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Volumn 204, Issue 3, 2011, Pages 138-146

Analysis of miRNA-gene expression-genomic profiles reveals complex mechanisms of microRNA deregulation in osteosarcoma

Author keywords

Bioinformatics; MicroRNA; Oncogenesis; Osteosarcoma; Post transcriptional regulation

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PROTEIN FOS; PROTEIN P21; RAS PROTEIN; WNT PROTEIN; MICRORNA;

EID: 79960673180     PISSN: 22107762     EISSN: 22107770     Source Type: Journal    
DOI: 10.1016/j.cancergen.2010.12.012     Document Type: Article
Times cited : (129)

References (59)
  • 1
    • 0030964763 scopus 로고    scopus 로고
    • Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature
    • Bridge J.A., Nelson M., McComb E., et al. Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature. Cancer Genet Cytogenet 1997, 95:74-87.
    • (1997) Cancer Genet Cytogenet , vol.95 , pp. 74-87
    • Bridge, J.A.1    Nelson, M.2    McComb, E.3
  • 2
    • 0035474699 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis identifies gains of 1p35 approximately p36 and chromosome 19 in osteosarcoma
    • Zielenska M., Bayani J., Pandita A., et al. Comparative genomic hybridization analysis identifies gains of 1p35 approximately p36 and chromosome 19 in osteosarcoma. Cancer Genet Cytogenet 2001, 130:14-21.
    • (2001) Cancer Genet Cytogenet , vol.130 , pp. 14-21
    • Zielenska, M.1    Bayani, J.2    Pandita, A.3
  • 3
    • 0036964784 scopus 로고    scopus 로고
    • Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma
    • van Dartel M., Cornelissen P.W., Redeker S., et al. Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma. Cancer Genet Cytogenet 2002, 139:91-96.
    • (2002) Cancer Genet Cytogenet , vol.139 , pp. 91-96
    • van Dartel, M.1    Cornelissen, P.W.2    Redeker, S.3
  • 4
    • 0037438773 scopus 로고    scopus 로고
    • Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping
    • Ozaki T., Neumann T., Wai D., et al. Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping. Cancer Genet Cytogenet 2003, 140:145-152.
    • (2003) Cancer Genet Cytogenet , vol.140 , pp. 145-152
    • Ozaki, T.1    Neumann, T.2    Wai, D.3
  • 5
    • 0038668852 scopus 로고    scopus 로고
    • Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors
    • Sandberg A.A., Bridge J.A. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors. Cancer Genet Cytogenet 2003, 145:1-30.
    • (2003) Cancer Genet Cytogenet , vol.145 , pp. 1-30
    • Sandberg, A.A.1    Bridge, J.A.2
  • 6
    • 0141889935 scopus 로고    scopus 로고
    • High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays
    • Squire J.A., Pei J., Marrano P., et al. High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. Genes Chromosomes Cancer 2003, 38:215-225.
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 215-225
    • Squire, J.A.1    Pei, J.2    Marrano, P.3
  • 7
    • 9944265673 scopus 로고    scopus 로고
    • Combined spectral karyotyping, multicolor banding, and microarray comparative genomic hybridization analysis provides a detailed characterization of complex structural chromosomal rearrangements associated with gene amplification in the osteosarcoma cell line MG-63
    • Lim G., Karaskova J., Vukovic B., et al. Combined spectral karyotyping, multicolor banding, and microarray comparative genomic hybridization analysis provides a detailed characterization of complex structural chromosomal rearrangements associated with gene amplification in the osteosarcoma cell line MG-63. Cancer Genet Cytogenet 2004, 153:158-164.
    • (2004) Cancer Genet Cytogenet , vol.153 , pp. 158-164
    • Lim, G.1    Karaskova, J.2    Vukovic, B.3
  • 8
    • 13144300881 scopus 로고    scopus 로고
    • Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma
    • Man T.K., Lu X.Y., Jaeweon K., et al. Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. BMC Cancer 2004, 4:45.
    • (2004) BMC Cancer , vol.4 , pp. 45
    • Man, T.K.1    Lu, X.Y.2    Jaeweon, K.3
  • 9
    • 13944261238 scopus 로고    scopus 로고
    • An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma
    • Lim G., Karaskova J., Beheshti B., et al. An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma. Genes Chromosomes Cancer 2005, 42:392-403.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 392-403
    • Lim, G.1    Karaskova, J.2    Beheshti, B.3
  • 10
    • 35548992257 scopus 로고    scopus 로고
    • Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization
    • Selvarajah S., Yoshimoto M., Maire G., et al. Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization. Cancer Genet Cytogenet 2007, 179:52-61.
    • (2007) Cancer Genet Cytogenet , vol.179 , pp. 52-61
    • Selvarajah, S.1    Yoshimoto, M.2    Maire, G.3
  • 11
    • 54249116805 scopus 로고    scopus 로고
    • Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH
    • Selvarajah S., Yoshimoto M., Ludkovski O., et al. Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet Genome Res 2008, 122:5-15.
    • (2008) Cytogenet Genome Res , vol.122 , pp. 5-15
    • Selvarajah, S.1    Yoshimoto, M.2    Ludkovski, O.3
  • 12
    • 38649098169 scopus 로고    scopus 로고
    • A review of clinical and molecular prognostic factors in osteosarcoma
    • Clark J.C., Dass C.R., Choong P.F. A review of clinical and molecular prognostic factors in osteosarcoma. J Cancer Res Clin Oncol 2008, 134:281-297.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 281-297
    • Clark, J.C.1    Dass, C.R.2    Choong, P.F.3
  • 13
    • 65549107328 scopus 로고    scopus 로고
    • Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling
    • Sadikovic B., Yoshimoto M., Chilton-MacNeill S., et al. Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling. Hum Mol Genet 2009, 18:1962-1975.
    • (2009) Hum Mol Genet , vol.18 , pp. 1962-1975
    • Sadikovic, B.1    Yoshimoto, M.2    Chilton-MacNeill, S.3
  • 14
    • 70649090109 scopus 로고    scopus 로고
    • Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways
    • Cleton-Jansen A.M., Anninga J.K., Briaire-de Bruijn I.H., et al. Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. Br J Cancer 2009, 101:2064.
    • (2009) Br J Cancer , vol.101 , pp. 2064
    • Cleton-Jansen, A.M.1    Anninga, J.K.2    Briaire-de Bruijn, I.H.3
  • 15
    • 67650465624 scopus 로고    scopus 로고
    • LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    • Kresse S.H., Ohnstad H.O., Paulsen E.B., et al. LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. Genes Chromosomes Cancer 2009, 48:679-693.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 679-693
    • Kresse, S.H.1    Ohnstad, H.O.2    Paulsen, E.B.3
  • 16
    • 62549112664 scopus 로고    scopus 로고
    • Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma.
    • Neoplasia 11:260-268 (following 268).
    • Maire G, Yoshimoto M, Chilton-MacNeill S, et al. Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. Neoplasia 11:260-268 (263p following 268).
    • Maire, G.1    Yoshimoto, M.2    Chilton-MacNeill, S.3
  • 17
    • 75149191872 scopus 로고    scopus 로고
    • Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma
    • Pasic I., Shlien A., Durbin A.D., et al. Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. Cancer Res 2010, 70:160-171.
    • (2010) Cancer Res , vol.70 , pp. 160-171
    • Pasic, I.1    Shlien, A.2    Durbin, A.D.3
  • 18
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin G.A., Croce C.M. MicroRNA signatures in human cancers. Nat Rev Cancer 2006, 6:857-866.
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 19
    • 33645314379 scopus 로고    scopus 로고
    • MicroRNAs and leukemias: how strong is the connection?
    • Calin G.A., Garzon R., Cimmino A., et al. MicroRNAs and leukemias: how strong is the connection?. Leuk Res 2006, 30:653-655.
    • (2006) Leuk Res , vol.30 , pp. 653-655
    • Calin, G.A.1    Garzon, R.2    Cimmino, A.3
  • 20
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 21
    • 41149100145 scopus 로고    scopus 로고
    • MicroRNA expression signature of human sarcomas
    • Subramanian S., Lui W.O., Lee C.H., et al. MicroRNA expression signature of human sarcomas. Oncogene 2008, 27:2015-2026.
    • (2008) Oncogene , vol.27 , pp. 2015-2026
    • Subramanian, S.1    Lui, W.O.2    Lee, C.H.3
  • 22
    • 68949161794 scopus 로고    scopus 로고
    • Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples
    • He C., Xiong J., Xu X., et al. Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. Biochem Biophys Res Commun 2009, 388:35-40.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 35-40
    • He, C.1    Xiong, J.2    Xu, X.3
  • 23
    • 70450237022 scopus 로고    scopus 로고
    • Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells
    • Song B., Wang Y., Xi Y., et al. Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene 2009, 28:4065-4074.
    • (2009) Oncogene , vol.28 , pp. 4065-4074
    • Song, B.1    Wang, Y.2    Xi, Y.3
  • 24
    • 33749528151 scopus 로고    scopus 로고
    • MiRNAs and apoptosis: RNAs to die for
    • Jovanovic M., Hengartner M.O. miRNAs and apoptosis: RNAs to die for. Oncogene 2006, 25:6176-6187.
    • (2006) Oncogene , vol.25 , pp. 6176-6187
    • Jovanovic, M.1    Hengartner, M.O.2
  • 25
    • 43049101535 scopus 로고    scopus 로고
    • MiRNA modulation of the cellular stress response
    • Babar I.A., Slack F.J., Weidhaas J.B. miRNA modulation of the cellular stress response. Future Oncol 2008, 4:289-298.
    • (2008) Future Oncol , vol.4 , pp. 289-298
    • Babar, I.A.1    Slack, F.J.2    Weidhaas, J.B.3
  • 26
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J., Getz G., Miska E.A., et al. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 27
    • 0037226307 scopus 로고    scopus 로고
    • Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas
    • Bayani J., Zielenska M., Pandita A., et al. Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas. Genes Chromosomes Cancer 2003, 36:7-16.
    • (2003) Genes Chromosomes Cancer , vol.36 , pp. 7-16
    • Bayani, J.1    Zielenska, M.2    Pandita, A.3
  • 28
    • 77952065237 scopus 로고    scopus 로고
    • Expression analysis of genes associated with human osteosarcoma tumors show correlation of RUNX2 overexpression with poor response to chemotherapy
    • Sadikovic B., Thorner P., ChiltonMacNeill S., et al. Expression analysis of genes associated with human osteosarcoma tumors show correlation of RUNX2 overexpression with poor response to chemotherapy. BMC Cancer 2010, 10:202.
    • (2010) BMC Cancer , vol.10 , pp. 202
    • Sadikovic, B.1    Thorner, P.2    ChiltonMacNeill, S.3
  • 29
    • 0028987057 scopus 로고
    • The World Health Organization's histologic classification of bone tumors. A commentary on the second edition
    • Schajowicz F., Sissons H.A., Sobin L.H. The World Health Organization's histologic classification of bone tumors. A commentary on the second edition. Cancer 1995, 75:1208-1214.
    • (1995) Cancer , vol.75 , pp. 1208-1214
    • Schajowicz, F.1    Sissons, H.A.2    Sobin, L.H.3
  • 31
    • 44349128983 scopus 로고    scopus 로고
    • Inferring microRNA activities by combining gene expression with microRNA target prediction
    • Cheng C., Li L.M. Inferring microRNA activities by combining gene expression with microRNA target prediction. PLoS One 2008, 3:e1989.
    • (2008) PLoS One , vol.3
    • Cheng, C.1    Li, L.M.2
  • 32
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 33
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • Krek A., Grun D., Poy M.N., et al. Combinatorial microRNA target predictions. Nat Genet 2005, 37:495-500.
    • (2005) Nat Genet , vol.37 , pp. 495-500
    • Krek, A.1    Grun, D.2    Poy, M.N.3
  • 34
    • 84870650556 scopus 로고    scopus 로고
    • VENNY. An interactive tool for comparing lists with Venn Diagrams.
    • Oliveros JC. VENNY. An interactive tool for comparing lists with Venn Diagrams. http://www.bioinfogp.cnb.csic.es/tools/venny/index.html.
    • Oliveros, J.C.1
  • 35
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4:44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 36
    • 0037499970 scopus 로고    scopus 로고
    • MatchMiner: a tool for batch navigation among gene and gene product identifiers
    • Bussey K.J., Kane D., Sunshine M., et al. MatchMiner: a tool for batch navigation among gene and gene product identifiers. Genome Biol 2003, 4:R27.
    • (2003) Genome Biol , vol.4
    • Bussey, K.J.1    Kane, D.2    Sunshine, M.3
  • 37
    • 19944427138 scopus 로고    scopus 로고
    • Gene amplifications in osteosarcoma-CGH microarray analysis
    • Atiye J., Wolf M., Kaur S., et al. Gene amplifications in osteosarcoma-CGH microarray analysis. Genes Chromosomes Cancer 2005, 42:158-163.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 158-163
    • Atiye, J.1    Wolf, M.2    Kaur, S.3
  • 38
    • 50349094229 scopus 로고    scopus 로고
    • Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma
    • Lu X.Y., Lu Y., Zhao Y.J., et al. Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. Mol Cancer Res 2008, 6:937-946.
    • (2008) Mol Cancer Res , vol.6 , pp. 937-946
    • Lu, X.Y.1    Lu, Y.2    Zhao, Y.J.3
  • 39
    • 33846882630 scopus 로고    scopus 로고
    • Molecular pathogenesis of osteosarcoma
    • Kansara M., Thomas D.M. Molecular pathogenesis of osteosarcoma. DNA Cell Biol 2007, 26:1-18.
    • (2007) DNA Cell Biol , vol.26 , pp. 1-18
    • Kansara, M.1    Thomas, D.M.2
  • 40
    • 0036888453 scopus 로고    scopus 로고
    • Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas
    • Ozaki T., Schaefer K.L., Wai D., et al. Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas. Int J Cancer 2002, 102:355-365.
    • (2002) Int J Cancer , vol.102 , pp. 355-365
    • Ozaki, T.1    Schaefer, K.L.2    Wai, D.3
  • 41
    • 0345714858 scopus 로고    scopus 로고
    • Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma
    • Lau C.C., Harris C.P., Lu X.Y., et al. Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma. Genes Chromosomes Cancer 2004, 39:11-21.
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 11-21
    • Lau, C.C.1    Harris, C.P.2    Lu, X.Y.3
  • 42
    • 70449359177 scopus 로고    scopus 로고
    • Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma
    • Yen C.C., Chen W.M., Chen T.H., et al. Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. Int J Oncol 2009, 35:775-788.
    • (2009) Int J Oncol , vol.35 , pp. 775-788
    • Yen, C.C.1    Chen, W.M.2    Chen, T.H.3
  • 43
    • 26444495099 scopus 로고    scopus 로고
    • Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas
    • Entz-Werle N., Stoetzel C., Berard-Marec P., et al. Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. Int J Cancer 2005, 117:349-355.
    • (2005) Int J Cancer , vol.117 , pp. 349-355
    • Entz-Werle, N.1    Stoetzel, C.2    Berard-Marec, P.3
  • 44
    • 34247603882 scopus 로고    scopus 로고
    • COPS3 amplification and clinical outcome in osteosarcoma
    • Yan T., Wunder J.S., Gokgoz N., et al. COPS3 amplification and clinical outcome in osteosarcoma. Cancer 2007, 109:1870-1876.
    • (2007) Cancer , vol.109 , pp. 1870-1876
    • Yan, T.1    Wunder, J.S.2    Gokgoz, N.3
  • 45
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • Wang S., Aurora A.B., Johnson B.A., et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008, 15:261-271.
    • (2008) Dev Cell , vol.15 , pp. 261-271
    • Wang, S.1    Aurora, A.B.2    Johnson, B.A.3
  • 46
    • 66049084202 scopus 로고    scopus 로고
    • MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo
    • Liu B., Peng X.C., Zheng X.L., et al. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 2009, 66:169-175.
    • (2009) Lung Cancer , vol.66 , pp. 169-175
    • Liu, B.1    Peng, X.C.2    Zheng, X.L.3
  • 47
    • 49149114863 scopus 로고    scopus 로고
    • Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells
    • Zhu H., Wu H., Liu X., et al. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol 2008, 76:582-588.
    • (2008) Biochem Pharmacol , vol.76 , pp. 582-588
    • Zhu, H.1    Wu, H.2    Liu, X.3
  • 48
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce C.M. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009, 10:704-714.
    • (2009) Nat Rev Genet , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 49
    • 52949114558 scopus 로고    scopus 로고
    • A microRNA signature for a BMP2-induced osteoblast lineage commitment program
    • Li Z., Hassan M.Q., Volinia S., et al. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A 2008, 105:13906-13911.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13906-13911
    • Li, Z.1    Hassan, M.Q.2    Volinia, S.3
  • 50
    • 72849121740 scopus 로고    scopus 로고
    • A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
    • Li H., Xie H., Liu W., et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest 2009, 119:3666-3677.
    • (2009) J Clin Invest , vol.119 , pp. 3666-3677
    • Li, H.1    Xie, H.2    Liu, W.3
  • 51
    • 77149136767 scopus 로고    scopus 로고
    • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    • Huang J., Zhao L., Xing L., et al. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 2010, 28:357-364.
    • (2010) Stem Cells , vol.28 , pp. 357-364
    • Huang, J.1    Zhao, L.2    Xing, L.3
  • 52
    • 58949092519 scopus 로고    scopus 로고
    • Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression
    • Yang C., Yang S., Wood K.B., et al. Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. Apoptosis 2009, 14:124-133.
    • (2009) Apoptosis , vol.14 , pp. 124-133
    • Yang, C.1    Yang, S.2    Wood, K.B.3
  • 53
    • 43249116904 scopus 로고    scopus 로고
    • Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells
    • Al-Romaih K., Sadikovic B., Yoshimoto M., et al. Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. Neoplasia 2008, 10:471-480.
    • (2008) Neoplasia , vol.10 , pp. 471-480
    • Al-Romaih, K.1    Sadikovic, B.2    Yoshimoto, M.3
  • 54
    • 30144435660 scopus 로고    scopus 로고
    • Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies
    • Syed N., Smith P., Sullivan A., et al. Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies. Blood 2006, 107:250-256.
    • (2006) Blood , vol.107 , pp. 250-256
    • Syed, N.1    Smith, P.2    Sullivan, A.3
  • 55
    • 37549066863 scopus 로고    scopus 로고
    • Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells
    • Jacinto F.V., Ballestar E., Ropero S., et al. Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. Cancer Res 2007, 67:11481-11486.
    • (2007) Cancer Res , vol.67 , pp. 11481-11486
    • Jacinto, F.V.1    Ballestar, E.2    Ropero, S.3
  • 56
    • 77950598222 scopus 로고    scopus 로고
    • Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma
    • Pellegrino R., Calvisi D.F., Ladu S., et al. Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma. Hepatology 2010, 51:857-868.
    • (2010) Hepatology , vol.51 , pp. 857-868
    • Pellegrino, R.1    Calvisi, D.F.2    Ladu, S.3
  • 57
    • 74049083778 scopus 로고    scopus 로고
    • Insight into microRNA regulation by analyzing the characteristics of their targets in humans
    • Hu Z. Insight into microRNA regulation by analyzing the characteristics of their targets in humans. BMC Genomics 2009, 10:594.
    • (2009) BMC Genomics , vol.10 , pp. 594
    • Hu, Z.1
  • 58
    • 58149240996 scopus 로고    scopus 로고
    • The inhibition of the highly expressed Mir-221 and Mir-222 impairs the growth of prostate carcinoma xenografts in mice
    • Mercatelli N., Coppola V., Bonci D., et al. The inhibition of the highly expressed Mir-221 and Mir-222 impairs the growth of prostate carcinoma xenografts in mice. PLOS one 2009, 3:e4029.
    • (2009) PLOS one , vol.3
    • Mercatelli, N.1    Coppola, V.2    Bonci, D.3
  • 59
    • 67649998366 scopus 로고    scopus 로고
    • MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice
    • Bonauer A, Carmona G, Iwasaki M, et al. MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice. Science 2009, 324:1710-1713.
    • (2009) Science , vol.324 , pp. 1710-1713
    • Bonauer, A.1    Carmona, G.2    Iwasaki, M.3


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