A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 4, 2012, Pages 1949-1959

  Fang, Yue ^a,b   Hu, Lingling ^a,b   Zhou, Xin ^b,c   Jaiseng, Wurentuya ^b   Zhang, Ben ^a,b   Takami, Tomonori ^b,d   Kuno, Takayoshi ^a,b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JINZHOU MEDICAL UNIVERSITY   (China)

^d JCL Bioassay Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; AMINO ACID; CLOTRIMAZOLE; ERGOSTEROL; MICAFUNGIN; NUCLEIC ACID; TERBINAFINE;

AMINO ACID METABOLISM; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BIOGENESIS; CELL POLARITY; CELL WALL; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEACETYLATION; GENETIC SCREENING; HISTONE ACETYLATION; LIPID METABOLISM; LIPOGENESIS; MEIOSIS; MEMBRANE TRANSPORT; MITOCHONDRION; MUTANT; NONHUMAN; NUCLEIC ACID METABOLISM; PRIORITY JOURNAL; RIBOSOME; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION;

ANTIFUNGAL AGENTS; CELL MEMBRANE; CELL WALL; CELLULASE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOTRIMAZOLE; DRUG RESISTANCE, FUNGAL; ERGOSTEROL; GENE DELETION; GENETIC COMPLEMENTATION TEST; GENOME-WIDE ASSOCIATION STUDY; HISTONES; MICROBIAL SENSITIVITY TESTS; NAPHTHALENES; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84863341244     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05126-11     Document Type: Article

References (43)

1. Alamgir M, Erukova V, Jessulat M, Azizi A, Golshani A. 2010. Chemical-genetic profile analysis of five inhibitory compounds in yeast. BMC Chem. Biol. 10:6.
2. Anderson JB. 2005. Evolution of antifungal-drug resistance: mechanisms and pathogen fitness. Nat. Rev. Microbiol. 3:547-556. (Pubitemid 40903878)
3. Arndt GM, Atkins D. 1996. pH sensitivity of Schizosaccharomyces pombe: effect on the cellular phenotype associated with lacZ gene expression. Curr. Genet. 29:457-461. (Pubitemid 126450522)
4. Bankaitis VA, Johnson LM, Emr SD. 1986. Isolation of yeast mutants defective in protein targeting to the vacuole. Proc. Natl. Acad. Sci. U. S. A. 83:9075-9079. (Pubitemid 17223539)
5. Bartolommei G, Devaux N, Tadini-Buoninsegni F, Moncelli M, Apell HJ. 2008. Effect of clotrimazole on the pump cycle of the Na,K-ATPase. Biophys. J. 95:1813-1825.
6. Brun S, et al. 2003. Relationships between respiration and susceptibility to azole antifungals in Candida glabrata. Antimicrob. Agents Chemother. 47:847-853. (Pubitemid 36254205)
7. Chen SC, Sorrell TC. 2007. Antifungal agents. Med. J. Aust. 187:404-409.
8. Cheng H, et al. 2002. Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. Mol. Biol. Cell 13:2963-2976.
9. Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.
10. Cowen LE. 2008. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat. Rev. Microbiol. 6:187-198. (Pubitemid 351256314)
11. Craven RJ, Mallory JC, Hand RA. 2007. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. J. Biol. Chem. 282:36543-36551.
12. Daicho K, et al. 2007. The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. Biochim. Biophys. Acta 1768:1681-1690. (Pubitemid 46890790)
13. Defontaine A, et al. 1999. In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata. J. Med. Microbiol. 48:663-670. (Pubitemid 29349475)
14. Dell'Angelica EC. 2009. AP-3-dependent trafficking and disease: the first decade. Curr. Opin. Cell Biol. 21:552-559.
15. 2+-dependent pathways in fission yeast. Mol. Biol. Cell 17:4790-4800.
16. Enoch DA, Ludlam HA, Brown NM. 2006. Invasive fungal infections: a review of epidemiology and management options. J. Med. Microbiol. 55:809-818. (Pubitemid 43974685)
17. Fang Y, et al. 2009. Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast. Genes Cells 14:759-771.
18. Ferrari S, et al. 2011. Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice. Antimicrob. Agents Chemother. 55:1852-1860.
19. He Y, et al. 2006. Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway. Genes Cells 11:207-221.
20. 2+ Galpha gene identify residues involved in GDP-GTP exchange. Eukaryot. Cell 9:626-633.
21. Iwaki T, et al. 2008. Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. Microbiology 154:830-841. (Pubitemid 351736297)
22. Jiang B, Brown JL, Sheraton J, Fortin N, Bussey H. 1994. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10:341-353. (Pubitemid 24118966)
23. Jourdain I, et al. 2009. Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Biochem. J. 420:169-177.
24. Kennedy PJ, et al. 2008. A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol. Sci. 106:124-139.
25. Kim DU, et al. 2010. Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 28:617-623.
26. Kontoyiannis DP. 2000. Modulation of fluconazole sensitivity by the interaction of mitochondria and erg3p in Saccharomyces cerevisiae. J. Antimicrob. Chemother. 46:191-197. (Pubitemid 30639287)
27. Liu C, et al. 2005. Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. EMBO J. 24:3940-3951. (Pubitemid 41638000)
28. Ma Y, Kuno T, Kita A, Asayama Y, Sugiura R. 2006. Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogenactivated protein kinase signaling in fission yeast. Mol. Biol. Cell 17:5028-5037. (Pubitemid 44907348)
29. Martinez-Rossi NM, Peres NT, Rossi A. 2008. Antifungal resistance mechanisms in dermatophytes. Mycopathologia 166:369-383.
30. Miyatake M, et al. 2007. Valproic acid affects membrane trafficking and cell-wall integrity in fission yeast. Genetics 175:1695-1705. (Pubitemid 46789955)
31. Moreno S, Klar A, Nurse P. 1991. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194:795-823.
32. Moreton RS. 1989. Yeast lipid estimation by enzymatic and nuclear magnetic resonance methods. Appl. Environ. Microbiol. 55:3009-3011. (Pubitemid 19272177)
33. Munn AL, Heese-Peck A, Stevenson BJ, Pichler H, Riezman H. 1999. Specific sterols required for the internalization step of endocytosis in yeast. Mol. Biol. Cell 10:3943-3957. (Pubitemid 29534036)
34. Onyewu C, Blankenship JR, Del Poeta M, Heitman J. 2003. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrob. Agents Chemother. 47:956-964. (Pubitemid 36254221)
35. Schuman P, et al. 1998. Mucosal candidal colonization and candidiasis in women with or at risk for human immunodeficiency virus infection. HIV Epidemiology Research Study (HERS) Group. Clin. Infect. Dis. 27:1161-1167. (Pubitemid 29242466)
36. Smith WL, Edlind TD. 2002. Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. Antimicrob. Agents Chemother. 46:3532-3539. (Pubitemid 35192922)
37. Sugiura R, et al. 2003. Feedback regulation of MAPK signalling by an RNA-binding protein. Nature 424:961-965. (Pubitemid 37051689)
38. Toda T, et al. 1996. The fission yeast pmk1+ gene encodes a novel mitogen- activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Mol. Cell. Biol. 16:6752-6764. (Pubitemid 26389734)
39. Wang L, Griffiths K, Jr, Zhang YH, Ivey FD, Hoffman CS. 2005. Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics 171:1523-1533.
40. Wilson LS, et al. 2002. The direct cost and incidence of systemic fungal infections. Value Health 5:26-34. (Pubitemid 34160368)
41. Witzke A, Lindner K, Munson K, Apell HJ. 2010. Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry 49:4524-4532.
42. Xia L, Jaafar L, Cashikar A, Flores-Rozas H. 2007. Identification of genes required for protection from doxorubicin by a genome-wide screen in Saccharomyces cerevisiae. Cancer Res. 67:11411-11418. (Pubitemid 350248569)
43. Ye Y, et al. 2007. Geranylgeranyl diphosphate synthase in fission yeast is a heteromer of farnesyl diphosphate synthase (FPS), Fps1, and an FPS-like protein, Spo9, essential for sporulation. Mol. Biol. Cell 18:3568-3581. (Pubitemid 47378694)