Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24765-24775

  Yonesu, Kiyoaki ^a   Kubota, Kazuishi ^a   Tamura, Masakazu ^a   Inaba, Shin Ichi ^a   Honda, Tomohiro ^a   Yahara, Chizuko ^a   Watanabe, Nobuaki ^a   Matsuoka, Tatsuji ^a   Nara, Futoshi ^a,b  

^a DAIICHI SANKYO CO   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANOLAMINES; BIOCHEMISTRY; BLOOD; CHEMICAL ACTIVATION; MASS SPECTROMETRY; NITROGEN COMPOUNDS; PHOSPHORYLATION; PURIFICATION; SPHINGOSINES; SULFUR COMPOUNDS;

AMMONIUM SULFATE PRECIPITATION; AUTOIMMUNE DISEASE; HIGHLY-CORRELATED; MULTIPLE SCLEROSIS; PHARMACOKINETICS AND PHARMACODYNAMICS; POTENTIAL BENEFITS; SPHINGOSINE 1 PHOSPHATES; SPHINGOSINE KINASE;

ENZYMES;

1 DEOXY 1 MORPHOLINOFRUCTOSE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMMONIUM SULFATE; CS 0777; CS 0777 PHOSPHATE; DRUG METABOLITE; ENZYME INHIBITOR; FINGOLIMOD; FRUCTOSAMINE 3 KINASE; FRUCTOSAMINE 3 KINASE RELATED PROTEIN; FTY 720 PHOSPHATE; GLYCOSYLATED PROTEIN; N,N DIMETHYLSPHINGOSINE; PHOSPHOTRANSFERASE; PRODRUG; RST 7501; RST 7501 PHOSPHATE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATOR; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; SUGAR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; CELL LYSATE; CELL STRAIN HEK293; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE; ERYTHROCYTE; HEMOLYSATE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PHOSPHORYLATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

RATTUS;

EID: 79960123872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.217299     Document Type: Article

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