Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-seckel syndrome fibroblasts

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 9, 2013, Pages 1001-1009

  Tivey, Hannah S E ^a   Rokicki, Michal J ^a   Barnacle, James R ^a   Rogers, Matthew J ^a   Bagley, Mark C ^b   Kipling, David ^a   Davis, Terence ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

ATR; Caveolin 1.; Chromosome instability; Fragile sites; p53; Premature aging; Progeroid syndromes; Replication stress; Telomeres; Werner syndrome

Indexed keywords

ACTIN; ATR PROTEIN, HUMAN; CAV1 PROTEIN, HUMAN; CAVEOLIN 1; CELL CYCLE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE INHIBITOR; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TELOMERASE; TERT PROTEIN, HUMAN;

ARTICLE; ATR; CAVEOLIN-1.; CELL AGING; CELL CULTURE; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; DRUG ANTAGONISM; DRUG EFFECT; DWARFISM; ENZYMOLOGY; FIBROBLAST; FRAGILE SITES; GENETICS; HUMAN; METABOLISM; MICROCEPHALY; MUTATION; PATHOLOGY; PREMATURE AGING; PROGEROID SYNDROMES; REPLICATION STRESS; SIGNAL TRANSDUCTION; TELOMERES; TUMOR SUPPRESSOR GENE; WERNER SYNDROME;

ATR; CAVEOLIN-1.; CHROMOSOME INSTABILITY; FRAGILE SITES; P53; PREMATURE AGING; PROGEROID SYNDROMES; REPLICATION STRESS; TELOMERES; WERNER SYNDROME;

ACTINS; CAVEOLIN 1; CELL AGING; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; DWARFISM; FIBROBLASTS; GENES, P53; HUMANS; MAP KINASE SIGNALING SYSTEM; MICROCEPHALY; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TELOMERASE;

EID: 84882283830     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls336     Document Type: Article

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