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Volumn 148, Issue 3, 2013, Pages 335-343

Cytokine inhibition as a strategy for treating systemic lupus erythematosus

Author keywords

Cytokine Inhibitors; Lupus

Indexed keywords

ABF 13; ADALIMUMAB; AMG 714; ANTIRHEUMATIC AGENT; B N 10; BRODALUMAB; BS 10; CANAKINUMAB; CERTOLIZUMAB PEGOL; CYTOKINE; CYTOKINE RECEPTOR ANTAGONIST; ETANERCEPT; GOLIMUMAB; GSK 1070806; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 6; IXEKIZUMAB; PLACEBO; R H IL 18BP; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT INTERLEUKIN 18; RECOMBINANT INTERLEUKIN 18BP; RILONACEPT; SECUKINUMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; USTEKINUMAB;

EID: 84881110807     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2012.11.001     Document Type: Review
Times cited : (27)

References (107)
  • 1
    • 0025990288 scopus 로고
    • Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
    • Linker-Israeli M., et al. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J. Immunol. 1991, 147(1):117-123.
    • (1991) J. Immunol. , vol.147 , Issue.1 , pp. 117-123
    • Linker-Israeli, M.1
  • 2
    • 84862324329 scopus 로고    scopus 로고
    • Serum and urinary cytokine levels of SLE patients
    • Brugos B., et al. Serum and urinary cytokine levels of SLE patients. Pharmazie 2012, 67(5):411-413.
    • (2012) Pharmazie , vol.67 , Issue.5 , pp. 411-413
    • Brugos, B.1
  • 3
    • 0026560191 scopus 로고
    • Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression
    • Kitani A., et al. Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression. Clin. Exp. Immunol. 1992, 88(1):75-83.
    • (1992) Clin. Exp. Immunol. , vol.88 , Issue.1 , pp. 75-83
    • Kitani, A.1
  • 4
    • 83655164152 scopus 로고    scopus 로고
    • The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis
    • Lee Y.H., et al. The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus 2012, 21(1):60-67.
    • (2012) Lupus , vol.21 , Issue.1 , pp. 60-67
    • Lee, Y.H.1
  • 5
    • 73649123508 scopus 로고    scopus 로고
    • Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
    • Cash H., et al. Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. J. Rheumatol. 2010, 37(1):60-70.
    • (2010) J. Rheumatol. , vol.37 , Issue.1 , pp. 60-70
    • Cash, H.1
  • 6
    • 0032494191 scopus 로고    scopus 로고
    • Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus
    • Richards H.B., et al. Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus. J. Exp. Med. 1998, 188(5):985-990.
    • (1998) J. Exp. Med. , vol.188 , Issue.5 , pp. 985-990
    • Richards, H.B.1
  • 7
    • 84863043835 scopus 로고    scopus 로고
    • Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: current perspectives and future directions
    • Ogata A., Tanaka T. Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: current perspectives and future directions. Int. J. Rheumatol. 2012, 2012:946048.
    • (2012) Int. J. Rheumatol. , vol.2012 , pp. 946048
    • Ogata, A.1    Tanaka, T.2
  • 8
    • 75749113331 scopus 로고    scopus 로고
    • Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
    • Illei G.G., et al. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum. 2010, 62(2):542-552.
    • (2010) Arthritis Rheum. , vol.62 , Issue.2 , pp. 542-552
    • Illei, G.G.1
  • 9
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes I.B., Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 2007, 7(6):429-442.
    • (2007) Nat. Rev. Immunol. , vol.7 , Issue.6 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 10
    • 81455154445 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus
    • Postal M., Appenzeller S. The role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus. Cytokine 2011, 56(3):537-543.
    • (2011) Cytokine , vol.56 , Issue.3 , pp. 537-543
    • Postal, M.1    Appenzeller, S.2
  • 11
    • 0023874728 scopus 로고
    • Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis
    • Jacob C.O., McDevitt H.O. Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis. Nature 1988, 331(6154):356-358.
    • (1988) Nature , vol.331 , Issue.6154 , pp. 356-358
    • Jacob, C.O.1    McDevitt, H.O.2
  • 12
    • 0024330731 scopus 로고
    • Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury
    • Brennan D.C., et al. Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury. J. Immunol. 1989, 143(11):3470-3475.
    • (1989) J. Immunol. , vol.143 , Issue.11 , pp. 3470-3475
    • Brennan, D.C.1
  • 13
    • 84865068306 scopus 로고    scopus 로고
    • Gene expression of cytokines (TNF-alpha, IFN-gamma), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus
    • Rana A., et al. Gene expression of cytokines (TNF-alpha, IFN-gamma), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus. Lupus 2012, 21(10):1105-1112.
    • (2012) Lupus , vol.21 , Issue.10 , pp. 1105-1112
    • Rana, A.1
  • 14
    • 84863583259 scopus 로고    scopus 로고
    • Large scale analysis of tumor necrosis factor alpha levels in systemic lupus erythematosus
    • Weckerle C.E., et al. Large scale analysis of tumor necrosis factor alpha levels in systemic lupus erythematosus. Arthritis Rheum. 2012, 64(9):2947-2952.
    • (2012) Arthritis Rheum. , vol.64 , Issue.9 , pp. 2947-2952
    • Weckerle, C.E.1
  • 15
    • 80052423831 scopus 로고    scopus 로고
    • Etanercept-induced lupus accompanied by hemophagocytic syndrome
    • Araki D., et al. Etanercept-induced lupus accompanied by hemophagocytic syndrome. Intern. Med. 2011, 50(17):1843-1848.
    • (2011) Intern. Med. , vol.50 , Issue.17 , pp. 1843-1848
    • Araki, D.1
  • 16
    • 77950862020 scopus 로고    scopus 로고
    • Tumour necrosis factor inhibitor-related lupus: safety of switching agents
    • Luong J.M., et al. Tumour necrosis factor inhibitor-related lupus: safety of switching agents. Clin. Rheumatol. 2010, 29(5):551-553.
    • (2010) Clin. Rheumatol. , vol.29 , Issue.5 , pp. 551-553
    • Luong, J.M.1
  • 17
    • 71449111969 scopus 로고    scopus 로고
    • Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic
    • Wetter D.A., Davis M.D. Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic. Mayo Clin. Proc. 2009, 84(11):979-984.
    • (2009) Mayo Clin. Proc. , vol.84 , Issue.11 , pp. 979-984
    • Wetter, D.A.1    Davis, M.D.2
  • 18
    • 80053415444 scopus 로고    scopus 로고
    • Anti-nuclear antibody positivity and the use of certolizumab in inflammatory bowel disease patients who have had arthralgias or lupus-like reactions from infliximab or adalimumab
    • Verma H.D., et al. Anti-nuclear antibody positivity and the use of certolizumab in inflammatory bowel disease patients who have had arthralgias or lupus-like reactions from infliximab or adalimumab. J. Dig. Dis. 2011, 12(5):379-383.
    • (2011) J. Dig. Dis. , vol.12 , Issue.5 , pp. 379-383
    • Verma, H.D.1
  • 19
    • 79957867348 scopus 로고    scopus 로고
    • Successful switch of patients with rheumatoid arthritis developing anti-tumor necrosis factor (anti-TNF)-induced lupus to another anti-TNF agent
    • (author reply 1217-8)
    • Ye C., et al. Successful switch of patients with rheumatoid arthritis developing anti-tumor necrosis factor (anti-TNF)-induced lupus to another anti-TNF agent. J. Rheumatol. 2011, 38(6):1216. (author reply 1217-8).
    • (2011) J. Rheumatol. , vol.38 , Issue.6 , pp. 1216
    • Ye, C.1
  • 20
    • 14744276518 scopus 로고    scopus 로고
    • Cross-regulation of TNF and IFN-alpha in autoimmune diseases
    • Palucka A.K., et al. Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(9):3372-3377.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.9 , pp. 3372-3377
    • Palucka, A.K.1
  • 21
    • 49049107714 scopus 로고    scopus 로고
    • A bridge between interferon-alpha and tumor necrosis factor in lupus
    • Aringer M., Crow M.K. A bridge between interferon-alpha and tumor necrosis factor in lupus. J. Rheumatol. 2008, 35(8):1473-1476.
    • (2008) J. Rheumatol. , vol.35 , Issue.8 , pp. 1473-1476
    • Aringer, M.1    Crow, M.K.2
  • 22
    • 49049114716 scopus 로고    scopus 로고
    • Influence of functional interleukin 10/tumor necrosis factor-alpha polymorphisms on interferon-alpha, IL-10, and regulatory T cell population in patients with systemic lupus erythematosus receiving antimalarial treatment
    • Lopez P., et al. Influence of functional interleukin 10/tumor necrosis factor-alpha polymorphisms on interferon-alpha, IL-10, and regulatory T cell population in patients with systemic lupus erythematosus receiving antimalarial treatment. J. Rheumatol. 2008, 35(8):1559-1566.
    • (2008) J. Rheumatol. , vol.35 , Issue.8 , pp. 1559-1566
    • Lopez, P.1
  • 23
    • 59249096762 scopus 로고    scopus 로고
    • Differences in binding and effector functions between classes of TNF antagonists
    • Arora T., et al. Differences in binding and effector functions between classes of TNF antagonists. Cytokine 2009, 45(2):124-131.
    • (2009) Cytokine , vol.45 , Issue.2 , pp. 124-131
    • Arora, T.1
  • 24
    • 0031770199 scopus 로고    scopus 로고
    • The combined inactivation of tumor necrosis factor and interleukin-6 prevents induction of the major acute phase proteins by endotoxin
    • Bopst M., et al. The combined inactivation of tumor necrosis factor and interleukin-6 prevents induction of the major acute phase proteins by endotoxin. Eur. J. Immunol. 1998, 28(12):4130-4137.
    • (1998) Eur. J. Immunol. , vol.28 , Issue.12 , pp. 4130-4137
    • Bopst, M.1
  • 25
    • 0031778836 scopus 로고    scopus 로고
    • Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    • Botto M., et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 1998, 19(1):56-59.
    • (1998) Nat. Genet. , vol.19 , Issue.1 , pp. 56-59
    • Botto, M.1
  • 26
    • 80051751701 scopus 로고    scopus 로고
    • Complement system and rheumatoid arthritis: relationships with autoantibodies, serological, clinical features, and anti-TNF treatment
    • Di Muzio G., et al. Complement system and rheumatoid arthritis: relationships with autoantibodies, serological, clinical features, and anti-TNF treatment. Int. J. Immunopathol. Pharmacol. 2011, 24(2):357-366.
    • (2011) Int. J. Immunopathol. Pharmacol. , vol.24 , Issue.2 , pp. 357-366
    • Di Muzio, G.1
  • 27
    • 0034671575 scopus 로고    scopus 로고
    • Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy
    • Williams R.O., et al. Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy. J. Immunol. 2000, 165(12):7240-7245.
    • (2000) J. Immunol. , vol.165 , Issue.12 , pp. 7240-7245
    • Williams, R.O.1
  • 28
    • 0029112253 scopus 로고
    • Induction of apoptosis in mature T cells by tumour necrosis factor
    • Zheng L., et al. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995, 377(6547):348-351.
    • (1995) Nature , vol.377 , Issue.6547 , pp. 348-351
    • Zheng, L.1
  • 29
    • 77955409102 scopus 로고    scopus 로고
    • Anti-TNF-alpha therapies in systemic lupus erythematosus
    • Zhu L.J., Yang X., Yu X.Q. Anti-TNF-alpha therapies in systemic lupus erythematosus. J. Biomed. Biotechnol. 2010, 2010:465898.
    • (2010) J. Biomed. Biotechnol. , vol.2010 , pp. 465898
    • Zhu, L.J.1    Yang, X.2    Yu, X.Q.3
  • 30
    • 34547597694 scopus 로고    scopus 로고
    • Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus
    • Zhu L., et al. Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus. Clin. Rheumatol. 2007, 26(9):1481-1489.
    • (2007) Clin. Rheumatol. , vol.26 , Issue.9 , pp. 1481-1489
    • Zhu, L.1
  • 31
    • 67049162417 scopus 로고    scopus 로고
    • Efficacy and safety of infliximab in active SLE: a pilot study
    • Uppal S.S., Hayat S.J., Raghupathy R. Efficacy and safety of infliximab in active SLE: a pilot study. Lupus 2009, 18(8):690-697.
    • (2009) Lupus , vol.18 , Issue.8 , pp. 690-697
    • Uppal, S.S.1    Hayat, S.J.2    Raghupathy, R.3
  • 32
    • 5644258326 scopus 로고    scopus 로고
    • Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study
    • Aringer M., et al. Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study. Arthritis Rheum. 2004, 50(10):3161-3169.
    • (2004) Arthritis Rheum. , vol.50 , Issue.10 , pp. 3161-3169
    • Aringer, M.1
  • 33
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010, 10(3):170-181.
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.3 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 34
    • 82755187763 scopus 로고    scopus 로고
    • IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells
    • Le Buanec H., et al. IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(47):18995-19000.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , Issue.47 , pp. 18995-19000
    • Le Buanec, H.1
  • 35
    • 0027513170 scopus 로고
    • Interleukin-10
    • Moore K.W., et al. Interleukin-10. Annu. Rev. Immunol. 1993, 11:165-190.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 165-190
    • Moore, K.W.1
  • 36
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R., et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75(2):263-274.
    • (1993) Cell , vol.75 , Issue.2 , pp. 263-274
    • Kuhn, R.1
  • 37
    • 0037103150 scopus 로고    scopus 로고
    • IL-10 regulates murine lupus
    • Yin Z., et al. IL-10 regulates murine lupus. J. Immunol. 2002, 169(4):2148-2155.
    • (2002) J. Immunol. , vol.169 , Issue.4 , pp. 2148-2155
    • Yin, Z.1
  • 38
    • 0026584291 scopus 로고
    • Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
    • Rousset F., et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 1992, 89(5):1890-1893.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , Issue.5 , pp. 1890-1893
    • Rousset, F.1
  • 39
    • 0029103042 scopus 로고
    • Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4
    • Rousset F., et al. Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4. Int. Immunol. 1995, 7(8):1243-1253.
    • (1995) Int. Immunol. , vol.7 , Issue.8 , pp. 1243-1253
    • Rousset, F.1
  • 40
    • 84866750489 scopus 로고    scopus 로고
    • Serum cytokine profile in patients with active lupus nephritis
    • Koenig K.F., et al. Serum cytokine profile in patients with active lupus nephritis. Cytokine 2012, 60(2):410-416.
    • (2012) Cytokine , vol.60 , Issue.2 , pp. 410-416
    • Koenig, K.F.1
  • 41
    • 84863238148 scopus 로고    scopus 로고
    • Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE
    • Su D.L., et al. Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. J. Biomed. Biotechnol. 2012, 2012:347141.
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 347141
    • Su, D.L.1
  • 42
    • 27744575802 scopus 로고    scopus 로고
    • The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus
    • Wang H., et al. The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus. Cell. Immunol. 2005, 235(2):117-121.
    • (2005) Cell. Immunol. , vol.235 , Issue.2 , pp. 117-121
    • Wang, H.1
  • 43
    • 33750341662 scopus 로고    scopus 로고
    • IL-10 regulation of lupus in the NZM2410 murine model
    • Blenman K.R., et al. IL-10 regulation of lupus in the NZM2410 murine model. Lab. Invest. 2006, 86(11):1136-1148.
    • (2006) Lab. Invest. , vol.86 , Issue.11 , pp. 1136-1148
    • Blenman, K.R.1
  • 44
    • 1842866220 scopus 로고    scopus 로고
    • Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody
    • Ravirajan C.T., et al. Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody. Rheumatology (Oxford) 2004, 43(4):442-447.
    • (2004) Rheumatology (Oxford) , vol.43 , Issue.4 , pp. 442-447
    • Ravirajan, C.T.1
  • 45
    • 0033883903 scopus 로고    scopus 로고
    • Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus
    • Llorente L., et al. Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus. Arthritis Rheum. 2000, 43(8):1790-1800.
    • (2000) Arthritis Rheum. , vol.43 , Issue.8 , pp. 1790-1800
    • Llorente, L.1
  • 46
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117(14):3720-3732.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3720-3732
    • Dinarello, C.A.1
  • 47
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 2009, 27:519-550.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 48
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C., et al. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 2006, 203(7):1685-1691.
    • (2006) J. Exp. Med. , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1
  • 49
    • 78650470600 scopus 로고    scopus 로고
    • Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus
    • Migliorini P., et al. Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus. Eur. Cytokine Netw. 2010, 21(4):264-271.
    • (2010) Eur. Cytokine Netw. , vol.21 , Issue.4 , pp. 264-271
    • Migliorini, P.1
  • 50
    • 0031457105 scopus 로고    scopus 로고
    • Low levels of interleukin-1 receptor antagonist coincide with kidney involvement in systemic lupus erythematosus
    • Sturfelt G., et al. Low levels of interleukin-1 receptor antagonist coincide with kidney involvement in systemic lupus erythematosus. Br. J. Rheumatol. 1997, 36(12):1283-1289.
    • (1997) Br. J. Rheumatol. , vol.36 , Issue.12 , pp. 1283-1289
    • Sturfelt, G.1
  • 51
    • 77954473988 scopus 로고    scopus 로고
    • Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease
    • Brugos B., et al. Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease. Hum. Immunol. 2010, 71(9):874-877.
    • (2010) Hum. Immunol. , vol.71 , Issue.9 , pp. 874-877
    • Brugos, B.1
  • 52
    • 0347320524 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States
    • Parks C.G., et al. Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States. Ann. Rheum. Dis. 2004, 63(1):91-94.
    • (2004) Ann. Rheum. Dis. , vol.63 , Issue.1 , pp. 91-94
    • Parks, C.G.1
  • 53
    • 65549124475 scopus 로고    scopus 로고
    • Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
    • Jacob C.O., et al. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(15):6256-6261.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , Issue.15 , pp. 6256-6261
    • Jacob, C.O.1
  • 54
    • 33747512850 scopus 로고    scopus 로고
    • IL-1 beta-deficient mice are resistant to induction of experimental SLE
    • Voronov E., et al. IL-1 beta-deficient mice are resistant to induction of experimental SLE. Eur. Cytokine Netw. 2006, 17(2):109-116.
    • (2006) Eur. Cytokine Netw. , vol.17 , Issue.2 , pp. 109-116
    • Voronov, E.1
  • 55
    • 84874206379 scopus 로고    scopus 로고
    • IL-1 family cytokines trigger sterile inflammatory disease
    • Lukens J.R., Gross J.M., Kanneganti T.D. IL-1 family cytokines trigger sterile inflammatory disease. Front. Immunol. 2012, 3:315.
    • (2012) Front. Immunol. , vol.3 , pp. 315
    • Lukens, J.R.1    Gross, J.M.2    Kanneganti, T.D.3
  • 56
    • 4344643654 scopus 로고    scopus 로고
    • IL-1RA in refractory systemic lupus erythematosus
    • Moosig F., et al. IL-1RA in refractory systemic lupus erythematosus. Lupus 2004, 13(8):605-606.
    • (2004) Lupus , vol.13 , Issue.8 , pp. 605-606
    • Moosig, F.1
  • 57
    • 16344374294 scopus 로고    scopus 로고
    • Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis
    • Ostendorf B., et al. Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis. Ann. Rheum. Dis. 2005, 64(4):630-633.
    • (2005) Ann. Rheum. Dis. , vol.64 , Issue.4 , pp. 630-633
    • Ostendorf, B.1
  • 58
    • 0033772374 scopus 로고    scopus 로고
    • Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus
    • Wong C.K., et al. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 2000, 9(8):589-593.
    • (2000) Lupus , vol.9 , Issue.8 , pp. 589-593
    • Wong, C.K.1
  • 59
    • 67649197343 scopus 로고    scopus 로고
    • Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
    • Doreau A., et al. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 2009, 10(7):778-785.
    • (2009) Nat. Immunol. , vol.10 , Issue.7 , pp. 778-785
    • Doreau, A.1
  • 60
    • 79953323051 scopus 로고    scopus 로고
    • IL-17-producing T cells in lupus nephritis
    • Apostolidis S.A., Crispin J.C., Tsokos G.C. IL-17-producing T cells in lupus nephritis. Lupus 2011, 20(2):120-124.
    • (2011) Lupus , vol.20 , Issue.2 , pp. 120-124
    • Apostolidis, S.A.1    Crispin, J.C.2    Tsokos, G.C.3
  • 61
    • 84862833461 scopus 로고    scopus 로고
    • Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus
    • Yang J., et al. Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus. Rheumatology (Oxford) 2011, 50(8):1366-1372.
    • (2011) Rheumatology (Oxford) , vol.50 , Issue.8 , pp. 1366-1372
    • Yang, J.1
  • 62
    • 66049151440 scopus 로고    scopus 로고
    • Th17 and natural Treg cell population dynamics in systemic lupus erythematosus
    • Yang J., et al. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 2009, 60(5):1472-1483.
    • (2009) Arthritis Rheum. , vol.60 , Issue.5 , pp. 1472-1483
    • Yang, J.1
  • 63
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy M.J., et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 2007, 8(12):1390-1397.
    • (2007) Nat. Immunol. , vol.8 , Issue.12 , pp. 1390-1397
    • McGeachy, M.J.1
  • 64
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish C.L., et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005, 201(2):233-240.
    • (2005) J. Exp. Med. , vol.201 , Issue.2 , pp. 233-240
    • Langrish, C.L.1
  • 65
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • Crispin J.C., et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 2008, 181(12):8761-8766.
    • (2008) J. Immunol. , vol.181 , Issue.12 , pp. 8761-8766
    • Crispin, J.C.1
  • 66
    • 77953536871 scopus 로고    scopus 로고
    • Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity
    • Chen X.Q., et al. Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity. J. Clin. Immunol. 2010, 30(2):221-225.
    • (2010) J. Clin. Immunol. , vol.30 , Issue.2 , pp. 221-225
    • Chen, X.Q.1
  • 67
    • 84865704333 scopus 로고    scopus 로고
    • IL-17: A new actor in IFN-driven systemic autoimmune diseases
    • Ambrosi A., Espinosa A., Wahren-Herlenius M. IL-17: A new actor in IFN-driven systemic autoimmune diseases. Eur. J. Immunol. 2012, 42(9):2274-2284.
    • (2012) Eur. J. Immunol. , vol.42 , Issue.9 , pp. 2274-2284
    • Ambrosi, A.1    Espinosa, A.2    Wahren-Herlenius, M.3
  • 68
    • 70349238893 scopus 로고    scopus 로고
    • The role of IL-23/IL-17 axis in lupus nephritis
    • Zhang Z., Kyttaris V.C., Tsokos G.C. The role of IL-23/IL-17 axis in lupus nephritis. J. Immunol. 2009, 183(5):3160-3169.
    • (2009) J. Immunol. , vol.183 , Issue.5 , pp. 3160-3169
    • Zhang, Z.1    Kyttaris, V.C.2    Tsokos, G.C.3
  • 69
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C., et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 2012, 366(13):1190-1199.
    • (2012) N. Engl. J. Med. , vol.366 , Issue.13 , pp. 1190-1199
    • Leonardi, C.1
  • 70
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese M.C., et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 2010, 62(4):929-939.
    • (2010) Arthritis Rheum. , vol.62 , Issue.4 , pp. 929-939
    • Genovese, M.C.1
  • 71
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012, 61(12):1693-1700.
    • (2012) Gut , vol.61 , Issue.12 , pp. 1693-1700
    • Hueber, W.1
  • 72
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W., et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci. Transl. Med. 2010, 2(52):52ra72.
    • (2010) Sci. Transl. Med. , vol.2 , Issue.52
    • Hueber, W.1
  • 73
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study, Ann
    • (in press)
    • M.C. Genovese, et al., Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study, Ann. Rheum. Dis. (in press), http://dx.doi/10.1136/annrheumdis-2012-201601.
    • Rheum. Dis.
    • Genovese, M.C.1
  • 74
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp K.A., et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N. Engl. J. Med. 2012, 366(13):1181-1189.
    • (2012) N. Engl. J. Med. , vol.366 , Issue.13 , pp. 1181-1189
    • Papp, K.A.1
  • 75
    • 77953196382 scopus 로고    scopus 로고
    • Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice
    • Kyttaris V.C., et al. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J. Immunol. 2010, 184(9):4605-4609.
    • (2010) J. Immunol. , vol.184 , Issue.9 , pp. 4605-4609
    • Kyttaris, V.C.1
  • 76
    • 77949450368 scopus 로고    scopus 로고
    • The use of ustekinumab in autoimmune disease
    • Ryan C., et al. The use of ustekinumab in autoimmune disease. Expert. Opin. Biol. Ther. 2010, 10(4):587-604.
    • (2010) Expert. Opin. Biol. Ther. , vol.10 , Issue.4 , pp. 587-604
    • Ryan, C.1
  • 77
    • 80051700035 scopus 로고    scopus 로고
    • Successful treatment of subacute lupus erythematosus with ustekinumab
    • De Souza A., et al. Successful treatment of subacute lupus erythematosus with ustekinumab. Arch. Dermatol. 2011, 147(8):896-898.
    • (2011) Arch. Dermatol. , vol.147 , Issue.8 , pp. 896-898
    • De Souza, A.1
  • 78
    • 84860191325 scopus 로고    scopus 로고
    • Response to ustekinumab in a patient with both severe psoriasis and hypertrophic cutaneous lupus
    • Winchester D., Duffin K.C., Hansen C. Response to ustekinumab in a patient with both severe psoriasis and hypertrophic cutaneous lupus. Lupus 2012, 21(9):1007-1010.
    • (2012) Lupus , vol.21 , Issue.9 , pp. 1007-1010
    • Winchester, D.1    Duffin, K.C.2    Hansen, C.3
  • 79
    • 0034610970 scopus 로고    scopus 로고
    • Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    • Kennedy M.K., et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 2000, 191(5):771-780.
    • (2000) J. Exp. Med. , vol.191 , Issue.5 , pp. 771-780
    • Kennedy, M.K.1
  • 80
    • 79952246247 scopus 로고    scopus 로고
    • Role of IL-15 in immune-mediated and infectious diseases
    • Di Sabatino A., et al. Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev. 2011, 22(1):19-33.
    • (2011) Cytokine Growth Factor Rev. , vol.22 , Issue.1 , pp. 19-33
    • Di Sabatino, A.1
  • 81
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziato F., et al. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204(8):1849-1861.
    • (2007) J. Exp. Med. , vol.204 , Issue.8 , pp. 1849-1861
    • Annunziato, F.1
  • 82
    • 71649100833 scopus 로고    scopus 로고
    • Trans-presentation: a novel mechanism regulating IL-15 delivery and responses
    • Stonier S.W., Schluns K.S. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol. Lett. 2010, 127(2):85-92.
    • (2010) Immunol. Lett. , vol.127 , Issue.2 , pp. 85-92
    • Stonier, S.W.1    Schluns, K.S.2
  • 83
    • 28544441190 scopus 로고    scopus 로고
    • IL-15 and IL-15R in leucocytes from patients with systemic lupus erythematosus
    • Baranda L., et al. IL-15 and IL-15R in leucocytes from patients with systemic lupus erythematosus. Rheumatology (Oxford) 2005, 44(12):1507-1513.
    • (2005) Rheumatology (Oxford) , vol.44 , Issue.12 , pp. 1507-1513
    • Baranda, L.1
  • 84
    • 58849147143 scopus 로고    scopus 로고
    • Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against SLE
    • Bo H., et al. Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against SLE. Scand. J. Immunol. 2009, 69(2):119-129.
    • (2009) Scand. J. Immunol. , vol.69 , Issue.2 , pp. 119-129
    • Bo, H.1
  • 85
    • 0033174339 scopus 로고    scopus 로고
    • Elevated serum interleukin-15 levels in systemic lupus erythematosus
    • Park Y.B., et al. Elevated serum interleukin-15 levels in systemic lupus erythematosus. Yonsei Med. J. 1999, 40(4):343-348.
    • (1999) Yonsei Med. J. , vol.40 , Issue.4 , pp. 343-348
    • Park, Y.B.1
  • 86
    • 0034869941 scopus 로고    scopus 로고
    • Serum interleukin-15 is elevated in systemic lupus erythematosus
    • Aringer M., et al. Serum interleukin-15 is elevated in systemic lupus erythematosus. Rheumatology (Oxford) 2001, 40(8):876-881.
    • (2001) Rheumatology (Oxford) , vol.40 , Issue.8 , pp. 876-881
    • Aringer, M.1
  • 87
    • 0036635843 scopus 로고    scopus 로고
    • Proinflammatory interferon-gamma-inducing monokines (interleukin-12, interleukin-18, interleukin-15)-serum profile in patients with systemic lupus erythematosus
    • Robak E., et al. Proinflammatory interferon-gamma-inducing monokines (interleukin-12, interleukin-18, interleukin-15)-serum profile in patients with systemic lupus erythematosus. Eur. Cytokine Netw. 2002, 13(3):364-368.
    • (2002) Eur. Cytokine Netw. , vol.13 , Issue.3 , pp. 364-368
    • Robak, E.1
  • 88
    • 6344269986 scopus 로고    scopus 로고
    • Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    • Ferrari-Lacraz S., et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J. Immunol. 2004, 173(9):5818-5826.
    • (2004) J. Immunol. , vol.173 , Issue.9 , pp. 5818-5826
    • Ferrari-Lacraz, S.1
  • 89
    • 25444519432 scopus 로고    scopus 로고
    • Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study
    • Baslund B., et al. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum. 2005, 52(9):2686-2692.
    • (2005) Arthritis Rheum. , vol.52 , Issue.9 , pp. 2686-2692
    • Baslund, B.1
  • 90
    • 84857117757 scopus 로고    scopus 로고
    • Elevated interleukin-18 and skewed Th1:Th2 immune response in lupus nephritis
    • Liu X., Bao C., Hu D. Elevated interleukin-18 and skewed Th1:Th2 immune response in lupus nephritis. Rheumatol. Int. 2012, 32(1):223-229.
    • (2012) Rheumatol. Int. , vol.32 , Issue.1 , pp. 223-229
    • Liu, X.1    Bao, C.2    Hu, D.3
  • 91
    • 4644286915 scopus 로고    scopus 로고
    • Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis
    • Calvani N., et al. Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis. Clin. Exp. Immunol. 2004, 138(1):171-178.
    • (2004) Clin. Exp. Immunol. , vol.138 , Issue.1 , pp. 171-178
    • Calvani, N.1
  • 92
    • 33847336449 scopus 로고    scopus 로고
    • Interleukin-18 and the pathogenesis of inflammatory diseases
    • Dinarello C.A. Interleukin-18 and the pathogenesis of inflammatory diseases. Semin. Nephrol. 2007, 27(1):98-114.
    • (2007) Semin. Nephrol. , vol.27 , Issue.1 , pp. 98-114
    • Dinarello, C.A.1
  • 93
    • 82755162135 scopus 로고    scopus 로고
    • Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus
    • Kahlenberg J.M., et al. Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. J. Immunol. 2011, 187(11):6143-6156.
    • (2011) J. Immunol. , vol.187 , Issue.11 , pp. 6143-6156
    • Kahlenberg, J.M.1
  • 94
    • 79551573789 scopus 로고    scopus 로고
    • Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice
    • Menke J., et al. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Kidney Int. 2011, 79(4):452-463.
    • (2011) Kidney Int. , vol.79 , Issue.4 , pp. 452-463
    • Menke, J.1
  • 95
    • 0032532016 scopus 로고    scopus 로고
    • Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme)
    • Kim Y.M., et al. Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). J. Immunol. 1998, 161(8):4122-4128.
    • (1998) J. Immunol. , vol.161 , Issue.8 , pp. 4122-4128
    • Kim, Y.M.1
  • 96
    • 0032400918 scopus 로고    scopus 로고
    • Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis
    • Wildbaum G., et al. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J. Immunol. 1998, 161(11):6368-6374.
    • (1998) J. Immunol. , vol.161 , Issue.11 , pp. 6368-6374
    • Wildbaum, G.1
  • 97
    • 84861480337 scopus 로고    scopus 로고
    • High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosus
    • Shimizu C., et al. High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosus. Mod. Rheumatol. 2012, 22(1):73-79.
    • (2012) Mod. Rheumatol. , vol.22 , Issue.1 , pp. 73-79
    • Shimizu, C.1
  • 98
    • 77956261780 scopus 로고    scopus 로고
    • Expressions of IL-18 and its binding protein in peripheral blood leukocytes and kidney tissues of lupus nephritis patients
    • Hu D., et al. Expressions of IL-18 and its binding protein in peripheral blood leukocytes and kidney tissues of lupus nephritis patients. Clin. Rheumatol. 2010, 29(7):717-721.
    • (2010) Clin. Rheumatol. , vol.29 , Issue.7 , pp. 717-721
    • Hu, D.1
  • 99
    • 34548174188 scopus 로고    scopus 로고
    • Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis
    • Liang D., et al. Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis. Cell. Mol. Immunol. 2006, 3(4):303-306.
    • (2006) Cell. Mol. Immunol. , vol.3 , Issue.4 , pp. 303-306
    • Liang, D.1
  • 100
    • 75349084506 scopus 로고    scopus 로고
    • High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein
    • Novick D., et al. High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein. J. Autoimmun. 2010, 34(2):121-126.
    • (2010) J. Autoimmun. , vol.34 , Issue.2 , pp. 121-126
    • Novick, D.1
  • 101
    • 0034326652 scopus 로고    scopus 로고
    • IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18
    • Debets R., et al. IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18. J. Immunol. 2000, 165(9):4950-4956.
    • (2000) J. Immunol. , vol.165 , Issue.9 , pp. 4950-4956
    • Debets, R.1
  • 102
    • 0032983336 scopus 로고    scopus 로고
    • Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response
    • Novick D., et al. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity 1999, 10(1):127-136.
    • (1999) Immunity , vol.10 , Issue.1 , pp. 127-136
    • Novick, D.1
  • 103
    • 0035927494 scopus 로고    scopus 로고
    • A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18
    • Novick D., et al. A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine 2001, 14(6):334-342.
    • (2001) Cytokine , vol.14 , Issue.6 , pp. 334-342
    • Novick, D.1
  • 104
    • 18844481515 scopus 로고    scopus 로고
    • Defective NK cell activity and Th1 response in IL-18-deficient mice
    • Takeda K., et al. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998, 8(3):383-390.
    • (1998) Immunity , vol.8 , Issue.3 , pp. 383-390
    • Takeda, K.1
  • 105
    • 0035664487 scopus 로고    scopus 로고
    • Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
    • Plater-Zyberk C., et al. Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. J. Clin. Invest. 2001, 108(12):1825-1832.
    • (2001) J. Clin. Invest. , vol.108 , Issue.12 , pp. 1825-1832
    • Plater-Zyberk, C.1
  • 106
    • 0038685647 scopus 로고    scopus 로고
    • Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice
    • Smeets R.L., et al. Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice. Gene Ther. 2003, 10(12):1004-1011.
    • (2003) Gene Ther. , vol.10 , Issue.12 , pp. 1004-1011
    • Smeets, R.L.1
  • 107
    • 33746687953 scopus 로고    scopus 로고
    • Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasis
    • Tak P.P., Bacchi M., Bertolino M. Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasis. Eur. J. Drug Metab. Pharmacokinet. 2006, 31(2):109-116.
    • (2006) Eur. J. Drug Metab. Pharmacokinet. , vol.31 , Issue.2 , pp. 109-116
    • Tak, P.P.1    Bacchi, M.2    Bertolino, M.3


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