Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

Biochemical Journal

Volumn 400, Issue 1, 2006, Pages 179-188

  Dif, Nicolas ^a   Euthine, Vanessa ^a   Gonnet, Estelle ^a   Laville, Martine ^a,b   Vidal, Hubert ^a,b   Lefai, Etienne ^a  

^a UNIVERSITÉ LYON 1   (France)

^b HOSPICES CIVILS DE LYON   (France)

Author keywords

Insulin; Liver X receptor (LXR); Promoter; Sterol regulatory element binding protein 1c (SREBP 1c); Sterol response element; Transcription

Indexed keywords

ACTIVATION ANALYSIS; CELLS; GENES; GENETIC ENGINEERING; INSULIN; MUSCLE;

LIVER X RECEPTOR (LXR); PROMOTERS; STEROL-REGULATORY-ELEMENT-BINDING PROTEIN-1C (SREBP-1C); STEROL-RESPONSE ELEMENTS;

PROTEINS;

INSULIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR;

ADENOVIRUS; ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SKELETAL MUSCLE;

ADIPOSE TISSUE; BINDING SITES; CELL LINE; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; HUMANS; INSULIN; MUSCLE, SKELETAL; MUTATION; PERFUSION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 33751117989     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060499     Document Type: Article

References (38)

1. O'Brien, R. M. and Granner, D. K. (1996) Regulation of gene expression by insulin. Physiol. Rev. 76, 1109-1161
2. Rome, S., Clement, K., Rabasa-Lhoret, R., Loizon, E., Poitou, C., Barsh, G. S., Riou, J. P., Laville, M. and Vidal, H. (2003) Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. J. Biol. Chem. 278, 18063-18068
3. Ducluzeau, P. H., Perretti, N., Laville, M., Andreelli, F., Vega, N., Riou, J. P. and Vidal, H. (2001) Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50, 1134-1142
4. Patti, M. E. (2004) Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology? Curr. Opin. Clin. Nutr. Metab. Care 7, 383-390
5. Latasa, M. J., Griffin, M. J., Moon, Y. S., Kang, C. and Sul, H. S. (2003) Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals. Mol. Cell. Biol. 23, 5896-5907
6. Oh, S. Y., Park, S. K., Kim, J. W., Ahn, Y. H., Park, S. W. and Kim, K. S. (2003) Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver. J. Biol. Chem. 278, 28410-28417
7. Gosmain, Y., Lefai, E., Ryser, S., Roques, M. and Vidal, H. (2004) Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells. Diabetes 53, 321-329
8. Osborne, T. F. (2000) Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J. Biol. Chem. 275, 32379-32382
9. Foufelle, F. and Ferre, P. (2002) New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J. 366, 377-391
10. Brown, M. S. and Goldstein, J. S. (1999) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. U.S.A. 96, 11041-11048
11. Brown, M. S. and Goldstein, J. L. (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340
12. Amemiya-Kudo, M., Shimano, H., Hasty, A. H., Yahagi, N., Yoshikawa, T., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K. et al. (2002) Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. J. Lipid Res. 43, 1220-1235
13. Gosmain, Y., Dif, N., Berbe, V., Loizon, E., Rieusset, J., Vidal, H. and Lefai, E. (2005) Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues. J. Lipid Res. 46, 697-705
14. Shimomura, I., Bashmakov, Y., Ikemoto, S., Horton, J. D., Brown, M. S. and Goldstein, J. L. (1999) Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. U.S.A. 96, 13656-13661
15. Guillet-Deniau, I., Mieulet, V., Le Lay, S., Achouri, Y., Carré, D., Girard, J., Foufelle, F. and Ferré, P. (2002) Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression. Diabetes 51, 1722-1728
16. Azzout-Marniche, D., Becard, D., Guichard, C., Foretz, M., Ferre, P. and Foufelle, F. (2000) Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem. J. 350, 389-393
17. Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K. et al. (2000) Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. J. Biol. Chem. 275, 31078-31085
18. Repa, J. J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J. M., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L. and Mangelsdorf, D. J. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 14, 2819-2830
19. Cagen, L. M., Deng, X., Wilcox, H. G., Park, E. A., Raghow, R. and Elam, M. B. (2005) Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem. J. 385, 207-216
20. Schultz, J. R., Tu, H., Luk, A., Repa, J. J., Medina, J. C., Li, L., Schwendner, S., Wang, S., Thoolen, M., Mangelsdorf, D. J. et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14, 2831-2838
21. Yoshikawa, T., Shimano, H., Amemiya-Kudo, M., Yahagi, N., Hasty, A. H., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K. et al. (2001) Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol. Cell. Biol. 21, 2991-3000
22. Cozzone, D., Debard, C., Dif, N., Ricard, N, Disse, E., Vouillarmet, J., Rabasa-Lhoret, R., Laville, M., Pruneau, D., Rieusset, J. et al. (2006) Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells. Diabetologia 49, 990-999
23. DeBose-Boyd, R. A., Ou, J., Goldstein, J. L. and Brown, M. S. (2001) Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc. Natl. Acad. Sci. U.S.A. 98, 1477-1482
24. Chen, G., Liang, G., Ou, J., Goldstein, J. L. and Brown, M. S. (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc. Natl. Acad. Sci. U.S.A. 101, 11245-11250
25. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
26. Zabarovsky, E. R., Gizatullin, R., Podowski, R. M., Zabarovska, V. V., Xie, L., Muravenko, O. V., Kozyrev, S., Petrenko, L., Skobeleva, N., Li, J. et al. (2000) Notl clones in the analysis of the human genome. Nucleic Acids Res. 28, 1635-1639
27. Chaussade, C., Pirola, L., Bonnafous, S., Blondeau, F., Brenz-Verca, S., Tronchere, H., Portis, F., Rusconi, S., Payrastre, B., Laporte, J. and Van Obberghen, E. (2003) Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol. Endocrinol. 17, 2448-2460
28. Kast-Woelbern, H. R., Dana, S. L., Cesario, R. M., Sun, L., de Grandpre, L. Y., Brooks, M. E., Osburn, D. L., Reifel-Miller, A., Klausing, K. and Leibowitz, M. D. (2004) Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis. J. Biol. Chem. 279, 23908-23915
29. Roth, G., Kotzka, J., Kremer, L., Lehr, S., Lohaus, C., Meyer, H. E., Krone, W. and Muller-Wieland, D. (2000) MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. J. Biol. Chem. 275, 33302-33307
30. Giandomenico, V., Simonsson, M., Gronroos, E. and Ericsson, J. (2003) Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol. Cell. Biol. 23, 2587-2599
31. Kim, K. H., Song, M. J., Yoo, E. J., Choe, S. S., Park, S. D. and Kim, J. B. (2004) Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c. J. Biol. Chem. 279, 51999-52006
32. Sundqvist, A., Bengoechea-Alonso, M. T., Ye, X., Lukiyancnuk, V., Jin, J., Harper, J. W. and Ericsson, J. (2005) Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell. Metab. 1, 379-391
33. Sakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S. and Goldstein, J. L. (1996) Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85, 1037-1046
34. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L. and Brown, M. S. (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110, 489-500
35. Yabe, D., Brown, M. S. and Goldstein, J. L. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 99, 12753-12758
36. Hegarty, B. D., Bobard, A., Hainault, I., Ferre, P., Bossard, P. and Foufelle, F. (2005) Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc, Natl. Acad. Sci. U.S.A. 102, 791-796
37. Engelking, L. J., Kuriyama, H., Hammer, R. E., Horton, J. D., Brown, M. S., Goldstein, J. L. and Liang, G. (2004) Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J. Clin. Invest. 113, 1168-1175
38. Yabe, D., Komuro, R., Liang, G., Goldstein, J. L. and Brown, M. S. (2003) Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 100, 3155-3160