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Hayes-Jordan A, Doherty D, West S, et al. Outcome after surgical resection of recurrent rhabdomyosarcoma. J Pediatr Surg 2006; 31:4. Although published a few years ago, this is the only article published in more than a decade regarding this issue. The conclusion of this article is that, even though recurrent RMS is rare, aggressive surgical therapy is warranted in certain patients.
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This article from Europe is the most recent on second-look operation. Please also see a US article by Rodeberg just accepted for publication in Journal of Clinical Oncology. Second-look operations are to be distinguished from operations for recurrent disease. In second-look operation, there is a planned re-operation at the completion of protocol-prescribed chemotherapy and radiotherapy. There has been previous controversy about the utility of routine second-look operations in the absence of any radiographic findings. They conclude that in some sites there is still utility in this approach
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Cecchetto BG, Carretto E, Bisogno G, et al. Complete second look operation and radiotherapy in locally advanced nonalveolar rhabdomyosarcoma in children: a report from the AIEOP soft tissue sarcoma committee. Pediatric Blood Cancer 2008; 51:593-597. This article from Europe is the most recent on second-look operation. Please also see a US article by Rodeberg just accepted for publication in Journal of Clinical Oncology. Second-look operations are to be distinguished from operations for recurrent disease. In second-look operation, there is a planned re-operation at the completion of protocol-prescribed chemotherapy and radiotherapy. There has been previous controversy about the utility of routine second-look operations in the absence of any radiographic findings. They conclude that in some sites there is still utility in this approach.
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