Immunohistochemical distribution of activated nuclear factor κB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats

Histochemistry and Cell Biology

Volumn 123, Issue 6, 2005, Pages 585-593

  Orfila, Claudine ^a   Lepert, Jean Claude ^a   Alric, Laurent ^b   Carrera, Georges ^a   Béraud, Maryse ^a   Pipy, Bernard ^a  

^a IFR 31   (France)

^b CHU PURPAN   (France)

Author keywords

Carbon tetrachloride (CCl4); Liver immunohistochemistry; NF kappa B (NF B); Peroxisome proliferator activated receptors (PPARs); Rat

Indexed keywords

CARBON TETRACHLORIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL ISOLATION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; FATTY LIVER; IMMUNOHISTOCHEMISTRY; INTOXICATION; KUPFFER CELL; LIVER CELL; LIVER CIRRHOSIS; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT;

ANIMALS; CARBON TETRACHLORIDE; CHRONIC DISEASE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; KUPFFER CELLS; LIVER; LIVER DISEASES; MALE; NF-KAPPA B; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PPAR ALPHA; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 23744479064     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-005-0785-2     Document Type: Article

References (41)

1. Alric L, Pinelli E, Carrera G, Vinel J, Beraud M, Duffaut M, Pascal JP, Pipy B (1996) Involvement of calcium in macrophage leukotriene release during experimental cirrhosis. Hepatology 23:614-622
2. 4. Inflamm Res 49:700-707
3. Angermuller S, Fahimi HD (1988) Heterogenous staining of D-amino acid oxidase in peroxisomes of rat liver and kidney. A light and electron microscopic study. Histochemistry 88:277-285
4. Armendariz-Borunda J, Seyer JM, Postlethwaite AE, Kang AH (1991) Kupffer cells from carbon tetrachloride-injured rat livers produce chemotactic factors for fibroblasts and monocytes: the role of tumor necrosis factor-α. Hepatology 14:895-900
5. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H (1997) Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans. Diabetes 46:1319-1327
6. Auwerx J, Martin G, Guerre-Milo M, Staels B (1996) Transcription adipocyte differentiation and obesity. J Molec Med 74:347-352
7. Beier K, Volki A, Fahimi HD (1997) TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver. FEBS Lett 412:385-387
8. Braissant O, Foufelle F, Scotto C, Dauça M, Wahli W (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, -γ in the adult rat. Endocrinology 137:354-366
9. Burr AW, Carpenter MR, Hines JE, Gullick WJ, Burt AD (1993) Intrahepatic distribution of transforming growth factor-alpha (TGF alpha) during liver regeneration following carbon tetrachloride-induced necrosis. J Pathol 170:95-100
10. Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, Teissier E, Minnich A, Jaye M, Duverger N, Bewer HB, Fruchart JC, Clavey V, Staels B (2001) PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7:53-58
11. Chung SW, Kang BY, Kim SH, Kim YM, Cho D, Trinchieri G, Kim TS (2000) Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between PPARγ and NF-κB. J Biol Chem 276:32861-32867
12. Davies GF, Khandelwal RL, Roesler WJ (1999) Troglitazone induces expression of PPARγ in liver. Mol Cell Biol Res Commun 2:202-208
13. Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B (1999) Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κ and AP-1. J Biol Chem 274:32048-32054
14. ElSisi AE, Hall P, Sim WL, Earnest DL, Sipes IG (1993) Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. Toxicol Appl Pharmacol 119:280-288
15. Everett L, Galli A, Crabb D (2000) The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 20:191-199
16. Gossart S, Cambon C, Orfila C, Seguélas MH, Lepert JC, Rami J, Carré P, Pipy B (1996) Reactive oxygen intermediates as regulators of TNF-α production in rat lung inflammation induced by silica. J Immunol 156:1540-1548
17. Hu E, Tontonoz P, Spiegelman BM (1995) Transdifferentiation of myoblasts by the adipocyte transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci 92:9856-9860
18. Huang Q, Yeldandi AV, Alvares K, Ide H, Reddy JK, Rao MS (1995) Localization of peroxisome proliferator-activated receptor in mouse and rat tissues and demonstration of its nuclear translocation in transfected CV-1 cells. Int J Oncol 6:307-312
19. Imuro Y, Frankenberg MV, Arteel GE, Bradford BU, Wall CA, Thurman RG (1997) Female rats exhibit greater susceptibility to early alcohol-induced injury than males. Am J Physiol Gastrointest Liver Physiol 272:G1186-G1194
20. Ip E, Farrell G, Robertson G, Leclercq I (2004) Administration of the potent PPARalpha agonist, WY-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 39:1286-1296
21. Jiang C, Ting AT, Seed B (1998) PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82-86
22. Johnson SJ, Hines JE, Burt AD (1992) Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol 166:351-358
23. Kon K, Ikejima K, Hirose M, Yoshikawa M, Enomoto N, Kitamura T, Takei Y, Sato N (2002) Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride. Biochem Biophys Res Commun 15:55-61
24. Lemberger T, Braissant O, Juge-Aubry C, Keller H, Saladin R, Staels B, Auwerx J, Burger AG, Meier CA, Wahli W (1996) PPAR tissue distribution and interactions with other hormone-signaling pathways. Ann N Y Acad Sci 804:231-251
25. Loud AV (1968) A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J Cell Biol 37:27-46
26. 4-induces hepatitis. Mediators Inflamm 13:62
27. Marx N, Sukhova G, Murphy C, Libby P, Plutzky J (1998) Macrophages in human atheroma contain PPARγ. Am J Pathol 153:17-23
28. Moller DE, Berger JP (2003) Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord 27(Suppl 3):S17-21
29. Mukherjee R, Jow L, Noonan D, McDonnell D (1994) Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51:157-166
30. Neve BP, Fruchart J, Staels B (2000) Role of the peroxisome proliferator-activated receptors (PPAR) in atheroscleosis. Biochem Pharmacol 60:1245-1250
31. Orfila C, Lepert JC, Gossart S, Frisach MF, Cambon C, Pipy B (1998) Immunocytochemical characterization of lung macrophage surface phenotypes and expression of cytokines in acute experimental silicosis in mice. Histochem J 30:857-867
32. Orfila C, Lepert JC, Alric L, Carrera G, Beraud M, Vinel JP, Pipy B (1999) Expression of TNF-alpha and immunohistochemical distribution of hepatic macrophage surface markers in carbon tetrachloride-induced chronic liver injury in rats. Histochem J 31:677-685
33. Peters JM, Rusyn I, Rose ML, Gonzalez FJ, Thurman G (2000) Peroxisome proliferator-activated receptor α is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis 21:823-826
34. Poynter ME, Daynes RA (1998) Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 49:32833-32841
35. Proctor E, Chatamra K (1982) High yield micronodular cirrhosis in the rat. Gastroenterology 83:1183-1190
36. Rao MS, Papreddy K, Musunuri S, Okonkwo A (2002) Preventional/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator- activated receptor alpha ligand in rats. In vivo 16:145-152
37. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79-82
38. Rusyn I, Rose ML, Bojes HK, Thurman RG (2000) Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. Antiox Redox Signal 2:607-621
39. Schreck R, Albermann KAJ, Baeurle PA (1992) Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukariotic cells (a review). Free Radic Res Commun 17:221-237
40. Sorensen HN, Treuter E, Gustafsson JA (1998) Regulation of peroxisome proliferator-activated receptors. Vitam Horm 54:121-126
41. Spencer NF, Poynter ME, Im SY, Daynes RA (1997) Constitutive activation of NF-kappa B in an animal model of aging. Int Immunol 9:1581-1588