Epigenetic effects of ethanol on the liver and gastrointestinal system

Alcohol Research: Current Reviews

Volumn 35, Issue 1, 2012, Pages 47-55

  Shukla, Shivendra D ^a   Lim, Robert W ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Alcohol consumption; Alcohol induced epigenetic alterations; Alcoholic liverdisease; Cell signaling; DNA methylation; Epigenetic effects; Epigenetic mechanisms; Epigenetics; Ethanol; Ethanol metabolism; Gastrointestinal system; Hepatic carcinoma; Histoneacetylation; Immune system; Liver; Liver cancer; Micrornas (miRNAs); Oxidative stress; Steatohepatitis

Indexed keywords

ALCOHOL; CENTRAL DEPRESSANT AGENT;

ALCOHOL LIVER DISEASE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GASTROINTESTINAL TRACT; GENETIC EPIGENESIS; GENETICS; HUMAN; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; OXIDATIVE STRESS; REVIEW;

CARCINOMA, HEPATOCELLULAR; CENTRAL NERVOUS SYSTEM DEPRESSANTS; EPIGENESIS, GENETIC; ETHANOL; GASTROINTESTINAL TRACT; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; LIVER NEOPLASMS; OXIDATIVE STRESS;

EID: 84881519120     PISSN: 21683492     EISSN: 21694796     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

1. Ara, A.I.; Xia, M.; Ramani, K., et al. S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology 47(5):1655-1666, 2008. PMiD: 18393372
2. Aroor, A.R.; James, T.T.; Jackson, D.E.; and Shukla, S.D. Differential changes in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol. Alcoholism: Clinical and Experimental Research 34(9):1543-1551, 2010. PMiD: 20586759
3. Bala, S.; Marcos, M.; Kodys, K., et al. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor (TNFa) production via increased mRNA half-life in alcoholic liver disease. Journal of Biological Chemistry 286(2):1436-1444, 2011. PMiD: 21062749
4. Bardag-Gorce, F.; French, B.A.; Joyce, M., et al. Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels. Experimental and Molecular Pathology 82(2):197-202, 2007.PMiD: 17208223
5. Cao, P.; Deng, Z.; Wan, M., et al. MicroRNA-101 negatively regulates EZh2 and its expression is modulated by androgen receptor and HiF-1 alpha/HiF-1 beta. Molecular Cancer 9:108, 2010. PMiD: 20478051
6. Castoldi, M.; Vujic spasic, M.; Altamura, S., et al. The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. Journal of Clinical Investigation 121(4):1386-1396, 2011. PMiD: 21364282
7. Choi, S.W.; Stickel, F.; Baik, H.W., et al. Chronic alcohol consumption induces genomic but not p53-specific DNA hypomethylation in rat colon. Journal of Nutrition 129(11):1945-1950, 1999. PMiD: 10539767
8. Choudhury, M., and Shukla, S.D. Surrogate alcohols and their metabolites modify histone H3 acetylation: involvement of histone acetyl transferase and histone deacetylase. Alcoholism: Clinical and Experimental Research 32(5):829-839, 2008. PMiD: 18336638
9. Choudhury, M.; Pandey, R.S.; Clemens, D.L., et al. knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells. Alcohol 45(4):311-324, 2011. PMiD: 21367571
10. Choudhury, M.; Park, P.H.; Jackson, D.; and shukla, S.D. Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes. Alcohol 44(6):531-540, 2010. PMiD: 20705415
11. Coulouarn, C.; Corlu, A.; Glaise, D., et al. Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. Cancer Research 72(10):2533-2542, 2012. PMiD: 22419664
12. Dannenberg, L.o.; Chen, H.J.; Tian, H.; and Edenberg, H.J. Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. Alcoholism: Clinical and Experimental Research 30(6):928-937, 2006. PMiD: 16737450
13. Dippold, R.P.; Vadigepalli, R.; Gonye, G.E.; and Hoek, J.B. Chronic ethanol feeding enhances mir-21 induction during liver regeneration while inhibiting proliferation in rats. American Journal of Physiology. Gastroinstestinal and Liver Physiology 303(6):G733-G743, 2012. PMiD: 22790595
14. Dippold, R.P.; Vadigepall, R.; Gonye, G.E., et al. Chronic ethanol feeding alters miRNA expression dymanics during liver regeneration. Alcoholism: Clinical and Experimental Research, 37(suppl 1):E59-E69, 2013. PMiD: 22823254
15. Dolgniuc, A.; Petrasek, J.; Kodys, K., et al. MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcoholism: Clinical and Experimental Research 33(10):1704-1710, 2009. PMiD: 19572984
16. Esau, C.; Davis, S.; Murray, S.F., et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabolism 3(2):87-98, 2006. PMiD: 16459310
17. Foster, S.L.; Hargreaves, D.C.; and Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 447(7147):972-978, 2007. PMiD: 17538624
18. James, T.T.; Aroor, A.R.; Lim, R.W.; and shukla, S.D. Histone H3 phosphorylation (ser10, ser28) and phos-phoacetylation (K9s10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol. Journal of Pharmacology and Experimental Therapeutics 340(2):237-247, 2012. PMiD: 22025646
19. Kelly, T.J.; Lerin, C.; Haas, W., et al. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1 p through lysine acetylation. Journal of Biological Chemistry 284(30):19945-19952, 2009. PMiD: 19491097
20. Kendrick, S.F.; O'Boyle, G.; Mann, J., et al. Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology 51(6):1988-1997, 2010. PMiD: 20232292
21. Keshavarzian, A.; Farhadi, A.; Forsythy, C.B., et al. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotox-emia prior to development of alcoholic steatohepatitis in rats. Journal of Hepatology 50(3):538-547, 2009.PMiD:19155080
22. Kim, J., and shukla, S.D. Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissues. Alcohol and Alcoholism 41(2):126-132, 2006. PMiD: 16314425
23. Kim, J., and shukla, S.D. Histone H3 modifications in rat hepatic stellate cells by ethanol. Alcohol and Alcoholism 40(5):367-372, 2005. PMiD: 15939707
24. Kirpich, I.; Ghare, S.; Zhang, J., et al. Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3. Alcoholism: Clinical and Experimental Research 36(9):1578-1586, 2012.PMiD: 22375794
25. Kutay, H.; Klepper, C.; Wang, B., et al. Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1(N/+)) mice to hepatic steatosis upon feeding liquid alcohol diet. PLoS One 7(8):e41949, 2012. PMiD: 22905112
26. Lambert, M.P.; Paliwal, A, Vaissiere, T., et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. Journal of Hepatology 54(4):705-715, 2011. PMiD:21146512
27. Lee, J.; Padhye, A.; sharma, A., et al. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. Journal of Biological Chemistry 285(17): 12604-12611, 2010.PMiD: 20185821
28. Lee, Y., and shukla, S.D. Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acet aldehyde. European Journal of Pharmacology 573(1-3):29-38, 2007.PMiD: 17643407
29. Li, Y.; Kong, D.; Ahmad, A., et al. Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion. Epigenetics 7(8):940-949, 2012. PMiD: 22805767
30. Lu, S.C., and Mato, J.M. S-Adenosylmethionine in liver health, injury, and cancer. Physiological Reviews 92(4):1515-1542, 2012. PMiD: 23073625
31. Maa, M.C.; Chang, M.Y.; Hsieh, M.Y., et al. Butyrate reduced lipolpolysaccharide-mediated macrophage migration by suppression of src enhancement and focal adhesion kinase activity. Journal of Nutritional Biochemistry 21 (12):1186-1192, 2010. PMiD: 20149623
32. Mandrekar, P., and Szabo, G. signalling pathways in alcohol-induced liver inflammation. Journal of Hepatology 50(6):1258-1266, 2009. PMiD: 19398236
33. Miranda, R.C.; Pietrzykowski, A.Z.; Tang, Y., et al. MicroRNAs: Master regulators of ethanol abuse and toxicity? Alcoholism: Clinical and Experimental Research 34(4):575-587, 2010. PMiD: 20102566
34. Oliva, J.; French, B.A.; Li, J., et al. Sirt1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol. Experimental and Molecular Pathology 85(3):155-159, 2008. PMiD: 18793633
35. Ouko, L.A.; shantikumar, K.; Knezovich, J., et al. Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes: implications for fet al alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research 33(9):1615-1627, 2009. PMiD: 19519716
36. Pal-Bhadra, M.; Bhadra, U.; Jackson, D.E., et al. Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes. Life Sciences 81(12):979-987, 2007. PMID: 17826801
37. Park, P.H.; Lim, R.W.; and Shukla, S.D. Gene selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed alcohol. Alcohol and Alcoholism 47(3):233-239, 2012. PMiD:22301686
38. Park, P.H.; Lim, R.W.; and Shukla, S.D. Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: Potential mechanism for gene expression. American Journal of Physiology. Gastrointestinal and Liver Physiology 289(6):G1124-G1136, 2005. PMiD: 16081763
39. Park, P.H.; Miller, R.; and Shukla, S.D. Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. Biochemical and Biophysical Research Communications 306(2):501-504, 2003. PMiD: 12804592
40. Pochareddy, S., and Edenberg, H.J. Chronic alcohol exposure alters gene expression in HepG2 cells. Alcoholism: Clinical and Experimental Research 36(6):1021-1033, 2012.PMID: 22150570
41. Saeed, R.W.; Varma, S.; Peng, T., et al. Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. Journal of Immunology 173(10): 6376-6383, 2004. PMiD: 15528377
42. Shen, Z.; Ajmo, J.M.; Rogers, C.Q., et al. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-a production in cultured macrophage cell lines. American Journal of Physiology. Gastrointestinal and Liver Physiology 296(5):G1047-G1053, 2009. PMiD: 19299582
43. Shepard, B.D.; Joseph, R.A.; Kannarkat, G.T., et al. Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function. Hepatology 48(5):1671-1679, 2008. PMiD: 18697214
44. Shukla, S.D., and Aroor, A.R. Epigenetic effects of ethanol on liver and gastrointestinal injury. World Journal of Gastroenterology 12(33):5265-5271, 2006. PMiD:16981253
45. Shukla, S.D.; Pruett, S.B.; Szabo, G.; and Arteel, G.E. Binge ethanol and liver: New molecular developments. Alcoholism: Clinical and Experimental Research, Epub ahead of print, 2013. PMiD: 23347137
46. Shukla, S.D.; Velazquez, J.; French, S.W., et al. Emerging role of epigenetics in the actions of alcohol. Alcoholism: Clinical and Experimental Research 32(9):1525-1534, 2008. PMID: 18616668
47. Sun, Z.; Feng, D.; Everett, L.J., et al. Circadian epigenom-ic remodeling and hepatic lipogenesis: Lessons from HDAC3. Cold Spring Harbor Symposia on Quantitative Biology 76:49-55, 2011. PMiD: 21900149
48. Tang, Y.; Banan, A.; Forsyth, C.B., et al. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcoholism: Clinical and Experimental Research 32(2):355-364, 2008.PMID: 18162065
49. Trajkovski, M.; Hausser, J.; Soutschek, J., et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474(7353):649-653, 2011. PMiD: 21654750
50. Wani, N.A.; Hamid, A.; and Kaur, J. Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes. Molecular and Cellular Biochemistry 363(1-2):157-166, 2012. PMiD: 22147198
51. Whittaker, R.; Loy, P.A.; Sisman, E., et al. Identification of microRNAs that control lipid droplet formation and growth in hepatocytes via high-content screening. Journal of Biomolecular Screening 15(7):798-805, 2010. PMiD: 20639500
52. Yao, X.H., and Nyomba, B.L. Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 294(6): R1797-R1806,2008.PMID: 18385463
53. Yeligar, S.; Tsukamoto, H.; and Kalra, V.K. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microRNA-199. Journal of Immunology 183:5232-5243, 2009. PMiD: 19783678
54. Yin, H.; Hu, M.; Zhang, R., et al. MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. Journal of Biological Chemistry 287(13):9817-9826, 2012. PMiD: 223080