Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

Neuro-Oncology

Volumn 3, Issue 2, 2001, Pages 73-81

  Iida, Takashi ^a,b   Furuta, Akiko ^a,b   Kawashima, Masatou ^a   Nishida, Jun Ichi ^a   Nakabeppu, Yusaku ^a,b   Iwaki, Toru ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXO 7 HYDRODEOXYGUANOSINE; 8 OXODGTPASE; 8-OXO-7-HYDRODEOXYGUANOSINE; 8-OXODGTPASE; DEOXYGUANOSINE; DRUG DERIVATIVE; PHOSPHATASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOPSY; BRAIN TUMOR; CASE REPORT; CHEMISTRY; CHILD; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFANT; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AUTOPSY; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; DEOXYGUANOSINE; DNA REPAIR ENZYMES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MIDDLE AGED; PHOSPHORIC MONOESTER HYDROLASES; REACTIVE OXYGEN SPECIES;

EID: 0035319295     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/15228517-3-2-73     Document Type: Article

References (41)

1. Akiyama, M., Maki, H., Sekiguchi, M., and Horiuchi T. (1989) A specific role of MutT protein: To prevent dG.dA mispairing in DNA replication. Proc. Natl. Acad. Sci. U.S.A. 86, 3949-3952.
2. Bestwick, R.K., Moffett, G.L., and Mathews, C.K. (1982) Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells. J. Biol. Chem. 257, 9300-9304.
3. Boiteux, S., and Radicella, J.P. (1999) Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress. Biochimie 81, 59-67.
4. Cobbs, C.S., Brenman, J.E., Aldape, K.D., Bredt, D.S., and Israel, M.A. (1995) Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res. 55, 727-730.
5. Floyd, R.A. (1990) The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis 11, 1447-1450.
6. Fraga, C.G., Shigenaga, M.K., Park, J.W., Degan, P., and Ames, B.N. (1990) Oxidative damage to DNA during aging: 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. U.S.A. 87, 4533-4537.
7. Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y., and Kasai, H. (1999) The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J. Biol. Chem. 274, 18201-18205.
8. Furuichi, M., Yoshida, M.C., Oda, H., Tajiri, T., Nakabeppu, Y., Tsuzuki, T, and Sekiguchi, M. (1994) Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dG TPase for prevention of A:T to C:G transversion. Genomics 24, 485-490.
9. Inoue, M., Osaki, T., Noguchi, M., Hirohashi, S., Yasumoto, K., and Kasai, H. (1998) Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA. Jpn. J. Cancer Res. 89, 691-695.
10. Kakuma, T., Nishida, J., Tsuzuki, T., and Sekiguchi, M. (1995) Mouse MTH1 protein with 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphatase activity that prevents transversion mutation: cDNA cloning and tissue distribution. J. Biol. Chem. 270, 25942-25948.
11. Kang, D., Nishida, J., Iyama, A., Nakabeppu, Y., Furuichi, M., Fujiwara, T., Sekiguchi, M., and Takeshige, K. (1995) Intracellular localization of 8-oxo-dG TPase in human cells, with special reference to the role of the enzyme in mitochondria. J. Biol. Chem. 270, 14659-14665.
12. Kennedy, C.H., Cueto, R., Belinsky, S.A., Lechner, J.F., and Pryor, W.A. (1998) Overexpression of hMTH1 mRNA: A molecular marker of oxidative stress in lung cancer cells. FEBS Lett. 429, 17-20.
13. Kondo, S., Toyokuni, S., Iwasa, Y., Tanaka, T., Onodera, H., Hiai, H., and Imamura, M. (1999) Persistent oxidative stress in human colorectal carcinoma, but not in adenoma. Free Radic. Biol. Med. 27, 401-410.
14. Lee, B.M., Jang, J.J., and Kim, H.S. (1998) Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma. Cancer Lett. 125, 61-68.
15. Maki, H., and Sekiguchi, M. (1992) MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355, 273-275.
16. Matsui, M., Nishigori, C, Toyokuni, S., Takada, J., Akaboshi, M., Ishikawa, M., Imamura, S., and Miyachi, Y. (1999) The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2′-deoxyguanosine in arsenic-related Bowen's disease. J. Invest Dermatol. 113, 26-31.
17. Michaels, M.L, Cruz, C., Grollman, A.P., and Miller, J.H. (1992) Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl. Acad. Sci. U.S.A. 89, 7022-7025.
18. Musarrat, J., Arezina-Wilson, J., and Wani, A.A. (1996) Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur. J. Cancer 32A, 1209-1214.
19. Nishioka, K., Ohtsubo, T., Oda, H., Fujiwara, T., Kang, D., Sugimachi, K., and Nakabeppu, Y. (1999). Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol. Biol. Cell 10, 1637-1652.
20. Nowak, S., Zukiel, R., Olsen, A., Siboska, G., Gawronska I., and Barciszewski, J. (1999). 8-Oxo-guanosine as a marker of neoplastic process in brain. Neurol. Neurochir. Pol. 33, 1339-1348.
21. Oda, H., Nakabeppu, Y., Furuichi, M., and Sekiguchi, M. (1997). Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase: Alternative splicing of transcription products. J. Biol. Chem. 272, 17843-17850.
22. Oda, H., Taketomi, A., Maruyama, R., Itoh, R., Nishioka, K., Yakushiji, H., Suzuki, T., Sekiguchi, M., and Nakabeppu, Y. (1999). Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism. Nucleic Adds Res. 27, 4335-4343.
23. Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T., and Nakabeppu, Y. (2000) Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res. 28, 1355-1364.
24. Okamoto, K., Toyokuni, S., Uchida, K., Ogawa, O., Takenewa, J., Kakehi, Y., Kinoshita, H., Hattori-Nakakuki, Y., Hiai, H., and Yoshida, O. (1994) Formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Int. J. Cancer 58, 825-829.
25. Okamoto, K., Toyokuni, S., Kim, W.J., Ogawa, O., Kakehi, Y., Arao, S., Hiai H., and Yoshida, O. (1996) Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: Evidence of persistent oxidative stress in cancer. Int. J. Cancer 65, 437-441.
26. Olinski, R., Zastawny, T., Budzbon, J., Skokowski, J., Zegarski, W., and Dizdaroglu, M. (1992) DNA base modifications in chromatin of human cancerous tissues. FEBS Lett. 309, 193-198.
27. Oliva, M.R., Ripoll, F., Muniz, P., Iradi, A., Trullenque, R., Valls, V., Drehmer, E., and Saez, G.T. (1997) Genetic alterations and oxidative metabolism in sporadic colorectal tumors from a Spanish community. Mol. Carcinog. 18, 232-243.
28. Sakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S., Maki, H., and Sekiguchi, M. (1993) Cloning and expression of cDNA for human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268, 23524-23530.
29. Sekiguchi, M. (1996) MutT-related error avoidance mechanism for DNA synthesis. Genes Cells 1, 139-145.
30. Shimura-Miura, H., Hattori, N., Kang, D., Miyako, K., Nakabeppu, Y., and Mizuno, Y. (1999) Increased 8-oxo-dG TPase in the mitochondria of substantia nigral neurons in Parkinson's disease. Ann. Neurol. 46, 920-924.
31. Slupska, M.M., Baikalov, C., Luther, W.M., Chiang, J.-H., Wei, Y.-F., and Miller, J.H. (1996) Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J. Bacteriol. 178, 3885-3892.
32. Slupska, M.M., Luther, W.M., Chiang, J.-H., Yang, H., and Miller, J.H. (1999) Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J. Bacteriol. 181, 6210-6213.
33. Tajiri, T., Maki, H., and Sekiguchi, M. (1995) Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutat Res. 336, 257-267.
34. Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y., and Nakamura, Y. (2000) A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404, 42-49.
35. Tchou, J., Kasai, H., Shibutani, S., Chung, M.H., Laval, J., Grollman, A.P., and Nishimura, S. (1991) 8-oxo-guanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc. Natl. Acad. Sci. U.S.A. 88, 4690-4694.
36. Toyokuni, S., Okamoto, K., Yodoi, J., and Hiai, H. (1995) Persistent oxidative stress in cancer. FEBS Lett. 358, 1-3.
37. Toyokuni, S., Tanaka, T., Hattori, Y., Nishiyama, Y., Yoshida, A., Uchida, K., Hiai, H., Ochi, H., and Osawa, T. (1997) Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest 76, 365-374.
38. Wani, G., Milo, G.E., and D'Ambrosio, S.M. (1998) Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells. Cancer Lett. 125, 123-130.
39. Yakushiji, H., Maraboeuf, F., Takahashi, M., Deng, Z.-S., Kawabata, S., Nakabbeppu, Y., and Sekiguchi, M. (1997) Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity. Mutat. Res. 384, 181-194.
40. Yamamoto, T., Hosokawa, K., Tamura, T., Kanno, H., Urabe, M., and Honjo, H. (1996) Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in women with or without gynecologic cancer. J. Obstet. Gynecol. Res. 22, 359-363.
41. Yoshii, Y., Saito, A., Zhao, D.W., and Nose, T. (1999) Copper/zinc superoxide dismutase, nuclear DNA content, and progression in human gliomas. J. Neurooncol. 42, 103-108.