Butein suppresses bile acid-induced hepatocyte apoptosis through a JNK-dependent but ERK-independent pathway

Planta Medica

Volumn 73, Issue 8, 2007, Pages 778-781

  Kim, So Yeon ^a   Park, Eun Jeon ^a   Zhao, Yu Zhe ^a   Dong, Hwan Sohn ^a  

^a Wonkwang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BILE ACID; BUTEIN; CASPASE 3; CASPASE 8; CASPASE 9; DNA FRAGMENT; GLYCOCHENODEOXYCHOLIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; CHALCONE DERIVATIVE; DIAGNOSTIC AGENT; PLANT EXTRACT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIVER CELL; NONHUMAN; RAT; DRUG EFFECT; HUMAN; METABOLISM; PHYTOTHERAPY; POISON IVY;

RATTUS;

APOPTOSIS; BILE ACIDS AND SALTS; CHALCONES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHYTOTHERAPY; PLANT EXTRACTS; RHUS;

EID: 34547806182     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-981547     Document Type: Article

References (20)

1. Lee JC, Lee KY, Kim J, Na CS, Jung NC, Chung GH et al. Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem Toxicol 2004; 42: 1383-8.
2. Lee JC, Lim KT, Jang YS. Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and antiapoptotic properties. Biochim Biophys Acta 2002; 1570: 181-91.
3. Chan SC, Chang YS, Wang JP, Chen SC, Kuo SC. Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera. Planta Med 1998; 64: 153-8.
4. Sogawa S, Nihro Y, Ueda H, Mild T, Matsumoto H, Satoh T. Protective effects of hydroxychalcones on free radical-induced cell damage. Biol Pharm Bull. 1994; 17:251-6.
5. Woo SW, Lee SH, Kang HC, Park EJ, Zhao YZ, Kim YC et al. Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. J Pharm Pharmacol 2003; 55: 347-52.
6. Lee SH, Nan JX, Zhao Y, Woo SW, Park EJ, Kang TH et al. The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta Med 2003; 69: 990-4.
7. Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 2005; 10: 927-39.
8. Qiao L, Yacoub A, Studer E, Gupta S, Pei XY, Grant S et al. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 2002; 35: 779-89.
9. Zeid IM, Bronk SF, Fesmier PJ, Gores GJ. Cytoprotection by fructose and other ketohexoses during bile salt-induced apoptosis of hepatocytes. Hepatology 1997; 25: 81-6.
10. Gumpricht E, Dahl R, Devereaux MW, Sokol RJ. Licorice compounds glycyrrhizin and 18β-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. J Biol Chem 2005; 280: 10556-63.
11. Graf D, Kurz AK, Fischer R, Reinehr R, Haussinger D. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Gastroenterology 2002; 122: 1411-27.
12. Satoh MS, Lindahl T. Role of poly (ADP-ribose) formation in DNA repair. Nature 1992; 356: 356-8.
13. Allen RT, Hunter WJ, Agrawal DK. Morphological and biochemical characterization and analysis of apoptosis. Pharmacol Toxicol Methods 1997; 37: 215-8.
14. Rao YP, Studer EJ, Stravitz RT, Gupta S, Qiao L, Dent P et al. Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes. Hepatology 2002; 35: 307-14.
15. Zhuang S, Schnellmann RG. A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther 2006; 319: 91-7.
16. Czaja MJ. The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death. Am J Physiol Gastrointest Liver Physiol 2003; 284: G875-9.
17. Marderstein EL, Bucher B, Guo Z, Feng X, Reid K, Geller DA. Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase. Surgery 2003; 134: 280-4.
18. Jung CH, Kim JH, Hong MH, Seog HM, Oh SH, Lee PJ et al. Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 2007; 110: 490-7.
19. Park EJ, Zhao YZ, Na M, Bae K, Kim YH, Lee BH et al. Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes. Planta Med 2003;69:33-7.
20. Park EJ, Zhao YZ, Kim YH, Lee BH, Sohn DH. Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro. Planta Med 2005; 71: 82-4.