-
1
-
-
80054872790
-
Alcoholic liver disease: pathogenesis and new therapeutic targets
-
Gao B, Bataller R, (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141: 1572-1585.
-
(2011)
Gastroenterology
, vol.141
, pp. 1572-1585
-
-
Gao, B.1
Bataller, R.2
-
2
-
-
40749113642
-
Alcohol, cofactors and the genetics of hepatocellular carcinoma
-
Yu MC, Yuan JM, Lu SC, (2008) Alcohol, cofactors and the genetics of hepatocellular carcinoma. J Gastroenterol Hepatol 23 Suppl 1: S92-97.
-
(2008)
J Gastroenterol Hepatol
, vol.23
-
-
Yu, M.C.1
Yuan, J.M.2
Lu, S.C.3
-
3
-
-
34447259792
-
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
-
Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, et al. (2007) Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr 86: 14-24.
-
(2007)
Am J Clin Nutr
, vol.86
, pp. 14-24
-
-
Purohit, V.1
Abdelmalek, M.F.2
Barve, S.3
Benevenga, N.J.4
Halsted, C.H.5
-
4
-
-
32044431702
-
Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease
-
McClain C, Barve S, Joshi-Barve S, Song Z, Deaciuc I, et al. (2005) Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease. Alcohol Clin Exp Res 29: 180S-188S.
-
(2005)
Alcohol Clin Exp Res
, vol.29
-
-
McClain, C.1
Barve, S.2
Joshi-Barve, S.3
Song, Z.4
Deaciuc, I.5
-
5
-
-
58849156556
-
Molecular mechanisms of alcoholic fatty liver
-
Purohit V, Gao B, Song BJ, (2009) Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 33: 191-205.
-
(2009)
Alcohol Clin Exp Res
, vol.33
, pp. 191-205
-
-
Purohit, V.1
Gao, B.2
Song, B.J.3
-
6
-
-
50849099168
-
Emerging role of epigenetics in the actions of alcohol
-
Shukla SD, Velazquez J, French SW, Lu SC, Ticku MK, et al. (2008) Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res 32: 1525-1534.
-
(2008)
Alcohol Clin Exp Res
, vol.32
, pp. 1525-1534
-
-
Shukla, S.D.1
Velazquez, J.2
French, S.W.3
Lu, S.C.4
Ticku, M.K.5
-
7
-
-
70350028850
-
Mammalian cytosine methylation at a glance
-
Ooi SK, O'Donnell AH, Bestor TH, (2009) Mammalian cytosine methylation at a glance. J Cell Sci 122: 2787-2791.
-
(2009)
J Cell Sci
, vol.122
, pp. 2787-2791
-
-
Ooi, S.K.1
O'Donnell, A.H.2
Bestor, T.H.3
-
8
-
-
80054790080
-
DNA methylation: superior or subordinate in the epigenetic hierarchy?
-
Jin B, Li Y, Robertson KD, (2011) DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer 2: 607-617.
-
(2011)
Genes Cancer
, vol.2
, pp. 607-617
-
-
Jin, B.1
Li, Y.2
Robertson, K.D.3
-
9
-
-
80053144962
-
A decade of exploring the cancer epigenome - biological and translational implications
-
Baylin SB, Jones PA, (2011) A decade of exploring the cancer epigenome- biological and translational implications. Nat Rev Cancer 11: 726-734.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
10
-
-
15744401773
-
Eukaryotic cytosine methyltransferases
-
Goll MG, Bestor TH, (2005) Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74: 481-514.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 481-514
-
-
Goll, M.G.1
Bestor, T.H.2
-
11
-
-
55949104585
-
The MBD protein family-reading an epigenetic mark?
-
Dhasarathy A, Wade PA, (2008) The MBD protein family-reading an epigenetic mark? Mutat Res 647: 39-43.
-
(2008)
Mutat Res
, vol.647
, pp. 39-43
-
-
Dhasarathy, A.1
Wade, P.A.2
-
12
-
-
79960844248
-
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
-
Lai AY, Wade PA, (2011) Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat Rev Cancer 11: 588-596.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 588-596
-
-
Lai, A.Y.1
Wade, P.A.2
-
13
-
-
0035943709
-
Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
-
Bachman KE, Rountree MR, Baylin SB, (2001) Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem 276: 32282-32287.
-
(2001)
J Biol Chem
, vol.276
, pp. 32282-32287
-
-
Bachman, K.E.1
Rountree, M.R.2
Baylin, S.B.3
-
14
-
-
33746836121
-
Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription
-
Majumder S, Ghoshal K, Datta J, Smith DS, Bai S, et al. (2006) Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription. J Biol Chem.
-
(2006)
J Biol Chem
-
-
Majumder, S.1
Ghoshal, K.2
Datta, J.3
Smith, D.S.4
Bai, S.5
-
15
-
-
0036494563
-
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice
-
Eads CA, Nickel AE, Laird PW, (2002) Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res 62: 1296-1299.
-
(2002)
Cancer Res
, vol.62
, pp. 1296-1299
-
-
Eads, C.A.1
Nickel, A.E.2
Laird, P.W.3
-
16
-
-
0036232616
-
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair
-
Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW, (2002) DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol 22: 2906-2917.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2906-2917
-
-
Trinh, B.N.1
Long, T.I.2
Nickel, A.E.3
Shibata, D.4
Laird, P.W.5
-
17
-
-
77956645469
-
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer
-
Kinney SR, Moser MT, Pascual M, Greally JM, Foster BA, et al. (2011) Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Mol Cell Biol 30: 4159-4174.
-
(2011)
Mol Cell Biol
, vol.30
, pp. 4159-4174
-
-
Kinney, S.R.1
Moser, M.T.2
Pascual, M.3
Greally, J.M.4
Foster, B.A.5
-
18
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science 300: 489-492.
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
Hodgson, J.G.2
Eden, A.3
Jackson-Grusby, L.4
Dausman, J.5
-
19
-
-
26444473234
-
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
-
Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, et al. (2005) Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A 102: 13580-13585.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13580-13585
-
-
Yamada, Y.1
Jackson-Grusby, L.2
Linhart, H.3
Meissner, A.4
Eden, A.5
-
20
-
-
0020395484
-
The feeding of alcohol in liquid diets: two decades of applications and 1982 update
-
Lieber CS, DeCarli LM, (1982) The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol Clin Exp Res 6: 523-531.
-
(1982)
Alcohol Clin Exp Res
, vol.6
, pp. 523-531
-
-
Lieber, C.S.1
DeCarli, L.M.2
-
21
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41: 1313-1321.
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
van Natta, M.3
Behling, C.4
Contos, M.J.5
-
22
-
-
70350054798
-
Role of miR-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid defined diet in C57BL/6 mice
-
Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, et al. (2009) Role of miR-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid defined diet in C57BL/6 mice. Hepatology in press.
-
(2009)
Hepatology in Press
-
-
Wang, B.1
Majumder, S.2
Nuovo, G.3
Kutay, H.4
Volinia, S.5
-
23
-
-
66149093022
-
Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance
-
Huang W, Bansode R, Mehta M, Mehta KD, (2009) Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance. Hepatology 49: 1525-1536.
-
(2009)
Hepatology
, vol.49
, pp. 1525-1536
-
-
Huang, W.1
Bansode, R.2
Mehta, M.3
Mehta, K.D.4
-
24
-
-
0035200941
-
Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms
-
Ghoshal K, Majumder S, Zhu Q, Hunzeker J, Datta J, et al. (2001) Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms. Mol Cell Biol 21: 8301-8317.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 8301-8317
-
-
Ghoshal, K.1
Majumder, S.2
Zhu, Q.3
Hunzeker, J.4
Datta, J.5
-
25
-
-
66249127951
-
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation
-
Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, et al. (2009) A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res 69: 4277-4285.
-
(2009)
Cancer Res
, vol.69
, pp. 4277-4285
-
-
Datta, J.1
Ghoshal, K.2
Denny, W.A.3
Gamage, S.A.4
Brooke, D.G.5
-
26
-
-
0037013280
-
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma
-
Majumder S, Ghoshal K, Datta J, Bai S, Dong X, et al. (2002) Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. J Biol Chem 277: 16048-16058.
-
(2002)
J Biol Chem
, vol.277
, pp. 16048-16058
-
-
Majumder, S.1
Ghoshal, K.2
Datta, J.3
Bai, S.4
Dong, X.5
-
27
-
-
77950095763
-
TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
-
Wang B, Hsu SH, Majumder S, Kutay H, Huang W, et al. (2010) TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 29: 1787-1797.
-
(2010)
Oncogene
, vol.29
, pp. 1787-1797
-
-
Wang, B.1
Hsu, S.H.2
Majumder, S.3
Kutay, H.4
Huang, W.5
-
28
-
-
0142135512
-
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas
-
Motiwala T, Ghoshal K, Das A, Majumder S, Weichenhan D, et al. (2003) Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene 22: 6319-6331.
-
(2003)
Oncogene
, vol.22
, pp. 6319-6331
-
-
Motiwala, T.1
Ghoshal, K.2
Das, A.3
Majumder, S.4
Weichenhan, D.5
-
29
-
-
67449155879
-
Quantification of regional DNA methylation by liquid chromatography/tandem mass spectrometry
-
Liu Z, Wu J, Xie Z, Liu S, Fan-Havard P, et al. (2009) Quantification of regional DNA methylation by liquid chromatography/tandem mass spectrometry. Anal Biochem 391: 106-113.
-
(2009)
Anal Biochem
, vol.391
, pp. 106-113
-
-
Liu, Z.1
Wu, J.2
Xie, Z.3
Liu, S.4
Fan-Havard, P.5
-
30
-
-
0038462288
-
A turn of the sulfatide in Alzheimer's disease
-
Irizarry MC, (2003) A turn of the sulfatide in Alzheimer's disease. Ann Neurol 54: 7-8.
-
(2003)
Ann Neurol
, vol.54
, pp. 7-8
-
-
Irizarry, M.C.1
-
31
-
-
4544341015
-
Linear models and empirical bayes methods for assessing differential expression in microarray experiments
-
Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
-
(2004)
Stat Appl Genet Mol Biol
, vol.3
-
-
Smyth, G.K.1
-
32
-
-
38049087506
-
Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error
-
Gordon D, Haynes C, Yang Y, Kramer PL, Finch SJ, (2007) Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error. Genet Epidemiol 31: 853-870.
-
(2007)
Genet Epidemiol
, vol.31
, pp. 853-870
-
-
Gordon, D.1
Haynes, C.2
Yang, Y.3
Kramer, P.L.4
Finch, S.J.5
-
33
-
-
0036889153
-
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure
-
Ghoshal K, Datta J, Majumder S, Bai S, Dong X, et al. (2002) Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol 22: 8302-8319.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8302-8319
-
-
Ghoshal, K.1
Datta, J.2
Majumder, S.3
Bai, S.4
Dong, X.5
-
34
-
-
77956415182
-
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors
-
Ghoshal K, Motiwala T, Claus R, Yan P, Kutay H, et al. (2010) HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PLoS One 5: e10338.
-
(2010)
PLoS One
, vol.5
-
-
Ghoshal, K.1
Motiwala, T.2
Claus, R.3
Yan, P.4
Kutay, H.5
-
35
-
-
58249088751
-
MicroRNAs: target recognition and regulatory functions
-
Bartel DP, (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
36
-
-
42449086421
-
miR-148 targets human DNMT3b protein coding region
-
Duursma AM, Kedde M, Schrier M, le Sage C, Agami R, (2008) miR-148 targets human DNMT3b protein coding region. RNA 14: 872-877.
-
(2008)
RNA
, vol.14
, pp. 872-877
-
-
Duursma, A.M.1
Kedde, M.2
Schrier, M.3
le Sage, C.4
Agami, R.5
-
37
-
-
78149464376
-
Formation of acetaldehyde-derived DNA adducts due to alcohol exposure
-
Yu HS, Oyama T, Isse T, Kitagawa K, Pham TT, et al. (2011) Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chem Biol Interact 188: 367-375.
-
(2011)
Chem Biol Interact
, vol.188
, pp. 367-375
-
-
Yu, H.S.1
Oyama, T.2
Isse, T.3
Kitagawa, K.4
Pham, T.T.5
-
38
-
-
84859171807
-
MYC on the Path to Cancer
-
Dang CV, (2012) MYC on the Path to Cancer. Cell 149: 22-35.
-
(2012)
Cell
, vol.149
, pp. 22-35
-
-
Dang, C.V.1
-
39
-
-
4644353364
-
Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
-
Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, et al. (2004) Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 40: 972-980.
-
(2004)
Hepatology
, vol.40
, pp. 972-980
-
-
Nakajima, T.1
Kamijo, Y.2
Tanaka, N.3
Sugiyama, E.4
Tanaka, E.5
-
40
-
-
79960556965
-
Epigenome-wide association studies for common human diseases
-
Rakyan VK, Down TA, Balding DJ, Beck S, (2011) Epigenome-wide association studies for common human diseases. Nat Rev Genet 12: 529-541.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 529-541
-
-
Rakyan, V.K.1
Down, T.A.2
Balding, D.J.3
Beck, S.4
-
41
-
-
77953624215
-
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
-
Pan W, Zhu S, Yuan M, Cui H, Wang L, et al. (2010) MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184: 6773-6781.
-
(2010)
J Immunol
, vol.184
, pp. 6773-6781
-
-
Pan, W.1
Zhu, S.2
Yuan, M.3
Cui, H.4
Wang, L.5
-
42
-
-
77954234485
-
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
-
Huang J, Wang Y, Guo Y, Sun S, (2010) Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 52: 60-70.
-
(2010)
Hepatology
, vol.52
, pp. 60-70
-
-
Huang, J.1
Wang, Y.2
Guo, Y.3
Sun, S.4
-
43
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416: 552-556.
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
Jair, K.W.4
Yen, R.W.5
-
44
-
-
77249137168
-
Principles and challenges of genomewide DNA methylation analysis
-
Laird PW, (2010) Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet 11: 191-203.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 191-203
-
-
Laird, P.W.1
-
45
-
-
70350070340
-
Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha
-
Kang X, Zhong W, Liu J, Song Z, McClain CJ, et al. (2009) Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. Hepatology 50: 1241-1250.
-
(2009)
Hepatology
, vol.50
, pp. 1241-1250
-
-
Kang, X.1
Zhong, W.2
Liu, J.3
Song, Z.4
McClain, C.J.5
-
46
-
-
67349132443
-
Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress
-
Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, et al. (2009) Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. J Hepatol 50: 1236-1246.
-
(2009)
J Hepatol
, vol.50
, pp. 1236-1246
-
-
Okiyama, W.1
Tanaka, N.2
Nakajima, T.3
Tanaka, E.4
Kiyosawa, K.5
|