Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling

Molecular and Cellular Proteomics

Volumn 12, Issue 8, 2013, Pages 2313-2323

  Sakurai, Hidetaka ^a   Kubota, Kazuishi ^a   Inaba, Shin Ichi ^a   Takanaka, Kaoru ^a   Shinagawa, Akira ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE TISSUE NONSPECIFIC ENZYME; CS 0777 PHOSPHATE; DRUG METABOLIZING ENZYME; FINGOLIMOD; KIDNEY ENZYME; PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; ALPL PROTEIN, HUMAN; AMINOALCOHOL; CS 0777; IMMUNOSUPPRESSIVE AGENT; ISOENZYME; PROPANEDIOL DERIVATIVE; PYRROLE DERIVATIVE; SPHINGOSINE;

ARTICLE; AUTOIMMUNE DISEASE; BIOCHEMISTRY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; HUMAN; HUMAN TISSUE; METHODOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEOMIC CORRELATION PROFILING; PROTEOMICS; ANALOGS AND DERIVATIVES; ENZYMOLOGY; ISOLATION AND PURIFICATION; KIDNEY; METABOLISM; PROCEDURES;

ALKALINE PHOSPHATASE; AMINO ALCOHOLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOENZYMES; KIDNEY; PROPYLENE GLYCOLS; PROTEOMICS; PYRROLES; SPHINGOSINE;

EID: 84881114867     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M112.023853     Document Type: Article

References (44)

1. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N. H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-769
2. Lin, H., Lee, E., Hestir, K., Leo, C., Huang, M., Bosch, E., Halenbeck, R., Wu, G., Zhou, A., Behrens, D., Hollenbaugh, D., Linnemann, T., Qin, M., Wong, J., Chu, K., Doberstein, S. K., and Williams, L. T. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320, 807-811
3. Perocchi, F., Gohil, V. M., Girgis, H. S., Bao, X. R., McCombs, J. E., Palmer, A. E., and Mootha, V. K. (2010) MICU1 encodes a mitochondrial EF hand protein required for Ca(2-) uptake. Nature 467, 291-296
4. Kubota, K., Sakikawa, C., Katsumata, M., Nakamura, T., and Wakabayashi, K. (2002) PDGF BB purified from osteoclasts acts as osteoblastogenesis inhibitory factor (OBIF). J. Biomol. Tech. 13, 62-71
5. Kubota, K., Nakahara, K., Ohtsuka, T., Yoshida, S., Kawaguchi, J., Fujita, Y., Ozeki, Y., Hara, A., Yoshimura, C., Furukawa, H., Haruyama, H., Ichikawa, K., Yamashita, M., Matsuoka, T., and iijima, Y. (2004) Identification of 2phosphodiesterase, which plays a role in the 2-5A system regulated by interferon. J. Biol. Chem. 279, 37832-37841
6. Yonesu, K., Kubota, K., Tamura, M., Inaba, S., Honda, T., Yahara, C., Watanabe, N., Matsuoka, T., and Nara, F. (2011) Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes. J. Biol. Chem. 286, 24765-24775
7. Kubota, K., Anjum, R., Yu, Y., Kunz, R. C., Andersen, J. N., Kraus, M., Keilhack, H., Nagashima, K., Krauss, S., Paweletz, C., Hendrickson, R. C., Feldman, A. S., Wu, C. L., Rush, J., Villén, J., and Gygi, S. P. (2009) Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat. Biotechnol. 27, 933-940
8. Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., and Mann, M. (2003) Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570-574
9. Foster, L. J., de Hoog, C. L., Zhang, Y., Xie, X., Mootha, V. K., and Mann, M. (2006) A mammalian organelle map by protein correlation profiling. Cell 125, 187-199
10. Kuromitsu, S., Yokota, H., Hiramoto, M., Yuri, M., Naitou, M., Nakamura, N., Kawabata, S., Kobori, M., Katoh, M., Furuchi, K., Mita, H., and Yamada, T. (2009) Combination of MS protein identification and bioassay of chromatographic fractions to identify biologically active substances from complex protein sources. Mol. Cell. Proteomics 8, 1318-1323
11. Compston, A., and Coles, A. (2008) Multiple sclerosis. Lancet 372, 1502-1517
12. Brinkmann, V., Billich, A., Baumruker, T., Heining, P., Schmouder, R., Francis, G., Aradhye, S., and Burtin, P. (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9, 883-897
13. Ransohoff, R. M. (2007) Natalizumab for Multiple Sclerosis. N. Engl. J. Med. 356, 2622-2629
14. Galetta, S. L., and Markowitz, C. (2005) US FDA-Approved disease-modifying treatments for multiple sclerosis: review of adverse effect profiles. CNS Drugs 19, 239-252
15. Marsolais, D., and Rosen, H. (2009) Chemical modulators of sphingosine- 1-phosphate receptors as barrier-oriented therapeutic molecules. Nat. Rev. Drug Discov. 8, 297-307
16. Horga., A., Castilló., J., and Montalban., X. (2010) Fingolimod for relapsing multiple sclerosis: an update. Expert Opin. Pharmacother. 11, 1183-1196
17. Fujita, T., Hirose, R., Yoneta, M., Sasaki, S., Inoue, K., Kiuchi, M., Hirase, S., Chiba, K., Sakamoto, H., and Arita, M. (1996) Potent Immunosuppressants, 2-Alkyl-2-Aminopropane-1,3-diols. J. Med. Chem. 39, 4451-4459
18. Brinkmann, V., Pinschewer, D. D., Feng, L., and Chen, S. (2001) FTY720: altered lymphocyte traffic results in allograft protection. Transplantation 72, 764-769
19. Kharel, Y., Lee, S., Snyder, A. H., Sheasley-O'Neill, S. L., Morris, M. A., Setiady, Y., Zhu, R., Zigler, M. A., Burcin, T. L., Ley, K., Tung, K. S., Engelhard, V. H., Macdonald, T. L., Pearson-White, S., and Lynch, K. R. (2005) Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY7. J. Biol. Chem. 280, 36865-36872
20. Zemann, B., Kinzel, B., Müller, M., Reuschel, R., Mechtcheriakova, D., Urtz, N., Bornancin, F., Baumruker, T., and Billich, A. (2006) Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY7. Blood 107, 1454-1458
21. Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E., Baumruker, T., Hiestand, P., Foster, C. A., Zollinger, M., and Lynch, K. R. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277, 21453-21457
22. Mandala, S., Hajdu, R., Bergstrom, J., Quackenbush, E., Xie, J., Milligan, J., Thornton, R., Shei, G. J., Card, D, Keohane, C., Rosenbach, M., Hale, J., Lynch, C. L., Rupprecht, K., Parsons, W., and Rosen, H. (2002) Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346-349
23. Nishi, T., Miyazaki, S., Takemoto, T., Suzuki, K., iiio, Y., Nakajima, K., Ohnuki, T., Kawase, Y., Nara, F., Inaba, S., Izumi, T., Yuita, H., Oshima, K., Doi, H., Inoue, R., Tomisato, W., Kagari, T., and Shimozato, T. (2011) Discovery of CS-0777: A potent, selective, and orally active S1P1agonist. ACS Med Chem Lett 2, 368-372
24. Sanna, M. G., Liao, J., Jo, E., Alfonso, C., Ahn, M. Y., Peterson, M. S., Webb, B., Lefebvre, S., Chun, J., Gray, N., and Rosen, H. (2004) Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279, 13839-13848
25. Forrest, M., Sun, S. Y., Hajdu, R., Bergstrom, J., Card, D., Doherty, G., Hale, J., Keohane, C., Meyers, C., Milligan, J., Mills, S., Nomura, N., Rosen, H., Rosenbach, M., Shei, G. J., Singer, III, Tian, M., West, S., White, V., Xie, J., Proia, R. L., and Mandala, S. (2004) Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther. 309, 758-768
26. Moberly, J. B., Rohatagi, S., Zahir, H., Hsu, C., Noveck, R. J., and Truitt, K. E. (2011) Pharmacological modulation of peripheral T and B lymphocytes by a selective sphingosine 1-phosphate receptor-1 modulator. J. Clin. Pharmacol 52, 996-1006
27. Billich, A., Bornancin, F., Dévay, P., Mechtcheriakova, D., Urtz, N., and Baumruker, T. (2003) Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J. Biol. Chem. 278, 47408-47415
28. Paugh, S. W., Payne, S. G., Barbour, S. E., Milstien, S., and Spiegel, S. (2003) The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type. FEBS Lett. 554, 189-193
29. Mechtcheriakova, D., Wlachos, A., Sobanov, J., Bornancin, F., Zlabinger, G., Baumruker, T., and Billich, A. (2007) FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase. FEBS Lett. 581, 3063-3068
30. Wessel, D., and Flügge, U. I. (1984) A method for the quantitaive recovery of protein in diluted solution in the presence of detergents and lipid. Anal. Biochem. 138, 141-143
31. Rappsilber, J., Ishihama, Y., and Mann, M. (2003) Stop and go extraction tips for matrix-Assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. Anal. Chem. 75, 663-670
32. Cox, J., Matic, I., Hilger, M., Nagaraj, N., Selbach, M., Olsen, J. V., and Mann, M. (2009) A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics. Nat. Protoc. 4, 698-705
33. Cox, J., Neuhauser, N., Michalski, A., Scheltema, R. A., Olsen, J. V., and Mann, M. (2011) Andromeda: a peptide search engine integrated into the MaxQuant environment. J. Proteome Res. 10, 1794-1805
34. Kersey, P. J., Duarte, J., Williams, A., Karavidopoulou, Y., Birney, E., and Apweiler, R. (2004) The International Protein Index: An integrated database for proteomics experiments. Proteomics 4, 1985-1988
35. Martins, M. J., Negrão, M. R., and Hipólito-Reis, C. (2001) Alkaline phosphatase from rat liver and kidney is differentially modulated. Clin. Biochem. 34, 463-468
36. Kozlenkov, A., Le Du, M. H., Cuniasse, P., Ny, T., Hoylaerts, M. F., and Millán, J. L. (2004) Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. J. Bone Miner. Res. 19, 1862-1872
37. Cox, J., and Mann, M. (2008) MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26, 1367-1372
38. Sigal, Y. J., McDermott, M. I., and Morris, A. J. (2005) Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem. J. 387, 281-293
39. Le Stunff, H., Peterson, C., Thornton, R., Milstien, S., Mandala, S. M., and Spiegel, S. (2002) Characterization of murine sphingosine-1-phosphate phosphohydrolase. J. Biol. Chem. 277, 8920-8927
40. Kovarik, J. M., Dole, K., Riviere, G. J., Pommier, F., Maton, S., Jin, Y., Lasseter, K. C., and Schmouder, R. L. (2009) Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition. J. Clin. Pharmacol. 49, 212-218
41. Fishman, W. H. (1974) Perspectives on alkaline phosphatase isoenzymes. Am. J. Med. 56, 617-650
42. Ghosh, N. K., and Fishman, W. H. (1968) Purification and properties of molecular-weight variants of human placental alkaline phosphatase. biochem. J. 108, 779-792
43. Doellgast, G. J., and Fishman, W. H. (1974) Purification of human placental alkaline phosphatase. Biochem. J. 141, 103-112
44. Cathala, G., and Brunel, C. (1975) Bovine kidney alkaline phosphatase. Purification, subunit structure, and metalloenzyme properties. J. Biol. Chem. 250, 6040-6045