Effects of bosentan, an edothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2

Biopharmaceutics and Drug Disposition

Volumn 28, Issue 1, 2007, Pages 13-18

  Mano, Yuji ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Bosentan; BSEP; Inhibition; MRP2; Stimulation

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; BILE SALT; BILE SALT EXPORT PUMP; BOSENTAN; ESTRADIOL 17 GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN 2; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; ABCB11 PROTEIN, HUMAN; ABCB11 PROTEIN, RAT; ABCC2 PROTEIN, RAT; ADENOSINE PHOSPHATE; DRUG DERIVATIVE; ENDOTHELIN RECEPTOR; ESTRADIOL; ESTRADIOL 17 BETA GLUCURONIDE; ESTRADIOL-17 BETA-GLUCURONIDE; GLYCOPROTEIN P; P GLYCOPROTEIN 2; P-GLYCOPROTEIN 2; SULFONAMIDE;

ARTICLE; BILE FLOW; BILE SECRETION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; IC 50; IN VITRO STUDY; LEPIDOPTERA; MEMBRANE VESICLE; NONHUMAN; PROTEIN FUNCTION; RAT; TRANSPORT KINETICS; ANIMAL; ARMYWORM; CELL LINE; CYTOPLASM VESICLE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CYTOPLASMIC VESICLES; ESTRADIOL; HUMANS; P-GLYCOPROTEINS; RATS; RECEPTORS, ENDOTHELIN; SPODOPTERA; SULFONAMIDES; TAUROCHOLIC ACID;

EID: 33846532456     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.527     Document Type: Article

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