메뉴 건너뛰기




Volumn 14, Issue 10, 2013, Pages 1157-1166

Notch-associated MicroRNAs in cancer

Author keywords

Gene silencing; MicroRNAs; Notch signaling; Tumorigenesis

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADAM10 ENDOPEPTIDASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GAMMA SECRETASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MICRORNA 122; MICRORNA 144; MICRORNA 150; MICRORNA 181C; MICRORNA 199B; MICRORNA 200; MICRORNA 29; MICRORNA 34; MICRORNA 34A; MICRORNA 34C; MICRORNA 524; MYC PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR ZEB1; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; WNT1 PROTEIN; WNT4 PROTEIN;

EID: 84881334111     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113149990188     Document Type: Review
Times cited : (12)

References (107)
  • 1
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770-776.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 2
    • 4444293744 scopus 로고    scopus 로고
    • Notch signaling in mammary development and oncogenesis
    • Callahan R, Egan SE. Notch signaling in mammary development and oncogenesis. J Mammary Gland Biol Neoplasia 2004; 9: 145-63.
    • (2004) J Mammary Gland Biol Neoplasia , vol.9 , pp. 145-163
    • Callahan, R.1    Egan, S.E.2
  • 3
    • 33748155240 scopus 로고    scopus 로고
    • Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials
    • Shi W, Harris AL. Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J Mammary Gland Biol Neoplasia 2006; 11: 41-52.
    • (2006) J Mammary Gland Biol Neoplasia , vol.11 , pp. 41-52
    • Shi, W.1    Harris, A.L.2
  • 5
    • 33644782668 scopus 로고    scopus 로고
    • Recent insights into the role of Notch signaling in tumorigenesis
    • Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006; 107: 2223-33.
    • (2006) Blood , vol.107 , pp. 2223-2233
    • Leong, K.G.1    Karsan, A.2
  • 6
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or tumour suppressor?
    • Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003; 3: 756-67.
    • (2003) Nat Rev Cancer , vol.3 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 7
    • 33644752839 scopus 로고    scopus 로고
    • Notch signaling
    • Miele L. Notch signaling. Clin Cancer Res 2006; 12: 1074-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 1074-1079
    • Miele, L.1
  • 8
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: Unfolding the activation mechanism
    • Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137: 216-33.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 9
    • 0030877659 scopus 로고    scopus 로고
    • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    • Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 1997; 90: 281-91.
    • (1997) Cell , vol.90 , pp. 281-291
    • Blaumueller, C.M.1    Qi, H.2    Zagouras, P.3    Artavanis-Tsakonas, S.4
  • 10
    • 0032493302 scopus 로고    scopus 로고
    • The Notch1 receptor is cleaved constitutively by a furin-like convertase
    • Logeat F, Bessia C, Brou C, et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 1998; 95: 8108-12.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8108-8112
    • Logeat, F.1    Bessia, C.2    Brou, C.3
  • 11
    • 0032235397 scopus 로고    scopus 로고
    • Structural conservation of Notch receptors and ligands
    • Fleming RJ. Structural conservation of Notch receptors and ligands. Semin Cell Dev Biol 1998; 9: 599-607.
    • (1998) Semin Cell Dev Biol , vol.9 , pp. 599-607
    • Fleming, R.J.1
  • 12
    • 0033868818 scopus 로고    scopus 로고
    • A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrinmetalloprotease TACE
    • Brou C, Logeat F, Gupta N, et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrinmetalloprotease TACE. Mol Cell 2000; 5: 207-16.
    • (2000) Mol Cell , vol.5 , pp. 207-216
    • Brou, C.1    Logeat, F.2    Gupta, N.3
  • 13
    • 0033867521 scopus 로고    scopus 로고
    • A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
    • Mumm JS, Schroeter EH, Saxena MT, et al. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell 2000; 5: 197-206.
    • (2000) Mol Cell , vol.5 , pp. 197-206
    • Mumm, J.S.1    Schroeter, E.H.2    Saxena, M.T.3
  • 14
    • 0033524444 scopus 로고    scopus 로고
    • CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
    • Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci USA 1999; 96: 23-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 23-28
    • Hsieh, J.J.1    Zhou, S.2    Chen, L.3    Young, D.B.4    Hayward, S.D.5
  • 15
    • 0029085935 scopus 로고
    • Signalling downstream of activated mammalian Notch
    • Jarriault S, Brou C, Logeat F, et al. Signalling downstream of activated mammalian Notch. Nature 1995; 377: 355-8.
    • (1995) Nature , vol.377 , pp. 355-358
    • Jarriault, S.1    Brou, C.2    Logeat, F.3
  • 16
    • 0032145527 scopus 로고    scopus 로고
    • A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
    • Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 1998; 12: 2269-77.
    • (1998) Genes Dev , vol.12 , pp. 2269-2277
    • Kao, H.Y.1    Ordentlich, P.2    Koyano-Nakagawa, N.3
  • 17
    • 3342967780 scopus 로고    scopus 로고
    • Modulation of Notch signaling by mastermindlike (MAML) transcriptional co-activators and their involvement in tumorigenesis
    • Wu L, Griffin JD. Modulation of Notch signaling by mastermindlike (MAML) transcriptional co-activators and their involvement in tumorigenesis. Semin Cancer Biol 2004; 14: 348-56.
    • (2004) Semin Cancer Biol , vol.14 , pp. 348-356
    • Wu, L.1    Griffin, J.D.2
  • 18
    • 0033662392 scopus 로고    scopus 로고
    • MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
    • Wu L, Aster JC, Blacklow SC, et al. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 2000; 26: 484-9.
    • (2000) Nat Genet , vol.26 , pp. 484-489
    • Wu, L.1    Aster, J.C.2    Blacklow, S.C.3
  • 19
    • 0036837899 scopus 로고    scopus 로고
    • Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
    • Wu L, Sun T, Kobayashi K, Gao P, Griffin J D. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol 2002; 22: 7688-700.
    • (2002) Mol Cell Biol , vol.22 , pp. 7688-7700
    • Wu, L.1    Sun, T.2    Kobayashi, K.3    Gao, P.4    Griffin, J.D.5
  • 20
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: Multiple effectors of the Notch signaling pathway
    • Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003; 194: 237-55.
    • (2003) J Cell Physiol , vol.194 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 21
    • 33845987566 scopus 로고    scopus 로고
    • Over expression of the Notch1 intracellular domain (NICD) inhibits cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
    • Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Over expression of the Notch1 intracellular domain (NICD) inhibits cellular proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem 2006.
    • (2006) J Biol Chem
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3    Chen, H.4
  • 22
    • 0034902568 scopus 로고    scopus 로고
    • Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): Implication for cell cycle disruption in transformation by Notch(ic)
    • Ronchini C, Capobianco AJ. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 2001; 21: 5925-34.
    • (2001) Mol Cell Biol , vol.21 , pp. 5925-5934
    • Ronchini, C.1    Capobianco, A.J.2
  • 23
    • 33746546368 scopus 로고    scopus 로고
    • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 2006; 20: 2096-109.
    • (2006) Genes Dev , vol.20 , pp. 2096-2109
    • Weng, A.P.1    Millholland, J.M.2    Yashiro-Ohtani, Y.3
  • 24
    • 0031594575 scopus 로고    scopus 로고
    • NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
    • Oswald F, Liptay S, Adler G, Schmid RM. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol 1998; 18: 2077-88.
    • (1998) Mol Cell Biol , vol.18 , pp. 2077-2088
    • Oswald, F.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 25
    • 0033613401 scopus 로고    scopus 로고
    • Involvement of Notch1 in the development of mouse mammary tumors
    • Dievart A, Beaulieu N, Jolicoeur P. Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 1999; 18: 5973-81.
    • (1999) Oncogene , vol.18 , pp. 5973-5981
    • Dievart, A.1    Beaulieu, N.2    Jolicoeur, P.3
  • 26
    • 0030910099 scopus 로고    scopus 로고
    • Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH
    • Chen Y, Fischer WH, Gill GN. Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J Biol Chem 1997; 272: 14110-4.
    • (1997) J Biol Chem , vol.272 , pp. 14110-14114
    • Chen, Y.1    Fischer, W.H.2    Gill, G.N.3
  • 27
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-5.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 28
    • 54549108798 scopus 로고    scopus 로고
    • MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
    • Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008; 455: 1124-8.
    • (2008) Nature , vol.455 , pp. 1124-1128
    • Tay, Y.1    Zhang, J.2    Thomson, A.M.3    Lim, B.4    Rigoutsos, I.5
  • 29
    • 76249119007 scopus 로고    scopus 로고
    • Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
    • Melton C, Judson RL, Blelloch R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature 2010; 463(7281): 621-6.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 621-626
    • Melton, C.1    Judson, R.L.2    Blelloch, R.3
  • 30
    • 40349094597 scopus 로고    scopus 로고
    • MicroRNA-373 induces expression of genes with complementary promoter sequences
    • Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA 2008; 105: 1608-13.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1608-1613
    • Place, R.F.1    Li, L.C.2    Pookot, D.3    Noonan, E.J.4    Dahiya, R.5
  • 32
  • 33
    • 20444467290 scopus 로고    scopus 로고
    • A microRNA polycistron as a potential human oncogene
    • He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature 2005; 435: 828-33.
    • (2005) Nature , vol.435 , pp. 828-833
    • He, L.1    Thomson, J.M.2    Hemann, M.T.3
  • 35
    • 33646258751 scopus 로고    scopus 로고
    • Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer
    • Xi Y, Shalgi R, Fodstad O, Pilpel Y, Ju J. Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res 2006; 12: 2014-24.
    • (2006) Clin Cancer Res , vol.12 , pp. 2014-2024
    • Xi, Y.1    Shalgi, R.2    Fodstad, O.3    Pilpel, Y.4    Ju, J.5
  • 36
    • 37049010980 scopus 로고    scopus 로고
    • The guardian's little helper: MicroRNAs in the p53 tumor suppressor network
    • He X, He L, Hannon GJ. The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res 2007; 67: 11099-101.
    • (2007) Cancer Res , vol.67 , pp. 11099-11101
    • He, X.1    He, L.2    Hannon, G.J.3
  • 37
    • 77951884078 scopus 로고    scopus 로고
    • Cross-talk between miRNA and Notch signaling pathways in tumor development and progression
    • Wang Z, Li Y, Kong D, et al. Cross-talk between miRNA and Notch signaling pathways in tumor development and progression. Cancer Lett 2010; 292: 141-8.
    • (2010) Cancer Lett , vol.292 , pp. 141-148
    • Wang, Z.1    Li, Y.2    Kong, D.3
  • 38
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006; 9: 435-43.
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3
  • 39
    • 32944462300 scopus 로고    scopus 로고
    • Rapid alteration of microRNA levels by histone deacetylase inhibition
    • Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res 2006; 66: 1277-81.
    • (2006) Cancer Res , vol.66 , pp. 1277-1281
    • Scott, G.K.1    Mattie, M.D.2    Berger, C.E.3    Benz, S.C.4    Benz, C.C.5
  • 40
    • 47949100595 scopus 로고    scopus 로고
    • Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
    • Newman MA, Thomson JM, Hammond SM. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. Rna 2008; 14: 1539-49.
    • (2008) Rna , vol.14 , pp. 1539-1549
    • Newman, M.A.1    Thomson, J.M.2    Hammond, S.M.3
  • 41
    • 52049124806 scopus 로고    scopus 로고
    • Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28
    • Piskounova E, Viswanathan SR, Janas M, et al. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem 2008; 283: 21310-4.
    • (2008) J Biol Chem , vol.283 , pp. 21310-21314
    • Piskounova, E.1    Viswanathan, S.R.2    Janas, M.3
  • 42
    • 48649103982 scopus 로고    scopus 로고
    • A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stemcell commitment
    • Rybak A, Fuchs H, Smirnova L, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stemcell commitment. Nat Cell Biol 2008; 10: 987-93.
    • (2008) Nat Cell Biol , vol.10 , pp. 987-993
    • Rybak, A.1    Fuchs, H.2    Smirnova, L.3
  • 43
    • 40849108663 scopus 로고    scopus 로고
    • Selective blockade of microRNA processing by Lin28
    • Viswanathan S R, Daley G Q, Gregory R I. Selective blockade of microRNA processing by Lin28. Science 2008; 320: 97-100.
    • (2008) Science , vol.320 , pp. 97-100
    • Viswanathan, S.R.1    Daley, G.Q.2    Gregory, R.I.3
  • 44
    • 34848922072 scopus 로고    scopus 로고
    • miRNAs play a tune
    • Hobert O. miRNAs play a tune. Cell 2007; 131: 22-4.
    • (2007) Cell , vol.131 , pp. 22-24
    • Hobert, O.1
  • 45
    • 84866179216 scopus 로고    scopus 로고
    • Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1
    • Fragoso R, Mao T, Wang S, et al. Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet 2012; 8: e1002855.
    • (2012) PLoS Genet , vol.8
    • Fragoso, R.1    Mao, T.2    Wang, S.3
  • 47
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    • Brabletz S, Bajdak K, Meidhof S, et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J 2011; 30: 770-82.
    • (2011) EMBO J , vol.30 , pp. 770-782
    • Brabletz, S.1    Bajdak, K.2    Meidhof, S.3
  • 48
    • 0037224740 scopus 로고    scopus 로고
    • The ADAMs family of metalloproteases: Multidomain proteins with multiple functions
    • Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003; 17: 7-30.
    • (2003) Genes Dev , vol.17 , pp. 7-30
    • Seals, D.F.1    Courtneidge, S.A.2
  • 49
    • 70450285075 scopus 로고    scopus 로고
    • MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib
    • Bai S, Nasser MW, Wang B, et al. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem 2009; 284: 32015-27.
    • (2009) J Biol Chem , vol.284 , pp. 32015-32027
    • Bai, S.1    Nasser, M.W.2    Wang, B.3
  • 50
    • 66149114383 scopus 로고    scopus 로고
    • MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
    • Tsai WC, Hsu PW, Lai TC, et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology 2009; 49: 1571-82.
    • (2009) Hepatology , vol.49 , pp. 1571-1582
    • Tsai, W.C.1    Hsu, P.W.2    Lai, T.C.3
  • 51
    • 79958717094 scopus 로고    scopus 로고
    • Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29
    • Li H, Solomon E, Duhachek Muggy S, Sun D, Zolkiewska A. Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29. J Biol Chem 2011; 286: 21500-10.
    • (2011) J Biol Chem , vol.286 , pp. 21500-21510
    • Li, H.1    Solomon, E.2    Duhachek, M.S.3    Sun, D.4    Zolkiewska, A.5
  • 52
    • 77649273214 scopus 로고    scopus 로고
    • Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex
    • Ishitani T, Hirao T, Suzuki M, et al. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat Cell Biol 2010; 12: 278-85.
    • (2010) Nat Cell Biol , vol.12 , pp. 278-285
    • Ishitani, T.1    Hirao, T.2    Suzuki, M.3
  • 53
    • 83755173483 scopus 로고    scopus 로고
    • Cutting edge: MicroRNA-181 promotes human NK cell development by regulating Notch signaling
    • Cichocki F, Felices M, McCullar V, et al. Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol 2011; 187: 6171-5.
    • (2011) J Immunol , vol.187 , pp. 6171-6175
    • Cichocki, F.1    Felices, M.2    McCullar, V.3
  • 54
    • 70350374350 scopus 로고    scopus 로고
    • Numb regulates post-endocytic trafficking and degradation of Notch1
    • McGill MA, Dho SE, Weinmaster G, McGlade CJ. Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem 2009; 284: 26427-38.
    • (2009) J Biol Chem , vol.284 , pp. 26427-26438
    • McGill, M.A.1    Dho, S.E.2    Weinmaster, G.3    McGlade, C.J.4
  • 55
    • 0037663379 scopus 로고    scopus 로고
    • Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    • McGill MA, McGlade CJ. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 2003; 278: 23196-203.
    • (2003) J Biol Chem , vol.278 , pp. 23196-23203
    • McGill, M.A.1    McGlade, C.J.2
  • 56
    • 84862173056 scopus 로고    scopus 로고
    • MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation
    • Fineberg SK, Datta P, Stein CS, Davidson BL. MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation. PloS one 2012; 7: e38562.
    • (2012) PloS One , vol.7
    • Fineberg, S.K.1    Datta, P.2    Stein, C.S.3    Davidson, B.L.4
  • 57
    • 77950518606 scopus 로고    scopus 로고
    • Genome-wide RNAmediated interference screen identifies miR-19 targets in Notchinduced T-cell acute lymphoblastic leukaemia
    • Mavrakis KJ, Wolfe AL, Oricchio E, et al. Genome-wide RNAmediated interference screen identifies miR-19 targets in Notchinduced T-cell acute lymphoblastic leukaemia. Nat Cell Biol 2010; 12: 372-9.
    • (2010) Nat Cell Biol , vol.12 , pp. 372-379
    • Mavrakis, K.J.1    Wolfe, A.L.2    Oricchio, E.3
  • 58
    • 80052632447 scopus 로고    scopus 로고
    • MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumorpropagating cells and supports neural differentiation in medulloblastoma
    • de Antonellis P, Medaglia C, Cusanelli E, et al. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumorpropagating cells and supports neural differentiation in medulloblastoma. PloS one 2011; 6: e24584.
    • (2011) PloS One , vol.6
    • de Antonellis, P.1    Medaglia, C.2    Cusanelli, E.3
  • 59
    • 79953329774 scopus 로고    scopus 로고
    • The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice
    • Yang Y, Ahn YH, Gibbons DL, et al. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest 2011; 121: 1373-85.
    • (2011) J Clin Invest , vol.121 , pp. 1373-1385
    • Yang, Y.1    Ahn, Y.H.2    Gibbons, D.L.3
  • 60
    • 84868621391 scopus 로고    scopus 로고
    • The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
    • Chen L, Zhang W, Yan W, et al. The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. Carcinogenesis 2012; 33: 2276-82.
    • (2012) Carcinogenesis , vol.33 , pp. 2276-2282
    • Chen, L.1    Zhang, W.2    Yan, W.3
  • 61
    • 84863531464 scopus 로고    scopus 로고
    • miRNA-34c regulates Notch signaling during bone development
    • Bae Y, Yang T, Zeng HC, et al. miRNA-34c regulates Notch signaling during bone development. Hum Mol Genet 2012; 21: 2991-3000.
    • (2012) Hum Mol Genet , vol.21 , pp. 2991-3000
    • Bae, Y.1    Yang, T.2    Zeng, H.C.3
  • 62
    • 77953920780 scopus 로고    scopus 로고
    • MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
    • Pang RT, Leung CO, Ye TM, et al. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis 2010; 31: 1037-44.
    • (2010) Carcinogenesis , vol.31 , pp. 1037-1044
    • Pang, R.T.1    Leung, C.O.2    Ye, T.M.3
  • 63
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447: 1130-4.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3
  • 64
    • 34547458550 scopus 로고    scopus 로고
    • p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • Bommer GT, Gerin I, Feng Y, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 2007; 17: 1298-307.
    • (2007) Curr Biol , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3
  • 65
    • 34249822779 scopus 로고    scopus 로고
    • Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    • Raver-Shapira N, Marciano E, Meiri E, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007; 26: 731-43.
    • (2007) Mol Cell , vol.26 , pp. 731-743
    • Raver-Shapira, N.1    Marciano, E.2    Meiri, E.3
  • 66
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ 2010; 17: 193-9.
    • (2010) Cell Death Differ , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 67
    • 70350221952 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    • Li Y, Guessous F, Zhang Y, et al. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 2009; 69: 7569-76.
    • (2009) Cancer Res , vol.69 , pp. 7569-7576
    • Li, Y.1    Guessous, F.2    Zhang, Y.3
  • 68
    • 77953498262 scopus 로고    scopus 로고
    • microRNA-34a is tumor suppressive in brain tumors and glioma stem cells
    • Guessous F, Zhang Y, Kofman A, et al. microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 2010; 9: 1031-6.
    • (2010) Cell Cycle , vol.9 , pp. 1031-1036
    • Guessous, F.1    Zhang, Y.2    Kofman, A.3
  • 69
    • 84867077740 scopus 로고    scopus 로고
    • Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells
    • Ji X, Wang Z, Geamanu A, et al. Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells. International journal of cancer. Int J Cancer 2012; 131: 2668-77.
    • (2012) International journal of cancer. Int J Cancer , vol.131 , pp. 2668-2677
    • Ji, X.1    Wang, Z.2    Geamanu, A.3
  • 70
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji Q, Hao X, Meng Y, et al. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC cancer 2008; 8: 266.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3
  • 71
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS one 2009; 4: e6816.
    • (2009) PloS One , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 72
    • 79960673180 scopus 로고    scopus 로고
    • Analysis of miRNAgene expression-genomic profiles reveals complex mechanisms of microRNA deregulation in osteosarcoma
    • Maire G, Martin JW, Yoshimoto M, et al. Analysis of miRNAgene expression-genomic profiles reveals complex mechanisms of microRNA deregulation in osteosarcoma. Cancer Genet 2011; 204: 138-46.
    • (2011) Cancer Genet , vol.204 , pp. 138-146
    • Maire, G.1    Martin, J.W.2    Yoshimoto, M.3
  • 73
    • 84858632494 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo
    • Yan K, Gao J, Yang T, et al. MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PloS one 2012; 7: e33778.
    • (2012) PloS One , vol.7
    • Yan, K.1    Gao, J.2    Yang, T.3
  • 74
    • 80155126639 scopus 로고    scopus 로고
    • A NOTCH3-mediated squamous cell differentiation program limits expansion of EMTcompetent cells that express the ZEB transcription factors
    • Ohashi S, Natsuizaka M, Naganuma S, et al. A NOTCH3-mediated squamous cell differentiation program limits expansion of EMTcompetent cells that express the ZEB transcription factors. Cancer Res 2011; 71: 6836-47.
    • (2011) Cancer Res , vol.71 , pp. 6836-6847
    • Ohashi, S.1    Natsuizaka, M.2    Naganuma, S.3
  • 75
    • 70450225266 scopus 로고    scopus 로고
    • MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation
    • Song G, Zhang Y, Wang L. MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem 2009; 284: 31921-7.
    • (2009) J Biol Chem , vol.284 , pp. 31921-31927
    • Song, G.1    Zhang, Y.2    Wang, L.3
  • 76
    • 79959842615 scopus 로고    scopus 로고
    • Modulation of microRNA expression in human T-cell development: Targeting of NOTCH3 by miR-150
    • Ghisi M, Corradin A, Basso K, et al. Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150. Blood 2011; 117: 7053-62.
    • (2011) Blood , vol.117 , pp. 7053-7062
    • Ghisi, M.1    Corradin, A.2    Basso, K.3
  • 77
    • 77952297768 scopus 로고    scopus 로고
    • Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
    • Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis 2010; 31: 777-84.
    • (2010) Carcinogenesis , vol.31 , pp. 777-784
    • Hashimoto, Y.1    Akiyama, Y.2    Otsubo, T.3    Shimada, S.4    Yuasa, Y.5
  • 78
    • 79952748822 scopus 로고    scopus 로고
    • DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
    • Sureban SM, May R, Lightfoot SA, et al. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res 2011; 71: 2328-38.
    • (2011) Cancer Res , vol.71 , pp. 2328-2338
    • Sureban, S.M.1    May, R.2    Lightfoot, S.A.3
  • 79
    • 84855279252 scopus 로고    scopus 로고
    • MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelialmesenchymal transition in breast tumor-initiating cells
    • Yu F, Jiao Y, Zhu Y, et al. MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelialmesenchymal transition in breast tumor-initiating cells. J Biol Chem 2012; 287: 465-73.
    • (2012) J Biol Chem , vol.287 , pp. 465-473
    • Yu, F.1    Jiao, Y.2    Zhu, Y.3
  • 80
    • 77953674754 scopus 로고    scopus 로고
    • How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize
    • Hughes DP. How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. Cancer Treat Res 2009; 152: 479-96.
    • (2009) Cancer Treat Res , vol.152 , pp. 479-496
    • Hughes, D.P.1
  • 81
    • 63449135077 scopus 로고    scopus 로고
    • MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma
    • Garzia L, Andolfo I, Cusanelli E, et al. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PloS one 2009; 4: e4998.
    • (2009) PloS One , vol.4
    • Garzia, L.1    Andolfo, I.2    Cusanelli, E.3
  • 82
    • 67650660754 scopus 로고    scopus 로고
    • The Notch signaling pathway: Transcriptional regulation at Notch target genes
    • Borggrefe T, Oswald F. The Notch signaling pathway: transcriptional regulation at Notch target genes. Cellular and molecular life sciences: CMLS 2009; 66: 1631-46.
    • (2009) Cellular and Molecular Life Sciences: CMLS , vol.66 , pp. 1631-1646
    • Borggrefe, T.1    Oswald, F.2
  • 83
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelialmesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, et al. Notch-1 induces epithelialmesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 2011; 307: 26-36.
    • (2011) Cancer Lett , vol.307 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3
  • 84
    • 84862331081 scopus 로고    scopus 로고
    • Notchmediated repression of miR-223 contributes to IGF1R regulation in T-ALL
    • Gusscott S, Kuchenbauer F, Humphries RK, Weng AP. Notchmediated repression of miR-223 contributes to IGF1R regulation in T-ALL. Leuk Res 2012; 36: 905-11.
    • (2012) Leuk Res , vol.36 , pp. 905-911
    • Gusscott, S.1    Kuchenbauer, F.2    Humphries, R.K.3    Weng, A.P.4
  • 85
    • 79957538250 scopus 로고    scopus 로고
    • Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis
    • Hamidi H, Gustafason D, Pellegrini M, Gasson J. Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis. PloS one 2011; 6: e20022.
    • (2011) PloS One , vol.6
    • Hamidi, H.1    Gustafason, D.2    Pellegrini, M.3    Gasson, J.4
  • 86
    • 34548082532 scopus 로고    scopus 로고
    • MiRNA expression analysis during normal zebrafish development and following inhibition of the Hedgehog and Notch signaling pathways
    • Thatcher EJ, Flynt AS, Li N, Patton JR, Patton JG. MiRNA expression analysis during normal zebrafish development and following inhibition of the Hedgehog and Notch signaling pathways. Dev Dyn 2007; 236: 2172-80.
    • (2007) Dev Dyn , vol.236 , pp. 2172-2180
    • Thatcher, E.J.1    Flynt, A.S.2    Li, N.3    Patton, J.R.4    Patton, J.G.5
  • 87
    • 72849108572 scopus 로고    scopus 로고
    • The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors
    • Kefas B, Comeau L, Floyd D H, et al. The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci 2009; 29: 15161-8.
    • (2009) J Neurosci , vol.29 , pp. 15161-15168
    • Kefas, B.1    Comeau, L.2    Floyd, D.H.3
  • 88
    • 0035222855 scopus 로고    scopus 로고
    • The ras signaling pathway in mammary tumorigenesis and metastasis
    • Malaney S, Daly R J. The ras signaling pathway in mammary tumorigenesis and metastasis. J Mammary Gland Biol Neoplasia 2001; 6: 101-13.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 101-113
    • Malaney, S.1    Daly, R.J.2
  • 89
    • 0344759138 scopus 로고    scopus 로고
    • Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients
    • Gohring UJ, Schondorf T, Kiecker VR, et al. Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients. Tumour Biol 1999; 20: 173-83.
    • (1999) Tumour Biol , vol.20 , pp. 173-183
    • Gohring, U.J.1    Schondorf, T.2    Kiecker, V.R.3
  • 90
    • 0036734148 scopus 로고    scopus 로고
    • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
    • Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 2002; 8: 979-86.
    • (2002) Nat Med , vol.8 , pp. 979-986
    • Weijzen, S.1    Rizzo, P.2    Braid, M.3
  • 91
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson S M, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005; 120: 635-47.
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 92
    • 79958045469 scopus 로고    scopus 로고
    • Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-kappaB signaling pathways
    • Wang Z, Banerjee S, Ahmad A, et al. Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-kappaB signaling pathways. PloS one 2011; 6: e20537.
    • (2011) PloS One , vol.6
    • Wang, Z.1    Banerjee, S.2    Ahmad, A.3
  • 93
    • 84868011894 scopus 로고    scopus 로고
    • Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness
    • Kashat M, Azzouz L, Sarkar SH, et al. Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness. Am J Transl Res 2012; 4: 432-42.
    • (2012) Am J Transl Res , vol.4 , pp. 432-442
    • Kashat, M.1    Azzouz, L.2    Sarkar, S.H.3
  • 94
    • 33644857012 scopus 로고    scopus 로고
    • Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
    • Ayyanan A, Civenni G, Ciarloni L, et al. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci USA 2006; 103: 3799-804.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3799-3804
    • Ayyanan, A.1    Civenni, G.2    Ciarloni, L.3
  • 95
    • 0041856097 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways
    • Espinosa L, Ingles-Esteve J, Aguilera C, Bigas A. Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem 2003; 278: 32227-35.
    • (2003) J Biol Chem , vol.278 , pp. 32227-32235
    • Espinosa, L.1    Ingles-Esteve, J.2    Aguilera, C.3    Bigas, A.4
  • 96
    • 0032522992 scopus 로고    scopus 로고
    • Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion
    • Uyttendaele H, Soriano JV, Montesano R, Kitajewski J. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev Biol 1998; 196: 204-17.
    • (1998) Dev Biol , vol.196 , pp. 204-217
    • Uyttendaele, H.1    Soriano, J.V.2    Montesano, R.3    Kitajewski, J.4
  • 97
    • 84868475728 scopus 로고    scopus 로고
    • MicroRNA therapeutics for cardiovascular disease: Opportunities and obstacles
    • van Rooij E, Olson EN. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat Rev Drug Discov 2012; 11: 860-72.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 860-972
    • van Rooij, E.1    Olson, E.N.2
  • 98
    • 84864539550 scopus 로고    scopus 로고
    • Exosomes and the emerging field of exosome-based gene therapy
    • O'Loughlin AJ, Woffindale CA, Wood MJ. Exosomes and the emerging field of exosome-based gene therapy. Curr Gene Therapy 2012; 12: 262-74.
    • (2012) Curr Gene Therapy , vol.12 , pp. 262-274
    • O'Loughlin, A.J.1    Woffindale, C.A.2    Wood, M.J.3
  • 99
    • 84869219338 scopus 로고    scopus 로고
    • miR-34-a microRNA replacement therapy is headed to the clinic
    • Bader AG. miR-34-a microRNA replacement therapy is headed to the clinic. Front Genet 2012; 3: 120.
    • (2012) Front Genet , vol.3 , pp. 120
    • Bader, A.G.1
  • 100
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
    • Iorio MV, Croce CM. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 2012; 4: 143-59.
    • (2012) EMBO Mol Med , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 101
    • 80052316514 scopus 로고    scopus 로고
    • Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    • Nalls D, Tang SN, Rodova M, Srivastava RK, Shankar S. Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PloS one 2011; 6: e24099.
    • (2011) PloS One , vol.6
    • Nalls, D.1    Tang, S.N.2    Rodova, M.3    Srivastava, R.K.4    Shankar, S.5
  • 102
    • 80052850129 scopus 로고    scopus 로고
    • Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism
    • Sureban SM, May R, Mondalek FG, et al. Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J Nanobiotechnology 2011; 9: 40.
    • (2011) J Nanobiotechnology , vol.9 , pp. 40
    • Sureban, S.M.1    May, R.2    Mondalek, F.G.3
  • 103
    • 78649466892 scopus 로고    scopus 로고
    • Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
    • Wang Z, Li Y, Ahmad A, et al. Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 2010; 1806: 258-67.
    • (2010) Biochim Biophys Acta , vol.1806 , pp. 258-267
    • Wang, Z.1    Li, Y.2    Ahmad, A.3
  • 104
    • 84878196578 scopus 로고    scopus 로고
    • Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells
    • Xia J, Duan Q, Ahmad A, et al. Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells. Curr Drug Targets 2012.
    • (2012) Curr Drug Targets
    • Xia, J.1    Duan, Q.2    Ahmad, A.3
  • 105
    • 84866280242 scopus 로고    scopus 로고
    • Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF
    • Roy S, Levi E, Majumdar AP, Sarkar FH. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J Hematol Oncol 2012; 5: 58.
    • (2012) J Hematol Oncol , vol.5 , pp. 58
    • Roy, S.1    Levi, E.2    Majumdar, A.P.3    Sarkar, F.H.4
  • 106
    • 84855405573 scopus 로고    scopus 로고
    • Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression
    • Bao B, Ali S, Banerjee S, et al. Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res 2012; 72: 335-45.
    • (2012) Cancer Res , vol.72 , pp. 335-345
    • Bao, B.1    Ali, S.2    Banerjee, S.3
  • 107
    • 84864464973 scopus 로고    scopus 로고
    • DIANA miRPath v.2.0: Investigating the combinatorial effect of microRNAs in pathways
    • Vlachos I S, Kostoulas N, Vergoulis T, et al. DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways. Nucleic Acids Res 2012; 40: W498-W504.
    • (2012) Nucleic Acids Res , vol.40
    • Vlachos, I.S.1    Kostoulas, N.2    Vergoulis, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.