Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis

Journal of Organic Chemistry

Volumn 78, Issue 15, 2013, Pages 7470-7481

  Engelhart, Curtis A ^a   Aldrich, Courtney C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION-ELIMINATION; CONCISE SYNTHESIS; MICROBIOLOGICAL EVALUATION; MYCOBACTERIUM TUBERCULOSIS; NUCLEOPHILIC AROMATIC SUBSTITUTION; STRUCTURAL STUDIES; SULFAMATE GROUPS; SULFONAMIDE DERIVATIVES;

BIOCHEMISTRY; BIOMOLECULES; BIOSYNTHESIS; CHEMICAL REACTIONS;

SULFUR COMPOUNDS;

5' AMINO 5' DEOXY 5' N [(8 HYDROXYCHROMON 3 YL)SULFONYL]ADENOSINE; 5' AMINO 5' DEOXY 5' N [(QUINOL 4 ON 3 YL)SULFONYL]ADENOSINE; 5' AMINO 5' DEOXY 5' N [[4 OXO 4H BENZO(E)(1,2)OXAZIN 3 YL]SULFONYL]ADENOSINE; 5' AMINO 5' N [(CHROMON 3 YL)SULFONYL] 5' DEOXY ADENOSINE; BENZOXAZINONE DERIVATIVE; CHROMONE 3 SULFONAMIDE; CHROMONE DERIVATIVE; METHYL 2 (TERTBUTYLDIMETHYLSILYLOXY)BENZOATE; METHYL 2,3 BIS(TERT BUTYLDIMETHYLSILYLOXY)BENZOATE; NUCLEOSIDE DERIVATIVE; QUINOLONE DERIVATIVE; SIDEROPHORE; SULFONAMIDE; TERT BUTYL (1 BENZYLQUINOL 4 ON 3 YL)SULFONYLCARBAMATE; TERT BUTYL (8 HYDROXYCHROMON 3 YL)SULFONYLCARBAMATE; TERT BUTYL (CHROMON 3 YL)SULFONYLCARBAMATE; TERT BUTYL [2 (2 FLUOROPHENYL) 2 OXOETHYL]SULFONYLCARBAMATE; TERT BUTYL [2 (2 HYDROXYPHENYL) 2 OXOETHYL]SULFONYLCARBAMATE; TERT BUTYL [2 (2,3 DIHYDROXYPHENYL) 2 OXOETHYL] SULFONYLCARBAMATE; TERT BUTYL [4 OXO 4H BENZO(E)(1,2)OXAZIN 3 YL]SULFONYLCARBAMATE; TERT BUTYL [8 (METHOXYMETHOXY)CHROMON 3 YL]SULFONYLCARBAMATE; TERT BUTYL CHLOROSULFONYLCARBAMATE; TERT-BUTYL [2 (2 FLUOROPHENYL) 1 (HYDROXYIMINO) 2 OXOETHYL]SULFONYLCARBAMATE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONFORMATIONAL TRANSITION; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; NITROSATION; NUCLEOPHILICITY; WHOLE CELL;

EID: 84881234135     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo400976f     Document Type: Article

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