Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6

Molecular and Cellular Biochemistry

Volumn 352, Issue 1-2, 2011, Pages 77-85

  Ma, Tianzhong ^a   Wang, Ning ^a   Su, Zhongjing ^a   Chen, Ling ^a   Zhu, Ningxia ^a   Ma, Changhui ^a   Chen, Xiancai ^a   Chen, Haibin ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; NF B; Proliferation; RNAi; Signal transduction; TRAF6

Indexed keywords

DEOXYURIDINE; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

APOPTOSIS; ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; ESOPHAGUS CARCINOMA; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 79959252739     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0741-5     Document Type: Article

References (30)

1. Trivers KF, Sabatino SA, Stewart SL (2008) Trends in esophageal cancer incidence by histology, United States, 1998-2003. Int J Cancer 123(6):1422-1428
2. Xing D, Tan W, Lin D (2003) Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population. Oncol Rep 10(5):1615-1623
3. Yoshinaga K, Yamashita K, Mimori K, Tanaka F, Inoue H, Mori M (2008) Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. Ann Surg Oncol 15(1):96-103
4. Chen HB, Pan K, Tang MK, Chui YL, Chen L, Su ZJ, Shen ZY, Li EM, Xie W, Lee KK (2008) Comparative proteomic analysis reveals differentially expressed proteins regulated by a potential tumor promoter, bre, in human esophageal carcinoma cells. Biochem Cell Biol 86(4):302-311
5. Inoue J, Gohda J, Akiyama T, Semba K (2007) Nf-kappaB activation in development and progression of cancer. Cancer Sci 98(3):268-274 (Pubitemid 46195594)
6. Karin M, Lin A (2002) Nf-kappaB at the crossroads of life and death. Nat Immunol 3(3):221-227
7. Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109:S81-S96
8. Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C, Jacks T (2009) Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462(7269):104-107
9. Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R (2004) Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101(10):2351-2362 (Pubitemid 39458693)
10. Shukla S, MacLennan GT, Fu P, Patel J, Marengo SR, Resnick MI, Gupta S (2004) Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. Neoplasia 6(4):390-400 (Pubitemid 38924854)
11. Demchenko YN, Glebov OK, Zingone A, Keats JJ, Bergsagel PL, Kuehl WM (2010) Classical and/or alternative NF-kappaB pathway activation in multiple myeloma. Blood 115(17):3541-3552
12. Levidou G, Korkolopoulou P, Nikiteas N, Tzanakis N, Thymara I, Saetta AA, Tsigris C, Rallis G, Vlasis K, Patsouris E (2007) Expression of nuclear factor kappaB in human gastric carcinoma: relationship with Ikappab A and prognostic significance. Virchows Arch 450(5):519-527 (Pubitemid 46676248)
13. Allen CT, Ricker JL, Chen Z, Van Waes C (2007) Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck. Head Neck 29(10):959-971
14. Tian F, Zang WD, Hou WH, Liu HT, Xue LX (2006) Nuclear factor-kb signaling pathway constitutively activated in esophageal squamous cell carcinoma cell lines and inhibition of growth of cells by small interfering RNA. Acta Biochim Biophys Sin 38(5):318-326
15. Heinemann S, Biesinger B, Fleckenstein B, Albrecht JC (2006) NF-kappaB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6. J Biol Chem 281(13):8565-8572
16. He L, Wu X, Siegel R, Lipsky PE (2006) TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB. J Biol Chem 281(16):11235-11249 (Pubitemid 43855549)
17. Inoue J, Gohda J, Akiyama T (2007) Characteristics and biological functions of TRAF6. Adv Exp Med Biol 597:72-79
18. Chen ZJ (2005) Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7(8):758-765
19. Funakoshi-Tago M, Kamada N, Shimizu T, Hashiguchi Y, Tago K, Sonoda Y, Kasahara T (2009) TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation. Cytokine 45(2):72-79
20. Sibley CR, Seow Y, Wood MJ (2010) Novel RNA-based strategies for therapeutic gene silencing. Mol Ther 18(3):466-476
21. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM (1996) Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274(5288):787-789
22. Karin M (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441(7092):431-436
23. Han SW, Roman J (2006) Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: prooncogenic effects mediated by PI3-kinase and NF-kappaB. Oncogene 25(31):4341-4349 (Pubitemid 44100504)
24. Hideshima T, Chauhan D, Richardson P, Mitsiades C, Mitsiades N, Hayashi T, Munshi N, Dang L, Castro A, Palombella V, Adams J, Anderson KC (2002) NF-kappaB as a therapeutic target in multiple myeloma. J Biol Chem 277(19):16639-16647 (Pubitemid 34967682)
25. Chen H, Li M, Campbell RA, Burkhardt K, Zhu D, Li SG, Lee HJ, Wang C, Zeng Z, Gordon MS, Bonavida B, Berenson JR (2006) Interference with nuclear factor kappaB and c-jun NH2-terminal kinase signaling by TRAF6c small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis. Oncogene 25(49):6520-6527 (Pubitemid 44607084)
26. Chandrasekar B, Mummidi S, Valente AJ, Patel DN, Bailey SR, Freeman GL, Hatano M, Tokuhisa T, Jensen LE (2005) The proatherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MYd88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-jun Nterminal kinase, and activator protein-1 signaling. J Biol Chem 280(28):26263-26277 (Pubitemid 41022224)
27. Yoon K, Jung EJ, Lee SY (2008) TRAF6-mediated regulation of the PI3 kinase (PI3k)-Akt-GSK3beta cascade is required for TNF-induced cell survival. Biochem Biophys Res Commun 371(1):118-121 (Pubitemid 351615219)
28. Armstrong AP, Tometsko ME, Glaccum M, Sutherland CL, Cosman D, Dougall WC (2002) A rank/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function. J Biol Chem 277(46):44347-44356 (Pubitemid 36157870)
29. Ichikawa D, Funakoshi-Tago M, Aizu-Yokota E, Sonoda Y, Inoue J, Kasahara T (2006) TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species. Biochem Biophys Res Commun 351(1):93-98 (Pubitemid 44635411)
30. Wu L, Nakano H, Wu Z (2006) The C-terminal activating region 2 of the epstein-barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1. J Biol Chem 281(4):2162-2169 (Pubitemid 43845806)