Iron metabolism in pathogenic bacteria

Annual Review of Microbiology

Volumn 54, Issue , 2000, Pages 881-941

  Ratledge, C ^a   Dover, L G ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Ferric uptake regulation (Fur) proteins; Host responses; Siderophores; Transferrin; Transport

Indexed keywords

FERRITIN; HEMOGLOBIN; REGULATOR PROTEIN; SIDEROPHORE; TRANSFERRIN;

BURKHOLDERIA; ENTEROBACTERIACEAE; GENE EXPRESSION; HOST PARASITE INTERACTION; IMMUNE RESPONSE; IRON CHELATION; IRON METABOLISM; IRON TRANSPORT; MYCOBACTERIUM; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS; REVIEW; VIBRIO; YERSINIA;

BACTERIA; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; FERRIC COMPOUNDS; HEMEPROTEINS; IRON; MEMBRANE PROTEINS; SIDEROPHORES; TRANSFERRIN;

EID: 0033759220     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.54.1.881     Document Type: Review

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229. Utilization of transferrin-bound iron by Haemophilus species of human and porcine origins
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233. Identification of the ferrioxamine B receptor, Fox B, in Escherichia coli K12
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237. Isolation and structure of the novel dihydroxamate siderophore alcaligin
238. Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice
239. Coordination of iron by ferric iron-binding protein of pathogenic Neisseria is homologous to the transferrins
240. The structure of enterochelin and related 2,3-dihydroxy N-benzoylserine conjugates from Escherichia coli
241. 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis
242. Vibrio cholerae iron transport: Haem transport genes are linked to one of two sets of tonB, exbB, exbD genes
243. Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa
244. Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa
245. Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum
246. Studies in diphtheria toxin production. I. The effect of iron and copper
247. Molecular characterization of a Campylobacter jejuni lipoprotein with homology to periplasmic siderophore-binding proteins
248. Iron acquisition in microbial pathogenesis
249. The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: Organization and siderophore-dependent regulation
250. Purification, characterization, gene sequence and significance of a bacterioferritin from Mycobacterium leprae
251. Iron and activated oxygen species in biology: The basic chemistry
252. Analysis of TbpA and TbpB functionality in defective mutants of Neisseria meningitidis
253. Ferric reductase of Legionella pneumophila
254. Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structure of apo- and holo-DtxR
255. Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied
256. Coordinate regulation of siderophore and exotoxin production: Molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene
257. Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4,2-bis-thiazoline synthetase activity from PchD
258. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for the assembly of the virulence-conferring siderophore mycobactin
259. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases
260. The pesticin receptor for Yersinia enterocolitica: A novel virulence factor with dual function
261. Framework-reactive siderophore analogs as potential cell-selective drugs: Design and synthesis of trimelamol-based iron chelators
262. Transport of iron by mycobactin in Mycobacterium smegmatis
263. Nutrition, growth and metabolism
264. Iron metabolism
265. The occurrence of carboxymycobactin, the siderophore of pathogenic mycobacteria, as a second extracellular siderophore in Mycobacterium smegmatis
266. Iron transport in Mycobacterium smegmatis: A restricted role for salicylic acid in the extracellular environment
267. The accumulation of salicylic acid by mycobacteria during growth on iron-deficient medium
268. Lipoprotein e(P4) is essential for haemin uptake by Haemophilus influenzae
269. Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosa
270. Iron supply of Pasteurella multocida and haemolytica
271. Iron regulated excretion of α-keto acids by Salmonella typhimurium
272. Discrimination between apo- and iron-loaded forms of transferrin by transferrin-binding protein B and its N-terminal subfragment
273. Identification and characterization of two divergently transcribed iron regulated genes in Mycobacterium tuberculosis
274. Antibacterial effect of scandium and indium complexes of enterochelin on Klebsiella pneumoniae
275. Antibacterial effect of scandium and indium complexes of enterochelin on Escherichia coli
276. Ferrichrome transport in Escherichia coli K-12: Altered substrate specificity of mutated periplasmic FhuD and interaction of FhuD with the integral membrane protein FhuB
277. + is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase
278. Studies and synthesis of siderophores, microbial iron chelators, and analogs as potential drug delivery agents
279. Thiazole and oxazole peptides: Biosynthesis and molecular machinery
280. Mycobacterium and the seduction of the macrophage
281. Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane
282. The binding of the ferric uptake regulation protein to a DNA fragment
283. Some structural features of iron-uptake regulation protein
284. Copurification of the FpvA ferric-pyoverdin receptor of Pseudomonas aeruginosa with its iron-free ligand: Implications for siderophore-mediated iron transport
285. Utilization of host iron sources by Corynebacterium diphtheriae: Identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin
286. Analysis of diphtheria toxin repressor-operator interactions and characterization of a mutant repressor with decreased binding activity for divalent metals
287. Characterization of iron dependent regulating protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae
288. Purifications and characterization of the diphtheria toxin repressor
289. Ironhydroxamate uptake systems in Bacillus subtilis: Identification of a lipoprotein as part of a binding protein-dependent transport system
290. Transport across the outer membrane of Escherichia coli K12 via the FhuA receptor is regulated by the TonB protein of the cytoplasmic membrane
291. Iron acquisition systems in the pathogenic Neisseria
292. FbpC is not essential for iron acquisition in Neisseria gonorrhoeae
293. Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa
294. Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pch DCBA operon in Pseudomonas aeruginosa
295. Three-dimensional structure of mare diferric lactoferrin at 2.6 A resolution
296. Isolation purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis
297. Determination of the structure of exochelin MN, the extracellular siderophore from Mycobacterium neoaurum
298. Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under oligogenic control: Linkage study of the candidate genes NRAMP1 and TNFA
299. Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization
300. Nucleotide sequence and genetic organisation of the ferric enterobactin transport system: Homology to other periplasmic binding protein-dependent systems in Escherichia coli
301. Outer membrane peptides of Yersinia pestis mediating siderophore-independent assimilation of iron
302. Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections
303. Mycobactins: Ironchelating growth factors from mycobacteria
304. 5-oxygenase
305. Isolation of a novel siderophore from Pseudomonas cepacia
306. Iron-regulated envelope proteins of mycobacteria grown in vitro and their occurrence in Mycobacterium avium and Mycobacterium leprae grown in vivo
307. Peptide bond formation in nonribosomal peptide biosynthesis
308. Rational reduction of the conformational space of a siderophore analog through nonbonded interactions: The role of entropy in enterobactin
309. Structural and spectroscopic characterization of chiral ferric triscatecholamides: Unravelling the design of enterobactin
310. Fur regulation in Yersinia species
311. Nucleotide sequence of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III)dicitrate in Escherichia coli
312. Virulence characteristics of clinical and environmental isolates of Vibrio vulnificus
313. Ornibactins: A new family of siderophores from Pseudomonas
314. Escherichia coli periplasmic protein FepB binds ferrienterobactin
315. Quorum-sensing and siderophore biosynthesis in Pseudomonas aeruginosa: Lasr/lasI mutants exhibit reduced pyoverdine biosynthesis
316. Identification of the vibriobactin receptor of Vibrio cholerae
317. Iron-regulated hemolysin production and utilization of heme and hemoglobin by Vibrio cholerae
318. Functional domains of the Escherichia coli ferric uptake regulator protein (Fur)
319. Non-iron metalloporphyrins: Potent antibacterial compounds that exploit haem/Hb uptake systems of pathogenic bacteria
320. Neisseria meningitidis tonB, exbB and exbD genes: Ton-dependent utilization of protein-bound iron in Neisseriae
321. Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: Interaction of the 1-1382 and 1383-2035 fragments
322. The identification and biosynthesis of siderochromes formed by Micrococcus denitrificans
323. Binding of the metalloregulatory protein DtxR to the diphtheria tox operator requires a divalent heavy metal iron and protects the palindromic sequences from DNaseI digestion
324. Iron, DtxR, and the regulation of diphtheria toxin expression
325. Siderophores
326. Identification and cloning of a fur homologue from Neisseria meningitidis
327. Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization
328. Gene expression and regulation
329. Ferric reductase is a potential iron acquisition mechanism for Histoplasma capsulatum
330. A single amino acid change in AngR, a protein encoded by pJM1-like virulence plasmids, results in hyperproduction of anguibactin
331. Characterization of the Vibrio anguillarum fur gene: Role in regulation of expression of the FatA outer membrane protein and catechols
332. True and false chlorosis
333. Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouse
334. In vivo inhibition of TonB-dependent processes by a TonB box consensus pentapeptide
335. The response of Pseudomonas aeruginosa to iron: Genetics, biochemistry and virulence
336. Iron regulation of siderophore biosynthesis and transport in Pseudomonas putida WC S358: Involvement of a transcriptional activator and of the Fur protein
337. Gene regulation of siderophore-mediated iron acquisition in Pseudomonas: Not only the Fur repressor
338. Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications
339. Iron-regulated salicylate synthesis by Pseudomonas spp.
340. Siderophore production by Yersinia pestis and its relation to virulence
341. The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake
342. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system
343. Immunization with recombinant transferrin binding protein B enchances clearance of non type-able Haemophilus influenzae from rat lung
344. The development of awareness of iron-withholding defense
345. Structural and functional analysis of mutant Fur proteins with impaired regulatory function
346. Characterization of the angR gene of Vibrio anguillarum: Essential role in virulence
347. Structure of the metal-iron activated diphtheria toxin repressor/tox operator complex
348. Reduction of iron (III) by Escherichia coli K12: Lack of involvement of the respiratory chains
349. Microbial Siderophores. Biotechnology
350. Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa
351. Characterization of exochelins of Mycobacterium avium: Evidence for saturated and unsaturated and for acid and ester forms
352. Identification of Fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry
353. Iron uptake mechanisms in pathogenic bateria
354. Multiple haem-utilization loci in Helicobacter pylori
355. A multifunctional ATP-binding cassette transporter system from Vibrio cholerae transports vibriobactin and enterobactin
356. Iron acquisition from transferrin and lactoferrin by Pseudomonas aeruginosa
357. Total synthesis of mycobactin analogues as potent antimycobacterial agents using a minimal protecting group strategy
358. Analysis of the immunological responses of transferrin and lactoferrin receptor proteins from Moraxella catarrhalis
359. Analysis of the exochelin locus in Mycobacterium smegmatis: Biosynthesis genes have homology with genes of the peptide synthetase family
360. Exochelin genes in Mycobacterium smegmatis: Identification of an ABC transporter and two nonribosomal peptide synthetase genes
361. Mechanistically novel iron (III) transport system in Serratia marcesens
362. Role of iron in Nramp1-mediated inhibition of mycobacterial growth