The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes

Leukemia Research

Volumn 34, Issue 4, 2010, Pages 507-512

  da Costa, Simone V ^a   Roela, Rosimeire A ^a   Junqueira, Mara Souza ^a   Arantes, Camila ^b   Brentani, M Mitzi ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

Author keywords

Bone marrow stromal cell; Leukemia inhibitor factor; MAPK; p38MAPK; Pediatric myelodysplastic syndromes; Serum

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CELL CULTURE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MALE; MYELODYSPLASTIC SYNDROME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SCHOOL CHILD; SIGNAL TRANSDUCTION; STROMA CELL;

ANTHRACENES; BONE MARROW CELLS; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; FEMALE; FLAVONOIDS; HUMANS; IMIDAZOLES; INFANT; LEUKEMIA INHIBITORY FACTOR; MALE; MYELODYSPLASTIC SYNDROMES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDINES; SERUM; STROMAL CELLS;

EID: 76749100084     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.10.012     Document Type: Article

References (17)

1. Cazzola M., and Malcovati L. Myelodysplastic syndromes-coping with ineffective hematopoiesis. N Engl J Med 352 (2005) 536-538
2. López-Karpovitch X., Barrales-Benítez O., Flores M., and Piedras J. Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia. Cytokine 20 4 (2002) 154-162
3. Kim D.H., Yoo K.H., Choi K.S., Choi J., Choi S.Y., Yang S.E., et al. Gene expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cell. Cytokine 31 2 (2005) 119-126
4. Roela R.A., Carraro D.M., Brentani H.P., Kaiano J.H., Simão D.F., Guarnieiro R., et al. Gene stage-specific expression in the microenvironment of pediatric myelodysplastic syndromes. Leukemia Res 31 5 (2007) 579-589
5. Narendran A., Hawkins L.M., Ganjavi H., Vanek W., Gee M.F., Barlow J.W., et al. Characterization of bone marrow stromal abnormalities in a patient with constitutional trisomy 8 mosaicism and myelodysplastic syndrome. Pediatr Hematol Oncol 21 3 (2004) 209-221
6. Shih C.C., Hu M.C., Hu J., Weng Y., Yazaki P.J., Medeiros J., et al. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood 95 6 (2000) 1957-1966
7. Lorgeot V., Rougier F., Fixe P., Cornu E., Praloran V., and Denizot Y. Spontaneous and inducible production of leukaemia inhibitory factor by human bone marrow stromal cells. Cytokine 9 10 (1997) 754-758
8. Rougier F., Cornu E., Praloran V., and Denizot Y. IL-6 and IL-8 production by human bone marrow stromal cells. Cytokine 10 (1998) 93-97
9. Nakao T., Kim S., Ohta K., Kawano H., Hino M., Miura K., et al. Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. Br J Pharmacol 136 7 (2002) 975-984
10. Navas T.A., Mohindru M., Estes M., Ma J.Y., Sokol L., Pahanish P., et al. Inhibition of overactivated p38MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood 108 13 (2006) 4170-4177
11. Navas T., Zhou L., Estes M., Haghnazari E., Nguyen A.N., Mo Y., et al. Inhibition of p38alpha MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment. Leukemia Lymphoma 49 10 (2008) 1963-1975
12. Zebisch A., Czernilofsky A.P., Keri G., Smigelskaite J., Sill H., and Troppmair J. Signaling through RAS-RAF-MEK-ERK: from basics to bedside. Curr Med Chem 14 5 (2007) 601-623
13. Katsoulidis E., Li Y., Yoon P., Sassano A., Altman J., Kannan-Thulasiraman P., et al. Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Res 65 19 (2005) 9029-9037
14. Greenberg P. Treatment of myelodysplastic syndrome with agents interfering with inhibitory cytokines. Ann Rheum Dis 60 Suppl. 3 (2001) iii41-iii42
15. Borojevic R., Roela R.A., Rodarte R.S., Thiago L.S., Pasini F.S., Conti F.M., et al. Bone marrow stroma in childhood myelodysplastic syndrome: composition, ability to sustain hematopoiesis in vitro, and altered gene expression. Leukemia Res 28 8 (2004) 831-844
16. Dvorak P., and Hampl A. Basic fibroblast growth factor and its receptors in human embryonic stem cells. Folia Histochem Cytobiol 43 4 (2005) 203-208 [review]
17. Zhou L., Opalinska J., and Verma A. p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure. Cell Cycle 6 5 (2007) 534-537