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Volumn 30, Issue 6, 2006, Pages 928-937

Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation

Author keywords

5 Aza 2 deoxycytidine; Alcohol Dehydrogenase; DNA Methylation; Epigenetics; Gene Regulation; Histone Acetylation; Trichostatin A

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALCOHOL DEHYDROGENASE; DNA; HISTONE; TRANSCRIPTION FACTOR; TRICHOSTATIN A;

EID: 33744773543     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00107.x     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 0018718742 scopus 로고
    • Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
    • Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB 1979 Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature (London) 282 : 615 616.
    • (1979) Nature (London) , vol.282 , pp. 615-616
    • Aden, D.P.1    Fogel, A.2    Plotkin, S.3    Damjanov, I.4    Knowles, B.B.5
  • 2
    • 13844250333 scopus 로고    scopus 로고
    • DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism
    • Bonsch D, Lenz B, Kornhuber J, Bleich S 2005 DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport 16 : 167 170.
    • (2005) Neuroreport , vol.16 , pp. 167-170
    • Bonsch, D.1    Lenz, B.2    Kornhuber, J.3    Bleich, S.4
  • 3
    • 11244313061 scopus 로고    scopus 로고
    • Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism
    • Bonsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S 2004 Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm 111 : 1611 1616.
    • (2004) J Neural Transm , vol.111 , pp. 1611-1616
    • Bonsch, D.1    Lenz, B.2    Reulbach, U.3    Kornhuber, J.4    Bleich, S.5
  • 4
    • 0024535834 scopus 로고
    • Further cellular investigation of the human hepatoblastoma-derived cell line HepG
    • morphology and immunocytochemical studies of hepatic-secreted proteins.
    • Bouma ME, Rogier E, Verthier N, Labarre C, Feldmann G 1989 Further cellular investigation of the human hepatoblastoma-derived cell line HepG : morphology and immunocytochemical studies of hepatic-secreted proteins. In Vitro Cell Dev Biol 25 : 267 275.
    • (1989) In Vitro Cell Dev Biol , vol.25 , pp. 267-275
    • Bouma, M.E.1    Rogier, E.2    Verthier, N.3    Labarre, C.4    Feldmann, G.5
  • 5
    • 0029988447 scopus 로고    scopus 로고
    • Gene expression in a young multigene family
    • tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3.
    • Brown CJ, Zhang L, Edenberg HJ 1996 Gene expression in a young multigene family : tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3. DNA Cell Biol 15 : 187 196.
    • (1996) DNA Cell Biol , vol.15 , pp. 187-196
    • Brown, C.J.1    Zhang, L.2    Edenberg, H.J.3
  • 6
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB 1999 Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21 : 103 107.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 7
    • 0025016926 scopus 로고
    • Cis-acting sequences involved in protein binding and in vitro transcription of the human alcohol dehydrogenase gene ADH2
    • Carr LG, Edenberg HJ 1990 Cis-acting sequences involved in protein binding and in vitro transcription of the human alcohol dehydrogenase gene ADH2. J Biol Chem 265 : 1658 1664.
    • (1990) J Biol Chem , vol.265 , pp. 1658-1664
    • Carr, L.G.1    Edenberg, H.J.2
  • 8
    • 25144442698 scopus 로고    scopus 로고
    • GATA-2 and HNF-3β regulate the human alcohol dehydrogenase 1A (ADH1A) gene
    • Dannenberg LO, Chen HJ, Edenberg HJ 2005 GATA-2 and HNF-3β regulate the human alcohol dehydrogenase 1A (ADH1A) gene. DNA Cell Biol 24 : 543 552.
    • (2005) DNA Cell Biol , vol.24 , pp. 543-552
    • Dannenberg, L.O.1    Chen, H.J.2    Edenberg, H.J.3
  • 9
    • 0033627694 scopus 로고    scopus 로고
    • Regulation of the mammalian alcohol dehydrogenase genes
    • Edenberg HJ 2000 Regulation of the mammalian alcohol dehydrogenase genes. Prog Nucleic Acid Res Mol Biol 64 : 295 341.
    • (2000) Prog Nucleic Acid Res Mol Biol , vol.64 , pp. 295-341
    • Edenberg, H.J.1
  • 10
    • 4243558084 scopus 로고    scopus 로고
    • Mapping of the human alcohol dehydrogenase genes
    • ADH7 is adjacent to the ADH1-ADH2-ADH3 cluster.
    • Edenberg HJ, Jerome RE 2000 Mapping of the human alcohol dehydrogenase genes : ADH7 is adjacent to the ADH1-ADH2-ADH3 cluster. Alcohol Clin Exp Res 24 suppl : 26A.
    • (2000) Alcohol Clin Exp Res , vol.24 , Issue.SUPPL.
    • Edenberg, H.J.1    Jerome, R.E.2
  • 11
    • 0036182132 scopus 로고    scopus 로고
    • Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation
    • El-Osta A, Kantharidis P, Zalcberg JR, Wolffe AP 2002 Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol 22 : 1844 1857.
    • (2002) Mol Cell Biol , vol.22 , pp. 1844-1857
    • El-Osta, A.1    Kantharidis, P.2    Zalcberg, J.R.3    Wolffe, A.P.4
  • 12
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RR, Issa JP, Davidson NE, Sidransky D, Baylin SB 1995 Inactivation of the CDKN2/p16MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55 : 4525 4530.
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.R.4    Issa, J.P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 13
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R 1994 Toxicity of 5-aza-2′- deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A 91 : 11797 11801.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 14
    • 0030710153 scopus 로고    scopus 로고
    • How does DNA methylation repress transcription?
    • Kass SU, Pruss D, Wolffe AP 1997 How does DNA methylation repress transcription? Trends Genet 13 : 444 449.
    • (1997) Trends Genet , vol.13 , pp. 444-449
    • Kass, S.U.1    Pruss, D.2    Wolffe, A.P.3
  • 15
    • 0033568312 scopus 로고    scopus 로고
    • ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
    • Kingston RE, Narlikar GJ 1999 ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev 13 : 2339 2352.
    • (1999) Genes Dev , vol.13 , pp. 2339-2352
    • Kingston, R.E.1    Narlikar, G.J.2
  • 16
    • 0019332750 scopus 로고
    • Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
    • Knowles BB, Howe CC, Aden DP 1980 Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209 : 497 499.
    • (1980) Science , vol.209 , pp. 497-499
    • Knowles, B.B.1    Howe, C.C.2    Aden, D.P.3
  • 17
    • 0033119021 scopus 로고    scopus 로고
    • Chromatin-modifying and -remodeling complexes
    • Kornberg RD, Lorch Y 1999 Chromatin-modifying and -remodeling complexes. Curr Opin Genet Dev 9 : 148 151.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 148-151
    • Kornberg, R.D.1    Lorch, Y.2
  • 18
    • 0033388858 scopus 로고    scopus 로고
    • In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment
    • Kuo MH, Allis CD 1999 In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment. Methods 19 : 425 433.
    • (1999) Methods , vol.19 , pp. 425-433
    • Kuo, M.H.1    Allis, C.D.2
  • 19
    • 0027465862 scopus 로고
    • A positive role for histone acetylation in transcription factor access to nucleosomal DNA
    • Lee DY, Hayes JJ, Pruss D, Wolffe AP 1993 A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72 : 73 84.
    • (1993) Cell , vol.72 , pp. 73-84
    • Lee, D.Y.1    Hayes, J.J.2    Pruss, D.3    Wolffe, A.P.4
  • 20
    • 9244222681 scopus 로고    scopus 로고
    • Functionality of allelic variations in human alcohol dehydrogenase gene family
    • assessment of a functional window for protection against alcoholism.
    • Lee SL, Höög JO, Yin SJ 2004 Functionality of allelic variations in human alcohol dehydrogenase gene family : assessment of a functional window for protection against alcoholism. Pharmacogenetics 14 : 725 732.
    • (2004) Pharmacogenetics , vol.14 , pp. 725-732
    • Lee, S.L.1    Höög, J.O.2    Yin, S.J.3
  • 21
    • 0036856355 scopus 로고    scopus 로고
    • MethPrimer
    • designing primers for methylation PCRs.
    • Li LC, Dahiya R 2002 MethPrimer : designing primers for methylation PCRs. Bioinformatics 11 : 1427 1431.
    • (2002) Bioinformatics , vol.11 , pp. 1427-1431
    • Li, L.C.1    Dahiya, R.2
  • 22
    • 0036315414 scopus 로고    scopus 로고
    • Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction
    • Liang G, Gonzalgo ML, Salem C, Jones PA 2002 Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction. Methods 27 : 150 155.
    • (2002) Methods , vol.27 , pp. 150-155
    • Liang, G.1    Gonzalgo, M.L.2    Salem, C.3    Jones, P.A.4
  • 23
    • 0015145188 scopus 로고
    • The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina
    • Mezey E, Holt PR 1971 The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina. Exp Mol Pathol 15 : 148 156.
    • (1971) Exp Mol Pathol , vol.15 , pp. 148-156
    • Mezey, E.1    Holt, P.R.2
  • 24
    • 0033119780 scopus 로고    scopus 로고
    • DNA methylation and chromatin modification
    • Ng HH, Bird A 1999 DNA methylation and chromatin modification. Curr Opin Genet Dev 9 : 158 163.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 158-163
    • Ng, H.H.1    Bird, A.2
  • 25
    • 0024002556 scopus 로고
    • Luciferase reporter gene vectors for analysis of promoters and enhancers
    • Nordeen SK 1988 Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6 : 454 458.
    • (1988) Biotechniques , vol.6 , pp. 454-458
    • Nordeen, S.K.1
  • 27
    • 0028787221 scopus 로고
    • CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2′ deoxycytidine
    • Otterson GA, Khleif SN, Chen W, Coxon AB, Kaye FJ 1995 CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2′ deoxycytidine. Oncogene 11 : 1211 1216.
    • (1995) Oncogene , vol.11 , pp. 1211-1216
    • Otterson, G.A.1    Khleif, S.N.2    Chen, W.3    Coxon, A.B.4    Kaye, F.J.5
  • 28
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing - a three-way connection
    • Razin A 1998 CpG methylation, chromatin structure and gene silencing - a three-way connection. EMBO J 17 : 4905 4908.
    • (1998) EMBO J , vol.17 , pp. 4905-4908
    • Razin, A.1
  • 29
    • 0002021183 scopus 로고    scopus 로고
    • Overview of epigenetic mechanisms
    • Russo V.E.A., Martienssen R.A., Riggs A.D. eds), pp. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • Riggs AD, Porter TN 1996 Overview of epigenetic mechanisms, in Epigenetic Mechanisms of Gene Regulation Russo VEA, Martienssen RA, Riggs AD eds), pp 29 45. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1996) Epigenetic Mechanisms of Gene Regulation , pp. 29-45
    • Riggs, A.D.1    Porter, T.N.2
  • 30
    • 0002145126 scopus 로고
    • Cellular biology and biochemistry of the retinoids
    • Sporn M.B., Roberts A.B., Goodman D.S. eds), pp. Academic Press, Orlando, FL.
    • Roberts AB, Sporn MB 1984 Cellular biology and biochemistry of the retinoids, in The Retinoids, Vol. 2 Sporn MB, Roberts AB, Goodman DS eds), pp 209 286. Academic Press, Orlando, FL.
    • (1984) The Retinoids , vol.2 , pp. 209-286
    • Roberts, A.B.1    Sporn, M.B.2
  • 31
    • 0015009635 scopus 로고
    • Developmental changes and polymorphism in human alcohol dehydrogenase
    • Smith M, Hopkinson DA, Harris H 1971 Developmental changes and polymorphism in human alcohol dehydrogenase. Ann Hum Genet 34 : 251 271.
    • (1971) Ann Hum Genet , vol.34 , pp. 251-271
    • Smith, M.1    Hopkinson, D.A.2    Harris, H.3
  • 32
    • 0015315257 scopus 로고
    • Alcohol dehydrogenase isozymes in adult human stomach and liver
    • evidence for activity of the ADH3 locus.
    • Smith M, Hopkinson DA, Harris H 1972 Alcohol dehydrogenase isozymes in adult human stomach and liver : evidence for activity of the ADH3 locus. Ann Hum Genet 35 : 243 253.
    • (1972) Ann Hum Genet , vol.35 , pp. 243-253
    • Smith, M.1    Hopkinson, D.A.2    Harris, H.3
  • 33
    • 0023948705 scopus 로고
    • Mapping protein-DNA interactions in vivo with formaldehyde
    • evidence that histone H4 is retained on a highly transcribed gene.
    • Solomon MJ, Larsen PL, Varshavsky A 1988 Mapping protein-DNA interactions in vivo with formaldehyde : evidence that histone H4 is retained on a highly transcribed gene. Cell 53 : 937 947.
    • (1988) Cell , vol.53 , pp. 937-947
    • Solomon, M.J.1    Larsen, P.L.2    Varshavsky, A.3
  • 34
    • 0001473216 scopus 로고
    • Formaldehyde-mediated DNA-protein crosslinking
    • a probe for in vivo chromatin structures.
    • Solomon MJ, Varshavsky A 1985 Formaldehyde-mediated DNA-protein crosslinking : a probe for in vivo chromatin structures. Proc Natl Acad Sci U S A 82 : 6470 6474.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 6470-6474
    • Solomon, M.J.1    Varshavsky, A.2
  • 35
    • 0032702598 scopus 로고    scopus 로고
    • Role of covalent modifications of histones in regulating gene expression
    • Spencer VA, Davie JR 1999 Role of covalent modifications of histones in regulating gene expression. Gene 240 : 1 12.
    • (1999) Gene , vol.240 , pp. 1-12
    • Spencer, V.A.1    Davie, J.R.2
  • 36
    • 0025727853 scopus 로고
    • Interactions of retinoids and transforming growth factor-β in regulation of cell differentiation and proliferation
    • Sporn MB, Roberts AB 1991 Interactions of retinoids and transforming growth factor-β in regulation of cell differentiation and proliferation. Mol Endocrinol 5 : 3 7.
    • (1991) Mol Endocrinol , vol.5 , pp. 3-7
    • Sporn, M.B.1    Roberts, A.B.2
  • 37
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • Tate PH, Bird AP 1993 Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 3 : 226 231.
    • (1993) Curr Opin Genet Dev , vol.3 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 38
    • 0027159741 scopus 로고
    • Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism
    • Thomasson HR, Crabb DW, Edenberg HJ 1993 Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 23 : 131 136.
    • (1993) Behav Genet , vol.23 , pp. 131-136
    • Thomasson, H.R.1    Crabb, D.W.2    Edenberg, H.J.3
  • 39
    • 1442323783 scopus 로고    scopus 로고
    • High throughput fluorescence quantitation using the ABI Prism® 7700 sequence detection system
    • Tian H, Edenberg HJ 2004 High throughput fluorescence quantitation using the ABI Prism® 7700 sequence detection system. Anal Biochem 326 : 287 288.
    • (2004) Anal Biochem , vol.326 , pp. 287-288
    • Tian, H.1    Edenberg, H.J.2
  • 40
    • 0029693220 scopus 로고    scopus 로고
    • The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
    • Van Lint C, Emiliani S, Verdin E 1996 The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr 5 : 245 253.
    • (1996) Gene Expr , vol.5 , pp. 245-253
    • Van Lint, C.1    Emiliani, S.2    Verdin, E.3
  • 41
    • 0026639157 scopus 로고
    • Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/Enhancer binding protein α, liver activator protein, and D-element-binding protein
    • Van Ooij C, Snyder RC, Paeper BW, Duester G 1992 Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/Enhancer binding protein α, liver activator protein, and D-element-binding protein. Mol Cell Biol 12 : 3023 3031.
    • (1992) Mol Cell Biol , vol.12 , pp. 3023-3031
    • Van Ooij, C.1    Snyder, R.C.2    Paeper, B.W.3    Duester, G.4
  • 42
    • 0029985730 scopus 로고    scopus 로고
    • Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
    • Vettese-Dadey M, Grant PA, Hebbes TR, Crane-Robinson C, Allis CD, Workman JL 1996 Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J 15 : 2508 2518.
    • (1996) EMBO J , vol.15 , pp. 2508-2518
    • Vettese-Dadey, M.1    Grant, P.A.2    Hebbes, T.R.3    Crane-Robinson, C.4    Allis, C.D.5    Workman, J.L.6
  • 43
    • 0026060619 scopus 로고
    • RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae
    • Vidal M, Gaber RF 1991 RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol 11 : 6317 6327.
    • (1991) Mol Cell Biol , vol.11 , pp. 6317-6327
    • Vidal, M.1    Gaber, R.F.2
  • 44
    • 0033994292 scopus 로고    scopus 로고
    • ATP-dependent chromatin-remodeling complexes
    • Vignali M, Hassan AH, Workman JL 2000 ATP-dependent chromatin-remodeling complexes. Mol Cell Biol 20 : 2167 2175.
    • (2000) Mol Cell Biol , vol.20 , pp. 2167-2175
    • Vignali, M.1    Hassan, A.H.2    Workman, J.L.3
  • 45
    • 0024081657 scopus 로고
    • Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter
    • Watt F, Molloy PL 1988 Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes Dev 2 : 1136 1143.
    • (1988) Genes Dev , vol.2 , pp. 1136-1143
    • Watt, F.1    Molloy, P.L.2
  • 46
    • 0023920996 scopus 로고
    • Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone
    • Wolfla CE, Ross RA, Crabb DW 1988 Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone. Arch Biochem Biophys 263 : 69 76.
    • (1988) Arch Biochem Biophys , vol.263 , pp. 69-76
    • Wolfla, C.E.1    Ross, R.A.2    Crabb, D.W.3
  • 47
    • 0034387004 scopus 로고    scopus 로고
    • 25 years after the nucleosome model
    • chromatin modifications.
    • Wu J, Grunstein M 2000 25 years after the nucleosome model : chromatin modifications. Trends Biochem Sci 25 : 619 623.
    • (2000) Trends Biochem Sci , vol.25 , pp. 619-623
    • Wu, J.1    Grunstein, M.2
  • 48
    • 0030825309 scopus 로고    scopus 로고
    • COBRA
    • a sensitive and quantitative DNA methylation assay.
    • Xiong Z, Laird PW 1997 COBRA : a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25 : 2532 2534.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 49
    • 0025285347 scopus 로고
    • The human class I alcohol dehydrogenase gene cluster
    • three genes are tandemly organized in an 80-kb-long segment of the genome.
    • Yasunami M, Kikuchi I, Sarapata D, Yoshida A 1990 The human class I alcohol dehydrogenase gene cluster : three genes are tandemly organized in an 80-kb-long segment of the genome. Genomics 7 : 152 158.
    • (1990) Genomics , vol.7 , pp. 152-158
    • Yasunami, M.1    Kikuchi, I.2    Sarapata, D.3    Yoshida, A.4
  • 50
    • 0024996768 scopus 로고
    • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by Trichostatin A
    • Yoshida M, Kijima M, Akita M, Beppu T 1990 Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by Trichostatin A. J Biol Chem 265 : 17174 17179.
    • (1990) J Biol Chem , vol.265 , pp. 17174-17179
    • Yoshida, M.1    Kijima, M.2    Akita, M.3    Beppu, T.4


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