Increased expression of DNA methyltransferase 3a in obese adipose tissue: Studies with transgenic mice

Obesity

Volumn 18, Issue 2, 2010, Pages 314-321

  Kamei, Yasutomi ^a   Suganami, Takayoshi ^a   Ehara, Tatsuya ^a   Kanai, Sayaka ^a   Hayashi, Koji ^b   Yamamoto, Yuji ^c   Miura, Shinji ^d   Ezaki, Osamu ^d   Okano, Masaki ^e   Ogawa, Yoshihiro ^a  

^a Tokyo Medical and Dental University ^*  (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^d NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^e RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CCL2 PROTEIN, MOUSE; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; FATTY ACID BINDING PROTEIN; INTERFERON REGULATORY FACTOR 9; MEMBRANE PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SFRP1 PROTEIN, MOUSE; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL; ARTICLE; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DNA METHYLATION; DNA MICROARRAY; ENZYMOLOGY; FAT INTAKE; GENE EXPRESSION PROFILING; GENETICS; GENOTYPE; MALE; METABOLISM; METHODOLOGY; MOUSE; OBESITY; PATHOLOGY; PHENOTYPE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; TRANSGENIC MOUSE; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; CHEMOKINE CCL2; DIETARY FATS; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FATTY ACID-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENOTYPE; INFLAMMATION MEDIATORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

MUS; MUS MUSCULUS;

EID: 75749127447     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.246     Document Type: Article

References (20)

1. Bouchard C, Tremblay A, Després JP et al. The response to long-term overfeeding in identical twins. N Engl J Med 1990;322:1477-1482.
2. Koza RA, Nikonova L, Hogan J et al. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet 2006;2:e81.
3. Takahashi M, Kamei Y, Ezaki O. Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab 2005;288:E117-E124.
4. Nikonova L, Koza RA, Mendoza T et al. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 2008;22:3925-3937.
5. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-257.
6. Wolff GL, Kodell RL, Moore SR, Cooney CA. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J 1998;12:949-957.
7. Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005;135:1382-1386.
8. Linhart HG, Lin H, Yamada Y et al. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev 2007;21:3110-3122.
9. Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 2005;25:2062-2068.
10. Toyoda T, Kamei Y, Kato H et al. Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue. Obesity (Silver Spring) 2008;16:1199-1207.
11. Ito A, Suganami T, Miyamoto Y et al. Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy. J Biol Chem 2007;282:25445-25452.
12. Kamei Y, Suganami T, Kohda T et al. Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS Lett 2007;581:91-96.
13. Sakamoto S, Potla R, Larner AC. Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. J Biol Chem 2004;279:40362-40367.
14. Suetake I, Shinozaki F, Miyagawa J, Takeshima H, Tajima S. DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction. J Biol Chem 2004;279:27816-27823.
15. Fuks F. DNA methylation and histone modifications: teaming up to silence genes. Curr Opin Genet Dev 2005;15:490-495.
16. Suzuki M, Yamada T, Kihara-Negishi F et al. Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. Oncogene 2006;25:2477-2488.
17. Gallais R, Demay F, Barath P et al. Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol Endocrinol 2007;21:2085-2098.
18. Oda M, Yamagiwa A, Yamamoto S et al. DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev 2006;20:3382-3394.
19. Oka M, Rodic N, Graddy J, Chang LJ, Terada N. CpG sites preferentially methylated by Dnmt3a in vivo. J Biol Chem 2006;281:9901-9908.
20. Abe M, Matsuda M, Kobayashi H et al. Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages. Arterioscler Thromb Vasc Biol 2008;28:871-877.