Laminar flow activates peroxisome proliferator-activated receptor-γ in vascular endothelial cells

Circulation

Volumn 110, Issue 9, 2004, Pages 1128-1133

  Liu, Yi ^a   Zhu, Yi ^a   Rannou, Francois ^a   Lee, Tzong Shyuan ^a   Formentin, Kitty ^a   Zeng, Lingfang ^a   Yuan, Xiaohui ^c   Wang, Nanping ^b   Chien, Shu ^b   Forman, Barry M ^c   Shyy, John Y J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Cells, endothelial; Inflammation; Receptors, peroxisome proliferator activated

Indexed keywords

CD36 ANTIGEN; CYTOCHROME P450; CYTOCHROME P450 EPOXYGENASE; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIGAND; LIPID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; TRANSCRIPTION FACTOR GAL PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN FUSION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATTLE; CELL STRAIN; CELL STRAIN THP 1; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LAMINAR FLOW; NONHUMAN; PARACRINE SIGNALING; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR RESPONSIVE ELEMENT; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD36; CATTLE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; INFLAMMATION; NAPHTHALENES; NF-KAPPA B; PHOSPHOLIPASES A; PPAR GAMMA; PYRONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHEOLOGY; RNA, MESSENGER; RNA, SMALL INTERFERING; STRESS, MECHANICAL; THIAZOLIDINEDIONES; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 4844231742     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000139850.08365.EC     Document Type: Article

References (36)

1. Nerem RM, Alexander RW, Chappell DC, et al. The study of the influence of flow on vascular endothelial biology. Am J Med Sci. 1998;316:169-175.
2. Wissler RW, for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. An overview of the quantitative influence of several risk factors on progression of atherosclerosis in young people in the United States. Am J Med Sci. 1995;310:S29-S36.
3. Topper JN, Cai J, Falb D, et al. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA. 1996;93:10417-10422.
4. Chappell DC, Varner SE, Nerem RM, et al. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res. 1998;82:532-539.
5. Shyy YJ, Hsieh HJ, Usami S, et al. Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc Natl Acad Sci U S A. 1994;91:4678-4682.
6. Hsieh HJ, Li NQ, Frangos JA. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C. J Cell Physiol. 1992;150:552-558.
7. Bao X, Lu C, Frangos JA. Temporal gradient in shear but not steady shear stress induces PDGF-α and MCP-1 expression in endothelial cells: role of NO, NFκB, and egr-1. Arterioscler Thromb Vasc Biol. 1999;19:996-1003.
8. Gimbrone MA Jr, Nagel T, Topper JN. Biomechanical activation: an emerging paradigm in endothelial adhesion biology. J Clin Invest. 1997;99:1809-1813.
9. Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology. 2003;144:2201-2207.
10. Nolte RT, Wisely GB, Westin S, et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature. 1998;395:137-143.
11. Plutzky J. Peroxisome proliferator-activated receptors in endothelial cell biology. Curr Opin Lipidol. 2001;12:511-518.
12. Hsueh WA, Law RE. PPARγ and atherosclerosis; effects on cell growth and movement. Arterioscler Thromb Vasc Biol. 2001;21:1891-1895.
13. Pasceri V, Wu HD, Willerson JT, et al. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-γ activators. Circulation. 2000;101:235-238.
14. Collins AR, Meehan WP, Kintscher U, et al. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2001;21:65-371.
15. Wang N, Verna L, Chen NG, et al. Constitutive activation of peroxisome proliferator-activated receptor-γ suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. J Biol Chem. 2002;277:34176- 34181.
16. Frangos JA, Eskin SG, McIntire LV, et al. Flow effects on prostacyclin production by cultured human endothelial cells. Science. 1985;227:1477-1479.
17. 2 is a ligand for the adipocyte determination factor PPARγ. Cell. 1995;83:803-812.
18. McIntyre TM, Pontsler AV, Silva AR, et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist. Proc Natl Acad Sci U S A. 2003;100:131-136.
19. Lee H, Shi W, Tontonoz P, et al. Role for peroxisome proliferator- activated receptor α in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res. 2000;87:516-521.
20. Schulman IG, Shao G, Heyman RA. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor γ (PPARγ) heterodimers: intermolecular synergy requires only the PPARγ hormone-dependent activation function. Mol Cell Biol. 1998;18:3483-3494.
21. Tontonoz P, Nagy L, Alvarez JG, et al. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241-252.
22. 2 derivatives really playing the part? Cell Signal. 2002;14:573-583.
23. Fahmi H, Di Battista JA, Pelletier JP, et al. Peroxisome proliferator-activated receptor γ activators inhibit interleukin-1β- induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. Arthritis Rheum. 2001;44:595-607.
24. Chen F, Kuhn DC, Gaydos LJ, et al. Induction of nitric oxide and nitric oxide synthase mRNA by silica and lipopolysaccharide in PMA-primed THP-1 cells. APMIS. 1996;104:176-182.
25. Tsao PS, Buitrago R, Chan JR, et al. Fluid flow inhibits endothelial adhesiveness: nitric oxide and transcriptional regulation of VCAM-1. Circulation. 1996;94:1682-1689.
26. Zeldin DC. Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem. 2001;276:36059-36062.
27. Straus DS, Glass CK. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev. 2001;21:185-210.
28. Bhagyalakshmi A, Berthiaume F, Reich KM, et al. Fluid shear stress stimulates membrane phospholipid metabolism in cultured human endothelial cells. J Vasc Res. 1992;29:443-449.
29. 2 synthase expression in vascular endothelial cells. Circ Res. 2000;86:967-973.
30. Kalgutkar AS, Marnett AB, Crews BC, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000;43:2860-2870.
31. Hope WC, Welton AF, Fiedler-Nagy C, et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol. 1983;32:367-371.
32. 2 and the ligation of PPARγ. J Clin Invest. 2003;112:945-955.
33. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev. 2002;82:131-185.
34. McCormick SM, Eskin SG, McIntire LV, et al. DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2001;98:8955-8960.
35. Dekker RJ, van Soest S, Fontijn RD, et al. Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). Blood. 2002;100:1689-1698.
36. Wagner CT, Durante W, Christodoulides N, et al. Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. J Clin Invest. 1997;100:589-596.