-
1
-
-
33746588738
-
The epidemiology of multiple sclerosis in Europe
-
DOI 10.1111/j.1468-1331.2006.01342.x
-
Pugliatti M, Rosati G, Carton H, et al. The epidemiology of multiple sclerosis in Europe. Eur J Neurol 2006;13:700-722 (Pubitemid 44143944)
-
(2006)
European Journal of Neurology
, vol.13
, Issue.7
, pp. 700-722
-
-
Pugliatti, M.1
Rosati, G.2
Carton, H.3
Riise, T.4
Drulovic, J.5
Vecsei, L.6
Milanov, I.7
-
2
-
-
54149084585
-
Multiple sclerosis
-
Compston A, Coles A. Multiple sclerosis. Lancet 2008;372:1502-1517
-
(2008)
Lancet
, vol.372
, pp. 1502-1517
-
-
Compston, A.1
Coles, A.2
-
3
-
-
16244368038
-
US FDA-approved disease-modifying treatments for multiple sclerosis: Review of adverse effect profiles
-
DOI 10.2165/00023210-200519030-00005
-
Galetta SL, Markowitz C. US FDA-approved disease-modifying treatments for multiple sclerosis: review of adverse effect profiles. CNS Drugs 2005;19:239-252 (Pubitemid 40460663)
-
(2005)
CNS Drugs
, vol.19
, Issue.3
, pp. 239-252
-
-
Galetta, S.L.1
Markowitz, C.2
-
4
-
-
34250779802
-
Natalizumab for multiple sclerosis
-
Ransohoff RM. Natalizumab for multiple sclerosis. N Engl J Med 2007;356:2622-2629
-
(2007)
N Engl J Med
, vol.356
, pp. 2622-2629
-
-
Ransohoff, R.M.1
-
5
-
-
42649146192
-
New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets
-
Huwiler A, Pfeilschifter J. New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochem Pharmacol 2008;75:1893-1900
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 1893-1900
-
-
Huwiler, A.1
Pfeilschifter, J.2
-
6
-
-
64049113731
-
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
-
Marsolais D, Rosen H. Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules. Nat Rev Drug Discov 2009;8:297-307
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 297-307
-
-
Marsolais, D.1
Rosen, H.2
-
7
-
-
33751165437
-
FTY720 versus MMF with cyclosporine in de novo renal transplantation: A 1-year, randomized controlled trial in Europe and Australasia
-
Salvadori M, Budde K, Charpentier B, et al. FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia. Am J Transplant 2006;6:2912-2921
-
(2006)
Am J Transplant
, vol.6
, pp. 2912-2921
-
-
Salvadori, M.1
Budde, K.2
Charpentier, B.3
-
8
-
-
33845923814
-
Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation
-
DOI 10.1097/01.tp.0000251718.95622.b3, PII 0000789020061227000032
-
Tedesco-Silva H, Pescovitz MD, Cibrik D, et al. Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation. Transplantation 2006;82:1689-1697 (Pubitemid 46035653)
-
(2006)
Transplantation
, vol.82
, Issue.12
, pp. 1689-1697
-
-
Tedesco-Silva, H.1
Pescovitz, M.D.2
Cibrik, D.3
Rees, M.A.4
Mulgaonkar, S.5
Kahan, B.D.6
Gugliuzza, K.K.7
Rajagopalan, P.R.8
Esmeraldo, R.D.M.9
Lord, H.10
Salvadori, M.11
Slade, J.M.12
-
9
-
-
43249119649
-
FTY720 (fingolimod) for relapsing multiple sclerosis
-
DOI 10.1586/14737175.8.5.699
-
Horga A, Montalban X. FTY720 (fingolimod) for relapsing multiple sclerosis. Expert Rev Neurother 2008;8:699-714 (Pubitemid 351656821)
-
(2008)
Expert Review of Neurotherapeutics
, vol.8
, Issue.5
, pp. 699-714
-
-
Horga, A.1
Montalban, X.2
-
10
-
-
14644391944
-
Generation and metabolism of bioactive sphingosine-1-phosphate
-
DOI 10.1002/jcb.20097
-
Le Stunff H, Milstien S, Spiegel S. Generation and metabolism of bioactive sphingosine-1-phosphate. J Cell Biochem 2004;92:882-899 (Pubitemid 44264239)
-
(2004)
Journal of Cellular Biochemistry
, vol.92
, Issue.5
, pp. 882-899
-
-
Le Stunff, H.1
Milstien, S.2
Spiegel, S.3
-
11
-
-
12544253058
-
Structural and functional characteristics of S1P receptors
-
DOI 10.1002/jcb.20127
-
Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem 2004;92:913-922 (Pubitemid 44264241)
-
(2004)
Journal of Cellular Biochemistry
, vol.92
, Issue.5
, pp. 913-922
-
-
Sanchez, T.1
Hla, T.2
-
12
-
-
13844271705
-
Edg8/S1P5: An oligodendroglial receptor with dual function on process retraction and cell survival
-
DOI 10.1523/JNEUROSCI.4645-04.2005
-
Jaillard C, Harrison S, Stankoff B, et al. Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci 2005;25:1459-1469 (Pubitemid 40250722)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.6
, pp. 1459-1469
-
-
Jaillard, C.1
Harrison, S.2
Stankoff, B.3
Aigrot, M.S.4
Calver, A.R.5
Duddy, G.6
Walsh, F.S.7
Pangalos, M.N.8
Arimura, N.9
Kaibuchi, K.10
Zalc, B.11
Lubetzki, C.12
-
13
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
-
DOI 10.1038/nri1650
-
Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 2005;5:560-570 (Pubitemid 40961333)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.7
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
14
-
-
34250832664
-
Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
-
DOI 10.1016/j.pharmthera.2007.04.006, PII S0163725807000836
-
Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 2007;115:84-105 (Pubitemid 46990553)
-
(2007)
Pharmacology and Therapeutics
, vol.115
, Issue.1
, pp. 84-105
-
-
Brinkmann, V.1
-
15
-
-
16644394172
-
Endothelial cell barrier regulation by sphingosine 1-phosphate
-
DOI 10.1002/jcb.20088
-
McVerry BJ, Garcia JG. Endothelial cell barrier regulation by sphingosine 1-phosphate. J Cell Biochem 2004;92:1075-1085 (Pubitemid 44264219)
-
(2004)
Journal of Cellular Biochemistry
, vol.92
, Issue.6
, pp. 1075-1085
-
-
McVerry, B.J.1
Garcia, J.G.N.2
-
16
-
-
33947147730
-
Sphingosine-1-phosphate signaling in the cardiovascular system
-
Peters SL, Alewijnse AE. Sphingosine-1-phosphate signaling in the cardiovascular system. Curr Opin Pharmacol 2007;7:186-192
-
(2007)
Curr Opin Pharmacol
, vol.7
, pp. 186-192
-
-
Peters, S.L.1
Alewijnse, A.E.2
-
17
-
-
36248956701
-
Finding a way out: Lymphocyte egress from lymphoid organs
-
Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 2007;8:1295-1301
-
(2007)
Nat Immunol
, vol.8
, pp. 1295-1301
-
-
Schwab, S.R.1
Cyster, J.G.2
-
18
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
DOI 10.1126/science.1070238
-
Mandala S, Hajdu R, Bergstrom J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002;296:346-349 (Pubitemid 34303689)
-
(2002)
Science
, vol.296
, Issue.5566
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.-J.8
Card, D.9
Keohane, C.10
Rosenbach, M.11
Hale, J.12
Lynch, C.L.13
Rupprecht, K.14
Parsons, W.15
Rosen, H.16
-
19
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
DOI 10.1074/jbc.C200176200
-
Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002;277:21453-21457 (Pubitemid 34952287)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
20
-
-
0032938741
-
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG- 1
-
Liu CH, Thangada S, Lee MJ, et al. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell 1999;10:1179-1190 (Pubitemid 29193739)
-
(1999)
Molecular Biology of the Cell
, vol.10
, Issue.4
, pp. 1179-1190
-
-
Liu, C.H.1
Thangada, S.2
Lee, M.-J.3
Van Brooklyn, J.R.4
Spiegel, S.5
Hla, T.6
-
21
-
-
2442679391
-
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors
-
Graler MH, Goetzl EJ. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. Faseb J 2004;18:551-553
-
(2004)
Faseb J
, vol.18
, pp. 551-553
-
-
Graler, M.H.1
Goetzl, E.J.2
-
22
-
-
34247874512
-
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
-
DOI 10.1074/jbc.M610318200
-
Oo ML, Thangada S, Wu MT, et al. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem 2007;282:9082-9089 (Pubitemid 47093504)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.12
, pp. 9082-9089
-
-
Myat, L.O.1
Thangada, S.2
Wu, M.-T.3
Liu, C.H.4
Macdonald, T.L.5
Lynch, K.R.6
Lin, C.-Y.7
Hla, T.8
-
23
-
-
65949105042
-
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
-
Mullershausen F, Zecri F, Cetin C, et al. Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol 2009;5:428-434
-
(2009)
Nat Chem Biol
, vol.5
, pp. 428-434
-
-
Mullershausen, F.1
Zecri, F.2
Cetin, C.3
-
24
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
DOI 10.1038/nature02284
-
Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004;427:355-360 (Pubitemid 38133663)
-
(2004)
Nature
, vol.427
, Issue.6972
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
Lesneski, M.J.4
Xu, Y.5
Brinkmann, V.6
Allende, M.L.7
Proia, R.L.8
Cyster, J.G.9
-
25
-
-
2442561611
-
1, on T-cells Controls Thymic Emigration
-
DOI 10.1074/jbc.M314291200
-
Allende ML, Dreier JL, Mandala S, Proia RL. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem 2004;279:15396-15401 (Pubitemid 38618938)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.15
, pp. 15396-15401
-
-
Allende, M.L.1
Dreier, J.L.2
Mandala, S.3
Proia, R.L.4
-
26
-
-
24644469502
-
Immunology: Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
-
DOI 10.1126/science.1113640
-
Schwab SR, Pereira JP, Matloubian M, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005;309:1735-1739 (Pubitemid 41285945)
-
(2005)
Science
, vol.309
, Issue.5741
, pp. 1735-1739
-
-
Schwab, S.R.1
Pereira, J.P.2
Matloubian, M.3
Xu, Y.4
Huang, Y.5
Cyster, J.G.6
-
27
-
-
0034609968
-
T-cell function and migration. Two sides of the same coin
-
von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000;343:1020-1034
-
(2000)
N Engl J Med
, vol.343
, pp. 1020-1034
-
-
Von Andrian, U.H.1
MacKay, C.R.2
-
28
-
-
34247379074
-
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
-
DOI 10.1126/science.1139221
-
Pappu R, Schwab SR, Cornelissen I, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007;316:295-298 (Pubitemid 46633109)
-
(2007)
Science
, vol.316
, Issue.5822
, pp. 295-298
-
-
Pappu, R.1
Schwab, S.R.2
Cornelissen, I.3
Pereira, J.P.4
Regard, J.B.5
Xu, Y.6
Camerer, E.7
Zheng, Y.-W.8
Huang, Y.9
Cyster, J.G.10
Coughlin, S.R.11
-
29
-
-
13244270031
-
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
-
DOI 10.1084/jem.20041509
-
Lo CG, Xu Y, Proia RL, Cyster JG. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med 2005;201:291-301 (Pubitemid 40189438)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.2
, pp. 291-301
-
-
Lo, C.G.1
Xu, Y.2
Proia, R.L.3
Cyster, J.G.4
-
30
-
-
0032525049
-
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
-
Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 1998;160:5037-5044 (Pubitemid 28215340)
-
(1998)
Journal of Immunology
, vol.160
, Issue.10
, pp. 5037-5044
-
-
Chiba, K.1
Yanagawa, Y.2
Masubuchi, Y.3
Kataoka, H.4
Kawaguchi, T.5
Ohtsuki, M.6
Hoshino, Y.7
-
31
-
-
0031741847
-
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720- induced lymphocyte homing
-
DOI 10.1046/j.1365-2567.1998.00639.x
-
Yanagawa Y, Masubuchi Y, Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing. Immunology 1998;95:591-594 (Pubitemid 28559152)
-
(1998)
Immunology
, vol.95
, Issue.4
, pp. 591-594
-
-
Yanagawa, Y.1
Masubuchi, Y.2
Chiba, K.3
-
32
-
-
0032103938
-
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo
-
Yanagawa Y, Sugahara K, Kataoka H, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol 1998;160:5493-5499 (Pubitemid 28267841)
-
(1998)
Journal of Immunology
, vol.160
, Issue.11
, pp. 5493-5499
-
-
Yanagawa, Y.1
Sugahara, K.2
Kataoka, H.3
Kawaguchi, T.4
Masubuchi, Y.5
Chiba, K.6
-
33
-
-
0033592304
-
FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation
-
Hwang MW, Matsumori A, Furukawa Y, et al. FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation. Circulation 1999;100:1322-1329 (Pubitemid 29440126)
-
(1999)
Circulation
, vol.100
, Issue.12
, pp. 1322-1329
-
-
Hwang, M.-W.1
Matsumori, A.2
Furukawa, Y.3
Ono, K.4
Okada, M.5
Iwasaki, A.6
Hara, M.7
Sasayama, S.8
-
34
-
-
0033980334
-
Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in rats
-
DOI 10.1006/exer.1999.0777
-
Kurose S, Ikeda E, Tokiwa M, et al. Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in rats. Exp Eye Res 2000;70:7-15 (Pubitemid 30046870)
-
(2000)
Experimental Eye Research
, vol.70
, Issue.1
, pp. 7-15
-
-
Kurose, S.1
Ikeda, E.2
Tokiwa, M.3
Hikita, N.4
Mochizuki, M.5
-
35
-
-
0037379202
-
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment
-
DOI 10.1124/jpet.102.045658
-
Fujino M, Funeshima N, Kitazawa Y, et al. Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J Pharmacol Exp Ther 2003;305:70-77 (Pubitemid 36378136)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.305
, Issue.1
, pp. 70-77
-
-
Fujino, M.1
Funeshima, N.2
Kitazawa, Y.3
Kimura, H.4
Amemiya, H.5
Suzuki, S.6
Li, X.-K.7
-
36
-
-
33645283403
-
FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration
-
Kataoka H, Sugahara K, Shimano K, et al. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol 2005;2:439-448
-
(2005)
Cell Mol Immunol
, vol.2
, pp. 439-448
-
-
Kataoka, H.1
Sugahara, K.2
Shimano, K.3
-
37
-
-
0037378735
-
+ T cells
-
Xie JH, Nomura N, Koprak SL, et al. Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells. J Immunol 2003;170:3662-3670 (Pubitemid 36359236)
-
(2003)
Journal of Immunology
, vol.170
, Issue.7
, pp. 3662-3670
-
-
Xie, J.H.1
Nomura, N.2
Koprak, S.L.3
Quackenbush, E.J.4
Forrest, M.J.5
Rosen, H.6
-
38
-
-
65449135255
-
Thymic emigration: Sphingosine-1-phosphate receptor-1- dependent models and beyond
-
Drennan MB, Elewaut D, Hogquist KA. Thymic emigration: sphingosine-1-phosphate receptor-1- dependent models and beyond. Eur J Immunol 2009;39:925-930
-
(2009)
Eur J Immunol
, vol.39
, pp. 925-930
-
-
Drennan, M.B.1
Elewaut, D.2
Hogquist, K.A.3
-
39
-
-
33644791607
-
The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo
-
DOI 10.1111/j.1600-6143.2005.01085.x
-
Lan YY, De Creus A, Colvin BL, et al. The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. Am J Transplant 2005;5:2649-2659 (Pubitemid 43920058)
-
(2005)
American Journal of Transplantation
, vol.5
, Issue.11
, pp. 2649-2659
-
-
Lan, Y.Y.1
De Creus, A.2
Colvin, B.L.3
Abe, M.4
Brinkmann, V.5
Coates, P.T.H.6
Thomson, A.W.7
-
40
-
-
2142730100
-
Central memory and effector memory T cell subsets: Function, generation, and maintenance
-
DOI 10.1146/annurev.immunol.22.012703.104702
-
Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004;22:745-763 (Pubitemid 38680440)
-
(2004)
Annual Review of Immunology
, vol.22
, pp. 745-763
-
-
Sallusto, F.1
Geginat, J.2
Lanzavecchia, A.3
-
41
-
-
54449099880
-
FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
-
Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology 2008;71:1261-1267
-
(2008)
Neurology
, vol.71
, pp. 1261-1267
-
-
Mehling, M.1
Brinkmann, V.2
Antel, J.3
-
42
-
-
0034142317
-
FTY720: A novel transplantation drug that modulates lymphocyte traffic rather than activation
-
DOI 10.1016/S0165-6147(99)01419-4, PII S0165614799014194
-
Brinkmann V, Pinschewer D, Chiba K, Feng L. FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. Trends Pharmacol Sci 2000;21:49-52 (Pubitemid 30100338)
-
(2000)
Trends in Pharmacological Sciences
, vol.21
, Issue.2
, pp. 49-52
-
-
Brinkmann, V.1
Pinschewer, D.2
Chiba, K.3
Feng, L.4
-
43
-
-
0034120178
-
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
-
Pinschewer DD, Ochsenbein AF, Odermatt B, et al. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J Immunol 2000;164:5761-5770 (Pubitemid 30389819)
-
(2000)
Journal of Immunology
, vol.164
, Issue.11
, pp. 5761-5770
-
-
Pinschewer, D.D.1
Ochsenbein, A.F.2
Odermatt, B.3
Brinkmann, V.4
Hengartner, H.5
Zinkernagel, R.M.6
-
44
-
-
3042743990
-
FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
-
DOI 10.1111/j.1600-6143.2004.00476.x
-
Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004;4:1019-1025 (Pubitemid 38868590)
-
(2004)
American Journal of Transplantation
, vol.4
, Issue.7
, pp. 1019-1025
-
-
Brinkmann, V.1
Cyster, J.G.2
Hla, T.3
-
45
-
-
39049115197
-
The B cell-old player, new position on the team
-
McFarland HF. The B cell-old player, new position on the team. N Engl J Med 2008;358:664-665
-
(2008)
N Engl J Med
, vol.358
, pp. 664-665
-
-
McFarland, H.F.1
-
46
-
-
55349135951
-
Novel therapeutic strategies for multiple sclerosis-a multifaceted adversary
-
Lopez-Diego RS, Weiner HL. Novel therapeutic strategies for multiple sclerosis-a multifaceted adversary. Nat Rev Drug Discov 2008;7:909-925
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 909-925
-
-
Lopez-Diego, R.S.1
Weiner, H.L.2
-
47
-
-
36549047503
-
Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis
-
DOI 10.1016/j.pharmthera.2007.08.005, PII S0163725807001738
-
Dev KK, Mullershausen F, Mattes H, et al. Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis. Pharmacol Ther 2008;117:77-93 (Pubitemid 350192672)
-
(2008)
Pharmacology and Therapeutics
, vol.117
, Issue.1
, pp. 77-93
-
-
Dev, K.K.1
Mullershausen, F.2
Mattes, H.3
Kuhn, R.R.4
Bilbe, G.5
Hoyer, D.6
Mir, A.7
-
48
-
-
0034924474
-
Sphingosine-1-phosphate induces proliferation of astrocytes: Regulation by intracellular signalling cascades
-
Pebay A, Toutant M, Premont J, et al. Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. Eur J Neurosci 2001;13:2067-2076 (Pubitemid 32664301)
-
(2001)
European Journal of Neuroscience
, vol.13
, Issue.12
, pp. 2067-2076
-
-
Pebay, A.1
Toutant, M.2
Premont, J.3
Calvo, C.-F.4
Venance, L.5
Cordier, J.6
Glowinski, J.7
Tence, M.8
-
49
-
-
34547431060
-
Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors
-
DOI 10.1111/j.1471-4159.2007.04629.x
-
Mullershausen F, Craveiro LM, Shin Y, et al. Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors. J Neurochem 2007;102:1151-1161 (Pubitemid 47174238)
-
(2007)
Journal of Neurochemistry
, vol.102
, Issue.4
, pp. 1151-1161
-
-
Mullershausen, F.1
Craveiro, L.M.2
Shin, Y.3
Cortes-Cros, M.4
Bassilana, F.5
Osinde, M.6
Wishart, W.L.7
Guerini, D.8
Thallmair, M.9
Schwab, M.E.10
Sivasankaran, R.11
Seuwen, K.12
Dev, K.K.13
-
50
-
-
39049125218
-
FTY720 modulates human oligodendrocyte progenitor process extension and survival
-
Miron VE, Jung CG, Kim HJ, et al. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann Neurol 2008;63:61-71
-
(2008)
Ann Neurol
, vol.63
, pp. 61-71
-
-
Miron, V.E.1
Jung, C.G.2
Kim, H.J.3
-
51
-
-
0033808179
-
Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth
-
MacLennan AJ, Devlin BK, Marks L, et al. Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. Dev Neurosci 2000;22:283-295
-
(2000)
Dev Neurosci
, vol.22
, pp. 283-295
-
-
MacLennan, A.J.1
Devlin, B.K.2
Marks, L.3
-
52
-
-
0142241216
-
Common signaling pathways link activation of murine PAR-1 LPA, and S1P receptors to proliferation of astrocytes
-
DOI 10.1124/mol.64.5.1199
-
Sorensen SD, Nicole O, Peavy RD, et al. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol Pharmacol 2003;64:1199-1209 (Pubitemid 37310753)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.5
, pp. 1199-1209
-
-
Sorensen, S.D.1
Nicole, O.2
Peavy, R.D.3
Montoya, L.M.4
Lee, C.J.5
Murphy, T.J.6
Traynelis, S.F.7
Hepler, J.R.8
-
53
-
-
0037440379
-
Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes
-
DOI 10.1002/glia.10180
-
Yamagata K, Tagami M, Torii Y, et al. Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. Glia 2003;41:199-206 (Pubitemid 36262197)
-
(2003)
GLIA
, vol.41
, Issue.2
, pp. 199-206
-
-
Yamagata, K.1
Tagami, M.2
Torii, Y.3
Takenaga, F.4
Tsumagari, S.5
Itoh, S.6
Yamori, Y.7
Nara, Y.8
-
54
-
-
3543132506
-
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension
-
Toman RE, Payne SG, Watterson KR, et al. Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. J Cell Biol 2004;166:381-392
-
(2004)
J Cell Biol
, vol.166
, pp. 381-392
-
-
Toman, R.E.1
Payne, S.G.2
Watterson, K.R.3
-
55
-
-
1042278008
-
Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells
-
Harada J, Foley M, Moskowitz MA, Waeber C. Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. J Neurochem 2004;88:1026-1039 (Pubitemid 38199325)
-
(2004)
Journal of Neurochemistry
, vol.88
, Issue.4
, pp. 1026-1039
-
-
Harada, J.1
Foley, M.2
Moskowitz, M.A.3
Waeber, C.4
-
56
-
-
28844457715
-
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors
-
Saini HS, Coelho RP, Goparaju SK, et al. Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. J Neurochem 2005;95:1298-1310
-
(2005)
J Neurochem
, vol.95
, pp. 1298-1310
-
-
Saini, H.S.1
Coelho, R.P.2
Goparaju, S.K.3
-
57
-
-
33645101159
-
S1P inhibits gap junctions in astrocytes: Involvement of G and Rho GTPase/ROCK
-
Rouach N, Pebay A, Meme W, et al. S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. Eur J Neurosci 2006;23:1453-1464
-
(2006)
Eur J Neurosci
, vol.23
, pp. 1453-1464
-
-
Rouach, N.1
Pebay, A.2
Meme, W.3
-
58
-
-
34247554847
-
Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
-
DOI 10.1096/fj.06-7420com
-
Novgorodov AS, El-Alwani M, Bielawski J, et al. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. Faseb J 2007;21:1503-1514 (Pubitemid 46684852)
-
(2007)
FASEB Journal
, vol.21
, Issue.7
, pp. 1503-1514
-
-
Novgorodov, A.S.1
El-Alwani, M.2
Bielawski, J.3
Obeid, L.M.4
Gudz, T.I.5
-
59
-
-
53049085954
-
Central nervous system-directed effects of FTY720 (fingolimod)
-
Miron VE, Schubart A, Antel JP. Central nervous system-directed effects of FTY720 (fingolimod). J Neurol Sci 2008;274:13-17
-
(2008)
J Neurol Sci
, vol.274
, pp. 13-17
-
-
Miron, V.E.1
Schubart, A.2
Antel, J.P.3
-
60
-
-
35348970884
-
Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis
-
DOI 10.1124/jpet.107.127183
-
Foster CA, Howard LM, Schweitzer A, et al. Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J Pharmacol Exp Ther 2007;323:469-475 (Pubitemid 350005125)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.323
, Issue.2
, pp. 469-476
-
-
Foster, C.A.1
Howard, L.M.2
Schweitzer, A.3
Persohn, E.4
Hiestand, P.C.5
Balatoni, B.6
Reuschel, R.7
Beerli, C.8
Schwartz, M.9
Billich, A.10
-
61
-
-
35548984947
-
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors
-
DOI 10.1124/jpet.107.123927
-
Coelho RP, Payne SG, Bittman R, et al. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J Pharmacol Exp Ther 2007;323:626-635 (Pubitemid 350005137)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.323
, Issue.2
, pp. 626-635
-
-
Coelho, R.P.1
Payne, S.G.2
Bittman, R.3
Spiegel, S.4
Sato-Bigbee, C.5
-
62
-
-
53149089045
-
Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
-
Miron VE, Hall JA, Kennedy TE, et al. Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am J Pathol 2008;173:1143-1152
-
(2008)
Am J Pathol
, vol.173
, pp. 1143-1152
-
-
Miron, V.E.1
Hall, J.A.2
Kennedy, T.E.3
-
63
-
-
35348940243
-
Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells
-
Jung CG, Kim HJ, Miron VE, et al. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia 2007;55:1656-1667
-
(2007)
Glia
, vol.55
, pp. 1656-1667
-
-
Jung, C.G.1
Kim, H.J.2
Miron, V.E.3
-
64
-
-
77951078157
-
Expression of brain-derived neurotrophic factor is regulated by fingolimod (FTY720) in cultured neurons
-
[P728]
-
Deogracias R, Klein C, Matsumoto T, et al. Expression of brain-derived neurotrophic factor is regulated by fingolimod (FTY720) in cultured neurons. Multiple Sclerosis 2008;14:S243 [P728]
-
(2008)
Multiple Sclerosis
, vol.14
-
-
Deogracias, R.1
Klein, C.2
Matsumoto, T.3
-
65
-
-
76449093957
-
S1P1 receptor signaling on cells of astrocytic lineages in experimental autoimmune encephalomyelitis: A role in disease progression and the efficacy of fingolimod (FTY720)
-
[P29]
-
Choi JW, Herr D, Lee CW, et al. S1P1 receptor signaling on cells of astrocytic lineages in experimental autoimmune encephalomyelitis: a role in disease progression and the efficacy of fingolimod (FTY720). Multiple Sclerosis 2008;14:S37 [P29]
-
(2008)
Multiple Sclerosis
, vol.14
-
-
Choi, J.W.1
Herr, D.2
Lee, C.W.3
-
66
-
-
77951287369
-
Astrocytic sphingosine-1-phosphate (S1P) receptor subtype 1 signalling influences levels of S1P and cytokines during experimental autoimmune encephalomyelitis and fingolimod (FTY720) intervention
-
[P227]
-
Choi JW, Herr D, Kennedy G, Chun J. Astrocytic sphingosine-1-phosphate (S1P) receptor subtype 1 signalling influences levels of S1P and cytokines during experimental autoimmune encephalomyelitis and fingolimod (FTY720) intervention. Multiple Sclerosis 2009;15:S58 [P227]
-
(2009)
Multiple Sclerosis
, vol.15
-
-
Choi, J.W.1
Herr, D.2
Kennedy, G.3
Chun, J.4
-
67
-
-
0036205659
-
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
-
Budde K, Schmouder RL, Brunkhorst R, et al. First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 2002;13:1073-1083 (Pubitemid 34274106)
-
(2002)
Journal of the American Society of Nephrology
, vol.13
, Issue.4
, pp. 1073-1083
-
-
Budde, K.1
Schmouder, R.L.2
Brunkhorst, R.3
Nashan, B.4
Lucker, P.W.5
Mayer, T.6
Choudhury, S.7
Skerjanec, A.8
Kraus, G.9
Neumayer, H.H.10
-
68
-
-
10744230053
-
Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients
-
DOI 10.1034/j.1600-6143.2003.00130.x
-
Budde K, Schmouder RL, Nashan B, et al. Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. Am J Transplant 2003;3:846-854 (Pubitemid 36827906)
-
(2003)
American Journal of Transplantation
, vol.3
, Issue.7
, pp. 846-854
-
-
Budde, K.1
Schmouder, R.L.2
Nashan, B.3
Brunkhorst, R.4
Lucker, P.W.5
Mayer, T.6
Brookman, L.7
Nedelman, J.8
Skerjanec, A.9
Bohler, T.10
Neumayer, H.-H.11
-
69
-
-
2342634478
-
Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects
-
DOI 10.1111/j.1365-2125.2003.02065.x
-
Kovarik JM, Schmouder R, Barilla D, et al. Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects. Br J Clin Pharmacol 2004;57:586-591 (Pubitemid 38582178)
-
(2004)
British Journal of Clinical Pharmacology
, vol.57
, Issue.5
, pp. 586-591
-
-
Kovarik, J.M.1
Schmouder, R.2
Barilla, D.3
Wang, Y.4
Kraus, G.5
-
70
-
-
0142040141
-
Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: A multicenter, randomized, placebo-controlled, phase i study
-
Kahan BD, Karlix JL, Ferguson RM, et al. Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. Transplantation 2003;76:1079-1084
-
(2003)
Transplantation
, vol.76
, pp. 1079-1084
-
-
Kahan, B.D.1
Karlix, J.L.2
Ferguson, R.M.3
-
71
-
-
27244457788
-
FTY720, a novel immunomodulator in de novo kidney transplant patients: Pharmacokinetics and exposure-response relationship
-
DOI 10.1177/0091270005279799
-
Skerjanec A, Tedesco H, Neumayer HH, et al. FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship. J Clin Pharmacol 2005;45:1268-1278 (Pubitemid 41513050)
-
(2005)
Journal of Clinical Pharmacology
, vol.45
, Issue.11
, pp. 1268-1278
-
-
Skerjanec, A.1
Tedesco, H.2
Neumayer, H.-H.3
Cole, E.4
Budde, K.5
Hsu, C.-H.6
Schmouder, R.7
-
72
-
-
1942508223
-
Multiple-Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects
-
DOI 10.1177/0091270004264165
-
Kovarik JM, Schmouder R, Barilla D, et al. Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J Clin Pharmacol 2004;44:532-537 (Pubitemid 38509722)
-
(2004)
Journal of Clinical Pharmacology
, vol.44
, Issue.5
, pp. 532-537
-
-
Kovarik, J.M.1
Schmouder, R.2
Barilla, D.3
Riviere, G.-J.4
Wang, Y.5
Hunt, T.6
-
73
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
DOI 10.1056/NEJMoa052643
-
Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355:1124-1140 (Pubitemid 44394919)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.11
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
Montalban, X.4
O'Connor, P.5
Polman, C.H.6
Haas, T.7
Korn, A.A.8
Karlsson, G.9
Radue, E.W.10
-
74
-
-
63849147004
-
Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study
-
O'Connor P, Comi G, Montalban X, et al. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology 2009;72:73-79
-
(2009)
Neurology
, vol.72
, pp. 73-79
-
-
O'Connor, P.1
Comi, G.2
Montalban, X.3
-
75
-
-
76449120437
-
Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
-
Comi G, O'Connor P, Montalban X, et al. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. Mult Scler 2010;16:197-207
-
(2010)
Mult Scler
, vol.16
, pp. 197-207
-
-
Comi, G.1
O'Connor, P.2
Montalban, X.3
-
76
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, et al. Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis. N Engl J Med 2010;362:402-415
-
(2010)
N Engl J Med
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
77
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
-
78
-
-
0036239322
-
Cell type-specific localization of human cardiac S1P receptors
-
Mazurais D, Robert P, Gout B, et al. Cell type-specific localization of human cardiac S1P receptors. J Histochem Cytochem 2002;50:661-670 (Pubitemid 34437559)
-
(2002)
Journal of Histochemistry and Cytochemistry
, vol.50
, Issue.5
, pp. 661-669
-
-
Mazurais, D.1
Robert, P.2
Gout, B.3
Berrebi-Bertrand, I.4
Laville, M.P.5
Calmels, T.6
-
79
-
-
76649100827
-
Phase i study with the selective S1P1/S1P5 receptor modulator BAF312 indicates that S1P1 rather than S1P3 mediates transient heart rate reduction in humans
-
[P437]
-
Gergely P, Wallstrom E, Nuesslein-Hildesheim B, et al. Phase I study with the selective S1P1/S1P5 receptor modulator BAF312 indicates that S1P1 rather than S1P3 mediates transient heart rate reduction in humans. Multiple Sclerosis 2009;15:S125 [P437]
-
(2009)
Multiple Sclerosis
, vol.15
-
-
Gergely, P.1
Wallstrom, E.2
Nuesslein-Hildesheim, B.3
-
80
-
-
14644408845
-
KACh
-
DOI 10.1111/j.1600-6143.2005.00754.x
-
Koyrakh L, Roman MI, Brinkmann V, Wickman K. The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I. Am J Transplant 2005;5:529-536 (Pubitemid 40313344)
-
(2005)
American Journal of Transplantation
, vol.5
, Issue.3
, pp. 529-536
-
-
Koyrakh, L.1
Roman, M.I.2
Brinkmann, V.3
Wickman, K.4
-
81
-
-
0037178737
-
Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: Differential role in vasoconstriction
-
Coussin F, Scott RH, Wise A, Nixon GF. Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. Circ Res 2002;91:151-157
-
(2002)
Circ Res
, vol.91
, pp. 151-157
-
-
Coussin, F.1
Scott, R.H.2
Wise, A.3
Nixon, G.F.4
-
82
-
-
20944434884
-
3
-
DOI 10.1161/01.RES.0000164321.91452.00
-
Tolle M, Levkau B, Keul P, et al. Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circ Res 2005;96:913-920 (Pubitemid 40604976)
-
(2005)
Circulation Research
, vol.96
, Issue.8
, pp. 913-920
-
-
Tolle, M.1
Levkau, B.2
Keul, P.3
Brinkmann, V.4
Giebing, G.5
Schonfelder, G.6
Schafers, M.7
Von Wnuck Lipinski, K.8
Jankowski, J.9
Jankowski, V.10
Chun, J.11
Zidek, W.12
Van Der Giet, M.13
-
83
-
-
25444483556
-
Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways
-
DOI 10.1186/1465-9921-6-48
-
Pfaff M, Powaga N, Akinci S, et al. Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respir Res 2005;6:48 (Pubitemid 41363575)
-
(2005)
Respiratory Research
, vol.6
, pp. 48
-
-
Pfaff, M.1
Powaga, N.2
Akinci, S.3
Schutz, W.4
Banno, Y.5
Wiegand, S.6
Kummer, W.7
Wess, J.8
Haberberger, R.V.9
-
84
-
-
33947376484
-
Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects
-
DOI 10.1002/bdd.535
-
Kovarik JM, Hartmann S, Bartlett M, et al. Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects. Biopharm Drug Dispos 2007;28:97-104 (Pubitemid 46455770)
-
(2007)
Biopharmaceutics and Drug Disposition
, vol.28
, Issue.2
, pp. 97-104
-
-
Kovarik, J.M.1
Hartmann, S.2
Bartlett, M.3
Riviere, G.-J.4
Neddermann, D.5
Wang, Y.6
Port, A.7
Schmouder, R.L.8
-
85
-
-
0142215631
-
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
-
DOI 10.1016/S0014-5793(03)01168-2
-
Paugh SW, Payne SG, Barbour SE, et al. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett 2003;554:189-193 (Pubitemid 37324838)
-
(2003)
FEBS Letters
, vol.554
, Issue.1-2
, pp. 189-193
-
-
Paugh, S.W.1
Payne, S.G.2
Barbour, S.E.3
Milstien, S.4
Spiegel, S.5
-
86
-
-
27744552046
-
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720
-
DOI 10.1074/jbc.M506293200
-
Kharel Y, Lee S, Snyder AH, et al. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem 2005;280:36865-36872 (Pubitemid 41587768)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.44
, pp. 36865-36872
-
-
Kharel, Y.1
Lee, S.2
Snyder, A.H.3
Sheasley-O'Neill, S.L.4
Morris, M.A.5
Setiady, Y.6
Zhu, R.7
Zigler, M.A.8
Burcin, T.L.9
Ley, K.10
Tung, K.S.K.11
Engelhard, V.H.12
Macdonald, T.L.13
Pearson-White, S.14
Lynch, K.R.15
-
87
-
-
32644444604
-
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
-
DOI 10.1182/blood-2005-07-2628
-
Zemann B, Kinzel B, Muller M, et al. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood 2006;107:1454-1458 (Pubitemid 43242381)
-
(2006)
Blood
, vol.107
, Issue.4
, pp. 1454-1458
-
-
Zemann, B.1
Kinzel, B.2
Muller, M.3
Reuschel, R.4
Mechtcheriakova, D.5
Urtz, N.6
Bornancin, F.7
Baumruker, T.8
Billich, A.9
-
88
-
-
9644262393
-
Overview of FTY720 clinical pharmacokinetics and pharmacology
-
DOI 10.1097/00007691-200412000-00001
-
Kovarik JM, Schmouder RL, Slade AJ. Overview of FTY720 clinical pharmacokinetics and pharmacology. Ther Drug Monit 2004;26:585-587 (Pubitemid 39579137)
-
(2004)
Therapeutic Drug Monitoring
, vol.26
, Issue.6
, pp. 585-587
-
-
Kovarik, J.M.1
Schmouder, R.L.2
Slade, A.J.3
-
89
-
-
31344464646
-
Fingolimod (FTY720) in severe hepatic impairment: Pharmacokinetics and relationship to markers of liver function
-
DOI 10.1177/0091270005283464
-
Kovarik JM, Schmouder RL, Hartmann S, et al. Fingolimod (FTY720) in severe hepatic impairment: pharmacokinetics and relationship to markers of liver function. J Clin Pharmacol 2006;46:149-156 (Pubitemid 43146445)
-
(2006)
Journal of Clinical Pharmacology
, vol.46
, Issue.2
, pp. 149-156
-
-
Kovarik, J.M.1
Schmouder, R.L.2
Hartmann, S.3
Riviere, G.-J.4
Picard, F.5
Voss, B.6
Weiss, M.7
Wagner, F.8
Schmidt, H.H.-J.9
-
90
-
-
16844364903
-
FTY720 pharmacokinetics in mild to moderate hepatic impairment
-
DOI 10.1177/0091270004274288
-
Kovarik JM, Schmouder RL, Serra D, et al. FTY720 pharmacokinetics in mild to moderate hepatic impairment. J Clin Pharmacol 2005;45:446-452 (Pubitemid 40490417)
-
(2005)
Journal of Clinical Pharmacology
, vol.45
, Issue.4
, pp. 446-452
-
-
Kovarik, J.M.1
Schmouder, R.L.2
Serra, D.3
Wang, Y.4
Wiegand, H.5
Dilzer, S.C.6
Lasseter, K.C.7
-
91
-
-
0141628364
-
Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: Discovery of potent S1P receptor agonists
-
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorg Med. Chem Lett 2003;13:3401-3404
-
(2003)
Bioorg Med. Chem Lett
, vol.13
, pp. 3401-3404
-
-
Clemens, J.J.1
Davis, M.D.2
Lynch, K.R.3
MacDonald, T.L.4
-
92
-
-
33747837449
-
Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses
-
DOI 10.1124/dmd.105.009001
-
Meno-Tetang GM, Li H, Mis S, et al. Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4- octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses. Drug Metab Dispos 2006;34:1480-1487 (Pubitemid 44285388)
-
(2006)
Drug Metabolism and Disposition
, vol.34
, Issue.9
, pp. 1480-1487
-
-
Meno-Tetang, G.M.L.1
Li, H.2
Mis, S.3
Pyszczynski, N.4
Heining, P.5
Lowe, P.6
Jusko, W.J.7
-
93
-
-
0347481389
-
Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases
-
DOI 10.1074/jbc.M307687200
-
Billich A, Bornancin F, Devay P, et al. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem 2003;278:47408-47415 (Pubitemid 37523181)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.48
, pp. 47408-47415
-
-
Billich, A.1
Bornancin, F.2
Devay, P.3
Mechtcheriakova, D.4
Urtz, N.5
Baumruker, T.6
-
94
-
-
20944435136
-
Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients
-
Park SI, Felipe CR, Machado PG, et al. Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients. Braz J Med Biol Res 2005;38:683-694 (Pubitemid 40867507)
-
(2005)
Brazilian Journal of Medical and Biological Research
, vol.38
, Issue.5
, pp. 683-694
-
-
Park, S.I.1
Felipe, C.R.2
Machado, P.G.3
Garcia, R.4
Skerjanec, A.5
Schmouder, R.6
Tedesco-Silva Jr., H.7
Medina-Pestana, J.O.8
-
95
-
-
0006645046
-
Role of CYP4F in the metabolic clearance of FTY720: Prediction of low drug to drug interaction potential
-
Zimmerlin AG, Patten CJ. Role of CYP4F in the metabolic clearance of FTY720: prediction of low drug to drug interaction potential. Transplantation 2000;69:S191
-
(2000)
Transplantation
, vol.69
-
-
Zimmerlin, A.G.1
Patten, C.J.2
-
96
-
-
58849124814
-
Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition
-
Kovarik JM, Dole K, Riviere GJ, et al. Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition. J Clin Pharmacol 2009;49:212-218
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 212-218
-
-
Kovarik, J.M.1
Dole, K.2
Riviere, G.J.3
-
97
-
-
0036148772
-
Update on pharmacokinetic/ pharmacodynamic studies with FTY720 and sirolimus
-
Kahan BD. Update on pharmacokinetic/ pharmacodynamic studies with FTY720 and sirolimus. Ther Drug Monit 2002;24:47-52
-
(2002)
Ther Drug Monit
, vol.24
, pp. 47-52
-
-
Kahan, B.D.1
-
98
-
-
0037068964
-
Clinical importance of the cytochromes P450
-
Nebert DW, Russell DW. Clinical importance of the cytochromes P450. Lancet 2002;360:1155-1162
-
(2002)
Lancet
, vol.360
, pp. 1155-1162
-
-
Nebert, D.W.1
Russell, D.W.2
-
99
-
-
1642345411
-
FTY720 disposition is not affected by demographic or clinical factors in de novo kidney transplant patients
-
[705]
-
Kovarik JM, Hsu CH, Skerjanec A, et al. FTY720 disposition is not affected by demographic or clinical factors in de novo kidney transplant patients. Am J Transplant 2003;5:S332[705]
-
(2003)
Am J Transplant
, vol.5
-
-
Kovarik, J.M.1
Hsu, C.H.2
Skerjanec, A.3
-
100
-
-
33847421937
-
Ethnic sensitivity study of fingollimod in white and Asian subjects
-
Kovarik JM, Slade A, Voss B, et al. Ethnic sensitivity study of fingolimod in white and Asian subjects. Int J Clin Pharmacol Ther 2007;45:98-109 (Pubitemid 46344141)
-
(2007)
International Journal of Clinical Pharmacology and Therapeutics
, vol.45
, Issue.2
, pp. 98-109
-
-
Kovarik, J.M.1
Slade, A.2
Voss, B.3
Schmidli, H.4
Riviere, G.J.5
Picard, F.6
Sugita, Y.7
Kawai, R.8
Mee-Lee, D.9
Schmouder, R.L.10
-
101
-
-
62449300643
-
Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy
-
Sensken SC, Bode C, Graler MH. Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy. J Pharmacol Exp Ther 2009;328:963-969
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 963-969
-
-
Sensken, S.C.1
Bode, C.2
Graler, M.H.3
-
102
-
-
3042750654
-
Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: Clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging
-
DOI 10.1002/jmri.20057
-
Rausch M, Hiestand P, Foster CA, et al. Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. J Magn Reson Imaging 2004;20:16-24 (Pubitemid 38857512)
-
(2004)
Journal of Magnetic Resonance Imaging
, vol.20
, Issue.1
, pp. 16-24
-
-
Rausch, M.1
Hiestand, P.2
Foster, C.A.3
Baumann, D.R.4
Cannet, C.5
Rudin, M.6
-
103
-
-
34548443292
-
FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis
-
DOI 10.1016/j.brainresbull.2007.06.023, PII S0361923007002055
-
Balatoni B, Storch MK, Swoboda EM, et al. FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain Res Bull 2007;74:307-316 (Pubitemid 47368881)
-
(2007)
Brain Research Bulletin
, vol.74
, Issue.5
, pp. 307-316
-
-
Balatoni, B.1
Storch, M.K.2
Swoboda, E.-M.3
Schonborn, V.4
Koziel, A.5
Lambrou, G.N.6
Hiestand, P.C.7
Weissert, R.8
Foster, C.A.9
-
104
-
-
61649121740
-
FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: Expression of central nervous system genes and reversal of blood-brain-barrier damage
-
Foster CA, Mechtcheriakova D, Storch MK, et al. FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage. Brain Pathol 2009;19:254-266
-
(2009)
Brain Pathol
, vol.19
, pp. 254-266
-
-
Foster, C.A.1
Mechtcheriakova, D.2
Storch, M.K.3
-
105
-
-
74049160871
-
FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses
-
Papadopoulos D, Rundle J, Patel R, et al. FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses. J Neurosci Res 2010;88:346-359
-
(2010)
J Neurosci Res
, vol.88
, pp. 346-359
-
-
Papadopoulos, D.1
Rundle, J.2
Patel, R.3
-
106
-
-
3242683494
-
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
-
DOI 10.1016/j.jneuroim.2004.04.015, PII S0165572804001560
-
Webb M, Tham CS, Lin FF, et al. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol 2004;153:108-121 (Pubitemid 38950933)
-
(2004)
Journal of Neuroimmunology
, vol.153
, Issue.1-2
, pp. 108-121
-
-
Webb, M.1
Tham, C.-S.2
Lin, F.-F.3
Lariosa-Willingham, K.4
Yu, N.5
Hale, J.6
Mandala, S.7
Chun, J.8
Rao, T.S.9
-
107
-
-
20544456156
-
FTY720, a novel immunomodulator: Efficacy and safety results from the first phase 2A study in de novo renal transplantation
-
DOI 10.1097/01.TP.0000121761.02129.A6
-
Tedesco-Silva H, Mourad G, Kahan BD, et al. FTY720, a novel immunomodulator: efficacy and safety results from the first phase IIA study in de novo renal transplantation. Transplantation 2005;79:1553-1560 (Pubitemid 40847587)
-
(2005)
Transplantation
, vol.79
, Issue.11
, pp. 1553-1560
-
-
Tedesco-Silva, H.1
Mourad, G.2
Kahan, B.D.3
Boira, J.G.4
Weimar, W.5
Mulgaonkar, S.6
Nashan, B.7
Madsen, S.8
Charpentier, B.9
Pellet, P.10
Vanrenterghem, Y.11
-
108
-
-
33745927144
-
FTY720: Placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects
-
DOI 10.1177/0091270006289853
-
Schmouder R, Serra D, Wang Y, et al. FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects. J Clin Pharmacol 2006;46:895-904 (Pubitemid 44050826)
-
(2006)
Journal of Clinical Pharmacology
, vol.46
, Issue.8
, pp. 895-904
-
-
Schmouder, R.1
Serra, D.2
Wang, Y.3
Kovarik, J.M.4
DiMarco, J.5
Hunt, T.L.6
Bastien, M.-C.7
-
109
-
-
33745800873
-
FTY720/cyclosporine regimens in De Novo renal transplantation: A 1-year dose-finding study
-
DOI 10.1111/j.1600-6143.2006.01404.x
-
Mulgaonkar S, Tedesco H, Oppenheimer F, et al. FTY720/ cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study. Am J Transplant 2006;6:1848-1857 (Pubitemid 44024956)
-
(2006)
American Journal of Transplantation
, vol.6
, Issue.8
, pp. 1848-1857
-
-
Mulgaonkar, S.1
Tedesco, H.2
Oppenheimer, F.3
Walker, R.4
Kunzendorf, U.5
Russ, G.6
Knoflach, A.7
Patel, Y.8
Ferguson, R.9
-
110
-
-
33947314300
-
Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients
-
DOI 10.1097/01.tp.0000253421.18892.b8, PII 0000789020070315000021
-
Oppenheimer F, Mulgaonkar S, Ferguson R, et al. Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients. Transplantation 2007;83:645-648 (Pubitemid 46440256)
-
(2007)
Transplantation
, vol.83
, Issue.5
, pp. 645-648
-
-
Oppenheimer, F.1
Mulgaonkar, S.2
Ferguson, R.3
Grinyo, J.4
Juarez, F.5
Ostrowski, M.6
Klinger, M.7
Walker, R.8
Torres, A.9
Preiss, R.10
Cremer, M.11
Jardine, A.12
-
111
-
-
47249147546
-
The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects
-
DOI 10.1111/j.1365-2125.2008.03199.x
-
Kovarik JM, Slade A, Riviere GJ, et al. The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects. Br J Clin Pharmacol 2008;66:199-206 (Pubitemid 351991450)
-
(2008)
British Journal of Clinical Pharmacology
, vol.66
, Issue.2
-
-
Kovarik, J.M.1
Slade, A.2
Riviere, G.-J.3
Neddermann, D.4
Maton, S.5
Hunt, T.L.6
Schmouder, R.L.7
-
112
-
-
14844288015
-
Reversible posterior leukoencephalopathy syndrome: A misnomer reviewed
-
DOI 10.1111/j.1445-5994.2004.00750.x
-
Stott VL, Hurrell MA, Anderson TJ. Reversible posterior leukoencephalopathy syndrome: a misnomer reviewed. Intern Med J 2005;35:83-90 (Pubitemid 40343439)
-
(2005)
Internal Medicine Journal
, vol.35
, Issue.2
, pp. 83-90
-
-
Stott, V.L.1
Hurrell, M.A.2
Anderson, T.J.3
-
113
-
-
64049116465
-
Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: A case report
-
Leypoldt F, Munchau A, Moeller F, et al. Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report. Neurology 2009;72:1022-1024
-
(2009)
Neurology
, vol.72
, pp. 1022-1024
-
-
Leypoldt, F.1
Munchau, A.2
Moeller, F.3
|