-
1
-
-
48649098334
-
pVHL: a multipurpose adaptor protein
-
Frew IJ, Krek W, (2008) pVHL: a multipurpose adaptor protein. Sci Signal 1: e30.
-
(2008)
Sci Signal
, vol.1
-
-
Frew, I.J.1
Krek, W.2
-
2
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim WY, Kaelin WG, (2004) Role of VHL gene mutation in human cancer. J Clin Oncol 22: 4991-5004.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
3
-
-
33947528891
-
Von Hippel-Lindau disease
-
Kaelin WG, (2007) Von Hippel-Lindau disease. Annu Rev Pathol 2: 145-173.
-
(2007)
Annu Rev Pathol
, vol.2
, pp. 145-173
-
-
Kaelin, W.G.1
-
4
-
-
0033597443
-
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
-
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, et al. (1999) Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284 (5414): 657-61.
-
(1999)
Science
, vol.284
, Issue.5414
, pp. 657-661
-
-
Kamura, T.1
Koepp, D.M.2
Conrad, M.N.3
Skowyra, D.4
Moreland, R.J.5
-
5
-
-
0033607291
-
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
-
Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, et al. (1999) Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci USA 96: 12436-12441.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12436-12441
-
-
Iwai, K.1
Yamanaka, K.2
Kamura, T.3
Minato, N.4
Conaway, R.C.5
-
6
-
-
0033565672
-
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
-
Lisztwan J, Imbert G, Wirbelauer C, Gstaiger M, Krek W, (1999) The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev 13: 1822-1833.
-
(1999)
Genes Dev
, vol.13
, pp. 1822-1833
-
-
Lisztwan, J.1
Imbert, G.2
Wirbelauer, C.3
Gstaiger, M.4
Krek, W.5
-
8
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
-
9
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
-
10
-
-
54549113030
-
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
-
Kaelin WG Jr, (2008) The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 865-873
-
-
Kaelin Jr., W.G.1
-
11
-
-
1642603441
-
von Hippel-Lindau tumor suppressor: not only HIF's executioner
-
Czyzyk-Krzeska MF, Meller J, (2004) von Hippel-Lindau tumor suppressor: not only HIF's executioner. Trends Mol Med 10: 146-149.
-
(2004)
Trends Mol Med
, vol.10
, pp. 146-149
-
-
Czyzyk-Krzeska, M.F.1
Meller, J.2
-
12
-
-
0035941291
-
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
-
Okuda H, Saitoh K, Hirai S, Iwai K, Takaki Y, et al. (2001) The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J Biol Chem 276: 43611-43617.
-
(2001)
J Biol Chem
, vol.276
, pp. 43611-43617
-
-
Okuda, H.1
Saitoh, K.2
Hirai, S.3
Iwai, K.4
Takaki, Y.5
-
13
-
-
34250308031
-
Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor
-
Grosfeld A, Stolze IP, Cockman ME, Pugh CW, Edelmann M, Kessler B, Bullock AN, Ratcliffe PJ, Masson N, (2007) Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor. J Biol Chem 282: 13264-13269.
-
(2007)
J Biol Chem
, vol.282
, pp. 13264-13269
-
-
Grosfeld, A.1
Stolze, I.P.2
Cockman, M.E.3
Pugh, C.W.4
Edelmann, M.5
Kessler, B.6
Bullock, A.N.7
Ratcliffe, P.J.8
Masson, N.9
-
14
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, et al. (1998) The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1: 959-968.
-
(1998)
Mol Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
Whaley, J.M.4
Stemmer-Rachamimov, A.O.5
-
15
-
-
34948883495
-
pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2
-
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, et al. (2007) pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Mol Cell 28: 15-27.
-
(2007)
Mol Cell
, vol.28
, pp. 15-27
-
-
Yang, H.1
Minamishima, Y.A.2
Yan, Q.3
Schlisio, S.4
Ebert, B.L.5
-
16
-
-
53349162212
-
Jade-1 inhibits Wnt signaling by ubiquitilating β-catenin and mediates Wnt pathway inhibition by pVHL
-
Chitalia VC, Foy RL, Bachschmid MM, Zeng LL, Panchenko MV, et al. (2008) Jade-1 inhibits Wnt signaling by ubiquitilating β-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol 10: 1208-1216.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1208-1216
-
-
Chitalia, V.C.1
Foy, R.L.2
Bachschmid, M.M.3
Zeng, L.L.4
Panchenko, M.V.5
-
17
-
-
1842589298
-
Modulation of different clusterin isoforms in human colon tumorigenesis,
-
Pucci S, Bonanno E, Pichiorri F, Angeloni C, Spagnoli LG, (2004) Modulation of different clusterin isoforms in human colon tumorigenesis, Oncogene 23: 2298-2304.
-
(2004)
Oncogene
, vol.23
, pp. 2298-2304
-
-
Pucci, S.1
Bonanno, E.2
Pichiorri, F.3
Angeloni, C.4
Spagnoli, L.G.5
-
18
-
-
33644996125
-
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer
-
Shannan B, Seifert M, Leskov K, Willis J, Boothman D, et al. (2006) Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death and Diff 13: 12-19.
-
(2006)
Cell Death and Diff
, vol.13
, pp. 12-19
-
-
Shannan, B.1
Seifert, M.2
Leskov, K.3
Willis, J.4
Boothman, D.5
-
19
-
-
0037837729
-
Synthesis and functional analyses of nuclear clusterin, a cell death protein
-
Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA, (2003) Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 274: 11590-11600.
-
(2003)
J Biol Chem
, vol.274
, pp. 11590-11600
-
-
Leskov, K.S.1
Klokov, D.Y.2
Li, J.3
Kinsella, T.J.4
Boothman, D.A.5
-
20
-
-
0025301469
-
A Apolipoprotein J: structure and tissue distribution
-
de Silva HV, Harmony JA, Stuart WD, Gil CM, Robbins J, (1990) A Apolipoprotein J: structure and tissue distribution. Biochemistry 29: 5380-5389.
-
(1990)
Biochemistry
, vol.29
, pp. 5380-5389
-
-
de Silva, H.V.1
Harmony, J.A.2
Stuart, W.D.3
Gil, C.M.4
Robbins, J.5
-
21
-
-
73949147037
-
Chapter 7: Cell protective functions of secretory Clusterin (sCLU)
-
Klock G, Baiersdörfer M, Koch-Brandt C, (2009) Chapter 7: Cell protective functions of secretory Clusterin (sCLU). Adv Cancer Res 104: 115-138.
-
(2009)
Adv Cancer Res
, vol.104
, pp. 115-138
-
-
Klock, G.1
Baiersdörfer, M.2
Koch-Brandt, C.3
-
22
-
-
73949149255
-
Chapter 5: Nuclear CLU (nCLU) and the fate of the cell
-
Bettuzzi S, Rizzi F, (2009) Chapter 5: Nuclear CLU (nCLU) and the fate of the cell. Adv Cancer Res 104: 59-88.
-
(2009)
Adv Cancer Res
, vol.104
, pp. 59-88
-
-
Bettuzzi, S.1
Rizzi, F.2
-
23
-
-
33144486527
-
Clusterin Is a Secreted Marker for a Hypoxia-Inducible Factor-Independent Function of the von Hippel-Lindau Tumor Suppressor Protein
-
Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, et al. (2006) Clusterin Is a Secreted Marker for a Hypoxia-Inducible Factor-Independent Function of the von Hippel-Lindau Tumor Suppressor Protein. Am J Pathol 168: 574-584.
-
(2006)
Am J Pathol
, vol.168
, pp. 574-584
-
-
Nakamura, E.1
Abreu-e-Lima, P.2
Awakura, Y.3
Inoue, T.4
Kamoto, T.5
-
24
-
-
75149150805
-
Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
-
Xue J, Li X, Jiao S, Wei Y, Wu G, Fang J, (2010) Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. Gastroenterology 138: 606-615.
-
(2010)
Gastroenterology
, vol.138
, pp. 606-615
-
-
Xue, J.1
Li, X.2
Jiao, S.3
Wei, Y.4
Wu, G.5
Fang, J.6
-
25
-
-
0344838401
-
von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
-
Kuznetsova AV, Meller J, Schnell PO, Nash JA, Ignacak ML, et al. (2003) von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci USA 100: 2706-2711.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2706-2711
-
-
Kuznetsova, A.V.1
Meller, J.2
Schnell, P.O.3
Nash, J.A.4
Ignacak, M.L.5
-
26
-
-
62149144092
-
Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells
-
Rizzi F, Caccamo AE, Belloni L, Bettuzzi S, (2009) Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J Cell Physiol 219: 314-323.
-
(2009)
J Cell Physiol
, vol.219
, pp. 314-323
-
-
Rizzi, F.1
Caccamo, A.E.2
Belloni, L.3
Bettuzzi, S.4
-
27
-
-
77955654403
-
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
-
Yang W-L, Zhang X, Lin H-K, (2010) Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene 29: 4493-4503.
-
(2010)
Oncogene
, vol.29
, pp. 4493-4503
-
-
Yang, W.-L.1
Zhang, X.2
Lin, H.-K.3
-
28
-
-
33645703930
-
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation
-
Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD, (2006) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation. Nature Cell Biol 8: 398-406.
-
(2006)
Nature Cell Biol
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
29
-
-
0034915764
-
Mechanisms underlying ubiquitination
-
Pickart CM, (2001) Mechanisms underlying ubiquitination. Annu Rev Biochem 70: 503-533.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 503-533
-
-
Pickart, C.M.1
-
30
-
-
69249150517
-
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system
-
van Wijk SJ, de Vries SJ, Kemmeren P, Huang A, Boelens R, et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol 5: 295.
-
(2009)
Mol Syst Biol
, vol.5
, pp. 295
-
-
van Wijk, S.J.1
de Vries, S.J.2
Kemmeren, P.3
Huang, A.4
Boelens, R.5
-
31
-
-
63649113239
-
The ubiquitin system
-
Nath D, Shadan S, (2009) The ubiquitin system. Nature 458: 421.
-
(2009)
Nature
, vol.458
, pp. 421
-
-
Nath, D.1
Shadan, S.2
-
32
-
-
63649116570
-
Ubiquitylation in innate and adaptive immunity
-
Bhoj VG, Chen ZJ, (2009) Ubiquitylation in innate and adaptive immunity. Nature 458: 430-437.
-
(2009)
Nature
, vol.458
, pp. 430-437
-
-
Bhoj, V.G.1
Chen, Z.J.2
-
33
-
-
27844442187
-
TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
-
Geetha T, Kenchappa RS, Wooten MW, Carter BD, (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J 24: 3859-3868.
-
(2005)
EMBO J
, vol.24
, pp. 3859-3868
-
-
Geetha, T.1
Kenchappa, R.S.2
Wooten, M.W.3
Carter, B.D.4
|