Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2)

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5339-5354

  Feng, Taotao ^a   Wang, Hai ^a   Su, Hong ^a   Lu, Hui ^a   Yu, Liqin ^a   Zhang, Xiaojin ^a   Sun, Haopeng ^a   You, Qidong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti tumor; HDAC inhibitors; HDAC6 selectivity; Homology modelling; Molecular docking; N hydroxyfurylacrylamide

Indexed keywords

3 [5 [[(BIPHENYL 4 YLMETHYL)(2 HYDROXYETHYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[(BIPHENYL 4 YLMETHYL)(2 PHENOXYETHYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[(BIPHENYL 4 YLMETHYL)(3 PHENOXYPROPYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[[(BIPHENYL 4 YLMETHYL)(ETHYL)]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[[(BIPHENYL 4 YLMETHYL)(ISOPROPYL)]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[[(BIPHENYL 4 YLMETHYL)(OCTYL)]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[[(BIPHENYL 4 YLMETHYL)(PENTYL)]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[[BENZYL[2 PARA TOLYLOXY]ETHYL]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[[BENZYL[3 PARA TOLYLOXY]PROPYL]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(2 HYDROXYETHYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(2 PHENOXYETHYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(3 PHENOXYPROPYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(4 PHENOXYBUTYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(BIPHENYL 4 YLMETHYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(BUTYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(ETHYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(HEXYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(ISOBUTYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(ISOPROPYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(OCTYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL(PROPYL)AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; 3 [5 [[BENZYL[4 (PARA TOLYLOXY)BUTYL]AMINO]METHYL]FURAN 2 YL] NITRO HYDROXYACRYLAMIDE; ACRYLAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIPROLIFERATIVE ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CANCER INHIBITION; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; PHYSICAL CHEMISTRY; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-TUMOR; HDAC INHIBITORS; HDAC6 SELECTIVITY; HOMOLOGY MODELLING; MOLECULAR DOCKING; N-HYDROXYFURYLACRYLAMIDE;

ACRYLAMIDE; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; HCT116 CELLS; HEP G2 CELLS; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MOLECULAR DOCKING SIMULATION; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881369198     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.009     Document Type: Article

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