Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe

Applied Biochemistry and Biotechnology

Volumn 170, Issue 7, 2013, Pages 1751-1766

  Neunzig, Ina ^a   Widjaja, Maria ^a   Peters, Frank T ^b   Maurer, Hans H ^c   Hehn, Alain ^d   Bourgaud, Frédéric ^d   Bureik, Matthias ^a  

^a PomBioTech GmbH Campus ^*  (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Biocatalysis; Cytochrome P450 reductase; Recombinant fission yeast; Strain development; Whole cell biotransformation

Indexed keywords

BIOCATALYSIS; CYTOCHROME P450 REDUCTASE; FISSION YEAST; STRAIN DEVELOPMENT; WHOLE-CELL BIOTRANSFORMATIONS;

BIOCHEMISTRY; BIOCONVERSION; BIOMOLECULES; METABOLITES; YEAST;

ENZYMES;

CCR1 PROTEIN; CYTOCHROME P450; CYTOCHROME P450 17; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 REDUCTASE; NADPH CYTOCHROME P450 OXIDOREDUCTASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; STEROID 21 MONOOXYGENASE; UNCLASSIFIED DRUG;

AMMI MAJUS; ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SYNTHESIS; FUNGAL CELL; FUNGAL STRAIN; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHIZOSACCHAROMYCES POMBE; WEED;

CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; GENETIC ENHANCEMENT; HUMANS; RECOMBINANT PROTEINS; TRANSFORMATION, BACTERIAL;

AMMI MAJUS; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 84881236582     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-013-0303-2     Document Type: Article

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