Dysfunctional mitochondrial dynamics in the pathophysiology of neurodegenerative diseases

Journal of Cell Death

Volumn 6, Issue 1, 2013, Pages 27-35

  Haun, Florian ^a,b,c,d   Nakamura, Tomohiro ^a   Lipton, Stuart A ^a  

^a BURNHAM INSTITUTE   (United States)

^b Institute of Molecular Medicine and Cell Research   (Germany)

^c Spemann Graduate School of Biology and Medicine   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Dendritic spine loss; GTPase; Mitochondrial dysfunction; Neurodegeneration; Reactive nitrogen species; S nitrosothiol

Indexed keywords

AMYLOID BETA PROTEIN; DYNAMIN RELATED PROTEIN 1; MITOCHONDRIAL PROTEIN; REACTIVE NITROGEN SPECIES; SUMO 1 PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AUTOSOMAL DOMINANT OPTIC ATROPHY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUNTINGTON CHOREA; MITOCHONDRIAL DYNAMICS; NITROSYLATION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION;

EID: 84880935418     PISSN: None     EISSN: 11790660     Source Type: Journal    
DOI: 10.4137/JCD.S10847     Document Type: Review

References (55)

1. Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science. 2012;337(6098):1062-1065.
2. Hoppins S, Nunnari J. The molecular mechanism of mitochondrial fusion. Biochim Biophys Acta. 2009;1793(1):20-26.
3. Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol. 2010;11(12):872-884.
4. Sheng ZH, Cai Q. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci. 2012;13:77-93.
5. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci. 2008;9(7): 505-518.
6. Olichon A, Guillou E, Delettre C, et al. Mitochondrial dynamics and disease, OPA1. Biochim Biophys Acta. 2006;1763(5-6):500-509.
7. Su B, Wang X, Zheng L, Perry G, Smith M, Zhu X. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta. 2010;1802(1):135-142.
8. Shirendeb U, Reddy AP, Manczak M, et al. Abnormal mitochondrial dynamics, mitochondrial loss, and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage. Hum Mol Genet. 2011;20(7):1438-1455.
9. Zuchner S, Mersiyanova IV, Muglia M, et al. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet. 2004;36(5):449-451.
10. Alexander C, Votruba M, Pesch UE, et al. OPA1, encoding a dynaminrelated GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat Genet. 2000;26(2):211-215.
11. Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, Leonard JV. A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med. 2007;356(17):1736-1741.
12. Cho D-H, Nakamura T, Fang J, et al. S-Nitrosylation of Drp1 Mediates b-Amyloid-Related Mitochondrial Fission and Neuronal Injury. Science. 2009;324(5923):102-105.
13. Wang X, Su B, Lee HG, et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci. 2009;29(28):9090-9103.
14. Reilly MM, Murphy SM, Laurá M. Charcot-Marie-Tooth disease. J Peripher Nerv Syst. 2011;16(1):1-14.
15. Lawson VH, Graham BV, Flanigan KM. Clinical and electrophysiologic features of CMT2A with mutations in the mitofusin 2 gene. Neurology. 2005;65(2):197-204.
16. Chen H, Vermulst M, Wang YE, et al. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010;141(2):280-289.
17. Misko A, Jiang S, Wegorzewska I, Milbrandt J, Baloh RH. Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/ Milton complex. J Neurosci. 2010;30(12):4232-4240.
18. Ferré M, Amati-Bonneau P, Tourmen Y, Malthiéry Y, Reynier P. eOPA1: an online database for OPA1 mutations. Hum Mutat. 2005;25(5):423-428.
19. Davies VJ, Hollins AJ, Piechota MJ, et al. Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function. Hum Mol Genet. 2007;16(11)1307-1318.
20. Lee YJ, Jeong SY, Karbowski M, L SC, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol C. 2004;15(11):5001-5011.
21. Olichon A, Baricault L, Gas N, et al. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem. 2003;278(10):7743-7746.
22. Cho DH, Nakamura T, Lipton SA. Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci. 2010;67(20):3435-3447.
23. Ford MG, Jenni S, Nunnari J. The crystal structure of dynamin. Nature. 2011;477(7366):561-566.
24. Faelber K, Posor Y, Gao S, et al. Crystal structure of nucleotide-free dynamin. Nature. 2011;477(7366):556-560.
25. Chang CR, Manlandro CM, Arnoult D, et al. A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. J Biol Chem. 2010;285(42):32494-32503.
26. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K. Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem. 2007;282(15):11521-11529.
27. Cribbs JT, Strack S. Reversible phosphorylation of Drp1 by cyclic AMPdependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep. 2007;8(10):939-944.
28. Cereghetti GM, Stangherlin AM, de Brito O et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A. 2008;105(41):15803-15808.
29. Han XJ, Lu YF, Li SA, et al. CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol. 2008;182(3):573-585.
30. Figueroa-Romero C, Iniguez-Lluh JA, Stadler J, et al. SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J. 2009;23(11):3917-3927.
31. Braschi E, Zunino R, McBride HM. MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 2009;10(7):748-754.
32. Zunino R, Schauss A, Rippstein P, Andrade-Navarro M, McBride HM. The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J Cell Sci. 2007;120(7):1178-1188.
33. Zappia M, Braschi E, Xu L, McBride HM. Translocation of SENP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. J Biol Chem.2009;284(26):17783-17795.
34. Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep. 2006;7(10):1019-1022.
35. Yonashiro R, Ishido S, Kyo S, et al. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J. 2006;25(15):3618-3626.
36. Karbowski M, Neutzner A, Youle RJ. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol. 2007;178(1):71-84.
37. Wang H, Song P, Du L, et al. Parkin ubiquitinates Drp1 for proteasomedependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem. 2011;286(13):11649-11658.
38. Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998;392(6676):605-608.
39. Solano SM, Miller DW, Augood SJ, et al. Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease. Ann Neurol. 2000;47(2):201-210.
40. Nakamura T, Lipton SA. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death Differ. 2011;18(9):1478-1476.
41. Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS. Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol. 2005;6(2): 150-166.
42. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991;351(6329):714-718.
43. Brenman JE, Chao DS, Gee SH, et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell. 1996;84(5):757-767.
44. Chung KK, Thomas B, Li X, et al. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science. 2004;304(5675):1328-1331.
45. Uehara T, Nakamura T, Yao D, et al. S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 2006; 441(7092):513-517.
46. Yao D, Gu Z, Nakamura T, et al. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A. 2004;101(29):10810-10814.
47. Barsoum MJ, Yuan H, Gerencser AA, et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006;25(16):3900-3911.
48. Brennan AM, Suh SW, Won SJ, et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci. 2009;12(7):857-863.
49. Lipton SA, Choi YB, Pan ZH, et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and realted nitroso-compounds. Nature. 1993;364(6438):626-632.
50. Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A. Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med. 2001; 30(5):463-488.
51. Manczak M, Calkins MJ, Reddy PH. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet. 2011;20(13):2495-2509.
52. Wang X, Su B, Siedlak SL, et al. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins Proc Natl Acad Sci U S A. 2008;105(49): 19318-19323.
53. Okamoto S, Pouladi MA, Talantova M, et al. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med. 2009;15(12):1407-1413.
54. Haun F, Nakamura T, Shiu AD, et al. S-Nitrosylation of Drp1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal. 2013 June 20, [Epub ahead of print].
55. Qu J, Nakamura T, Cao G, et al. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. Proc Natl Acad Sci U S A. 2011;108(34):14330-14335.