Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture

Pharmacological Research

Volumn 44, Issue 5, 2001, Pages 431-436

  Gutierrez Ruiz M C ^a   Bucio, L ^a   Correa, A ^a   Souza, V ^a   Hernandez E ^a   Gomez Quiroz L E ^a   Kershenobich, D ^b  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Acetaldehyde; Ethanol; Hepatic stellate cells; Hepatocytes; Metadoxine

Indexed keywords

ACETALDEHYDE; ALCOHOL; COLLAGEN; GLUTATHIONE; GLUTATHIONE DISULFIDE; INTERLEUKIN 6; INTERLEUKIN 8; METADOXINE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER DISEASE; ALCOHOLISM; ARTICLE; CELL STRAIN HEPG2; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER CELL; LIVER CELL CULTURE; LIVER FUNCTION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; STELLATE CELL;

EID: 0035198038     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0883     Document Type: Article

References (25)

1. Effects of pyridoxine on hepatic tryptophan pyrrolase activity during chronic ethanol administration
2. Metadoxine accelerates fatty liver recovery in alcoholic patients: Results of a randomized double-blind, placebo-control trial
3. Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: Protection by metadoxine
4. Effects of metadoxine on cellular status of glutathione and of enzymatic defense system following acute ethanol intoxication in rat
5. Action of metadoxine on isolated human and rat alcohol and aldehyde dehydrogenases. Effect on enzymes in chronic ethanol-fed rats
6. 4-induced liver fibrosis. Effect of pyridoxol L,2-pyrrolidon-5 carboxylate
7. 4-treated rats
8. Metadoxine in alcohol related pathology
9. Cytokine response and oxidative stress produced by ethanol, acetaldehyde and endotoxin treatment in HepG2 cells
10. Effect of endotoxin pretreatment on hepatic stellate cell response to ethanol and acetaldehyde
11. Regulation of the alpha 2(1) collagen gene transcription in fat-storing cells derived from a cirrhotic liver
12. Rapid calorimetric assay for cellular growth and survival: Application to proliferation and citotoxicity assays
13. Effects of ethanol on hepatic protein secretion and microtubules: Possible mediation by acetaldehyde
14. Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen
15. Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase
16. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissue
17. Microsomal lipid peroxidation
18. Protein measurement with the folin phenol reagent
19. Prevention of hepatocyte injury and lipid peroxidation by iron chelators and α-tocopherol in isolated iron-loaded rat hepatocytes
20. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid
21. Oxidative damage and fibrogenesis
22. Effect of pyrrolidone carboxylate (PCA) and pyridoxine in liver ethanol metabolism during chronic ethanol intake in rats
23. Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes
24. 2 collagen gene activity by JNK in hepatic stellate cells
25. Cytokine regulation of liver injury and repair