Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context

Mechanisms of Ageing and Development

Volumn 131, Issue 5, 2010, Pages 338-345

  Kulminski, Alexander M ^a   Culminskaya, Irina ^a   Ukraintseva, Svetlana V ^a   Arbeev, Konstantin G ^a   Land, Kenneth C ^a   Yashin, Anatoli I ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

ADRB2 polymorphisms; Framingham Heart Study; Healthy aging; Longevity

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; ATHEROSCLEROSIS; CANCER RISK; CARDIOVASCULAR RISK; CHILD; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEART INFARCTION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; RISK ASSESSMENT;

ADOLESCENT; ADULT; AGED; AGING; ALLELES; AMINO ACID SUBSTITUTION; CARDIOVASCULAR DISEASES; CHILD; CHILD, PRESCHOOL; EVOLUTION, MOLECULAR; FEMALE; HEALTH; HUMANS; LONGEVITY; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-2; RISK; YOUNG ADULT;

EID: 77953082631     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2010.04.001     Document Type: Article

References (65)

1. Bao X., Mills P.J., Rana B.K., Dimsdale J.E., Schork N.J., Smith D.W., Rao F., Milic M., O'Connor D.T., Ziegler M.G. Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function. Hypertension 2005, 46:301-307.
2. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
3. Barzilai N., Atzmon G., Schechter C., Schaefer E.J., Cupples A.L., Lipton R., Cheng S., Shuldiner A.R. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 2003, 290:2030-2040.
4. Benovic J.L. Novel beta2-adrenergic receptor signaling pathways. J. Allergy Clin. Immunol. 2002, 110:S229-S235.
5. Bochdanovits Z., Gosso F.M., van den Berg L., Rizzu P., Polderman T.J., Pardo L.M., Houlihan L.M., Luciano M., Starr J.M., Harris S.E., Deary I.J., de Geus E.J., Boomsma D.I., Heutink P., Posthuma D. A functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly. Behav. Genet. 2009, 39:15-23.
6. Bracken A.P., Pasini D., Capra M., Prosperini E., Colli E., Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 2003, 22:5323-5335.
7. Brodde O.E. Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases. Fundam. Clin. Pharmacol. 2008, 22:107-125.
8. Brodde O.E. Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol. Ther. 2008, 117:1-29.
9. Brodde O.E., Michel M.C. Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev. 1999, 51:651-690.
10. Buscher R., Herrmann V., Ring K.M., Kailasam M.T., O'Connor D.T., Parmer R.J., Insel P.A. Variability in phenylephrine response and essential hypertension: a search for human alpha(1B)-adrenergic receptor polymorphisms. J. Pharmacol. Exp. Ther. 1999, 291:793-798.
11. Christensen K., Johnson T.E., Vaupel J.W. The quest for genetic determinants of human longevity: challenges and insights. Nat. Rev. Genet. 2006, 7:436-448.
12. Contopoulos-Ioannidis D.G., Manoli E.N., Ioannidis J.P. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J. Allergy Clin. Immunol. 2005, 115:963-972.
13. Cupples L.A., Arruda H.T., Benjamin E.J., D'Agostino R.B., Demissie S., DeStefano A.L., Dupuis J., Falls K.M., Fox C.S., Gottlieb D.J., Govindaraju D.R., Guo C.Y., Heard-Costa N.L., Hwang S.J., Kathiresan S., Kiel D.P., Laramie J.M., Larson M.G., Levy D., Liu C.Y., Lunetta K.L., Mailman M.D., Manning A.K., Meigs J.B., Murabito J.M., Newton-Cheh C., O'Connor G.T., O'Donnell C.J., Pandey M., Seshadri S., Vasan R.S., Wang Z.Y., Wilk J.B., Wolf P.A., Yang Q., Atwood L.D. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med. Genet. 2007, 8(Suppl. 1):S1.
14. Dawber T.R. The Framingham Study: The Epidemiology of Atherosclerotic Disease 1980, Harvard University Press, Cambridge, Mass.
15. Flachsbart F., Caliebe A., Kleindorp R., Blanche H., von Eller-Eberstein H., Nikolaus S., Schreiber S., Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2700-2705.
16. Flegal K.M., Graubard B.I., Williamson D.F., Gail M.H. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005, 293:1861-1867.
17. Gail M.H., Johnson N.L. Proceedings of the American Statistical Association: Sesquicentennial Invited Papers Session 1989, American Statistical Association, Alexandria, VA.
18. George C.H. Genetic polymorphisms in beta1 and beta2 adrenergic receptors: variations without a theme?. Heart Rhythm 2008, 5:822-825.
19. Govindaraju D.R., Cupples L.A., Kannel W.B., O'Donnell C.J., Atwood L.D., D'Agostino R.B., Fox C.S., Larson M., Levy D., Murabito J., Vasan R.S., Splansky G.L., Wolf P.A., Benjamin E.J. Genetics of the Framingham Heart Study population. Adv. Genet. 2008, 62:33-65.
20. Guimaraes S., Moura D. Vascular adrenoceptors: an update. Pharmacol. Rev. 2001, 53:319-356.
21. Hadley E.C., Rossi W.K. Exceptional survival in human populations: National Institute on Aging perspectives and programs. Mech. Ageing Dev. 2005, 126:231-234.
22. Heckbert S.R., Hindorff L.A., Edwards K.L., Psaty B.M., Lumley T., Siscovick D.S., Tang Z., Durda J.P., Kronmal R.A., Tracy R.P. Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. Circulation 2003, 107:2021-2024.
23. Hindorff L.A., Heckbert S.R., Psaty B.M., Lumley T., Siscovick D.S., Herrington D.M., Edwards K.L., Tracy R.P. beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: the Cardiovascular Health Study. Am. J. Hypertens. 2005, 18:392-397.
24. Huang X.E., Hamajima N., Saito T., Matsuo K., Mizutani M., Iwata H., Iwase T., Miura S., Mizuno T., Tokudome S., Tajima K. Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer. Breast Cancer Res. 2001, 3:264-269.
25. Iaccarino G., Ciccarelli M., Sorriento D., Galasso G., Campanile A., Santulli G., Cipolletta E., Cerullo V., Cimini V., Altobelli G.G., Piscione F., Priante O., Pastore L., Chiariello M., Salvatore F., Koch W.J., Trimarco B. Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system. Circ. Res. 2005, 97:1182-1189.
26. Jalba M.S., Rhoads G.G., Demissie K. Association of codon 16 and codon 27 beta2-adrenergic receptor gene polymorphisms with obesity: a meta-analysis. Obesity (Silver Spring) 2008.
27. Johnson T.E. Genes, phenes, and dreams of immortality: the 2003 Kleemeier Award lecture. J. Gerontol. A: Biol. Sci. Med. Sci. 2005, 60:680-687.
28. Kannel W.B., Feinleib M., McNamara P.M., Garrison R.J., Castelli W.P. An investigation of coronary heart disease in families. The Framingham offspring study. Am. J. Epidemiol. 1979, 110:281-290.
29. Koropatnick T.A., Kimbell J., Chen R., Grove J.S., Donlon T.A., Masaki K.H., Rodriguez B.L., Willcox B.J., Yano K., Curb J.D. A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men. J. Gerontol. A: Biol. Sci. Med. Sci. 2008, 63:1235-1240.
30. Kulminski A.M., Culminskaya I.V., Ukraintseva S.V., Arbeev K.G., Akushevich I., Land K.C., Yashin A.I. Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction. Rejuvenation Res. 2010, 13(1):13-21.
31. Kuningas M., Mooijaart S.P., van Heemst D., Zwaan B.J., Slagboom P.E., Westendorp R.G. Genes encoding longevity: from model organisms to humans. Aging Cell 2008, 7:270-280.
32. Leineweber K., Buscher R., Bruck H., Brodde O.E. Beta-adrenoceptor polymorphisms. Naunyn Schmiedebergs Arch. Pharmacol. 2004, 369:1-22.
33. Levy D., DePalma S.R., Benjamin E.J., O'Donnell C.J., Parise H., Hirschhorn J.N., Vasan R.S., Izumo S., Larson M.G. Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses. BMC Genet. 2006, 7:30.
34. Matheson M.C., Ellis J.A., Raven J., Johns D.P., Walters E.H., Abramson M.J. Beta2-adrenergic receptor polymorphisms are associated with asthma and COPD in adults. J. Hum. Genet. 2006, 51:943-951.
35. McCarthy M.I., Abecasis G.R., Cardon L.R., Goldstein D.B., Little J., Ioannidis J.P., Hirschhorn J.N. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet. 2008, 9:356-369.
36. Medawar P.B. An Unsolved Problem of Biology; An Inaugural Lecture Delivered at University College, London, 6 December, 1951 1952, H.K. Lewis and Co., London.
37. Melzer D., Hurst A.J., Frayling T. Genetic variation and human aging: progress and prospects. J. Gerontol. A: Biol. Sci. Med. Sci. 2007, 62:301-307.
38. Murabito J.M., Evans J.C., Nieto K., Larson M.G., Levy D., Wilson P.W. Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study. Am. Heart J. 2002, 143:961-965.
39. Olshansky S.J., Perry D., Miller R.A., Butler R.N. Pursuing the longevity dividend: scientific goals for an aging world. Ann. N. Y. Acad. Sci. 2007, 1114:11-13.
40. Peel N., Bartlett H., McClure R. Healthy ageing: how is it defined and measured?. Aust. J. Ageing 2004, 23:115-119.
41. Penke L., Maniega S.M., Houlihan L.M., Murray C., Gow A.J., Clayden J.D., Bastin M.E., Wardlaw J.M., Deary I.J. White Matter Integrity in the Splenium of the Corpus Callosum is Related to Successful Cognitive Aging and Partly Mediates the Protective Effect of an Ancestral Polymorphism in ADRB2. Behav. Genet. 2010.
42. Petrone A., Zavarella S., Iacobellis G., Zampetti S., Vania A., Di Pietro S., Galgani A., Leonetti F., Di Mario U., Buzzetti R. Association of beta2 adrenergic receptor polymorphisms and related haplotypes with triglyceride and LDL-cholesterol levels. Eur. J. Hum. Genet. 2006, 14:94-100.
43. Pinelli M., Giacchetti M., Acquaviva F., Cocozza S., Donnarumma G., Lapice E., Riccardi G., Romano G., Vaccaro O., Monticelli A. Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus. BMC Med. Genet. 2006, 7:85.
44. Puddu P., Puddu G.M., Cravero E., Ferrari E., Muscari A. The genetic basis of essential hypertension. Acta Cardiol. 2007, 62:281-293.
45. Sala G., Di Castelnuovo A., Cuomo L., Gattone M., Giannuzzi P., Iacoviello L., De Blasi A. The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males. Thromb. Haemost. 2001, 85:231-233.
46. Salvioli S., Olivieri F., Marchegiani F., Cardelli M., Santoro A., Bellavista E., Mishto M., Invidia L., Capri M., Valensin S., Sevini F., Cevenini E., Celani L., Lescai F., Gonos E., Caruso C., Paolisso G., De Benedictis G., Monti D., Franceschi C. Genes, ageing and longevity in humans: problems, advantages and perspectives. Free Radic. Res. 2006, 40:1303-1323.
47. Sierra F., Hadley E., Suzman R., Hodes R. Prospects for life span extension. Annu. Rev. Med. 2008.
48. Singh G.K., Yu S.M. Infant mortality in the United States: trends, differentials, and projections, 1950 through 2010. Am. J. Public Health 1995, 85:957-964.
49. Snyder E.M., Joyner M.J., Turner S.T., Johnson B.D. Blood pressure variation in healthy humans: a possible interaction with beta-2 adrenergic receptor genotype and renal epithelial sodium channels. Med. Hypotheses 2005, 65:296-299.
50. Thaker P.H., Lutgendorf S.K., Sood A.K. The neuroendocrine impact of chronic stress on cancer. Cell Cycle 2007, 6:430-433.
51. Thomas D.C., Clayton D.G. Betting odds and genetic associations. J. Natl. Cancer Inst. 2004, 96:421-423.
52. Thompson T.C. Suppression of tumor suppressors in prostate cancer: the emergence of a novel oncogenic pathway. Cancer Cell 2007, 12:405-407.
53. Uotila P. The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer. Cancer Immunol. Immunother. 1996, 43:1-9.
54. Varambally S., Yu J., Laxman B., Rhodes D.R., Mehra R., Tomlins S.A., Shah R.B., Chandran U., Monzon F.A., Becich M.J., Wei J.T., Pienta K.J., Ghosh D., Rubin M.A., Chinnaiyan A.M. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005, 8:393-406.
55. Vijg J., Suh Y. Genetics of longevity and aging. Annu. Rev. Med. 2005, 56:193-212.
56. Visser H.P., Gunster M.J., Kluin-Nelemans H.C., Manders E.M., Raaphorst F.M., Meijer C.J., Willemze R., Otte A.P. The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. Br. J. Haematol. 2001, 112:950-958.
57. Wang H., Hao B., Chen X., Zhao N., Cheng G., Jiang Y., Liu Y., Lin C., Tan W., Lu D., Wei Q., Jin L., Lin D., He F. Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. Cancer Lett. 2006, 240:297-305.
58. Willcox B.J., Donlon T.A., He Q., Chen R., Grove J.S., Yano K., Masaki K.H., Willcox D.C., Rodriguez B., Curb J.D. FOXO3A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:13987-13992.
59. Willcox D.C., Willcox B.J., Wang N.C., He Q., Rosenbaum M., Suzuki M. Life at the extreme limit: phenotypic characteristics of supercentenarians in Okinawa. J. Gerontol. A: Biol. Sci. Med. Sci. 2008, 63:1201-1208.
60. Williams P.D., Day T. Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evolution 2003, 57:1478-1488.
61. Yu J., Cao Q., Mehra R., Laxman B., Tomlins S.A., Creighton C.J., Dhanasekaran S.M., Shen R., Chen G., Morris D.S., Marquez V.E., Shah R.B., Ghosh D., Varambally S., Chinnaiyan A.M. Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell 2007, 12:419-431.
62. Yu J.T., Tan L., Ou J.R., Zhu J.X., Liu K., Song J.H., Sun Y.P. Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility. Brain Res. 2008, 1210:216-222.
63. Ziegler A., Konig I.R., Thompson J.R. Biostatistical aspects of genome-wide association studies. Biomed. J. 2008, 50:8-28.
64. Zimmer C. Evolution: The Triumph of an Idea 2001, HarperCollins, New York.
65. Zintzaras E., Raman G., Kitsios G., Lau J. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch. Intern. Med. 2008, 168:1077-1089.