Propofol attenuates ischemia-reperfusion injury in the isolated rat heart

Anesthesia and Analgesia

Volumn 85, Issue 4, 1997, Pages 719-724

  Ko, Seong Hoon ^a   Yu, Choon Won ^a   Lee, Sang Kyi ^a   Choe, Huhn ^a   Chung, Myoung Ja ^a   Kwak, Yong Geun ^a   Chae, Soo Wan ^a   Song, He Sun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

INTRALIPID; LACTATE DEHYDROGENASE; PROPOFOL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HISTOPATHOLOGY; INTRAVENOUS ANESTHESIA; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STUNNED HEART MUSCLE;

ANESTHETICS, INTRAVENOUS; ANIMALS; CORONARY CIRCULATION; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 0030813065     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199710000-00002     Document Type: Article

References (30)

1. Sorbaza C, Pittarello D, Rizzoli G, et al. Propofol-fentanyl versus isoflurane-fentanyl anesthesia for coronary artery bypass grafting: effects on myocardial contractility and peripheral hemodynamics. J Cardiothorac Vasc Anesth 1995;9:18-23.
2. Higgins TL, Yared J, Estafanous FG, et al. Propofol versus midazolam for intensive care unit sedation after coronary artery bypass grafting. Crit Care Med 1994;22:1415-23.
3. Bolli R. Mechanism of myocardial "stunning." Circulation 1990; 82:723-31.
4. Murphy PG, Myers DS, Davies MJ, et al. The antioxidant potential of propofol (2,6-diisopropylphenol). Br J Anaesth 1992; 68:613-8.
5. Cook DJ, Housmans PR. Mechanism of the negative inotropic effect of propofol in isolated ferret ventricular myocardium. Anesthesiology 1994;80:859-71.
6. Yang C, Wong C, Yu C, et al. Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes. Anesthesiology 1996;84:626-35.
7. Legrand C, Bour JM, Jacob C, et al. Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium. J Biotechnol 1992;25: 231-43.
8. Lucchesi BR. Myocardial ischemia, reperfusion and free radical injury. Am J Cardiol 1990;65:141-231.
9. Hess ML, Manson NH. Molecular oxygen: friend and foe - the role of the oxygen free radical system in the calcium paradox and ischemia/reperfusion injury. J Mol Cell Cardiol 1984;16: 969-85.
10. Nakaya H, Tohse N, Kanno M. Electrophysiological derangements induced by lipid peroxidation in cardiac tissue. Am J Physiol 1987;253:H1089-97.
11. Josephson RA, Silverman HS, Lakatta EG, et al. Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J Biol Chem 1991;266:2354-61.
12. Hara A, Matsumura H, Abiko Y. Lidocaine attenuates both mechanical and metabolic changes induced by hydrogen peroxide in the rat heart. Am J Physiol 1993;265:H1478-85.
13. Kokita N, Hara A. Propofol attenuates hydrogen peroxide-induced mechanical and metabolic derangements in the isolated rat heart. Anesthesiology 1996;84:117-27.
14. Woodward B, Zakaria MVM. Effect of some free radical scavengers on reperfusion induced arrhythmias in the isolated rat heart. J Mol Cell Cardiol 1985;17:485-93.
15. Eriksson O, Pollesello P, Saris NEL. Inhibition of lipid peroxidation in isolated rat liver mitochondria by the general anesthetic propofol. Biochem Pharmacol 1992;44:391-3.
16. Steenbergen C, Murphy E, Watts JA, London RE. Correlation between cytosolic free calcium, contracture, ATP and irreversible ischemic injury in perfused rat heart. Circ Res 1990;66: 135-46.
17. Lefer AM, Tsao PS, Lefer DJ, Ma X-L. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia. FASEB J 1991;5:2029-34.
18. Park KW, Dai HB, Lowenstein E, Sellke FW. Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide. Anesth Analg 1995;81:1191-6.
19. 2+ channel blocker. Anesth Analg 1993;76:24-32.
20. Pabla R, Curtis MJ. Endogenous protection against reperfusion-induced ventricular fibrillation: role of neuronal versus non-neuronal sources of nitric oxide and species dependence in the rat versus rabbit isolated heart. J Mol Cell Cardiol 1996;28: 2097-110.
21. Bernstein EA, Eberli FR, Silverman AM, et al. Beneficial effects of felodifine on myocardial and coronary function during low-flow ischemia and reperfusion. Cardiovasc Drugs Ther 1996;10: 167-78.
22. Nayler WG, Fassold E, Yepez C. Pharmacological protection of mitochondrial function in hypoxic heart muscle: effect of verapamil, propranolol and methylprednisolone. Cardiovasc Res 1978;12:152-61.
23. Labovitz AJ, Barth C, Castello R, et al. Attenuation of myocardial ischemia during coronary occlusion by ultrashort-acting beta adrenergic blockade. Am Heart J 1991;121:1347-52.
24. Freedman BM, Hamm DP, Everson CT, et al. Enflurane enhances postischemic functional recovery in the isolated rat heart. Anesthesiology 1985;62:29-33.
25. Marijic J, Stowe DF, Turner LA, et al. Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart. Anesthesiology 1990;73:976-83.
26. Schlack W, Hollmann M, Stunneck J, Thämer V. Effect of halothane on myocardial reoxygenation injury in the isolated rat heart. Br J Anaesth 1996;76:860-7.
27. Cockshott ID. Propofol (Diprivan) pharmacokinetics and metabolism: an overview. Postgrad Med J 1985;61(Suppl 3): 45-50.
28. Morgan DJ, Campbell GA, Crankshaw DP. Pharmacokinetics of propofol when given by intravenous infusion. Br J Clin Pharmacol 1990;30:144-8.
29. Stephan H, Sonntag H, Schenk HD, et al. Effects of propofol on cardiovascular dynamics, myocardial blood flow and myocardial metabolism in patients with coronary artery disease. Br J Anaesth 1986;58:969-75.
30. Mayer N, Legat K, Weinstabl C, Zimpfer M. Effects of propofol on the function of normal, collateral-dependent, and ischemic myocardium. Anesth Analg 1993;76:33-9.