Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3599-3603

  Ackerstaff, E ^a   Pflug, B R ^a   Nelson, J B ^a   Bhujwalla, Z M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CHOLINE DERIVATIVE; GLYCEROPHOSPHORYLCHOLINE; PHOSPHORYLCHOLINE;

ANDROGEN SYNTHESIS; ARTICLE; CANCER RECURRENCE; HUMAN; HUMAN CELL; MALE; MALIGNANT TRANSFORMATION; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE DIAGNOSIS; SIGNAL TRANSDUCTION; STROMA CELL;

ANDROGENS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CHOLINE; EPITHELIAL CELLS; HUMANS; MALE; NEOPLASM METASTASIS; NEOPLASMS, HORMONE-DEPENDENT; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHATIDYLCHOLINES; PHOSPHORYLCHOLINE; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN;

EID: 0035328487     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Diagnosis and staging of prostatic carcinoma: What is really necessary?
2. Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution
3. Prostate cancer: Metabolic response to cryosurgery as detected with 3D H-1 MR spectroscopic imaging
4. Positron emission tomography of esophageal carcinoma using (11)C- choline and (18)F-fluorodeoxyglucose: A novel method of preoperative lymph node staging
5. Citrate alterations in primary and metastatic human prostatic adenocarcinomas: 1H magnetic resonance spectroscopy and biochemical study
6. Citrate as an in vivo marker to discriminate prostate cancer from benign prostatic hyperplasia and normal prostate peripheral zone: Detection via localized proton spectroscopy
7. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
8. Establishment of a new prostatic carcinoma cell line (TSU-Pr1)
9. Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma
10. Metastatic properties of the human prostatic cell line, PPC-1, in athymic nude mice
11. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
12. The LNCaP cell line - A new model for studies on human prostatic carcinoma
13. LNCaP model of human prostatic carcinoma
14. A high-resolution study of chromosome changes in a human prostatic carcinoma cell line (LNCaP)
15. Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice
16. Isolation of a human prostate carcinoma cell line (DU 145)
17. Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice
18. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
19. Chromosomal analysis of human prostatic adenocarcinoma cell lines
20. Chromosome identity of human prostate cancer cell lines, PC-3 and PPC-1
21. The role of stroma in prostatic carcinogenesis
22. Quantitative proton spectroscopy of canine brain: In vivo and in vitro correlations
23. In vivo 1H MRS choline: Correlation with in vitro chemistry/histology
24. PET imaging of prostate cancer using carbon-11-choline
25. Immortalization and transformation are associated with specific alterations in choline metabolism
26. Tumour phospholipid metabolism
27. Increase of GPC levels in cultured mammalian cells during acidosis: A 31P MR spectroscopic study using a continuous bioreactor system
28. Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method
29. Choline kinase inhibitors as a novel approach for antiproliferative drug design
30. Increased choline kinase activity and elevated phosphocholine levels in human colon cancer
31. Increased phospholipid fatty acid remodeling in human and rat prostatic adenocarcinoma tissues
32. Group II phospholipase A2 in human mate reproductive organs and genital tumors
33. Altered phosphatidylcholine metabolism in C3HI0T1/2 cells transfected with the Harvey-ras oncogene
34. Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines
35. Ha-ras-transformation alters the metabolism of phosphatidylethanolamine and phosphatidylcholine in NIH 3T3 fibroblasts
36. Alterations in sphingomyelin and fatty acids in human benign prostatic hyperplasia and prostatic cancer
37. Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines
38. Prostate cancer cell cycle regulators: Response to androgen withdrawal and development of androgen independence
39. Androgen receptor abnormalities
40. The human androgen receptor: Structure/function relationship in normal and pathological situations