Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 35, 2012, Pages 14188-14193

  Lin, Philana Ling ^a   Dartois, Veronique ^b   Johnston, Paul J ^c   Janssen, Christopher ^d   Via, Laura ^e   Goodwin, Michael B ^e   Klein, Edwin ^d   Barry III, Clifton E ^e   Flynn, JoAnne L ^c  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ETHAMBUTOL; ISONIAZID; METRONIDAZOLE; RIFAMPICIN; TUMOR NECROSIS FACTOR ANTIBODY;

ADD ON THERAPY; ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; BACTERIAL STRAIN; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; FIBROSIS; HEALING; HYPOXIA; LATENT TUBERCULOSIS; LOW DRUG DOSE; MACACA; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION; TREATMENT OUTCOME;

ANIMALS; ANTIPROTOZOAL AGENTS; ANTITUBERCULAR AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; DRUG THERAPY, COMBINATION; INTERFERON-GAMMA; ISONIAZID; LATENT TUBERCULOSIS; MACACA FASCICULARIS; METRONIDAZOLE; MYCOBACTERIUM TUBERCULOSIS; RECURRENCE; TUBERCULOMA; TUBERCULOSIS, PULMONARY;

ANIMALIA; BACILLI (CLASS); MACACA; MYCOBACTERIUM TUBERCULOSIS; PRIMATES;

EID: 84865540183     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121497109     Document Type: Article

References (26)

1. Barry CE, 3rd, et al. (2009) The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies. Nat Rev Microbiol 7:845-855.
2. Horsburgh CR, Jr. (2004) Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med 350:2060-2067.
3. Keane J (2004) Tumor necrosis factor blockers and reactivation of latent tuberculosis. Clin Infect Dis 39:300-302.
4. Dye C, Williams BG (2008) Eliminating human tuberculosis in the twenty-first century. J R Soc Interface 5:653-662. (Pubitemid 351589747)
5. Johnson JL, et al. (2009) Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion. Am J Respir Crit Care Med 180:558-563.
6. Leung CC, Rieder HL, Lange C, Yew WW (2011) Treatment of latent infection with Mycobacterium tuberculosis: Update 2010. Eur Respir J 37:690-711.
7. Smieja MJ, Marchetti CA, Cook DJ, Smaill FM (2000) Isoniazid for preventing tuberculosis in non-HIV infected persons. Cochrane Database Syst Rev (2):CD001363.
8. Nolan CM, Goldberg SV, Buskin SE (1999) Hepatotoxicity associated with isoniazid preventive therapy: A 7-year survey from a public health tuberculosis clinic. JAMA 281:1014-1018. (Pubitemid 29143893)
9. World Health Organization (2010) Global Tuberculosis Control WHO Report 2010 (WHO, Geneva).
10. Sterling TR, et al.; TB Trials Consortium PREVENT TB Study Team (2011) Three months of rifapentine and isoniazid for latent tuberculosis infection. N Engl J Med 365:2155-2166.
11. Via LE, et al. (2008) Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun 76:2333-2340.
12. Hoff DR, et al. (2008) Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. Antimicrob Agents Chemother 52:4137-4140.
13. Tsai MC, et al. (2006) Characterization of the tuberculous granuloma in murine and human lungs: Cellular composition and relative tissue oxygen tension. Cell Microbiol 8:218-232. (Pubitemid 43356045)
14. Wayne LG, Hayes LG (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64:2062-2069. (Pubitemid 26165667)
15. Sander P, et al. (2001) Mycobacterium bovis BCG recA deletion mutant shows increased susceptibility to DNA-damaging agents but wild-type survival in a mouse infection model. Infect Immun 69:3562-3568. (Pubitemid 32493268)
16. Brooks JV, Furney SK, Orme IM (1999) Metronidazole therapy in mice infected with tuberculosis. Antimicrob Agents Chemother 43:1285-1288. (Pubitemid 29214765)
17. Desai CR, et al. (1989) Role of metronidazole in improving response and specific drug sensitivity in advanced pulmonary tuberculosis. J Assoc Physicians India 37:694-697.
18. Capuano SV, 3rd, et al. (2003) Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection. Infect Immun 71:5831-5844.
19. Lin PL, et al. (2009) Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun 77:4631-4642.
20. Lamp KC, Freeman CD, Klutman NE, Lacy MK (1999) Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Clin Pharmacokinet 36:353-373. (Pubitemid 29261511)
21. Diedrich CR, et al. (2010) Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. PLoS ONE 5:e9611.
22. Lin PL, et al. (2010) Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model. Arthritis Rheum 62:340-350.
23. Walsh GP, et al. (1996) The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease. Nat Med 2:430-436. (Pubitemid 26191915)
24. Wolf RH, Gibson SV, Watson EA, Baskin GB (1988) Multidrug chemotherapy of tuberculosis in rhesus monkeys. Lab Anim Sci 38:25-33. (Pubitemid 18083320)
25. Flynn JL, Klein E (2011) Pulmonary tuberculosis in monkeys. A Color Atlas of Comparative Pulmonary Tuberculosis Histopathology, eds Leong FJ, Dartois V, Dick T (Taylor & Francis, New York), pp 83-106.
26. Lin PL, et al. (2006) Early events in Mycobacterium tuberculosis infection in cynomolgus macaques. Infect Immun 74:3790-3803. (Pubitemid 43993310)