-
1
-
-
82555196095
-
Systemic lupus erythematosus
-
Tsokos G.C. Systemic lupus erythematosus. N. Engl. J. Med. 2011, 365:2110-2121.
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 2110-2121
-
-
Tsokos, G.C.1
-
2
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker B.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 2001, 344:1031-1037.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
-
3
-
-
79959261430
-
Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases
-
Pamuk O.N., Tsokos G.C. Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases. Arthritis Res. Ther. 2010, 12:222.
-
(2010)
Arthritis Res. Ther.
, vol.12
, pp. 222
-
-
Pamuk, O.N.1
Tsokos, G.C.2
-
4
-
-
75749123824
-
Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases
-
Ghosh D., Tsokos G.C. Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases. Autoimmunity 2010, 43:48-55.
-
(2010)
Autoimmunity
, vol.43
, pp. 48-55
-
-
Ghosh, D.1
Tsokos, G.C.2
-
5
-
-
34547922794
-
Syk kinase as a treatment target for therapy in autoimmune diseases
-
Kyttaris V.C., Tsokos G.C. Syk kinase as a treatment target for therapy in autoimmune diseases. Clin. Immunol. 2007, 124:235-237.
-
(2007)
Clin. Immunol.
, vol.124
, pp. 235-237
-
-
Kyttaris, V.C.1
Tsokos, G.C.2
-
6
-
-
0032036481
-
Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain
-
Liossis S.N., Ding X.Z., Dennis G.J., Tsokos G.C. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J. Clin. Invest. 1998, 101:1448-1457.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1448-1457
-
-
Liossis, S.N.1
Ding, X.Z.2
Dennis, G.J.3
Tsokos, G.C.4
-
7
-
-
0034744286
-
Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus
-
Enyedy E.J., Nambiar M.P., Liossis S.N., Dennis G., Kammer G.M., Tsokos G.C. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum. 2001, 44:1114-1121.
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 1114-1121
-
-
Enyedy, E.J.1
Nambiar, M.P.2
Liossis, S.N.3
Dennis, G.4
Kammer, G.M.5
Tsokos, G.C.6
-
8
-
-
0037446543
-
The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells
-
Krishnan S., Warke V.G., Nambiar M.P., Tsokos G.C., Farber D.L. The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J. Immunol. 2003, 170:4189-4195.
-
(2003)
J. Immunol.
, vol.170
, pp. 4189-4195
-
-
Krishnan, S.1
Warke, V.G.2
Nambiar, M.P.3
Tsokos, G.C.4
Farber, D.L.5
-
9
-
-
0037443553
-
Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation
-
Nambiar M.P., Fisher C.U., Kumar A., Tsokos C.G., Warke V.G., Tsokos G.C. Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation. J. Immunol. 2003, 170:2871-2876.
-
(2003)
J. Immunol.
, vol.170
, pp. 2871-2876
-
-
Nambiar, M.P.1
Fisher, C.U.2
Kumar, A.3
Tsokos, C.G.4
Warke, V.G.5
Tsokos, G.C.6
-
10
-
-
2942586874
-
Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus
-
Krishnan S., et al. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J. Immunol. 2004, 172:7821-7831.
-
(2004)
J. Immunol.
, vol.172
, pp. 7821-7831
-
-
Krishnan, S.1
-
11
-
-
71849102938
-
Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells
-
Krishnan S., et al. Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells. J. Immunol. 2008, 181:8145-8152.
-
(2008)
J. Immunol.
, vol.181
, pp. 8145-8152
-
-
Krishnan, S.1
-
12
-
-
77957333252
-
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
-
Weinblatt M.E., Kavanaugh A., Genovese M.C., Musser T.K., Grossbard E.B., Magilavy D.B. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N. Engl. J. Med. 2010, 363:1303-1312.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1303-1312
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Genovese, M.C.3
Musser, T.K.4
Grossbard, E.B.5
Magilavy, D.B.6
-
13
-
-
78650294662
-
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
-
Genovese M.C., et al. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum. 2011, 63:337-345.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 337-345
-
-
Genovese, M.C.1
-
14
-
-
43949092440
-
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
-
Bahjat F.R., et al. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum. 2008, 58:1433-1444.
-
(2008)
Arthritis Rheum.
, vol.58
, pp. 1433-1444
-
-
Bahjat, F.R.1
-
15
-
-
77954229590
-
Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
-
Deng G.M., Liu L., Bahjat F.R., Pine P.R., Tsokos G.C. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 2010, 62:2086-2092.
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 2086-2092
-
-
Deng, G.M.1
Liu, L.2
Bahjat, F.R.3
Pine, P.R.4
Tsokos, G.C.5
-
16
-
-
84859972127
-
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
-
O'Shea J.J., Plenge R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 2012, 36:542-550.
-
(2012)
Immunity
, vol.36
, pp. 542-550
-
-
O'Shea, J.J.1
Plenge, R.2
-
17
-
-
0029164841
-
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
-
Macchi P., et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995, 377:65-68.
-
(1995)
Nature
, vol.377
, pp. 65-68
-
-
Macchi, P.1
-
18
-
-
0028857954
-
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development
-
Russell S.M., et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995, 270:797-800.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
-
19
-
-
3042563551
-
Jak3 and the pathogenesis of severe combined immunodeficiency
-
O'Shea J.J., et al. Jak3 and the pathogenesis of severe combined immunodeficiency. Mol. Immunol. 2004, 41:727-737.
-
(2004)
Mol. Immunol.
, vol.41
, pp. 727-737
-
-
O'Shea, J.J.1
-
20
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R., et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 2005, 352:1779-1790.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
-
21
-
-
84865308028
-
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes
-
Aug
-
Boisson-Dupuis S., et al. Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes. Curr. Opin. Immunol. Aug 2012, 24(4):364-378.
-
(2012)
Curr. Opin. Immunol.
, vol.24
, Issue.4
, pp. 364-378
-
-
Boisson-Dupuis, S.1
-
22
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
Fleischmann R., et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N. Engl. J. Med. 2012, 367:495-507.
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 495-507
-
-
Fleischmann, R.1
-
23
-
-
84864703156
-
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
-
van Vollenhoven R.F., et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N. Engl. J. Med. 2012, 367:508-519.
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 508-519
-
-
van Vollenhoven, R.F.1
-
24
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S., et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N. Engl. J. Med. 2012, 366:799-807.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 799-807
-
-
Verstovsek, S.1
-
25
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C., et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N. Engl. J. Med. 2012, 366:787-798.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 787-798
-
-
Harrison, C.1
-
26
-
-
78651414618
-
Overview of the biology of type I interferons
-
Kalliolias G.D., Ivashkiv L.B. Overview of the biology of type I interferons. Arthritis Res. Ther. 2010, 12(Suppl. 1):S1.
-
(2010)
Arthritis Res. Ther.
, vol.12
, Issue.SUPPL. 1
-
-
Kalliolias, G.D.1
Ivashkiv, L.B.2
-
27
-
-
84859060077
-
Type I interferons as biomarkers in autoimmune diseases
-
Kalliolias G.D., Kirou K.A. Type I interferons as biomarkers in autoimmune diseases. Biomark. Med. 2012, 6:137-140.
-
(2012)
Biomark. Med.
, vol.6
, pp. 137-140
-
-
Kalliolias, G.D.1
Kirou, K.A.2
-
28
-
-
80054684397
-
The dysregulation of cytokine networks in systemic lupus erythematosus
-
Apostolidis S.A., Lieberman L.A., Kis-Toth K., Crispin J.C., Tsokos G.C. The dysregulation of cytokine networks in systemic lupus erythematosus. J. Interferon Cytokine Res. 2011, 31:769-779.
-
(2011)
J. Interferon Cytokine Res.
, vol.31
, pp. 769-779
-
-
Apostolidis, S.A.1
Lieberman, L.A.2
Kis-Toth, K.3
Crispin, J.C.4
Tsokos, G.C.5
-
29
-
-
80054709328
-
The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus
-
Davis L.S., Hutcheson J., Mohan C. The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus. J. Interferon Cytokine Res. 2011, 31:781-789.
-
(2011)
J. Interferon Cytokine Res.
, vol.31
, pp. 781-789
-
-
Davis, L.S.1
Hutcheson, J.2
Mohan, C.3
-
30
-
-
77956256590
-
Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice
-
Wang S., et al. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus 2010, 19:1171-1180.
-
(2010)
Lupus
, vol.19
, pp. 1171-1180
-
-
Wang, S.1
-
31
-
-
80053531618
-
Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2
-
Lu L.D., et al. Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2. J. Immunol. 2011, 187:3840-3853.
-
(2011)
J. Immunol.
, vol.187
, pp. 3840-3853
-
-
Lu, L.D.1
-
32
-
-
61849183478
-
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain
-
Mohamed A.J., et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol. Rev. 2009, 228:58-73.
-
(2009)
Immunol. Rev.
, vol.228
, pp. 58-73
-
-
Mohamed, A.J.1
-
33
-
-
5444255783
-
Bruton's tyrosine kinase is essential for human B cell tolerance
-
Ng Y.S., Wardemann H., Chelnis J., Cunningham-Rundles C., Meffre E. Bruton's tyrosine kinase is essential for human B cell tolerance. J. Exp. Med. 2004, 200:927-934.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 927-934
-
-
Ng, Y.S.1
Wardemann, H.2
Chelnis, J.3
Cunningham-Rundles, C.4
Meffre, E.5
-
34
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg L.A., et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:13075-13080.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 13075-13080
-
-
Honigberg, L.A.1
-
35
-
-
16844376445
-
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
-
Juang Y.T., et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J. Clin. Invest. 2005, 115:996-1005.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 996-1005
-
-
Juang, Y.T.1
-
36
-
-
79551680278
-
Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV
-
Ichinose K., Juang Y.T., Crispin J.C., Kis-Toth K., Tsokos G.C. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV. Arthritis Rheum. 2011, 63:523-529.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 523-529
-
-
Ichinose, K.1
Juang, Y.T.2
Crispin, J.C.3
Kis-Toth, K.4
Tsokos, G.C.5
-
37
-
-
82755186809
-
Cutting edge: calcium/calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis
-
Ichinose K., et al. Cutting edge: calcium/calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis. J. Immunol. 2011, 187:5500-5504.
-
(2011)
J. Immunol.
, vol.187
, pp. 5500-5504
-
-
Ichinose, K.1
-
38
-
-
79953323051
-
IL-17-producing T cells in lupus nephritis
-
Apostolidis S.A., Crispin J.C., Tsokos G.C. IL-17-producing T cells in lupus nephritis. Lupus 2011, 20:120-124.
-
(2011)
Lupus
, vol.20
, pp. 120-124
-
-
Apostolidis, S.A.1
Crispin, J.C.2
Tsokos, G.C.3
-
39
-
-
33846536952
-
Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
-
Li Y., et al. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J. Immunol. 2007, 178:1938-1947.
-
(2007)
J. Immunol.
, vol.178
, pp. 1938-1947
-
-
Li, Y.1
-
40
-
-
77956361520
-
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
-
Biswas P.S., et al. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J. Clin. Invest. 2010, 120:3280-3295.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3280-3295
-
-
Biswas, P.S.1
-
41
-
-
79960943876
-
IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production
-
Lech M., et al. IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production. J. Am. Soc. Nephrol. 2011, 22:1443-1452.
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 1443-1452
-
-
Lech, M.1
-
42
-
-
84859921644
-
Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice
-
Stirzaker R., Biswas P., Gupta S., Song L., Bhagat G., Pernis A. Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice. Lupus 2012, 21:656-661.
-
(2012)
Lupus
, vol.21
, pp. 656-661
-
-
Stirzaker, R.1
Biswas, P.2
Gupta, S.3
Song, L.4
Bhagat, G.5
Pernis, A.6
-
43
-
-
34447640943
-
A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage
-
(discussion 131-122)
-
Suzuki Y., Shibuya M., Satoh S., Sugimoto Y., Takakura K. A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage. Surg. Neurol. 2007, 68:126-131. (discussion 131-122).
-
(2007)
Surg. Neurol.
, vol.68
, pp. 126-131
-
-
Suzuki, Y.1
Shibuya, M.2
Satoh, S.3
Sugimoto, Y.4
Takakura, K.5
-
44
-
-
27644449718
-
Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial
-
Vicari R.M., et al. Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial. J. Am. Coll. Cardiol. 2005, 46:1803-1811.
-
(2005)
J. Am. Coll. Cardiol.
, vol.46
, pp. 1803-1811
-
-
Vicari, R.M.1
-
45
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
46
-
-
0028107540
-
Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus
-
Warner L.M., Adams L.M., Sehgal S.N. Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus. Arthritis Rheum. 1994, 37:289-297.
-
(1994)
Arthritis Rheum.
, vol.37
, pp. 289-297
-
-
Warner, L.M.1
Adams, L.M.2
Sehgal, S.N.3
-
47
-
-
35948936095
-
Prevention of murine lupus disease in (NZBxNZW)F1 mice by sirolimus treatment
-
Ramos-Barron A., et al. Prevention of murine lupus disease in (NZBxNZW)F1 mice by sirolimus treatment. Lupus 2007, 16:775-781.
-
(2007)
Lupus
, vol.16
, pp. 775-781
-
-
Ramos-Barron, A.1
-
48
-
-
43249109614
-
Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice
-
Lui S.L., et al. Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice. Lupus 2008, 17:305-313.
-
(2008)
Lupus
, vol.17
, pp. 305-313
-
-
Lui, S.L.1
-
49
-
-
58549107810
-
Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice
-
Lui S.L., et al. Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice. Nephrol. Dial. Transplant. 2008, 23:2768-2776.
-
(2008)
Nephrol. Dial. Transplant.
, vol.23
, pp. 2768-2776
-
-
Lui, S.L.1
-
50
-
-
77953720799
-
MTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?
-
Fernandez D., Perl A. mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?. Discov. Med. 2010, 9:173-178.
-
(2010)
Discov. Med.
, vol.9
, pp. 173-178
-
-
Fernandez, D.1
Perl, A.2
-
51
-
-
33749345289
-
Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus
-
Fernandez D., Bonilla E., Mirza N., Niland B., Perl A. Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arthritis Rheum. 2006, 54:2983-2988.
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 2983-2988
-
-
Fernandez, D.1
Bonilla, E.2
Mirza, N.3
Niland, B.4
Perl, A.5
-
52
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu S. The role of PI3K in immune cells. Nat. Immunol. 2003, 4:313-319.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
53
-
-
56749156696
-
The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications
-
iii70-iii74
-
Weichhart T., Saemann M.D. The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann. Rheum. Dis. 2008, 67(Suppl. 3):iii70-iii74.
-
(2008)
Ann. Rheum. Dis.
, vol.67
, Issue.SUPPL. 3
-
-
Weichhart, T.1
Saemann, M.D.2
-
54
-
-
0036199607
-
Phosphoinositide 3-kinase in immunological systems
-
Fruman D.A., Cantley L.C. Phosphoinositide 3-kinase in immunological systems. Semin. Immunol. 2002, 14:7-18.
-
(2002)
Semin. Immunol.
, vol.14
, pp. 7-18
-
-
Fruman, D.A.1
Cantley, L.C.2
-
55
-
-
80052667108
-
Enhanced phosphoinositide 3-kinase delta activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death
-
Suarez-Fueyo A., Barber D.F., Martinez-Ara J., Zea-Mendoza A.C., Carrera A.C. Enhanced phosphoinositide 3-kinase delta activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death. J. Immunol. 2011, 187:2376-2385.
-
(2011)
J. Immunol.
, vol.187
, pp. 2376-2385
-
-
Suarez-Fueyo, A.1
Barber, D.F.2
Martinez-Ara, J.3
Zea-Mendoza, A.C.4
Carrera, A.C.5
-
56
-
-
84861192191
-
Attenuation of phosphoinositide 3-kinase delta signaling restrains autoimmune disease
-
Jun
-
Maxwell M.J., Tsantikos E., Kong A.M., Vanhaesebroeck B., Tarlinton D.M., Hibbs M.L. Attenuation of phosphoinositide 3-kinase delta signaling restrains autoimmune disease. J. Autoimmun. Jun 2012, 38(4):381-391.
-
(2012)
J. Autoimmun.
, vol.38
, Issue.4
, pp. 381-391
-
-
Maxwell, M.J.1
Tsantikos, E.2
Kong, A.M.3
Vanhaesebroeck, B.4
Tarlinton, D.M.5
Hibbs, M.L.6
-
57
-
-
24744449495
-
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
-
Barber D.F., et al. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. 2005, 11:933-935.
-
(2005)
Nat. Med.
, vol.11
, pp. 933-935
-
-
Barber, D.F.1
-
58
-
-
33846518435
-
Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus
-
Kyttaris V.C., Wang Y., Juang Y.T., Weinstein A., Tsokos G.C. Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. J. Immunol. 2007, 178:1960-1966.
-
(2007)
J. Immunol.
, vol.178
, pp. 1960-1966
-
-
Kyttaris, V.C.1
Wang, Y.2
Juang, Y.T.3
Weinstein, A.4
Tsokos, G.C.5
-
59
-
-
66149096223
-
Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity
-
Mulero M.C., et al. Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J. Biol. Chem. 2009, 284:9394-9401.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9394-9401
-
-
Mulero, M.C.1
-
60
-
-
79959852739
-
Calcium signaling in systemic lupus erythematosus T cells: a treatment target
-
Kyttaris V.C., Zhang Z., Kampagianni O., Tsokos G.C. Calcium signaling in systemic lupus erythematosus T cells: a treatment target. Arthritis Rheum. 2011, 63:2058-2066.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 2058-2066
-
-
Kyttaris, V.C.1
Zhang, Z.2
Kampagianni, O.3
Tsokos, G.C.4
-
61
-
-
79952534189
-
Regulation of chromatin by histone modifications
-
Bannister A.J., Kouzarides T. Regulation of chromatin by histone modifications. Cell Res. 2011, 21:381-395.
-
(2011)
Cell Res.
, vol.21
, pp. 381-395
-
-
Bannister, A.J.1
Kouzarides, T.2
-
62
-
-
77953747413
-
Tools and landscapes of epigenetics
-
Tarakhovsky A. Tools and landscapes of epigenetics. Nat. Immunol. 2010, 11:565-568.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 565-568
-
-
Tarakhovsky, A.1
-
63
-
-
84863621527
-
Cancer epigenetics: from mechanism to therapy
-
Dawson M.A., Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012, 150:12-27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
64
-
-
79955623575
-
Epigenetic alterations in autoimmune rheumatic diseases
-
Ballestar E. Epigenetic alterations in autoimmune rheumatic diseases. Nat. Rev. Rheumatol. 2011, 7:263-271.
-
(2011)
Nat. Rev. Rheumatol.
, vol.7
, pp. 263-271
-
-
Ballestar, E.1
-
65
-
-
84855961987
-
Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases
-
Hedrich C.M., Tsokos G.C. Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol. Med. 2011, 17:714-724.
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 714-724
-
-
Hedrich, C.M.1
Tsokos, G.C.2
-
66
-
-
79955552937
-
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
-
Vojinovic J., et al. Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2011, 63:1452-1458.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 1452-1458
-
-
Vojinovic, J.1
-
67
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
Nicodeme E., et al. Suppression of inflammation by a synthetic histone mimic. Nature 2010, 468:1119-1123.
-
(2010)
Nature
, vol.468
, pp. 1119-1123
-
-
Nicodeme, E.1
-
68
-
-
79958260145
-
A new epigenetic challenge: systemic lupus erythematosus
-
Javierre B.M., Richardson B. A new epigenetic challenge: systemic lupus erythematosus. Adv. Exp. Med. Biol. 2011, 711:117-136.
-
(2011)
Adv. Exp. Med. Biol.
, vol.711
, pp. 117-136
-
-
Javierre, B.M.1
Richardson, B.2
-
69
-
-
79251542357
-
Epigenetics in lupus
-
Zouali M. Epigenetics in lupus. Ann. N. Y. Acad. Sci. 2011, 1217:154-165.
-
(2011)
Ann. N. Y. Acad. Sci.
, vol.1217
, pp. 154-165
-
-
Zouali, M.1
-
70
-
-
75649151209
-
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
-
Javierre B.M., et al. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res. 2010, 20:170-179.
-
(2010)
Genome Res.
, vol.20
, pp. 170-179
-
-
Javierre, B.M.1
-
71
-
-
80051973863
-
Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents
-
Jeffries M.A., Sawalha A.H. Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents. Int. J. Clin. Rheumatol. 2011, 6:423-439.
-
(2011)
Int. J. Clin. Rheumatol.
, vol.6
, pp. 423-439
-
-
Jeffries, M.A.1
Sawalha, A.H.2
-
72
-
-
83355166950
-
CAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus
-
Hedrich C.M., Rauen T., Tsokos G.C. cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus. J. Biol. Chem. 2011, 286:43429-43436.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 43429-43436
-
-
Hedrich, C.M.1
Rauen, T.2
Tsokos, G.C.3
-
73
-
-
84856880805
-
CAMP-responsive element modulator alpha (CREMalpha) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE)
-
Hedrich C.M., Rauen T., Kis-Toth K., Kyttaris V.C., Tsokos G.C. cAMP-responsive element modulator alpha (CREMalpha) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J. Biol. Chem. 2012, 287:4715-4725.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 4715-4725
-
-
Hedrich, C.M.1
Rauen, T.2
Kis-Toth, K.3
Kyttaris, V.C.4
Tsokos, G.C.5
-
74
-
-
0037330279
-
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
-
Mishra N., Reilly C.M., Brown D.R., Ruiz P., Gilkeson G.S. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J. Clin. Invest. 2003, 111:539-552.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 539-552
-
-
Mishra, N.1
Reilly, C.M.2
Brown, D.R.3
Ruiz, P.4
Gilkeson, G.S.5
-
75
-
-
4644307426
-
Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid
-
Reilly C.M., et al. Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid. J. Immunol. 2004, 173:4171-4178.
-
(2004)
J. Immunol.
, vol.173
, pp. 4171-4178
-
-
Reilly, C.M.1
-
76
-
-
50849102708
-
The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice
-
Reilly C.M., et al. The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. J. Autoimmun. 2008, 31:123-130.
-
(2008)
J. Autoimmun.
, vol.31
, pp. 123-130
-
-
Reilly, C.M.1
-
77
-
-
0022969331
-
Successful treatment of autoimmunity in MRL/1 mice with LS-2616, a new immunomodulator
-
Tarkowski A., Gunnarsson K., Nilsson L.A., Lindholm L., Stalhandske T. Successful treatment of autoimmunity in MRL/1 mice with LS-2616, a new immunomodulator. Arthritis Rheum. 1986, 29:1405-1409.
-
(1986)
Arthritis Rheum.
, vol.29
, pp. 1405-1409
-
-
Tarkowski, A.1
Gunnarsson, K.2
Nilsson, L.A.3
Lindholm, L.4
Stalhandske, T.5
-
78
-
-
0023025518
-
Effects of LS-2616 administration upon the autoimmune disease of (NZB×NZW) F1 hybrid mice
-
Tarkowski A., Gunnarsson K., Stalhandske T. Effects of LS-2616 administration upon the autoimmune disease of (NZB×NZW) F1 hybrid mice. Immunology 1986, 59:589-594.
-
(1986)
Immunology
, vol.59
, pp. 589-594
-
-
Tarkowski, A.1
Gunnarsson, K.2
Stalhandske, T.3
-
79
-
-
11144357311
-
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship
-
Jonsson S., et al. Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship. J. Med. Chem. 2004, 47:2075-2088.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2075-2088
-
-
Jonsson, S.1
-
80
-
-
65949111512
-
Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides
-
Bjork P., et al. Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides. PLoS Biol. 2009, 7:e97.
-
(2009)
PLoS Biol.
, vol.7
-
-
Bjork, P.1
-
81
-
-
33845868493
-
S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
-
Foell D., Wittkowski H., Vogl T., Roth J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J. Leukoc. Biol. 2007, 81:28-37.
-
(2007)
J. Leukoc. Biol.
, vol.81
, pp. 28-37
-
-
Foell, D.1
Wittkowski, H.2
Vogl, T.3
Roth, J.4
-
82
-
-
34948900275
-
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
-
Vogl T., et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat. Med. 2007, 13:1042-1049.
-
(2007)
Nat. Med.
, vol.13
, pp. 1042-1049
-
-
Vogl, T.1
-
83
-
-
79953889854
-
Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus
-
Lood C., et al. Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus. Arthritis Res. Ther. 2011, 13:R60.
-
(2011)
Arthritis Res. Ther.
, vol.13
-
-
Lood, C.1
-
84
-
-
77953233075
-
The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
-
Loser K., et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat. Med. 2010, 16:713-717.
-
(2010)
Nat. Med.
, vol.16
, pp. 713-717
-
-
Loser, K.1
-
85
-
-
4444346776
-
The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus
-
Carlsten H., Jonsson C., Bokarewa M., Svensson L., Tarkowski A. The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus. Int. Immunopharmacol. 2004, 4:1515-1523.
-
(2004)
Int. Immunopharmacol.
, vol.4
, pp. 1515-1523
-
-
Carlsten, H.1
Jonsson, C.2
Bokarewa, M.3
Svensson, L.4
Tarkowski, A.5
-
86
-
-
84860460054
-
Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus
-
Bengtsson A.A., et al. Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus. Arthritis Rheum. 2012, 64:1579-1588.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 1579-1588
-
-
Bengtsson, A.A.1
-
87
-
-
84881113457
-
-
European League Against Rheumatism Annual Congress 2011 (EULAR), [THU0417]
-
Bengtsson A., Sturfelt G., Ronnblom L., Gunnarsson I., Svenungsson E., Jacobsen S., Lood C., Sparre B., Wallen Ohman M., Tuvesson H., Leanderson T. An exploratory study to evaluate changes in disease activity and biomarkers during treatment with ABR-215757 in patients with mild active systemic lupus erythematosus (SLE) 2011, European League Against Rheumatism Annual Congress 2011 (EULAR), [THU0417].
-
(2011)
An exploratory study to evaluate changes in disease activity and biomarkers during treatment with ABR-215757 in patients with mild active systemic lupus erythematosus (SLE)
-
-
Bengtsson, A.1
Sturfelt, G.2
Ronnblom, L.3
Gunnarsson, I.4
Svenungsson, E.5
Jacobsen, S.6
Lood, C.7
Sparre, B.8
Wallen Ohman, M.9
Tuvesson, H.10
Leanderson, T.11
-
88
-
-
84858217865
-
Placebo-controlled trial of oral laquinimod for multiple sclerosis
-
Comi G., et al. Placebo-controlled trial of oral laquinimod for multiple sclerosis. N. Engl. J. Med. 2012, 366:1000-1009.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1000-1009
-
-
Comi, G.1
-
89
-
-
84881084940
-
-
ACR, [Presentation number: 560]
-
Kaye J., Etzyoni R., Keshet-Katz R., Raymond E., Blaugrund E. Laquinimod Inhibits Disease Severity and Progression in Mouse Models of Lupus: Alone and in Combination with Standard of Care Agents 2011, ACR, [Presentation number: 560].
-
(2011)
Laquinimod Inhibits Disease Severity and Progression in Mouse Models of Lupus: Alone and in Combination with Standard of Care Agents
-
-
Kaye, J.1
Etzyoni, R.2
Keshet-Katz, R.3
Raymond, E.4
Blaugrund, E.5
-
90
-
-
50449086728
-
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
-
San Miguel J.F., et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N. Engl. J. Med. 2008, 359:906-917.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 906-917
-
-
San Miguel, J.F.1
-
91
-
-
34848870352
-
Bortezomib for the treatment of mantle cell lymphoma
-
Kane R.C., et al. Bortezomib for the treatment of mantle cell lymphoma. Clin. Cancer Res. 2007, 13:5291-5294.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5291-5294
-
-
Kane, R.C.1
-
92
-
-
33847714599
-
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
-
Meister S., et al. Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res. 2007, 67:1783-1792.
-
(2007)
Cancer Res.
, vol.67
, pp. 1783-1792
-
-
Meister, S.1
-
93
-
-
33744539521
-
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
-
Obeng E.A., Carlson L.M., Gutman D.M., Harrington W.J., Lee K.P., Boise L.H. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006, 107:4907-4916.
-
(2006)
Blood
, vol.107
, pp. 4907-4916
-
-
Obeng, E.A.1
Carlson, L.M.2
Gutman, D.M.3
Harrington, W.J.4
Lee, K.P.5
Boise, L.H.6
-
94
-
-
46749088320
-
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
-
Neubert K., et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat. Med. 2008, 14:748-755.
-
(2008)
Nat. Med.
, vol.14
, pp. 748-755
-
-
Neubert, K.1
-
95
-
-
0031861905
-
Long-lived plasma cells: a mechanism for maintaining persistent antibody production
-
Slifka M.K., Ahmed R. Long-lived plasma cells: a mechanism for maintaining persistent antibody production. Curr. Opin. Immunol. 1998, 10:252-258.
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 252-258
-
-
Slifka, M.K.1
Ahmed, R.2
-
96
-
-
84881106098
-
-
European League Against Rheumatism Annual Congress 2011 (EULAR), [OP0072]
-
Starke C., Frey S., Ubronaviciute V., Schett G., Winkler T., Voll R. Depletion of autoreactive short- and long-lived plasma cells within nephritic kidneys of lupus mice by bortezomib 2011, European League Against Rheumatism Annual Congress 2011 (EULAR), [OP0072].
-
(2011)
Depletion of autoreactive short- and long-lived plasma cells within nephritic kidneys of lupus mice by bortezomib
-
-
Starke, C.1
Frey, S.2
Ubronaviciute, V.3
Schett, G.4
Winkler, T.5
Voll, R.6
-
97
-
-
84856153814
-
The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture
-
Hainz N., et al. The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture. Nephron Exp. Nephrol. 2012, 120:e47-e58.
-
(2012)
Nephron Exp. Nephrol.
, vol.120
-
-
Hainz, N.1
-
98
-
-
34548183776
-
Neurotoxicity of bortezomib therapy in multiple myeloma: a single-center experience and review of the literature
-
Badros A., et al. Neurotoxicity of bortezomib therapy in multiple myeloma: a single-center experience and review of the literature. Cancer 2007, 110:1042-1049.
-
(2007)
Cancer
, vol.110
, pp. 1042-1049
-
-
Badros, A.1
-
99
-
-
84863012127
-
Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells
-
Ichikawa H.T., et al. Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells. Arthritis Rheum. 2012, 64:493-503.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 493-503
-
-
Ichikawa, H.T.1
-
100
-
-
84856103470
-
Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE
-
Seavey M.M., Lu L.D., Stump K.L., Wallace N.H., Ruggeri B.A. Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE. Int. Immunopharmacol. 2012, 12:257-270.
-
(2012)
Int. Immunopharmacol.
, vol.12
, pp. 257-270
-
-
Seavey, M.M.1
Lu, L.D.2
Stump, K.L.3
Wallace, N.H.4
Ruggeri, B.A.5
-
101
-
-
84881099907
-
-
European League Against Rheumatism Annual Congress 2011 (EULAR), [SAT0203]
-
Voll R.E., Alexander T., Peukert R., Rubbert A., Rech J., Braun T., Wiesener M., Eckardt K.-U., Hoyer B., Taddeo A., Reisch A., Burmester G.-R., Radbruch A., Schett G., Freiburg F. Successful treatment of refractory SLE patients with the proteasome inhibitor bortezomib - a case series 2012, European League Against Rheumatism Annual Congress 2011 (EULAR), [SAT0203].
-
(2012)
Successful treatment of refractory SLE patients with the proteasome inhibitor bortezomib - a case series
-
-
Voll, R.E.1
Alexander, T.2
Peukert, R.3
Rubbert, A.4
Rech, J.5
Braun, T.6
Wiesener, M.7
Eckardt, K.-U.8
Hoyer, B.9
Taddeo, A.10
Reisch, A.11
Burmester, G.-R.12
Radbruch, A.13
Schett, G.14
Freiburg, F.15
-
102
-
-
80052026069
-
Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus
-
Kyttaris V.C., Tsokos G.C. Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus. Curr. Opin. Rheumatol. 2011, 23:449-453.
-
(2011)
Curr. Opin. Rheumatol.
, vol.23
, pp. 449-453
-
-
Kyttaris, V.C.1
Tsokos, G.C.2
-
103
-
-
77953229472
-
T cells as therapeutic targets in SLE
-
Crispin J.C., Kyttaris V.C., Terhorst C., Tsokos G.C. T cells as therapeutic targets in SLE. Nat. Rev. Rheumatol. 2010, 6:317-325.
-
(2010)
Nat. Rev. Rheumatol.
, vol.6
, pp. 317-325
-
-
Crispin, J.C.1
Kyttaris, V.C.2
Terhorst, C.3
Tsokos, G.C.4
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