Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5′-O-[N-(salicyl)sulfamoyl]adenosine: Antibacterial nucleosides effective against Mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 51, Issue 23, 2008, Pages 7495-7507

  Gupte, Amol ^a   Boshoff, Helena I ^b   Wilson, Daniel J ^a   Neres, João ^a   Labello, Nicholas P ^a   Somu, Ravindranadh V ^a   Xing, Chengguo ^c   Barry III, Clifton E ^b   Aldrich, Courtney C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AZIDOPURINE DERIVATIVE; 5' O [N (2 HYDROXYBENZOYL)SULFAMOYL] 2 (4 PHENYL 1,2,3 TRIAZOL 1 YL)ADENOSINE; 5' O [N (SALICYL)SULFAMOYL]ADENOSINE DERIVATIVE; ADENOSINE DERIVATIVE; NUCLEOSIDE DERIVATIVE; PURINE DERIVATIVE; SIDEROPHORE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; DRUG TOLERABILITY; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VERO CELL;

ADENOSINE; ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; SIDEROPHORES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VERO CELLS;

EID: 57349154252     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8008037     Document Type: Article

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