Unraveling genetic origin of aging-related traits: Evolving concepts

Rejuvenation Research

Volumn 16, Issue 4, 2013, Pages 304-312

  Kulminski, Alexander M ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CANCER RISK; CARDIOVASCULAR DISEASE; ENDOPHENOTYPE; ENVIRONMENTAL EXPOSURE; GENE ACTIVITY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN GENOME; INHERITANCE; LIFESPAN; MOLECULAR MECHANICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT; REPRODUCTIVE SUCCESS; RISK FACTOR; SENESCENCE;

AGING; BIOLOGICAL EVOLUTION; HUMANS; INHERITANCE PATTERNS; QUANTITATIVE TRAIT, HERITABLE;

EID: 84882355149     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2013.1441     Document Type: Article

References (112)

1. Sierra F, Hadley E, Suzman R, Hodes R. Prospects for life span extension. Annu Rev Med 2009;60:457-469
2. Olshansky SJ, Perry D, Miller RA, Butler RN. Pursuing the longevity dividend: Scientific goals for an aging world. Ann NY Acad Sci 2007;1114:11-13
3. Robine J-M. Determining Health Expectancies. Wiley, Chichester, West Sussex, England, Hoboken, NJ, 2003
4. Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: Survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci 2003;58:232-237
5. Perls TT. The different paths to 100. Am J Clin Nutr 2006; 83:484S-487S.
6. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 2003;290:2030-2040
7. Willcox DC, Willcox BJ, Wang NC, He Q, Rosenbaum M, Suzuki M. Life at the extreme limit: Phenotypic characteristics of supercentenarians in Okinawa. J Gerontol A Biol Sci Med Sci 2008;63:1201-1208
8. Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 16 2008;105:13987-13992
9. Kulminski AM, Ukraintseva SV, Culminskaya IV, Arbeev KG, Land KC, Akushevich L, Yashin AI. Cumulative deficits and physiological indices as predictors of mortality and long life. J Gerontol A Biol Sci Med Sci 2008;63: 1053-1059
10. Cournil A, Kirkwood TB. If you would live long, choose your parents well. Trends Genet 2001;17:233-235
11. Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS. A family longevity selection score: Ranking sibships by their longevity, size, and availability for study. Am J Epidemiol 2009;170:1555-1562
12. Brown WM, Beck SR, Lange EM, Davis CC, Kay CM, Langefeld CD, Rich SS. Age-stratified heritability estimation in the Framingham Heart Study families. BMC Genet 2003;4(Suppl 1):S32
13. Herskind AM, McGue M, Holm NV, Sorensen TIA, Harvald B, Vaupel JW. The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet 1996;97:319-323
14. Iachine IA, Holm NV, Harris JR, Begun AZ, Iachina MK, Laitinen M, Kaprio J, Yashin AI. How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins. Twin Res 1998;1:196-205
15. Matteini AM, Fallin MD, Kammerer CM, Schupf N, Yashin AI, Christensen K, Arbeev KG, Barr G, Mayeux R, Newman AB, Walston JD. Heritability Estimates of Endophenotypes of Long and Health Life: The Long Life Family Study. J Gerontol A Biol Sci Med Sci 2010;65A: 1375-1379
16. Martin GM, Bergman A, Barzilai N. Genetic determinants of human health span and life span: Progress and new opportunities. PLoS Genet 2007;3:e125
17. Vijg J, Suh Y. Genetics of longevity and aging. Annu Rev Med 2005;56:193-212
18. Finch CE, Tanzi RE. Genetics of aging. Science 1997;278: 407-411
19. Visscher PM, Brown MA, McCarthy MI, Yang J. Five Years of GWAS Discovery. Am J Hum Genet 2012;90:7-24
20. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan J, Lamina C, Ziegler A, Zhang W, Zee RY, Wright AF, Witteman JC, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJ, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BW, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PK, Lucas G, Luben R, Loos RJ, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010;466:707-713
21. Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009;360:1696-1698
22. McClellan J, King MC. Genetic heterogeneity in human disease. Cell 2010;141:210-217
23. Stranger BE, Stahl EA, Raj T. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics 2011;187:367-383
24. Lee SH, Wray NR, Goddard ME, Visscher PM. Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011;88:294-305
25. Kraja AT, Hunt SC, Rao DC, Davila-Roman VG, Arnett DK, Province MA. Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies. Curr Hypertens Rep 2011;13: 46-54
26. Eichler EE, Flint J, Gibson G, Kong A, Leal SM, Moore JH, Nadeau JH. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet 2010;11:446-450
27. Gibson G. Rare and common variants: Twenty arguments. Nat Rev Genet 2011;13:135-145
28. Zeggini E. Next-generation association studies for complex traits. Nat Genet 2011;43:287-288
29. Frazer KA, Murray SS, Schork NJ, Topol EJ. Human genetic variation and its contribution to complex traits. Nat Rev Genet 2009;10:241-251
30. Swales JD. Platt versus pickering: An episode in recent medical history. 1985, London: Keynes Press. p. 155
31. Schork NJ, Murray SS, Frazer KA, Topol EJ. Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev 2009;19:212-219
32. Plomin R, Haworth CM, Davis OS. Common disorders are quantitative traits. Nat Rev Genet 2009;10:872-878
33. Fisher RA. The correlation between relatives on the supposition of Mendelian inheritance. Trans R Soc Edinburgh 1918;52:399-433
34. Wright S. Genetics of abnormal growth in the guinea pig. Cold Spring Harbor Symp Quant Biol 1934;2:137-147
35. Bodmer W, Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 2008;40:695-701
36. Gorlov IP, Gorlova OY, Frazier ML, Spitz MR, Amos CI. Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet 2011;79:199-206
37. Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, Abecasis G, Altshuler D, Nickerson DA, Boerwinkle E, Sunyaev S, Bustamante CD, Bamshad MJ, Akey JM. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 2012;337:64-69
38. Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P, Van Horn L, Tracy RP, Lloyd-Jones DM. Lifetime risks of cardiovascular disease. N Engl J Med 2012;366:321-329
39. Pawitan Y, Seng KC, Magnusson PKE. How many genetic variants remain to be discovered? PLoS One 2009;4(12) e7969. doi:10.1371/journal.pone.0007969
40. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009;461: 747-753
41. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: Consensus, uncertainty and challenges. Nat Rev Genet 2008;9:356-369
42. Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL. The human disease network. Proc Natl Acad Sci USA 2007;104:8685-8690
43. Chavali S, Barrenas F, Kanduri K, Benson M. Network properties of human disease genes with pleiotropic effects. BMC Syst Biol 2010;4:78
44. Weiss KM. Tilting at quixotic trait loci (QTL): An evolutionary perspective on genetic causation. Genetics 2008;179: 1741-1756
45. Mininö AM, Murphy SL, Xu J, Kochanek KD. Deaths: Final Data for 2008. National Vital Statistics Reports 2011;59: 1-127
46. Medawar PB. An Unsolved problem of biology; an inaugural lecture delivered at University College, London, 6 December, 1951. H.K. Lewis and Co., London, 1952
47. Kirkwood TB, Austad SN. Why do we age? Nature 2000; 408:233-238
48. Williams PD, Day T. Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evolution 2003;57:1478-1488
49. Williams GC. Pleiotropy, natural-selection, and the evolution of senescence. Evolution 1957;11:398-411
50. de Magalhaes JP, Church GM. Genomes optimize reproduction: Aging as a consequence of the developmental program. Physiology (Bethesda) 2005;20:252-259
51. Hawkes K, O'Connell JF, Jones NG, Alvarez H, Charnov EL. Grandmothering, menopause, and the evolution of human life histories. Proc Natl Acad Sci USA 1998;95:1336-1339
52. Oeppen J, Vaupel JW. Demography. Broken limits to life expectancy. Science 2002;296:1029-1031
53. Hershcopf RJ, Elahi D, Andres R, Baldwin HL, Raizes GS, Schocken DD, Tobin JD. Longitudinal changes in serum cholesterol in man: An epidemiologic search for an etiology. J Chronic Dis 1982;35:101-114
54. Scheen AJ. Diabetes mellitus in the elderly: Insulin resistance and/or impaired insulin secretioñDiabetes Metab 2005;31(Spec No 2):5S27-25S34
55. Yashin AI, Akushevich IV, Arbeev KG, Akushevich L, Ukraintseva SV, Kulminski A. Insights on aging and exceptional longevity from longitudinal data: Novel findings from the Framingham Heart Study. Age 2006;28:363-374
56. Sheu Y, Cauley JA, Wheeler VW, Patrick AL, Bunker CH, Ensrud KE, Orwoll ES, Zmuda JM. Age-related decline in bone density among ethnically diverse older men. Osteoporos Int 2011;22:599-605
57. Akushevich I, Kravchenko J, Ukraintseva S, Arbeev K, Yashin AI. Age patterns of incidence of geriatric disease in the U.S. Elderly population: Medicare-based analysis. J Am Geriatr Soc 2012;60:323-327
58. De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Yashin AI, Bonafe M, Franceschi C. Age-related changes of the 3¢ APOB-VNTR genotype pool in ageing cohorts. Ann Hum Genet 1998;62(Pt 2):115-122
59. Ilveskoski E, Perola M, Lehtimaki T, Laippala P, Savolainen V, Pajarinen J, Penttila A, Lalu KH, Mannikko A, Liesto KK, Koivula T, Karhunen PJ. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-Aged men: An autopsy study. Circulation 1999;100:608-613
60. Yashin AI, Ukraintseva SV, De Benedictis G, Anisimov VN, Butov AA, Arbeev K, Jdanov DA, Boiko SI, Begun AS, Bonafe M, Franceschi C. Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. J Gerontol A Biol Sci Med Sci 2001;56: B432-B442
61. Jarvik GP, Austin MA, Fabsitz RR, Auwerx J, Reed T, Christian JC, Deeb S. Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: Longitudinal apolipoprotein E genotype effects. Genet Epidemiol 1994;11:375-384
62. Jarvik GP, Goode EL, Austin MA, Auwerx J, Deeb S, Schellenberg GD, Reed T. Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: A longitudinal analysis. Am J Hum Genet 1997; 61:171-181
63. Kulminski AM, Culminskaya I, Arbeev KG, Ukraintseva SV, Stallard E, Arbeeva L, Yashin AI. The role of lipidrelated genes, aging-related processes, and environment in healthspan. Aging Cell 2013;12:237-246
64. Carey JR, Harshman LG, Liedo P, Muller HG, Wang JL, Zhang Z. Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. Aging Cell 2008;7:470-477
65. Kulminski AM, Molleman F, Culminskaya IV, Arbeev KG, Ukraintseva SV, Carey JR, Yashin AI. Date of eclosion modulates longevity: Insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. Exp Gerontol 2009;44:718-726
66. Kirkwood TB, Cordell HJ, Finch CE. Speed-bumps ahead for the genetics of later-life diseases. Trends Genet 2011;27: 387-388
67. Martin GM. Modalities of gene action predicted by the classical evolutionary biological theory of aging. Ann NY Acad Sci 2007;1100:14-20
68. Kulminski AM, Culminskaya I, Ukraintseva SV, Arbeev KG, Land KC, Yashin AI. Beta2-Adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context. Mech Ageing Dev 2010;131:338-345
69. Summers K, Crespi BJ. Xmrks the spot: Life history tradeoffs, sexual selection and the evolutionary ecology of oncogenesis. Mol Ecol 2010;19:3022-3024
70. Alexander DM, Williams LM, Gatt JM, Dobson-Stone C, Kuan SA, Todd EG, Schofield PR, Cooper NJ, Gordon E. The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades. Biol Psychol 2007;75:229-238
71. Schnebel EM, Grossfield J. Antagonistic pleiotropy -An interspecific Drosophila comparison. Evolution 1988;42: 306-311
72. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97:1837-1847
73. Weingart SN, Ship AN, Aronson MD. Confidential clinician-reported surveillance of adverse events among medical inpatients. J Gen Intern Med 2000;15:470-477
74. Veltman JA, Brunner HG. De novo mutations in human genetic disease. Nat Rev Genet 2012;13:565-575
75. Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D'Agostino RB, Sr. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: The Framingham Heart Study. Circulation 2006;113:2914-2918
76. Yashin AI, Begun AS, Boiko SI, Ukraintseva SV, Oeppen J. The new trends in survival improvement require a revision of traditional gerontological concepts. Exp Gerontol 2001; 37:157-167
77. Roach JC, Glusman G, Smit AF, Huff CD, Hubley R, Shannon PT, Rowen L, Pant KP, Goodman N, Bamshad M, Shendure J, Drmanac R, Jorde LB, Hood L, Galas DJ. Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science 2010;328:636-639
78. Franco OH, Karnik K, Osborne G, Ordovas JM, Catt M, van der Ouderaa F. Changing course in ageing research: The healthy ageing phenotype. Maturitas 2009;63:13-19
79. Martin GM. The biology of aging: 1985-2010 and beyond. FASEB J 2011;25:3756-3762
80. Sierra F, Hadley E, Suzman R, Hodes R. Prospects for life span extension. Annu Rev Med 2009;60:457-469
81. Jazwinski SM. Biological aging research today: Potential, peeves, and problems. Exp Gerontol 2002;37:1141-1146
82. MacRae CA, Vasan RS. Next-generation genome-wide association studies: Time to focus on phenotype? Circ Cardiovasc Genet 2011;4:334-336
83. Arking DE, Chakravarti A. Understanding cardiovascular disease through the lens of genome-wide association studies. Trends Genet 2009;25:387-394
84. Bloss CS, Pawlikowska L, Schork NJ. Contemporary human genetic strategies in aging research. Ageing Res Rev 2011;10:191-200
85. Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, Rudan I, McKeigue P, Wilson JF, Campbell H. Abundant pleiotropy in human complex diseases and traits. Am J Hum Genet 2011;89:607-618
86. Koga H, Kaushik S, Cuervo AM. Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev 2011;10:205-215
87. Kulminski AM, Culminskaya I, Ukraintseva SV, Arbeev KG, Arbeeva L, Wu D, Akushevich I, Land KC, Yashin AI. Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. Aging Cell 2011;10:533-541
88. Kulminski AM, Ukraintseva SV, Arbeev KG, Manton KG, Oshima J, Martin GM, Il'yasova D, Yashin AI. Healthprotective and adverse effects of the apolipoprotein E epsilon2 allele in older men. J Am Geriatr Soc 2008;56: 478-483
89. Crespi BJ. The origins and evolution of genetic disease risk in modern humans. Ann NY Acad Sci 2010;1206:80-109
90. Kulminski AM, Culminskaya IV, Ukraintseva SV, Arbeev KG, Akushevich I, Land KC, Yashin AI. Polymorphisms in the ACE and ADRB2 genes and risks of aging-Associated phenotypes: The case of myocardial infarction. Rejuvenation Res 2010;13:13-21
91. Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, Annese V, Dubinsky M, Rotter JI, Russell RK, Bradfield JP, Sleiman PM, Glessner JT, Walters T, Hou C, Kim C, Frackelton EC, Garris M, Doran J, Romano C, Catassi C, Van Limbergen J, Guthery SL, Denson L, Piccoli D, Silverberg MS, Stanley CA, Monos D, Wilson DC, Griffiths A, Grant SF, Satsangi J, Polychronakos C, Hakonarson H. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet 2010;19: 2059-2067
92. Barnes JA, Dix DJ, Collins BW, Luft C, Allen JW. Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia. Cell Stress Chaperones 2001;6:316-325
93. Ukraintseva SV, Arbeev KG, Akushevich I, Kulminski A, Arbeeva L, Culminskaya I, Akushevich L, Yashin AI. Trade-offs between cancer and other diseases: Do they exist and influence longevity? Rejuvenation Res 2010;13: 387-396
94. Weilbach FX, Toyka KV. Does Down's syndrome protect against multiple sclerosis? Eur Neurol 2002;47:52-55
95. Finch CE. Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition. Proc Natl Acad Sci USA 2010;107(Suppl 1):1718-1724
96. Charlesworth B. Evolution of senescence: Alzheimer's disease and evolution. Curr Biol 1996;6:20-22
97. Martin GM. APOE alleles and lipophylic pathogens. Neurobiol Aging 1999;20:441-443
98. van Heemst D, Mooijaart SP, Beekman M, Schreuder J, de Craen AJ, Brandt BW, Slagboom PE, Westendorp RG. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol 2005;40:11-15
99. van der Sluis S, Posthuma D, Dolan CV. TATES: Efficient multivariate genotype-phenotype analysis for genomewide association studies. PLoS Genet 2013;9:e1003235
100. Yang Q, Wang Y. Methods for analyzing multivariate phenotypes in genetic association studies. J Prob Statist 2012;2012:652569
101. Yashin AI, Ukraintseva SV, Akushevich IV, Arbeev KG, Kulminski A, Akushevich L. Trade-off between cancer and aging: What role do other diseases play? Evidence from experimental and human population studies. Mech Ageing Dev 2009;130:98-104
102. Stallard E. Underlying and multiple cause mortality at advanced ages: United States 1980-1998. N Am Actuarial J 2002;6:64-87
103. Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, Kiel DP, Lu KP, Seshadri S, Wolf PA. Inverse association between cancer and Alzheimer's disease: Results from the Framingham Heart Study. Br Med J 2012;344
104. Tabares-Seisdedos R, Rubenstein JL. Inverse cancer comorbidity: A serendipitous opportunity to gain insight into CNS disorders. Nat Rev Neurosci 2013;14:293-304
105. Yashin AI, Wu D, Arbeev KG, Ukraintseva SV. Polygenic effects of common single-nucleotide polymorphisms on life span: When association meets causality. Rejuvenation Res 2012;15:381-394
106. Day-Williams AG, Zeggini E. The effect of next-generation sequencing technology on complex trait research. Eur J Clin Invest 2011;41:561-567
107. Neale BM, Sham PC. The future of association studies: Gene-based analysis and replication. Am J Hum Genet 2004;75:353-362
108. Luo L, Peng G, Zhu Y, Dong H, Amos CI, Xiong M. Genome-wide gene and pathway analysis. Eur J Hum Genet 2010;18:1045-1053
109. Peng G, Luo L, Siu H, Zhu Y, Hu P, Hong S, Zhao J, Zhou X, Reveille JD, Jin L, Amos CI, Xiong M. Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet 2010;18:111-117
110. Barker DJ. The developmental origins of well-being. Philos Trans R Soc Lond B Biol Sci 2004;359:1359-1366
111. de Magalhaes JP, Finch CE, Janssens G. Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and possible solutions. Ageing Res Rev 2010;9:315-323
112. Rose SPR. Commentary: Heritability estimates -long past their sell-by date. Int J Epidemiol 2006;35:525-527