Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Epple, Laura M ^a,b   Dodd, Rebecca D ^c   Merz, Andrea L ^d   Dechkovskaia, Anjelika M ^c   Herring, Matthew ^a   Winston, Benjamin A ^a   Lencioni, Alex M ^a   Russell, Rae L ^a   Madsen, Helen ^a   Nega, Meheret ^a   Dusto, Nathaniel L ^a   White, Jason ^a   Bigner, Darell D ^c   Nicchitta, Christopher V ^c   Serkova, Natalie J ^a,d   Graner, Michael W ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIOXIDANT; CHAPERONE; CHOLESTEROL; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PHOSPHOLIPID; TEMOZOLOMIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TUMOR; CANCER PROGNOSIS; CANCER RESISTANCE; CELL METABOLISM; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DATA BASE; DRUG TARGETING; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; GLIOMA CELL; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPOGENESIS; METABOLISM; METABOLOMICS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEAR MAGNETIC RESONANCE; PHOSPHOLIPID METABOLISM; PROTEIN AGGREGATION; RNA TRANSLATION; TUMOR CELL LINE; TUMOR RECURRENCE; TUMOR XENOGRAFT; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL LINE, TUMOR; DACARBAZINE; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GLIOMA; HUMANS; LIPOGENESIS; MICE; MOLECULAR CHAPERONES; NEOPLASM GRADING; PROGNOSIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UNFOLDED PROTEIN RESPONSE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84881569183     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073267     Document Type: Article

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