Lysine-specific demethylase 1-selective inactivators: Protein-targeted drug delivery mechanism

Angewandte Chemie - International Edition

Volumn 52, Issue 33, 2013, Pages 8620-8624

  Ogasawara, Daisuke ^a,b   Itoh, Yukihiro ^a   Tsumoto, Hiroki ^c   Kakizawa, Taeko ^d   Mino, Koshiki ^e   Fukuhara, Kiyoshi ^d   Nakagawa, Hidehiko ^b   Hasegawa, Makoto ^e   Sasaki, Ryuzo ^f   Mizukami, Tamio ^e   Miyata, Naoki ^b   Suzuki, Takayoshi ^a,g  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^f Frontier Pharma   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

biological activity; drug delivery; drug design; kinetics; proteins

Indexed keywords

ACTIVE SITE; DELIVERY MECHANISM; DEMETHYLASE; DRUG DESIGN; MECHANISTIC STUDIES; NOVEL SERIES;

BIOACTIVITY; DRUG DELIVERY; ENZYME KINETICS; PROTEINS;

AMINO ACIDS;

AMINE OXIDASE (FLAVIN CONTAINING); ENZYME INHIBITOR; FLAVINE ADENINE NUCLEOTIDE; HISTONE DEMETHYLASE; KDM1A PROTEIN, HUMAN; LYSINE; MONOAMINE OXIDASE INHIBITOR; PEPTIDE FRAGMENT; PROTEIN; TRANYLCYPROMINE;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG DESIGN; ENZYME ACTIVE SITE; HUMAN; KINETICS; METABOLISM; MOLECULAR LIBRARY; X RAY CRYSTALLOGRAPHY;

BIOLOGICAL ACTIVITY; DRUG DELIVERY; DRUG DESIGN; KINETICS; PROTEINS;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; FLAVIN-ADENINE DINUCLEOTIDE; HISTONE DEMETHYLASES; HUMANS; LYSINE; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PEPTIDE FRAGMENTS; SMALL MOLECULE LIBRARIES; TRANYLCYPROMINE;

EID: 84882379526     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201303999     Document Type: Article

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