G, Yeh H, et al. Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure. Journal of Bone and Mineral Research 2009;25: 440-6.
    • (2009) Journal of Bone and Mineral Research , vol.25 , pp. 440-446
    • Body, J.J.1    Lipton, A.2    Gralow, J.3    Steger, G.G.4    Gao, G.5    Yeh, H.6
  • 22
    • 67649791971 scopus 로고    scopus 로고
    • Denosumab treatment of prostate cancer with bone metastases and increased urine N-telopeptide levels after therapy with intravenous bisphosphonates: Results of a randomized phase II trial
    • discussion 15-16
    • Fizazi K, Bosserman L, Gao G, Skacel T, Markus R. Denosumab treatment of prostate cancer with bone metastases and increased urine N-telopeptide levels after therapy with intravenous bisphosphonates: results of a randomized phase II trial. Journal of Urology 2009;182 509-15; discussion 15-6.
    • (2009) Journal of Urology , vol.182 , pp. 509-515
    • Fizazi, K.1    Bosserman, L.2    Gao, G.3    Skacel, T.4    Markus, R.5
  • 23
    • 79551568488 scopus 로고    scopus 로고
    • Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study
    • Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. Journal of Clinical Oncology 2010;28: 5132-9.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 5132-5139
    • Stopeck, A.T.1    Lipton, A.2    Body, J.J.3    Steger, G.G.4    Tonkin, K.5    De Boer, R.H.6
  • 24
    • 78650305549 scopus 로고    scopus 로고
    • The bone remodeling environment is a factor in breast cancer bone metastasis
    • Ooi LL, Zheng Y, Stalgis-Bilinski K, Dunstan CR. The bone remodeling environment is a factor in breast cancer bone metastasis. Bone 2011;48: 66-70.
    • (2011) Bone , vol.48 , pp. 66-70
    • Ooi, L.L.1    Zheng, Y.2    Stalgis-Bilinski, K.3    Dunstan, C.R.4
  • 28
    • 0035057590 scopus 로고    scopus 로고
    • Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis
    • Woitge HW, Horn E, Keck AV, Auler B, Seibel MJ, Pecherstorfer M. Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis. Clinical Chemistry 2001;47: 686-93. (Pubitemid 32275812)
    • (2001) Clinical Chemistry , vol.47 , Issue.4 , pp. 686-693
    • Woitge, H.W.1    Horn, E.2    Keck, A.V.3    Auler, B.4    Seibel, M.J.5    Pecherstorfer, M.6
  • 29
    • 27644471852 scopus 로고    scopus 로고
    • Clinical use of markers of bone turnover in metastatic bone disease
    • DOI 10.1038/ncponc0320, PII N0320
    • Seibel MJ. Clinical use of markers of bone turnover in metastatic bone disease. Nat Clin Pract Oncol 2005;2: 504-17 quiz 1 p following 33. (Pubitemid 41553935)
    • (2005) Nature Clinical Practice Oncology , vol.2 , Issue.10 , pp. 504-517
    • Seibel, M.J.1
  • 32
    • 33745203917 scopus 로고    scopus 로고
    • Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancer
    • Cook RJ, Coleman R, Brown J, Lipton A, Major P, Hei YJ, et al. Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancer. Clinical Cancer Research 2006;12: 3361-7.
    • (2006) Clinical Cancer Research , vol.12 , pp. 3361-3367
    • Cook, R.J.1    Coleman, R.2    Brown, J.3    Lipton, A.4    Major, P.5    Hei, Y.J.6
  • 33
    • 0034857236 scopus 로고    scopus 로고
    • Use of markers of bone turnover for monitoring bone metastases and the response to therapy
    • Lipton A, Costa L, Ali S, Demers L. Use of markers of bone turnover for monitoring bone metastases and the response to therapy. Seminars in Oncology 2001;28: 54-9. (Pubitemid 32844930)
    • (2001) Seminars in Oncology , vol.28 , Issue.4 SUPPL. 11 , pp. 54-59
    • Lipton, A.1    Costa, L.2    Ali, S.3    Demers, L.4
  • 34
    • 58149179539 scopus 로고    scopus 로고
    • Advancing treatment for metastatic bone cancer: Consensus recommendations from the Second Cambridge Conference
    • Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, et al. Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clinical Cancer Research 2008;14: 6387-95.
    • (2008) Clinical Cancer Research , vol.14 , pp. 6387-6395
    • Coleman, R.E.1    Guise, T.A.2    Lipton, A.3    Roodman, G.D.4    Berenson, J.R.5    Body, J.J.6
  • 35
    • 47149118386 scopus 로고    scopus 로고
    • Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid
    • DOI 10.1002/cncr.23529
    • Lipton A. Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid. Cancer 2008;113: 193-201. (Pubitemid 351976401)
    • (2008) Cancer , vol.113 , Issue.1 , pp. 193-201
    • Lipton, A.1    Cook, R.2    Saad, F.3    Major, P.4    Garnero, P.5    Terpos, E.6    Brown, J.E.7    Coleman, R.E.8
  • 36
    • 11144237716 scopus 로고    scopus 로고
    • Osteoblasts in prostate cancer metastasis to bone
    • DOI 10.1038/nrc1528
    • Logothetis CJ, Lin SH. Osteoblasts in prostate cancer metastasis to bone. Natural Review of Cancer 2005;5: 21-8. (Pubitemid 40052322)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.1 , pp. 21-28
    • Logothetis, C.J.1    Lin, S.-H.2
  • 37
    • 19944432878 scopus 로고    scopus 로고
    • Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors
    • Brown JE, Cook RJ, Major P, Lipton A, Saad F, Smith M, et al. Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors. Journal of the National Cancer Institute 2005;97: 59-69.
    • (2005) Journal of the National Cancer Institute , vol.97 , pp. 59-69
    • Brown, J.E.1    Cook, R.J.2    Major, P.3    Lipton, A.4    Saad, F.5    Smith, M.6
  • 38
    • 0036468002 scopus 로고    scopus 로고
    • Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status
    • DOI 10.1200/JCO.20.3.850
    • Costa L, Demers LM, Gouveia-Oliveira A, Schaller J, Costa EB, de Moura MC, et al. Prospective evaluation of the peptide-bound collagen type I crosslinks N-telopeptide and C-telopeptide in predicting bone metastases status. Journal of Clinical Oncology 2002;20: 850-6. (Pubitemid 34111395)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.3 , pp. 850-856
    • Costa, L.1    Demers, L.M.2    Gouveia-Oliveira, A.3    Schaller, J.4    Costa, E.B.5    De Moura, M.C.6    Lipton, A.7
  • 39
    • 33846139014 scopus 로고    scopus 로고
    • Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases
    • DOI 10.1007/s10555-006-9023-1, Special issue on Bone Metastasis and Cancer
    • Siclari VA, Guise TA, Chirgwin JM. Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases. Cancer and Metastasis Reviews 2006;25: 621-33. (Pubitemid 46075000)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.4 , pp. 621-633
    • Siclari, V.A.1    Guise, T.A.2    Chirgwin, J.M.3
  • 40
    • 77952305169 scopus 로고    scopus 로고
    • Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: An open label, randomised, phase 2 trial
    • Aft R. Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncology 2010;11: 421-8.
    • (2010) Lancet Oncology , vol.11 , pp. 421-428
    • Aft, R.1
  • 41
    • 0023037767 scopus 로고
    • Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose
    • Hauschka PV, Mavrakos AE, Iafrati MD, Doleman SE, Klagsbrun M. Growth factors in bone matrix. Isolation of multiple types by affinity chromato-graphy on heparin-Sepharose. Journal of Biological Chemistry 1986;261: 12665-74. (Pubitemid 17204223)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.27 , pp. 12665-12674
    • Hauschka, P.V.1    Mavrakos, A.E.2    Iafrati, M.D.3
  • 42
    • 0032323828 scopus 로고    scopus 로고
    • Advances in the osteoblast lineage
    • DOI 10.1139/bcb-76-6-899
    • Aubin JE. Advances in the osteoblast lineage. Biochemistry and Cell Biology 1998;76: 899-910. (Pubitemid 29450559)
    • (1998) Biochemistry and Cell Biology , vol.76 , Issue.6 , pp. 899-910
    • Aubin, J.E.1
  • 44
    • 33750689159 scopus 로고    scopus 로고
    • Targeting factors involved in bone remodeling as treatment strategies in prostate cancer bone metastasis
    • Vessella RL, Corey E. Targeting factors involved in bone remodeling as treatment strategies in prostate cancer bone metastasis. Clinical Cancer Research 2006;12: 6285s-290ss.
    • (2006) Clinical Cancer Research , vol.12
    • Vessella, R.L.1    Corey, E.2
  • 46
    • 3042548087 scopus 로고    scopus 로고
    • Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
    • DOI 10.1016/j.jtbi.2004.03.023, PII S0022519304001407
    • Lemaire V, FLFL Tobin, Greller LD, Cho CR, Suva LJ. Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. Journal of Theoretical Biology 2004;229: 293-309. (Pubitemid 38844935)
    • (2004) Journal of Theoretical Biology , vol.229 , Issue.3 , pp. 293-309
    • Lemaire, V.1    Tobin, F.L.2    Greller, L.D.3    Cho, C.R.4    Suva, L.J.5
  • 48
    • 0034166650 scopus 로고    scopus 로고
    • The mechanism of coupling: A role for the vasculature
    • Parfitt AM. The mechanism of coupling: a role for the vasculature. Bone 2000;26: 319-23.
    • (2000) Bone , vol.26 , pp. 319-323
    • Parfitt, A.M.1
  • 49
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • DOI 10.1038/nature01658
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423: 337-42. (Pubitemid 40852708)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 56
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397: 315-23.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 60
    • 77950284096 scopus 로고    scopus 로고
    • Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis
    • Ooi LL, Zhou H, Kalak R, Zheng Y, Conigrave AD, Seibel MJ, et al. Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research 2010;70: 1835-44.
    • (2010) Cancer Research , vol.70 , pp. 1835-1844
    • Ooi, L.L.1    Zhou, H.2    Kalak, R.3    Zheng, Y.4    Conigrave, A.D.5    Seibel, M.J.6
  • 61
    • 29244454128 scopus 로고    scopus 로고
    • Comparison of Fc-osteoprotegerin and zoledronic acid activities suggests that zoledronic acid inhibits prostate cancer in bone by indirect mechanisms
    • DOI 10.1038/sj.pcan.4500815, PII 4500815
    • Quinn JE, Brown LG, Zhang J, Keller ET, Vessella RL, Corey E. Comparison of Fc-osteoprotegerin and zoledronic acid activities suggests that zoledronic acid inhibits prostate cancer in bone by indirect mechanisms. Prostate Cancer Prostatic Disease 2005;8: 253-9. (Pubitemid 43118063)
    • (2005) Prostate Cancer and Prostatic Diseases , vol.8 , Issue.3 , pp. 253-259
    • Quinn, J.E.1    Brown, L.G.2    Zhang, J.3    Keller, E.T.4    Vessella, R.L.5    Corey, E.6
  • 63
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • DOI 10.1146/annurev.immunol.20.100301.064753
    • Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annual Review of Immunology 2002;20: 795-823. (Pubitemid 34293440)
    • (2002) Annual Review of Immunology , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 66
    • 0030756221 scopus 로고    scopus 로고
    • Hypercalcemia of malignancy
    • DOI 10.1016/S0002-9343(97)80047-2, PII S0002934397000478
    • Mundy GR, Guise TA. Hypercalcemia of malignancy. American Journal of Medicine 1997;103: 134-45. (Pubitemid 27352118)
    • (1997) American Journal of Medicine , vol.103 , Issue.2 , pp. 134-145
    • Mundy, G.R.1    Guise, T.A.2
  • 68
    • 33947414063 scopus 로고    scopus 로고
    • Significance of interleukin-6 (IL-6) in breast cancer (review)
    • DOI 10.1007/s10549-006-9328-3
    • Knupfer H, Preiss R. Significance of interleukin-6 (IL-6) in breast cancer (review). Breast Cancer Research and Treatment 2007;102: 129-35. (Pubitemid 46452175)
    • (2007) Breast Cancer Research and Treatment , vol.102 , Issue.2 , pp. 129-135
    • Knupfer, H.1    Preiss, R.2
  • 70
    • 0037025352 scopus 로고    scopus 로고
    • Transforming growth factor-β stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways
    • DOI 10.1074/jbc.M202561200
    • Kakonen SM, Selander KS, Chirgwin JM, Yin JJ, Burns S, Rankin WA, et al. Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. Journal of Biological Chemistry 2002;277: 24571-8. (Pubitemid 34951984)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.27 , pp. 24571-24578
    • Kakonen, S.-M.1    Selander, K.S.2    Chirgwin, J.M.3    Yin, J.J.4    Burns, S.5    Rankin, W.A.6    Grubbs, B.G.7    Dallas, M.8    Cui, Y.9    Guise, T.A.10
  • 73
    • 0023228836 scopus 로고
    • A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression
    • Suva LJ, Winslow GA, Wettenhall RE, Hammonds RG, Moseley JM, Diefenbach-Jagger H, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 1987;237: 893-6. (Pubitemid 17128278)
    • (1987) Science , vol.237 , Issue.4817 , pp. 893-896
    • Suva, L.J.1    Winslow, G.A.2    Wettenhall, R.E.H.3
  • 76
    • 0026598246 scopus 로고
    • Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium
    • Abou-Samra AB, Juppner H, Force T, Freeman MW, Kong XF, Schipani E, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proceedings of the National Academy of Sciences of the United States of America 1992;89: 2732-6.
    • (1992) Proceedings of the National Academy of Sciences of the United States of America , vol.89 , pp. 2732-2736
    • Abou-Samra, A.B.1    Juppner, H.2    Force, T.3    Freeman, M.W.4    Kong, X.F.5    Schipani, E.6
  • 78
    • 0030861712 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein and bone metastases
    • Guise TA. Parathyroid hormone-related protein and bone metastases. Cancer 1997;80: 1572-80. (Pubitemid 27444029)
    • (1997) Cancer , vol.80 , Issue.8 SUPPL. , pp. 1572-1580
    • Guise, T.A.1
  • 86
    • 0042707678 scopus 로고    scopus 로고
    • Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
    • DOI 10.1016/S8756-3282(03)00086-3
    • Bendre MS, Montague DC, Peery T, Akel NS, Gaddy D, Suva LJ. Interleukin-8 stimulation of steoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone 2003;33: 28-37. (Pubitemid 36952685)
    • (2003) Bone , vol.33 , Issue.1 , pp. 28-37
    • Bendre, M.S.1    Montague, D.C.2    Peery, T.3    Akel, N.S.4    Gaddy, D.5    Suva, L.J.6
  • 87
    • 26944459975 scopus 로고    scopus 로고
    • Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone
    • DOI 10.1677/erc.1.00543
    • Clines GA, Guise TA. Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone. Endocrine-Related Cancer 2005;12: 549-83. (Pubitemid 41482993)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.3 , pp. 549-583
    • Clines, G.A.1    Guise, T.A.2
  • 88
    • 84865237178 scopus 로고    scopus 로고
    • Systemic delivery of oncolytic adenoviruses targeting transforming growth factor-beta inhibits established bone metastasis in a prostate cancer mouse model
    • Hu Z, Gupta J, Zhang Z, Gerseny H, Berg A, Chen YJ, et al. Systemic delivery of oncolytic adenoviruses targeting transforming growth factor-beta inhibits established bone metastasis in a prostate cancer mouse model. Human Gene Therapy 2012;23: 871-82.
    • (2012) Human Gene Therapy , vol.23 , pp. 871-882
    • Hu, Z.1    Gupta, J.2    Zhang, Z.3    Gerseny, H.4    Berg, A.5    Chen, Y.J.6
  • 90
    • 78651399324 scopus 로고    scopus 로고
    • TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases
    • Mohammad KS, Javelaud D, Fournier PG, Niewolna M, McKenna CR, Peng XH, et al. TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases. Cancer Research 2011;71: 175-84.
    • (2011) Cancer Research , vol.71 , pp. 175-184
    • Mohammad, K.S.1    Javelaud, D.2    Fournier, P.G.3    Niewolna, M.4    McKenna, C.R.5    Peng, X.H.6
  • 91
    • 78650308466 scopus 로고    scopus 로고
    • TGF-beta in cancer and bone: Implications for treatment of bone metastases
    • Juarez P, Guise TA. TGF-beta in cancer and bone: implications for treatment of bone metastases. Bone 2011;48: 23-9.
    • (2011) Bone , vol.48 , pp. 23-29
    • Juarez, P.1    Guise, T.A.2
  • 92
    • 84865116604 scopus 로고    scopus 로고
    • Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases
    • Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, et al. Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases. Cancer Research 2012;72: 4238-49.
    • (2012) Cancer Research , vol.72 , pp. 4238-4249
    • Hiraga, T.1    Myoui, A.2    Hashimoto, N.3    Sasaki, A.4    Hata, K.5    Morita, Y.6
  • 93
    • 3042523539 scopus 로고    scopus 로고
    • Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice
    • DOI 10.1158/0008-5472.CAN-03-3763
    • Kim SJ, Uehara H, Yazici S, Langley RR, He J, Tsan R, et al. Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice. Cancer Research 2004;64: 4201-8. (Pubitemid 38802424)
    • (2004) Cancer Research , vol.64 , Issue.12 , pp. 4201-4208
    • Kim, S.J.1    Uehara, H.2    Yazici, S.3    Langley, R.R.4    He, J.5    Tsan, R.6    Fan, D.7    Killion, J.J.8    Fidler, I.J.9
  • 94
    • 59649103684 scopus 로고    scopus 로고
    • The alpha-receptor for platelet-derived growth factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells
    • Russell MR, Jamieson WL, Dolloff NG, Fatatis A. The alpha-receptor for platelet-derived growth factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells. Oncogene 2009;28: 412-21.
    • (2009) Oncogene , vol.28 , pp. 412-421
    • Russell, M.R.1    Jamieson, W.L.2    Dolloff, N.G.3    Fatatis, A.4
  • 96
    • 78650306070 scopus 로고    scopus 로고
    • Dysregulation of developmental pathways in bone metastasis
    • Sethi N, Kang Y. Dysregulation of developmental pathways in bone metastasis. Bone 2011;48: 16-22.
    • (2011) Bone , vol.48 , pp. 16-22
    • Sethi, N.1    Kang, Y.2
  • 97
    • 20444486612 scopus 로고    scopus 로고
    • Bisphosphonates and cancer-induced bone disease: Beyond their antiresorptive activity
    • DOI 10.1158/0008-5472.CAN-05-0264
    • Clezardin P, Ebetino FH, Fournier PG. Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity. Cancer Research 2005;65: 4971-4. (Pubitemid 40827299)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 4971-4974
    • Clezardin, P.1    Ebetino, F.H.2    Fournier, P.G.J.3
  • 98
    • 33644789211 scopus 로고    scopus 로고
    • Role of osteoprotegerin (OPG) in cancer
    • DOI 10.1042/CS20050175
    • Holen I, Shipman CM. Role of osteoprotegerin (OPG) in cancer. Clinical Science (London) 2006;110: 279-91. (Pubitemid 43348393)
    • (2006) Clinical Science , vol.110 , Issue.3 , pp. 279-291
    • Holen, I.1    Shipman, C.M.2
  • 100
    • 79953326119 scopus 로고    scopus 로고
    • Steps in prostate cancer progression that lead to bone metastasis
    • Jin JK, Dayyani F, Gallick GE. Steps in prostate cancer progression that lead to bone metastasis. International Journal of Cancer 2011;128: 2545-61.
    • (2011) International Journal of Cancer , vol.128 , pp. 2545-2561
    • Jin, J.K.1    Dayyani, F.2    Gallick, G.E.3
  • 104
    • 79958695940 scopus 로고    scopus 로고
    • Bisphosphonates: The first 40 years
    • Russell RG. Bisphosphonates: the first 40 years. Bone 2011;49: 2-19.
    • (2011) Bone , vol.49 , pp. 2-19
    • Russell, R.G.1
  • 105
    • 0014684354 scopus 로고
    • Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
    • Fleisch H, Russell RG, Francis MD. Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science 1969;165: 1262-4.
    • (1969) Science , vol.165 , pp. 1262-1264
    • Fleisch, H.1    Russell, R.G.2    Francis, M.D.3
  • 106
    • 0036148327 scopus 로고    scopus 로고
    • Actions of bisphosphonates in animal models of breast cancer
    • DOI 10.1186/bcr415
    • Padalecki SS, Guise TA. Actions of bisphosphonates in animal models of breast cancer. Breast Cancer Research 2002;4: 35-41. (Pubitemid 34097555)
    • (2002) Breast Cancer Research , vol.4 , Issue.1 , pp. 35-41
    • Padelecki, S.S.1    Guise, T.A.2
  • 107
    • 24944460279 scopus 로고    scopus 로고
    • Biological properties and mechanism of action of ibandronate: Application to the treatment of osteoporosis
    • DOI 10.1016/j.bone.2005.05.007, PII S8756328205002188
    • Epstein S, Zaidi M. Biological properties and mechanism of action of ibandronate: application to the treatment of osteoporosis. Bone 2005;37: 433-40. (Pubitemid 41317315)
    • (2005) Bone , vol.37 , Issue.4 , pp. 433-440
    • Epstein, S.1    Zaidi, M.2
  • 109
    • 13844297617 scopus 로고    scopus 로고
    • Ibandronate in metastatic bone disease: A review of preclinical data
    • DOI 10.1097/00001813-200502000-00001
    • Bauss F, Body JJ. Ibandronate in metastatic bone disease: a review of preclinical data. Anticancer Drugs 2005;16: 107-18. (Pubitemid 40250605)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.2 , pp. 107-118
    • Bauss, F.1    Body, J.-J.2
  • 111
    • 16444369671 scopus 로고    scopus 로고
    • Recent developments in bisphosphonates for patients with metastatic breast cancer
    • Gainford MC, Dranitsaris G, Clemons M. Recent developments in bispho-sphonates for patients with metastatic breast cancer. BMJ 2005;330: 769-73. (Pubitemid 40522339)
    • (2005) British Medical Journal , vol.330 , Issue.7494 , pp. 769-773
    • Gainford, M.C.1    Dranitsaris, G.2    Clemons, M.3
  • 112
    • 10644231736 scopus 로고    scopus 로고
    • The role of bisphosphonates in breast cancer
    • DOI 10.1016/j.breast.2004.09.004, PII S0960977604001456
    • Coleman RE. The role of bisphosphonates in breast cancer. Breast 2004;13(Suppl 1): S19-28. (Pubitemid 39654740)
    • (2004) Breast , vol.13 , Issue.1 SUPPL.
    • Coleman, R.E.1
  • 114
    • 35648968643 scopus 로고    scopus 로고
    • The role of bisphosphonates in early breast cancer
    • Paterson AH. The role of bisphosphonates in early breast cancer. Oncologist 2006;11(Suppl 1): 13-9.
    • (2006) Oncologist , vol.11 , Issue.SUPPL. 1 , pp. 13-19
    • Paterson, A.H.1
  • 118
    • 9444254706 scopus 로고    scopus 로고
    • Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients
    • DOI 10.1080/02841860410032885
    • Saarto T, Vehmanen L, Virkkunen P, Blomqvist C. Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients. Acta Oncologica 2004;43: 650-6. (Pubitemid 39563937)
    • (2004) Acta Oncologica , vol.43 , Issue.7 , pp. 650-656
    • Saarto, T.1    Vehmanen, L.2    Virkkunen, P.3    Blomqvist, C.4
  • 119
    • 33744828376 scopus 로고    scopus 로고
    • Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]
    • Powles T, Paterson A, McCloskey E, Schein P, Scheffler B, Tidy A, et al. Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]. Breast Cancer Research 2006;8: R13.
    • (2006) Breast Cancer Research , vol.8
    • Powles, T.1    Paterson, A.2    McCloskey, E.3    Schein, P.4    Scheffler, B.5    Tidy, A.6
  • 120
    • 0035148170 scopus 로고    scopus 로고
    • Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-Year results of a randomized controlled trial
    • Saarto T, Blomqvist C, Virkkunen P, Elomaa I. Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. Journal of Clinical Oncology 2001;19: 10-7. (Pubitemid 32063474)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.1 , pp. 10-17
    • Saarto, T.1    Blomqvist, C.2    Virkkunen, P.3    Elomaa, I.4
  • 121
    • 0035496754 scopus 로고    scopus 로고
    • Bisphosphonates in the treatment of metastatic breast cancer
    • Body JJ. Bisphosphonates in the treatment of metastatic breast cancer. Journal of Mammary Gland Biology and Neoplasia 2001;6: 477-85.
    • (2001) Journal of Mammary Gland Biology and Neoplasia , vol.6 , pp. 477-485
    • Body, J.J.1
  • 122
    • 0029782630 scopus 로고    scopus 로고
    • Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: Results from a multinational randomized controlled trial
    • Conte PF, Latreille J, Mauriac L, Calabresi F, Santos R, Campos D, et al. Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: results from a multinational randomized controlled trial. The Aredia Multinational Cooperative Group. Journal of Clinical Oncology 1996;14: 2552-9. (Pubitemid 26300123)
    • (1996) Journal of Clinical Oncology , vol.14 , Issue.9 , pp. 2552-2559
    • Conte, P.F.1    Latreille, J.2    Mauriac, L.3    Calabresi, F.4    Santos, R.5    Campos, D.6    Bonneterre, J.7    Francini, G.8    Ford, J.M.9
  • 123
    • 77952305169 scopus 로고    scopus 로고
    • Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: An open label, randomised, phase 2 trial
    • Aft R, Naughton M, Trinkaus K, Watson M, Ylagan L, Chavez-MacGregor M, et al. Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial. Lancet Oncology 2010;11: 421-8.
    • (2010) Lancet Oncology , vol.11 , pp. 421-428
    • Aft, R.1    Naughton, M.2    Trinkaus, K.3    Watson, M.4    Ylagan, L.5    Chavez-Macgregor, M.6
  • 124
    • 33646869430 scopus 로고    scopus 로고
    • Effect of zoledronic acid on pain associated with bone metastasis in patients with prostate cancer
    • DOI 10.1093/annonc/mdl041
    • Weinfurt KP, Anstrom KJ, Castel LD, Schulman KA, Saad F. Effect of zoledronic acid on pain associated with bone metastasis in patients with prostate cancer. Annals of Oncology 2006;17: 986-9. (Pubitemid 43778991)
    • (2006) Annals of Oncology , vol.17 , Issue.6 , pp. 986-989
    • Weinfurt, K.P.1    Anstrom, K.J.2    Castel, L.D.3    Schulman, K.A.4    Saad, F.5
  • 125
    • 0344664559 scopus 로고    scopus 로고
    • Zoledronic acid: A new parenteral bisphosphonate
    • DOI 10.1016/S0149-2918(03)80327-2
    • Li EC, Davis LE. Zoledronic acid: a new parenteral bisphosphonate. Clinical Therapeutics 2003;25: 2669-708. (Pubitemid 37510584)
    • (2003) Clinical Therapeutics , vol.25 , Issue.11 , pp. 2669-2708
    • Li, E.C.1    Davis, L.E.2
  • 126
    • 84868115722 scopus 로고    scopus 로고
    • The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis
    • Hadji P, Coleman R, Gnant M, Green J. The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis. Annals of Oncology 2012;23: 2782-90.
    • (2012) Annals of Oncology , vol.23 , pp. 2782-2790
    • Hadji, P.1    Coleman, R.2    Gnant, M.3    Green, J.4
  • 127
    • 79959565208 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-Month follow-up from the ABCSG-12 randomised trial
    • Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Heck D, Menzel C, et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncology 2011;12: 631-41.
    • (2011) Lancet Oncology , vol.12 , pp. 631-641
    • Gnant, M.1    Mlineritsch, B.2    Stoeger, H.3    Luschin-Ebengreuth, G.4    Heck, D.5    Menzel, C.6
  • 128
    • 79960128817 scopus 로고    scopus 로고
    • Impact of body mass index on the efficacy of endocrine therapy in premenopausal patients with breast cancer: An analysis of the prospective ABCSG-12 trial
    • Pfeiler G, Konigsberg R, Fesl C, Mlineritsch B, Stoeger H, Singer CF, et al. Impact of body mass index on the efficacy of endocrine therapy in premenopausal patients with breast cancer: an analysis of the prospective ABCSG-12 trial. Journal of Clinical Oncology 2011;29: 2653-9.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 2653-2659
    • Pfeiler, G.1    Konigsberg, R.2    Fesl, C.3    Mlineritsch, B.4    Stoeger, H.5    Singer, C.F.6
  • 129
    • 79958182699 scopus 로고    scopus 로고
    • Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II/III breast cancer
    • Coleman R, Woodward E, Brown J, Cameron D, Bell R, Dodwell D, et al. Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II/III breast cancer. Breast Cancer Research and Treatment 2011;127: 429-38.
    • (2011) Breast Cancer Research and Treatment , vol.127 , pp. 429-438
    • Coleman, R.1    Woodward, E.2    Brown, J.3    Cameron, D.4    Bell, R.5    Dodwell, D.6
  • 131
    • 84858199619 scopus 로고    scopus 로고
    • Intravenous bisphosphonates for breast cancer: Impact on patient outcomes and scientific concepts
    • Gnant M. Intravenous bisphosphonates for breast cancer: impact on patient outcomes and scientific concepts. Breast Disease 2011;33: 71-81.
    • (2011) Breast Disease , vol.33 , pp. 71-81
    • Gnant, M.1
  • 132
    • 39749155815 scopus 로고    scopus 로고
    • Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST study results
    • DOI 10.1002/cncr.23259
    • Bundred NJ, Campbell ID, Davidson N, DeBoer RH, Eidtmann H, Monnier A, et al. Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST Study results. Cancer 2008;112: 1001-10. (Pubitemid 351304583)
    • (2008) Cancer , vol.112 , Issue.5 , pp. 1001-1010
    • Bundred, N.J.1    Campbell, I.D.2    Davidson, N.3    DeBoer, R.H.4    Eidtmann, H.5    Monnier, A.6    Neven, P.7    Von Minckwitz, G.8    Miller, J.C.9    Schenk, N.L.10    Coleman, R.E.11
  • 133
    • 77954580167 scopus 로고    scopus 로고
    • Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study
    • Eidtmann H, de Boer R, Bundred N, Llombart-Cussac A, Davidson N, Neven P, et al. Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. Annals of Oncology 2010;21: 2188-94.
    • (2010) Annals of Oncology , vol.21 , pp. 2188-2194
    • Eidtmann, H.1    De Boer, R.2    Bundred, N.3    Llombart-Cussac, A.4    Davidson, N.5    Neven, P.6
  • 134
    • 84862926420 scopus 로고    scopus 로고
    • Immediate administration of zoledronic acid reduces aromatase inhibitor-aAssociated bone loss in postmenopausal women with early breast cancer: 12-Month analysis of the E-ZO-FAST trial
    • Llombart A, Frassoldati A, Paija O, Sleeboom HP, Jerusalem G, Mebis J, et al. Immediate administration of zoledronic acid reduces aromatase inhibitor-aAssociated bone loss in postmenopausal women with early breast cancer: 12-month analysis of the E-ZO-FAST trial. Clinical Breast Cancer 2012;12: 40-8.
    • (2012) Clinical Breast Cancer , vol.12 , pp. 40-48
    • Llombart, A.1    Frassoldati, A.2    Paija, O.3    Sleeboom, H.P.4    Jerusalem, G.5    Mebis, J.6
  • 135
    • 4143105644 scopus 로고    scopus 로고
    • Ibandronate: A clinical pharmacological and pharmacokinetic update
    • DOI 10.1177/0091270004267594
    • Barrett J, Worth E, Bauss F, Epstein S. Ibandronate: a clinical pharmacological and pharmacokinetic update. Journal of Clinical Pharmacology 2004;44: 951-65. (Pubitemid 39096810)
    • (2004) Journal of Clinical Pharmacology , vol.44 , Issue.9 , pp. 951-965
    • Barrett, J.1    Worth, E.2    Bauss, F.3    Epstein, S.4
  • 136
    • 33645102452 scopus 로고    scopus 로고
    • Ibandronate: Pharmacology and preclinical studies
    • Russell RG. Ibandronate: pharmacology and preclinical studies. Bone 2006;38 S7-12.
    • (2006) Bone , vol.38
    • Russell, R.G.1
  • 141
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-κ ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • DOI 10.1158/1078-0432.CCR-05-1933
    • Body JJ, Facon T, Coleman RE, Lipton A, Geurs F, Fan M, et al. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clinical Cancer Research 2006;12: 1221-8. (Pubitemid 43342512)
    • (2006) Clinical Cancer Research , vol.12 , Issue.4 , pp. 1221-1228
    • Body, J.-J.1    Facon, T.2    Coleman, R.E.3    Lipton, A.4    Geurs, F.5    Fan, M.6    Holloway, D.7    Peterson, M.C.8    Bekker, P.J.9
  • 142
    • 84855516339 scopus 로고    scopus 로고
    • Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: Results of a phase 3, randomised, placebo-controlled trial
    • Smith MR, Saad F, Coleman R, Shore N, Fizazi K, Tombal B, et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet 2012;379: 39-46.
    • (2012) Lancet , vol.379 , pp. 39-46
    • Smith, M.R.1    Saad, F.2    Coleman, R.3    Shore, N.4    Fizazi, K.5    Tombal, B.6
  • 143
    • 78149284767 scopus 로고    scopus 로고
    • RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    • Epub ahead of print
    • Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, et al. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature. 2010;Epub ahead of print.
    • (2010) Nature
    • Gonzalez-Suarez, E.1    Jacob, A.P.2    Jones, J.3    Miller, R.4    Roudier-Meyer, M.P.5    Erwert, R.6
  • 146
    • 0041331741 scopus 로고    scopus 로고
    • Increased bone remodeling due to ovariectomy dramatically increases tumoral growth in the 5T2 multiple myeloma mouse model
    • DOI 10.1016/S8756-3282(03)00196-0
    • Libouban H, Moreau MF, Basle MF, Bataille R, Chappard D. Increased bone remodeling due to ovariectomy dramatically increases tumoral growth in the 5T2 multiple myeloma mouse model. Bone 2003;33: 283-92. (Pubitemid 37103245)
    • (2003) Bone , vol.33 , Issue.3 , pp. 283-292
    • Libouban, H.1    Moreau, M.-F.2    Basle, M.F.3    Bataille, R.4    Chappard, D.5
  • 151
    • 30944436527 scopus 로고    scopus 로고
    • Mechanisms of disease: Roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis
    • DOI 10.1038/ncponc0381, PII N0381
    • Blair JM, Zhou H, Seibel MJ, Dunstan CR. Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Natural Clinical Practice Oncology 2006;3: 41-9. (Pubitemid 43108833)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.1 , pp. 41-49
    • Blair, J.M.1    Zhou, H.2    Seibel, M.J.3    Dunstan, C.R.4
  • 152
    • 0344011473 scopus 로고    scopus 로고
    • Markers of bone remodeling in metastatic bone disease
    • DOI 10.1210/jc.2003-030910
    • Fohr B, Dunstan CR, Seibel MJ. Clinical review 165: markers of bone remodeling in metastatic bone disease. Journal of Clinical Endocrinology and Metabolism 2003;88: 5059-75. (Pubitemid 37452696)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.11 , pp. 5059-5075
    • Fohr, B.1    Dunstan, C.R.2    Seibel, M.J.3
  • 154
    • 43949092127 scopus 로고    scopus 로고
    • The use of molecular markers of bone turnover in the management of patients with metastatic bone disease
    • DOI 10.1111/j.1365-2265.2007.03112.x
    • Seibel MJ. The use of molecular markers of bone turnover in the management of patients with metastatic bone disease. Clin ical Endocrinology (Oxford) 2008;68: 839-49. (Pubitemid 351703933)
    • (2008) Clinical Endocrinology , vol.68 , Issue.6 , pp. 839-849
    • Seibel, M.J.1
  • 155
    • 34548763826 scopus 로고    scopus 로고
    • Prostate cancer survival is dependent on season of diagnosis
    • DOI 10.1002/pros.20577
    • Lagunova Z, Porojnicu AC, Dahlback A, Berg JP, Beer TM, Moan J. Prostate cancer survival is dependent on season of diagnosis. Prostate 2007;67: 1362-70. (Pubitemid 47435784)
    • (2007) Prostate , vol.67 , Issue.12 , pp. 1362-1370
    • Lagunova, Z.1    Porojnicu, A.C.2    Dahlback, A.3    Berg, J.P.4    Beer, T.M.5    Moan, J.6
  • 156
    • 33947676900 scopus 로고    scopus 로고
    • A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer
    • Li H, Stampfer MJ, Hollis JB, Mucci LA, Gaziano JM, Hunter D, et al. A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer. PLoS Medicine 2007;4: e103.
    • (2007) PLoS Medicine , vol.4
    • Li, H.1    Stampfer, M.J.2    Hollis, J.B.3    Mucci, L.A.4    Gaziano, J.M.5    Hunter, D.6
  • 157
    • 3242879228 scopus 로고    scopus 로고
    • Geographic variation of prostate cancer mortality rates in the United States: Implications for prostate cancer risk related to vitamin D
    • author reply 2
    • Grant WB. Geographic variation of prostate cancer mortality rates in the United States: implications for prostate cancer risk related to vitamin D. International Journal of Cancer 2004;111: 470-1 author reply 2.
    • (2004) International Journal of Cancer , vol.111 , pp. 470-471
    • Grant, W.B.1
  • 158
    • 35148814409 scopus 로고    scopus 로고
    • Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone
    • DOI 10.1158/0008-5472.CAN-07-1046
    • Zheng Y, Zhou H, Modzelewski JR, Kalak R, Blair JM, Seibel MJ, et al. Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research 2007;67: 9542-8. (Pubitemid 47535945)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9542-9548
    • Zheng, Y.1    Zhou, H.2    Modzelewski, J.R.K.3    Kalak, R.4    Blair, J.M.5    Seibel, M.J.6    Dunstan, C.R.7
  • 160
    • 77956409606 scopus 로고    scopus 로고
    • Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis
    • Ooi LL, Zheng Y, Zhou H, TrivediT, Conigrave AD, Seibel MJ, et al. Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone 2010;47: 795-803.
    • (2010) Bone , vol.47 , pp. 795-803
    • Ooi, L.L.1    Zheng, Y.2    Zhou, H.3    Trivedi, T.4    Conigrave, A.D.5    Seibel, M.J.6
  • 162
    • 84856426449 scopus 로고    scopus 로고
    • Roles of bone marrow cells in skeletal metastases: No longer bystanders
    • Park SI, Soki FN, McCauley LK. Roles of bone marrow cells in skeletal metastases: no longer bystanders. Cancer Microenviron 2011;4: 237-46.
    • (2011) Cancer Microenviron , vol.4 , pp. 237-246
    • Park, S.I.1    Soki, F.N.2    McCauley, L.K.3
  • 163
    • 75049085147 scopus 로고    scopus 로고
    • Osteoimmunology and the effects of the immune system on bone
    • Takayanagi H. Osteoimmunology and the effects of the immune system on bone. Nature Reviews Rheumatology 2009;5: 667-76.
    • (2009) Nature Reviews Rheumatology , vol.5 , pp. 667-676
    • Takayanagi, H.1
  • 165
    • 33846044750 scopus 로고    scopus 로고
    • Bone marrow cells in the 'pre-metastatic niche': Within bone and beyond
    • DOI 10.1007/s10555-006-9036-9, Special issue on Bone Metastasis and Cancer
    • Kaplan RN, Psaila B, Lyden D. Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer and Metastasis Reviews 2006;25: 521-9. (Pubitemid 46071861)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.4 , pp. 521-529
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 168
    • 70350231667 scopus 로고    scopus 로고
    • Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis
    • Huang Y, Song N, Ding Y, Yuan S, Li X, Cai H, et al. Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Research 2009;69: 7529-37.
    • (2009) Cancer Research , vol.69 , pp. 7529-7537
    • Huang, Y.1    Song, N.2    Ding, Y.3    Yuan, S.4    Li, X.5    Cai, H.6
  • 169
    • 19944433608 scopus 로고    scopus 로고
    • Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
    • Sun YX, Schneider A, Jung Y, Wang J, Dai J, CookK, et al. Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. Journal of Bone and Mineral Research 2005;20: 318-29.
    • (2005) Journal of Bone and Mineral Research , vol.20 , pp. 318-329
    • Sun, Y.X.1    Schneider, A.2    Jung, Y.3    Wang, J.4    Dai, J.5    Cook, K.6
  • 171
    • 21344452789 scopus 로고    scopus 로고
    • Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    • DOI 10.1158/0008-5472.CAN-05-0749
    • Kelly T. Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Research 2005;65: 5778-84. (Pubitemid 40911181)
    • (2005) Cancer Research , vol.65 , Issue.13 , pp. 5778-5784
    • Kelly, T.1    Suva, L.J.2    Huang, Y.3    MacLeod, V.4    Miao, H.-Q.5    Walker, R.C.6    Sanderson, R.D.7
  • 172
    • 59149104024 scopus 로고    scopus 로고
    • Senescent stromal-derived osteopontin promotes preneoplastic cell growth
    • Pazolli E. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Research 2009;69: 1230-9.
    • (2009) Cancer Research , vol.69 , pp. 1230-1239
    • Pazolli, E.1


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