Effect of propofol on reperfusion injury after regional ischaemia in the isolated rat heart

British Journal of Anaesthesia

Volumn 83, Issue 6, 1999, Pages 903-908

  Ebel, D ^a   Schlack, W ^a   Comfere T ^a   Preckel, B ^a   Thamer V ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Anaesthetics i.v, propofol; Heart, ischaemia; Heart, isolated preparation; Heart, myocardial function; Rat

Indexed keywords

ANESTHETIC AGENT; INTRALIPID; LIPID EMULSION; PROPOFOL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART RATE; HEART VENTRICLE VOLUME; ISOLATED HEART; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0032721338     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/83.6.903     Document Type: Article

References (36)

1. Simpson PJ, Mickelson JK, Lucchesi BR. Free radical scavengers in myocardial ischemia. Fed Proc 1987; 46: 2413-21
2. Rosenkranz ER, Buckberg GD. Myocardial protection during surgical coronary reperfusion. J. Am Coll Cardiol of 1983; 1: 1235-46
3. Kloner RA, Przyklenk K, Whittaker P. Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues. Circulation 1989; 80: 1115-27
4. Jolly SR, Kane WJ, Bailie MB, Abrams GD, Lucchesi BR. Canine myocardial reperfusion injury: its reduction by the combined administration of superoxide dismutase and catalase. Circ Res 1984; 54: 277-85
5. Mitsos SE, Askew TE, Fantone JC, et al. Protective effects of N-2-mercaptopropionyl glycine against myocardial reperfusion injury after neutrophil depletion in the dog: evidence for the role of intracellular-derived free radicals. Circulation 1986; 73: 1077-86
6. Mitsos SE, Fantone JC, Gallagher KP, et al. Myocardial reperfusion injury: protection by a free radical scavenger, N-2-mercaptopropionyl glycine. J Cardiovasc Pharmacol 1986; 8: 978-88
7. Siegmund B, Schüter KD, Piper HM. Calcium and the oxygen paradox. Cardiovasc Res 1993; 27: 1778-83
8. Kokita N, Hara A. Propofol attenuates hydrogen peroxide-induced mechanical and metabolic derangements in the isolated rat heart Anesthesiology 1996; 84: 117-27
9. Puttick RM, Terrar DA. Differential effects of propofol and enflurane on contractions dependent on calcium derived from the sarcoplasmic reticulum of guinea pig isolated papillary muscles. Anesth Analg 1993; 77: 55-60
10. Cook DJ, Housmans PR. Mechanism of the negative inotropic effect of propofol in isolated ferret ventricular myocardium. Anesthesiology 1994; 80: 859-71
11. Puttick RM, Terrar DA. Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea-pig isolated ventricular myocytes. Br J Pharmacol 1992; 107: 559-65
12. Zhou W, Fontenot HJ, Liu S, Kennedy RH. Modulation of cardiac calcium channels by propofol. Anesthesiology 1997; 86: 670-5
13. Yamanoue T, Brum JM, Estafanous FG. Vasodilation and mechanism of action of propofol in porcine coronary artery. Anesthesiology 1994; 81: 443-51
14. 2+ channel blocker. Anesth Analg 1993; 76: 24-32
15. Tadokoro H, Miyazaki A, Satomura K, et al. Infarct size reduction with coronary venous retroinfusion of diltiazem in the acute occlusion/reperfusion porcine heart model. J Cardiovasc Pharmacol 1996; 28: 134-41
16. Herzog WR, Vogel RA, Schlossberg ML, Edenbaum LR, Scott HJ, Serebruany VL Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size. Int J Cardiol 1997; 59: 21-7
17. Bailey JM, Mora CT, Shafer SL. Pharmacokinetics of propofol in adult patients undergoing coronary revascularization. The Multicenter Study of Perioperative Ischemia Research Group. Anesthesiology 1996; 84: 1288-97
18. Kloner RA. Does reperfusion injury exist in human? J Am Coll Cardiol 1993; 21: 537-45
19. Simpson PJ, Lucchesi BR. Free radicals and myocardial ischemia and reperfusion injury. J Lab Clin Med 1987; 110: 13-30
20. Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (Diprivan) in elderly patients. Br J Anaesth 1988; 60: 146-50
21. Park KW, Dai HB, Lowenstein E, Sellke F. Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide. Anesth Analg 1995; 81: 1191-6
22. Schlack W, Uebing A, Schäfer M, et al. Intracoronary SIN-IC during reperfusion reduces infarct size in dog. J Cardiovasc Pharmacol 1995; 25: 424-31
23. Schlack W, Uebing A, Schäfer M, et al. Regional contractile blockade at the onset of reperfusion reduces infarct size in the dog heart. Pflügers Arch Eur J Physiol 1994; 428: 134-41
24. de Wolff MH, Nagels W, Leunens V, Vandermeersch E, Wouters PF. Effect of propofol on recovery from stunning in isolated rabbit hearts. Anesthesiology 1997; 87: A504
25. Ross S, Munoz H, Piriou V, Ryder WA, Foex P. A comparison of the effects of fentanyl and propofol on left ventricular contractility during myocardial stunning. Acta Anaesthesiol Scand 1998; 42: 23-31
26. Garcia-Dorado D, Inserte J, Ruiz-Meana M, et al. Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Ciculation 1997; 96: 3579-86
27. Liu X, Tosaki A, Engelman RM, Das DK. Salicylate reduces ventricular dysfunction and arrhythmias during reperfusion in isolated rat hearts. J Cardiovasc Pharmacol 1992; 19: 209-15
28. Schluter KD, Schwartz P, Siegmund B, Piper HM. Prevention of oxygen paradox in hypoxic-reoxygenated hearts. Am J Physiol 1991; 261: H416-23
29. Ko SH, Yu CW, Lee SK, et al. Propofol attenuates ischemia-reperfusion injury in the isolated rat heart. Anesth Analg 1997; 85: 719-24
30. Schulz R, Rose J, Skyschally A, Heusch G. Bradycardic agent UL-FS 49 attenuates ischemic regional myocardial dysfunction and reduces infarct size in swine: Comparison with the β-blocker atenolol. J Cardiovasc Pharmacol 1995; 25: 216-28
31. Nayler WG. Basic mechanisms involved in the protection of the ischaemic myocardium. The role of calcium antagonists. Drugs 1991; 42: 21-7
32. Schlack W, Ebel D, Grunert S, Halilovic S, Meyer O, Thämer V. Effect of heart rate reduction by 4-(N-ethyl-N-phenylamino)1,2-dimethyl-6-(methylamino) pyrimidinium chloride on infarct size in dog. Drug Res 1997; 48: 26-33
33. Kamikawa T, Yamazaki N. Effect of high plasma free fatty acids on the free radical formation of myocardial mitochondria isolated from ischemic dog hearts. Jpn Heart J 1981; 22: 939-49
34. Schlack W, Preckel B, Barthel H, Obal D, Thämer V. Halothane reduces reperfusion injury after regional ischaemia in the rabbit heart in vivo. Br J Anaesth 1997; 79: 88-96
35. Preckel B, Schlack W, Comfère T, Obal D, Barthel H, Thämer V. Influence of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo. Br J Anaesth 1998; 81: 905-12
36. Schlack W, Preckel B, Stunneck D, Thämer V. Effects of halothane, enflurane, isoflurane, sevoflurane and desflurane on myocardial reperfusion injury in the isolated rat heart. Br J Anaesth 1998; 81: 913-9