Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis

Biochemistry

Volumn 49, Issue 43, 2010, Pages 9292-9305

  Drake, Eric J ^a   Duckworth, Benjamin P ^b   Neres, João ^b   Aldrich, Courtney C ^b   Gulick, Andrew M ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACINETOBACTERS; ADENYLATE; ADENYLATION; BAUMANNII; BINDING MODES; BUILDING BLOCKES; CARRIER PROTEINS; COFACTORS; COMPETITIVE INHIBITION; DIHYDROXYBENZOATE; DIHYDROXYBENZOIC ACIDS; FLUORESCENCE POLARIZATION; GROWTH OF BACTERIA; HIGH-THROUGHPUT SCREENING; HUMAN PATHOGENS; NONRIBOSOMAL PEPTIDE SYNTHETASES; PARTIAL REACTIONS; PHENYL MOIETIES; SIDEROPHORES; STRUCTURAL CHARACTERIZATION; STRUCTURAL EXAMINATION; STRUCTURAL STUDIES; SYNTHESIS PATHWAYS; WILD TYPES;

ACIDS; AMINO ACIDS; BINDING ENERGY; CATALYSTS; ENZYMES; MOLECULES; PEPTIDES; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

2 (4 N DODECYL 1,2,3 TRIAZOL 1 YL)5' O (N (2 HYDROXYBENZOYL)SULFAMOYL) ADENOSINE; 2,3 DIHYDROXYBENZOIC ACID; 5' O (N (2,3 DIHYDROXYBENZOYL)SULFAMOYL)ADENOSINE; ACINETOBACTIN; ADENOSINE DERIVATIVE; ANTIINFECTIVE AGENT; PANTETHEINE; PEPTIDE SYNTHASE; PYROPHOSPHATE; SIDEROPHORE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ADENYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CHEMICAL ANALYSIS; CHEMICAL REACTION; COVALENT BOND; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE POLARIZATION IMMUNOASSAY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SYNTHESIS; WILD TYPE;

ACINETOBACTER BAUMANNII; BACTERIAL PROTEINS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; KINETICS; METABOLIC NETWORKS AND PATHWAYS; OXAZOLES; PEPTIDE SYNTHASES; PROTEIN BINDING;

ACINETOBACTER BAUMANNII;

EID: 78049279393     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101226n     Document Type: Article

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