Cracking the code: The promise of epigenetics

ACS Medicinal Chemistry Letters

Volumn 3, Issue 7, 2012, Pages 521-523

  Dhanak, Dashyant ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALANINE; AZACITIDINE; CRIZOTINIB; DNA METHYLTRANSFERASE; HISTONE DEACETYLASE; HYDROLASE; ISOCITRATE DEHYDROGENASE; MUTANT PROTEIN; ROMIDEPSIN; S ADENOSYLHOMOCYSTEINE; VEMURAFENIB; VORINOSTAT;

ACETYLATION; BINDING AFFINITY; CELL FUNCTION; CRYSTAL STRUCTURE; CUTANEOUS T CELL LYMPHOMA; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; DNA SEQUENCE; EPIGENETICS; GENE SILENCING; GENETIC TRANSCRIPTION; GENOMICS; HUMAN; HUNTINGTON CHOREA; MENTAL DISEASE; METHYLATION; MYELODYSPLASTIC SYNDROME; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

EID: 84863835423     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300141h     Document Type: Note

References (5)

1. Arrowsmith, C. H.; Bountra, C.; Fish, P. V.; Lee, K.; Schapira, M. Epigenetic protein families: A new frontier for drug discovery Nature Rev. Drug Discovery 2012, 11, 384-400
2. Kelly, T. K.; De Carvalho, D. D.; Jones, P. A. Epigenetic modifications as therapeutic targets Nat. Biotechnol. 2010, 28, 1069-1078
3. Spannhoff, A.; Hauser, A.; Heinke, R.; Sippl, W.; Jung, M. The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors ChemMedChem 2009, 4, 1568-1582
4. Jones, P. Development of second generation epigenetic agents Med. Chem. Commun. 2012, 3, 135-161
5. Luo, M. Current Chemical Biology Approaches to Interrogate Protein Methyltransferases ACS Chem. Biol. 2012, 7, 443-463