A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 5, 2006, Pages 547-556

  Drǎgan, Cǎlin Aurel ^a   Hartmann, Rolf W ^a   Bureik, Matthias ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

17 hydroxylase 17,20 lyase; CYP17; CYP21; Fission yeast; Inhibition; Prostate cancer; Schizosaccharomyces pombe; Steroid 21 hydroxylase

Indexed keywords

ANTINEOPLASTIC AGENT; BW 33; CYTOCHROME P450 17; CYTOCHROME P450 17 INHIBITOR; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR; KETOCONAZOLE; SA 40; STEROID 21 MONOOXYGENASE; STEROID 21 MONOOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; YZ 5AY;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FUNGAL STRAIN; HUMAN; HUMAN CELL; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SCHIZOSACCHAROMYCES POMBE;

ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYLATION; INHIBITORY CONCENTRATION 50; KETOCONAZOLE; MALE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; SCHIZOSACCHAROMYCES; STEROID HYDROXYLASES; STEROIDS;

MAMMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 33751172943     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360600774637     Document Type: Article

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