Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

Cell Communication and Signaling

Volumn 11, Issue 1, 2013, Pages

  Krüger, Janine ^a   Trappiel, Manuela ^a   Dagnell, Markus ^b   Stawowy, Philipp ^c   Meyborg, Heike ^c   Böhm, Christian ^a   Bhanot, Sanjay ^d   Östman, Arne ^b   Kintscher, Ulrich ^a   Kappert, Kai ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^d ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense oligonucleotides; Density enhanced phosphatase 1; Insulin receptor; Insulin resistance; Insulin signaling; Metabolic tissues; Obesity; Protein tyrosine phosphatase; Type 2 diabetes

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DENSITY ENHANCED PHOSPHATASE 1; GLUCOSE; GLUCOSTERIL; INSULIN; INSULIN RECEPTOR; ISIS 141923; ISIS 285564; LEPTIN; PHOSPHOROTHIOIC ACID; PROTEIN TYROSINE PHOSPHATASE; RECOMBINANT ENZYME; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; TYROSINE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; DRUG ACCUMULATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME REPRESSION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; METABOLIC DISORDER; METABOLISM; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CELL LINE; LIVER;

MUS;

ADIPOSE TISSUE; ANIMALS; CELL LINE; DIET, HIGH-FAT; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE, INBRED C57BL; MUSCLE, SKELETAL; OBESITY; OLIGONUCLEOTIDES, ANTISENSE; ORGAN SPECIFICITY; PHENOTYPE; PHOSPHORYLATION; RECEPTOR, INSULIN; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84880855092     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-11-49     Document Type: Article

References (44)

1. Pathophysiology of insulin resistance in human disease. Reaven GM, Physiol Rev 1995 75 473 486
2. Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans. Stull AJ, Wang ZQ, Zhang XH, Yu Y, Johnson WD, Cefalu WT, Diabetes 2012 61 1415 1422
3. Protein tyrosine phosphatases in the human genome. Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T, Cell 2004 117 699 711 (Pubitemid 38748887)
4. Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance. Xu E, Charbonneau A, Rolland Y, Bellmann K, Pao L, Siminovitch KA, Neel BG, Beauchemin N, Marette A, Diabetes 2012 61 1949 1958
5. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. Ahmad F, Azevedo JL, Cortright R, Dohm GL, Goldstein BJ, J Clin Invest 1997 100 449 458 (Pubitemid 27349093)
6. Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue. Ahmad F, Considine RV, Bauer TL, Ohannesian JP, Marco CC, Goldstein BJ, Metabolism 1997 46 1140 1145 (Pubitemid 27418501)
7. Protein tyrosine phosphatases: the quest for negative regulators of insulin action. Asante-Appiah E, Kennedy BP, Am J Physiol Endocrinol Metab 2003 284 663 E670
8. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI, et al. Nat Med 2006 12 549 556
9. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, et al. Science 1999 283 1544 1548
10. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, et al. Mol Cell Biol 2000 20 5479 5489 (Pubitemid 30482885)
11. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. Bandyopadhyay D, Kusari A, Kenner KA, Liu F, Chernoff J, Gustafson TA, Kusari J, J Biol Chem 1997 272 1639 1645 (Pubitemid 27043246)
12. Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. Ahmad F, Li PM, Meyerovitch J, Goldstein BJ, J Biol Chem 1995 270 20503 20508
13. Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys. Swarbrick MM, Havel PJ, Levin AA, Bremer AA, Stanhope KL, Butler M, Booten SL, Graham JL, McKay RA, Murray SF, et al. Endocrinology 2009 150 1670 1679
14. Inhibition of the protein tyrosine phosphatase SHP-1 increases glucose uptake in skeletal muscle cells by augmenting insulin receptor signaling and GLUT4 expression. Bergeron S, Dubois MJ, Bellmann K, Schwab M, Larochelle N, Nalbantoglu J, Marette A, Endocrinology 2011 152 4581 4588
15. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. Zhang S, Zhang ZY, Drug Discov Today 2007 12 373 381 (Pubitemid 46636379)
16. Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice. Pandey SK, Yu XX, Watts LM, Michael MD, Sloop KW, Rivard AR, Leedom TA, Manchem VP, Samadzadeh L, McKay RA, et al. J Biol Chem 2007 282 14291 14299 (Pubitemid 47100476)
17. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, et al. Proc Natl Acad Sci USA 2002 99 11357 11362 (Pubitemid 34920930)
18. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Ostman A, Yang Q, Tonks NK, Proc Natl Acad Sci USA 1994 91 9680 9684 (Pubitemid 24311871)
19. DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. Balavenkatraman KK, Jandt E, Friedrich K, Kautenburger T, Pool-Zobel BL, Ostman A, Bohmer FD, Oncogene 2006 25 6319 6324 (Pubitemid 44564747)
20. Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation. Kappert K, Paulsson J, Sparwel J, Leppanen O, Hellberg C, Ostman A, Micke P, FASEB J 2007 21 523 534 (Pubitemid 46213499)
21. Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. Kovalenko M, Denner K, Sandstrom J, Persson C, Gross S, Jandt E, Vilella R, Bohmer F, Ostman A, J Biol Chem 2000 275 16219 16226 (Pubitemid 30366934)
22. Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. Palka HL, Park M, Tonks NK, J Biol Chem 2003 278 5728 5735 (Pubitemid 36800817)
23. Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. a brute force approach based on "substrate-trapping" mutants. Walchli S, Curchod ML, Gobert RP, Arkinstall S, Hooft Van Huijsduijnen R, J Biol Chem 2000 275 9792 9796 (Pubitemid 30185214)
24. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB, J Biol Chem 2008 283 14230 14241
25. Antisense oligonucleotide pharmacokinetics and metabolism. Geary RS, Expert Opin Drug Metab Toxicol 2009 5 381 391
26. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Tarcic G, Boguslavsky SK, Wakim J, Kiuchi T, Liu A, Reinitz F, Nathanson D, Takahashi T, Mischel PS, Ng T, Yarden Y, Curr Biol 2009 19 1788 1798
27. The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. Iervolino A, Iuliano R, Trapasso F, Viglietto G, Melillo RM, Carlomagno F, Santoro M, Fusco A, Cancer Res 2006 66 6280 6287
28. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E, J Cell Biol 2006 174 593 604 (Pubitemid 44231870)
29. The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase. Tsuboi N, Utsunomiya T, Roberts RL, Ito H, Takahashi K, Noda M, Takahashi T, Biochem J 2008 413 193 200 (Pubitemid 351946875)
30. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. Omerovic J, Clague MJ, Prior IA, Biochem J 2010 426 65 72
31. Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. Sacco F, Tinti M, Palma A, Ferrari E, Nardozza AP, Hooft Van Huijsduijnen R, Takahashi T, Castagnoli L, Cesareni G, J Biol Chem 2009 284 22048 22058
32. Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM, Diabetes 2003 52 21 28 (Pubitemid 36042103)
33. Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase. Takahashi K, Mernaugh RL, Friedman DB, Weller R, Tsuboi N, Yamashita H, Quaranta V, Takahashi T, Proc Natl Acad Sci USA 2012 109 1985 1990
34. Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Varma V, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, Nolen GT, Kern EM, Nagarajan R, Spencer HJ 3rd, Lee MJ, et al. Diabetes 2008 57 432 439
35. Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. Foryst-Ludwig A, Clemenz M, Hohmann S, Hartge M, Sprang C, Frost N, Krikov M, Bhanot S, Barros R, Morani A, et al. PLoS Genet 2008 4 1000108
36. Diet-induced thermogenesis in cafeteria-fed rats: a myth? Maxwell GM, Nobbs S, Bates DJ, Am J Physiol 1987 253 264 E270
37. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE, Diabetes 2012 61 2495 2505
38. Adiponectin: action, regulation and association to insulin sensitivity. Lihn AS, Pedersen SB, Richelsen B, Obes Rev 2005 6 13 21
39. Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin. Christiansen T, Paulsen SK, Bruun JM, Ploug T, Pedersen SB, Richelsen B, J Clin Endocrinol Metab 2010 95 911 919
40. Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet. Kovacova Z, Vitkova M, Kovacikova M, Klimcakova E, Bajzova M, Hnevkovska Z, Rossmeislova L, Stich V, Langin D, Polak J, Eur J Endocrinol 2009 160 585 592
41. Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study. Madsen EL, Rissanen A, Bruun JM, Skogstrand K, Tonstad S, Hougaard DM, Richelsen B, Eur J Endocrinol 2008 158 179 187 (Pubitemid 351298534)
42. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Muller S, Knapp S, Cell 2009 136 352 363
43. Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility. Petermann A, Haase D, Wetzel A, Balavenkatraman KK, Tenev T, Guhrs KH, Friedrich S, Nakamura M, Mawrin C, Bohmer FD, Brain Pathol 2011 21 405 418
44. Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis. Trapasso F, Drusco A, Costinean S, Alder H, Aqeilan RI, Iuliano R, Gaudio E, Raso C, Zanesi N, Croce CM, Fusco A, DNA Cell Biol 2006 25 376 382 (Pubitemid 43954568)